Modeling goal-directed spatial navigation in the rat based on physiological
... We investigated the importance of hippocampal theta oscillations and the significance of phase differences of theta modulation in the cortical regions that are involved in goal-directed spatial navigation. Our models used representations of entorhinal cortex layer III (ECIII), hippocampus and prefro ...
... We investigated the importance of hippocampal theta oscillations and the significance of phase differences of theta modulation in the cortical regions that are involved in goal-directed spatial navigation. Our models used representations of entorhinal cortex layer III (ECIII), hippocampus and prefro ...
Experiencing Sensation and Perception
... types of experiments, it seems clear that there are two classes of thermorecetpors, warm receptors and cold receptors. The cold receptors respond to a temperature decrease and the warm receptors respond to a temperature increase across the skin. One way the difference between cold and warm receptors ...
... types of experiments, it seems clear that there are two classes of thermorecetpors, warm receptors and cold receptors. The cold receptors respond to a temperature decrease and the warm receptors respond to a temperature increase across the skin. One way the difference between cold and warm receptors ...
Linköping University Post Print the developmental age of the cells
... (Glut3) expression is reduced with increasing neuronal age (Fattoretti et al. 2001). Patel and Brewer (2003) found that the rate of glucose uptake in cultured embryonic neurons was threefold greater than in neurons taken from middle-aged and old donor rats. Thus, it is possible that the age of neuro ...
... (Glut3) expression is reduced with increasing neuronal age (Fattoretti et al. 2001). Patel and Brewer (2003) found that the rate of glucose uptake in cultured embryonic neurons was threefold greater than in neurons taken from middle-aged and old donor rats. Thus, it is possible that the age of neuro ...
Glyceraldehyde-3-Phosphate Dehydrogenase Is a GABAA Receptor
... GAPDH is the GABAAR endogenous kinase Preparations of GABAAR purified from bovine cerebral cortex consistently included an additional copurified 38 kDa polypeptide (P38) (Figs. 1 A, 2 A). At physiological [Mg 2⫹] (1 mM) and with [ 33P]ATP (without the addition of any protein kinase or of their activ ...
... GAPDH is the GABAAR endogenous kinase Preparations of GABAAR purified from bovine cerebral cortex consistently included an additional copurified 38 kDa polypeptide (P38) (Figs. 1 A, 2 A). At physiological [Mg 2⫹] (1 mM) and with [ 33P]ATP (without the addition of any protein kinase or of their activ ...
Central Nervous System
... If enough neurotransmitter is released, graded potential will be generated Eventually an action potential (nerve impulse) will occur in the neuron beyond the synapse ...
... If enough neurotransmitter is released, graded potential will be generated Eventually an action potential (nerve impulse) will occur in the neuron beyond the synapse ...
Structure of Receptive Fields in Area 3b of Primary Somatosensory
... determines the neuronal response to complex spatial patterns scanned across the skin. Several lines of evidence suggest that the neural signals that underlie the perception of tactile form and texture on the glabrous skin of the primate fingerpad are conveyed initially by the population of slowly ad ...
... determines the neuronal response to complex spatial patterns scanned across the skin. Several lines of evidence suggest that the neural signals that underlie the perception of tactile form and texture on the glabrous skin of the primate fingerpad are conveyed initially by the population of slowly ad ...
The Stress-Induced Atf3-Gelsolin Cascade Underlies
... Arc, have been implicated in the synaptic deficits associated with autism (Auerbach et al., 2011; Gkogkas et al., 2013; EbrahimiFakhari and Sahin, 2015); however, systematic translational profiling in these mTOR pathology disease models is lacking. TSC is an autosomal dominant multisystem disorder c ...
... Arc, have been implicated in the synaptic deficits associated with autism (Auerbach et al., 2011; Gkogkas et al., 2013; EbrahimiFakhari and Sahin, 2015); however, systematic translational profiling in these mTOR pathology disease models is lacking. TSC is an autosomal dominant multisystem disorder c ...
to get the file - Chair of Computational Biology
... means that the stability and three-dimensional structure of MPs are ultimately determined by lipid-protein physical chemistry. 2. α-Helical MPs are identified during translation on the ribosome by the signal recognition particle that initiates docking of the ribosome to the membrane-embedded multi-p ...
... means that the stability and three-dimensional structure of MPs are ultimately determined by lipid-protein physical chemistry. 2. α-Helical MPs are identified during translation on the ribosome by the signal recognition particle that initiates docking of the ribosome to the membrane-embedded multi-p ...
High acetylcholine sets circuit dynamics for attention and
... neocortical structures and commonly termed slow waves (Steriade, 1994; Steriade, 2001). Thus, there are striking changes in acetylcholine levels within cortical circuits which are correlated with striking changes in behavior and electroencephalographic dynamics within these structures. Computational ...
... neocortical structures and commonly termed slow waves (Steriade, 1994; Steriade, 2001). Thus, there are striking changes in acetylcholine levels within cortical circuits which are correlated with striking changes in behavior and electroencephalographic dynamics within these structures. Computational ...
PDF version - UTRGV Faculty Web
... (hereafter “legs,” which includes claws) has been profitably studied since the late nineteenth century (Atwood 1976, Wiens 1989). Because of the ease of removing claws, many studies used the peripheral innervation of the leg muscles to study synaptic physiology (reviewed in Atwood 1976, Atwood 1977) ...
... (hereafter “legs,” which includes claws) has been profitably studied since the late nineteenth century (Atwood 1976, Wiens 1989). Because of the ease of removing claws, many studies used the peripheral innervation of the leg muscles to study synaptic physiology (reviewed in Atwood 1976, Atwood 1977) ...
Y.I. Molkov, Baroreflex models, Encyclopedia of Computational
... the respiratory neurons. Baekey et al. (2010) have demonstrated that transient pressure pulses perturb the respiratory pattern in a phase-dependent manner, and those perturbations strongly depend on the integrity of the pons. The stimuli were delivered during inspiration, post-inspiration, or late e ...
... the respiratory neurons. Baekey et al. (2010) have demonstrated that transient pressure pulses perturb the respiratory pattern in a phase-dependent manner, and those perturbations strongly depend on the integrity of the pons. The stimuli were delivered during inspiration, post-inspiration, or late e ...
Temporal and spatial alterations in GPi neuronal encoding might
... dopamine depletion in Parkinson’s disease, hence the appearance of major motor symptoms, such as bradykinesia, due to an inability to select properly one motor program. However, this hypothesis does not take into account the time dimension underlying motor control (Roux et al., 2003) in spite of the ...
... dopamine depletion in Parkinson’s disease, hence the appearance of major motor symptoms, such as bradykinesia, due to an inability to select properly one motor program. However, this hypothesis does not take into account the time dimension underlying motor control (Roux et al., 2003) in spite of the ...
Full text in pdf format
... the CNS: γ-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in both vertebrates and invertebrates (Jackson et al. 1990, Lunt 1991, Nishimura et al. 2008), and is highly conserved in evolution; it has been suggested that GABA plays a role in various higher functions in the brai ...
... the CNS: γ-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in both vertebrates and invertebrates (Jackson et al. 1990, Lunt 1991, Nishimura et al. 2008), and is highly conserved in evolution; it has been suggested that GABