Response Characteristics of Spinal Cord Dorsal Horn Neurons in
... 10.1152/jn.00121.2004. The physiological mechanisms of chronic pain in patients with spinal cord injury (SCI) are poorly understood. In the present study, we explored response characteristics of dorsal horn neurons of spinally injured rats exhibiting chronic pain (pain-like response to innocuous mec ...
... 10.1152/jn.00121.2004. The physiological mechanisms of chronic pain in patients with spinal cord injury (SCI) are poorly understood. In the present study, we explored response characteristics of dorsal horn neurons of spinally injured rats exhibiting chronic pain (pain-like response to innocuous mec ...
Report - Ben Hayden
... how neuronal activity in CGp contributes to the neural processes that link specific reward outcomes to individual decisions. To do this, we analyzed the activity of 58 neurons in 2 monkeys (32 in monkey N and 26 in monkey B; data from 42 of these was analyzed in McCoy and Platt [2005]). Figure 2A sh ...
... how neuronal activity in CGp contributes to the neural processes that link specific reward outcomes to individual decisions. To do this, we analyzed the activity of 58 neurons in 2 monkeys (32 in monkey N and 26 in monkey B; data from 42 of these was analyzed in McCoy and Platt [2005]). Figure 2A sh ...
Optogenetic Brain Interfaces
... research to treat mental disease by speaking the electrical language of neurons, usually known as interventional psychiatry. Deep-brain stimulation (DBS) [2], [3] is an example of this approach which has been reasonably successful in treating some neurological diseases including Parkinson’s. Nonethe ...
... research to treat mental disease by speaking the electrical language of neurons, usually known as interventional psychiatry. Deep-brain stimulation (DBS) [2], [3] is an example of this approach which has been reasonably successful in treating some neurological diseases including Parkinson’s. Nonethe ...
BioCapture™ : Acquiring EEG data Quick Notes
... These patterns have particular frequency ranges and are associated with different states of brain function (e.g., waking and various levels of sleep). These patterns represent synchronized activity over a network of neurons. Delta waves are the slowest of the known EEG frequencies—no faster than 4 H ...
... These patterns have particular frequency ranges and are associated with different states of brain function (e.g., waking and various levels of sleep). These patterns represent synchronized activity over a network of neurons. Delta waves are the slowest of the known EEG frequencies—no faster than 4 H ...
View PDF - MRC Brain Network Dynamics Unit
... below the dura) correspond to layers 5/6 of the primary/secondary motor cortices (Paxinos and Watson, 1986). For thalamic stimulation, we used coordinates (3.7 mm posterior and 1.3 mm lateral of bregma, at depths of 5.4 –5.7 mm below the dura) that consistently led to an electrode track in the paraf ...
... below the dura) correspond to layers 5/6 of the primary/secondary motor cortices (Paxinos and Watson, 1986). For thalamic stimulation, we used coordinates (3.7 mm posterior and 1.3 mm lateral of bregma, at depths of 5.4 –5.7 mm below the dura) that consistently led to an electrode track in the paraf ...
Turning on the alarm - Center for Healthy Minds
... be very steep). For comparison with a basic linear temperature response model, we separately fit a linear model to the same series of 6 BOLD response magnitudes. For both models, a voxelwise goodness of fit statistic was also computed, R 2, which indicates the variance in BOLD response across differen ...
... be very steep). For comparison with a basic linear temperature response model, we separately fit a linear model to the same series of 6 BOLD response magnitudes. For both models, a voxelwise goodness of fit statistic was also computed, R 2, which indicates the variance in BOLD response across differen ...
Behavioral verification of associative learning in whisker
... measured reliably. The whisker stimulator in this procedure offers a good tool for time controlled stimulation. However, it is not really useful if it is required to determine precisely which whisker is being deflected. Stimulation of specific whiskers can be achieved only by trimming the undesired ...
... measured reliably. The whisker stimulator in this procedure offers a good tool for time controlled stimulation. However, it is not really useful if it is required to determine precisely which whisker is being deflected. Stimulation of specific whiskers can be achieved only by trimming the undesired ...
Repetitive Transcranial Magnetic Stimulation of the Right
... changes in monoamines (14). TMS has been shown to have some antidepressant-like effects (15–18). In a prior open pilot study (19), one session of slow TMS with 30-m/sec pulses, 15 stimuli to each side of the vertex, was found to be effective in lowering the core PTSD symptom of avoidance, as well as ...
... changes in monoamines (14). TMS has been shown to have some antidepressant-like effects (15–18). In a prior open pilot study (19), one session of slow TMS with 30-m/sec pulses, 15 stimuli to each side of the vertex, was found to be effective in lowering the core PTSD symptom of avoidance, as well as ...
Corina Wirth and Hans
... Since the discovery of the “barrel” map in the rodent somatosensory cortex by Woolsey and Van der Loos (1970), the barrels were regarded as a manifestation of the cortical columns in layer 4 (L4). It turned out that this structure is a well-suited model for investigating sensory information processi ...
... Since the discovery of the “barrel” map in the rodent somatosensory cortex by Woolsey and Van der Loos (1970), the barrels were regarded as a manifestation of the cortical columns in layer 4 (L4). It turned out that this structure is a well-suited model for investigating sensory information processi ...
NIH Public Access
... sequence for enhanced yellow fluorescence protein (EYFP, Supplementary Fig. 1a)8 into V1 of a knock-in mouse line expressing Cre-recombinase under the PV promoter (PV-ChR2, see Methods)9,10. Three weeks after injection, immunostaining confirmed EYFP expression specific to PV+ neurons (Fig. 1a). To m ...
... sequence for enhanced yellow fluorescence protein (EYFP, Supplementary Fig. 1a)8 into V1 of a knock-in mouse line expressing Cre-recombinase under the PV promoter (PV-ChR2, see Methods)9,10. Three weeks after injection, immunostaining confirmed EYFP expression specific to PV+ neurons (Fig. 1a). To m ...
pain and emotion interactions in subregions of the cingulate gyrus
... according to two cognitive domains3. The sensorydiscriminative domain involves stimulus localization and intensity, which can be assessed in a number of ways, including using the visual analogue scale, whereas the affective-motivational domain involves the affective component of pain, which can be m ...
... according to two cognitive domains3. The sensorydiscriminative domain involves stimulus localization and intensity, which can be assessed in a number of ways, including using the visual analogue scale, whereas the affective-motivational domain involves the affective component of pain, which can be m ...
physiology of pain – general mechanisms and individual differences
... continuous interaction between complex systems. Pain perception can be modulated or adjusted according to the emotional behavior of the subject – focusing on the pain leads to higher pain intensity, while positive thinking relieves some of the pain. Also, in certain cases (such as chronic back pain) ...
... continuous interaction between complex systems. Pain perception can be modulated or adjusted according to the emotional behavior of the subject – focusing on the pain leads to higher pain intensity, while positive thinking relieves some of the pain. Also, in certain cases (such as chronic back pain) ...
Plastic Effect of Tetanic Stimulation on Auditory Evoked Potentials
... cortex. Stimulation of the cortex or the cochlea electrically as well as acoustic stimulation can change the tonotopic map, as shown for different animal models (Stanton and Harrison, 1996). ........................................................................................................... 6 ...
... cortex. Stimulation of the cortex or the cochlea electrically as well as acoustic stimulation can change the tonotopic map, as shown for different animal models (Stanton and Harrison, 1996). ........................................................................................................... 6 ...
Full-Text PDF
... space with differing probabilities. Additionally, in the case when two neuronal activation curves intersect each other in the SD space; one neuron can be selectively activated with short-pulse-width; high-current stimuli while the other can be selectively activated with long-pulse-width; low-current ...
... space with differing probabilities. Additionally, in the case when two neuronal activation curves intersect each other in the SD space; one neuron can be selectively activated with short-pulse-width; high-current stimuli while the other can be selectively activated with long-pulse-width; low-current ...
Dorsal spinal cord stimulation obtunds the capacity of intrathoracic
... cardiovascular signals, were digitized (Cambridge Electronics Design, power 1401 data acquisition system) and analyzed using the Spike 2 software package (Cambridge Electronics Design). Ganglionic loci were identified from which action potentials with signal-to-noise ratios ⬎ 3:1 could be recorded. ...
... cardiovascular signals, were digitized (Cambridge Electronics Design, power 1401 data acquisition system) and analyzed using the Spike 2 software package (Cambridge Electronics Design). Ganglionic loci were identified from which action potentials with signal-to-noise ratios ⬎ 3:1 could be recorded. ...
download file
... kHz). In five rats, nine different randomly interleaved tone frequencies were paired with BF stimulation (1.3, 2, 3, 4, 5, 7, 9, 11.2, and 14 kHz). In this group, tones were presented at 30 – 40 dB above rat hearing threshold (Kelly and Masterton 1977) to activate similarly sized neural populations. ...
... kHz). In five rats, nine different randomly interleaved tone frequencies were paired with BF stimulation (1.3, 2, 3, 4, 5, 7, 9, 11.2, and 14 kHz). In this group, tones were presented at 30 – 40 dB above rat hearing threshold (Kelly and Masterton 1977) to activate similarly sized neural populations. ...
Dexterous Finger Movements in Primate Without Monosynaptic
... removal presumably due to low grip force so that more than one attempt was required. Another difference from the preoperative state was that the duration of the movement was substantially increased as is evident from the time-lines in Fig. 3, A–C (postoperative day 7). These defects became gradually ...
... removal presumably due to low grip force so that more than one attempt was required. Another difference from the preoperative state was that the duration of the movement was substantially increased as is evident from the time-lines in Fig. 3, A–C (postoperative day 7). These defects became gradually ...
the organization of behavioral repertoire in motor cortex
... movement control. Traditionally, motor control is studied by examining simple components of movements. This review, however, argues that much greater insight can be gained about specific mechanisms when the motor system is considered in the context of meaningful behavior. The animal’s behavioral repe ...
... movement control. Traditionally, motor control is studied by examining simple components of movements. This review, however, argues that much greater insight can be gained about specific mechanisms when the motor system is considered in the context of meaningful behavior. The animal’s behavioral repe ...
Module 5: Pain Management - Open.Michigan
... ability to use, share, and adapt it. These lectures have been modified in the process of making a publicly shareable version. The citation key on the following slide provides information about how you may share and adapt this material. Copyright holders of content included in this material should co ...
... ability to use, share, and adapt it. These lectures have been modified in the process of making a publicly shareable version. The citation key on the following slide provides information about how you may share and adapt this material. Copyright holders of content included in this material should co ...
Pictures of pain: their contribution to the
... fully cognitive and disembodied approach to esthetics’, had been held by several eminent 20th century art historians, notably Ernst Gombrich and others in the field such as R.G. Collingwood, for whom ‘Art came to be thought of as a matter of pure cognition’ (Freedberg and Gallese, 2007), and Nelson G ...
... fully cognitive and disembodied approach to esthetics’, had been held by several eminent 20th century art historians, notably Ernst Gombrich and others in the field such as R.G. Collingwood, for whom ‘Art came to be thought of as a matter of pure cognition’ (Freedberg and Gallese, 2007), and Nelson G ...
C fibres (dull pain)
... The physical injuries that these men had received was an escape from the life-threatening environment of battle to the safety of a hospital, or even release form the war. This relationship suggests that it is possible for the central nervous system to intervene between the stimulus and the sensation ...
... The physical injuries that these men had received was an escape from the life-threatening environment of battle to the safety of a hospital, or even release form the war. This relationship suggests that it is possible for the central nervous system to intervene between the stimulus and the sensation ...
Applications of Transcutaneous Electrical Nerve State-of-the-Art Update
... low frequency TENS (2 Hz; n = 20); and those receiving a placebo treatment (batteries removed from the unit; n = 20). Electrodes were placed on the face over the painful area. Stimulus intensity was set to three times the sensory threshold for patients in the high frequency group, and three to five ...
... low frequency TENS (2 Hz; n = 20); and those receiving a placebo treatment (batteries removed from the unit; n = 20). Electrodes were placed on the face over the painful area. Stimulus intensity was set to three times the sensory threshold for patients in the high frequency group, and three to five ...
Instructions (PDF Document)
... What capabilities do these hairs to encode information about the environment? We can make a few assumptions and see where they take us. First, most sensory systems have the ability to encode the intensity of a stimulus. Can intensity information be encoded in a single axon? We already know that the ...
... What capabilities do these hairs to encode information about the environment? We can make a few assumptions and see where they take us. First, most sensory systems have the ability to encode the intensity of a stimulus. Can intensity information be encoded in a single axon? We already know that the ...
Lin J, 2013 - Tsien lab Website - University of California San Diego
... We used ReaChR expressed in the vibrissa motor cortex to drive spiking and vibrissa motion in awake mice when excited with red light through intact skull. Precise vibrissa movements were evoked by expressing ReaChR in the facial motor nucleus in the brainstem and illumination with red light through ...
... We used ReaChR expressed in the vibrissa motor cortex to drive spiking and vibrissa motion in awake mice when excited with red light through intact skull. Precise vibrissa movements were evoked by expressing ReaChR in the facial motor nucleus in the brainstem and illumination with red light through ...
Increased taste intensity perception exhibited by
... neurological exam, especially sensory, motor, reflex and gait examinations. Briefly, all CBP patients had unrelenting pain for more than one year, primarily localized to the lumbosacral region, including buttocks and thighs, with or without pain radiating to the leg. Some CBP patients also indicated ...
... neurological exam, especially sensory, motor, reflex and gait examinations. Briefly, all CBP patients had unrelenting pain for more than one year, primarily localized to the lumbosacral region, including buttocks and thighs, with or without pain radiating to the leg. Some CBP patients also indicated ...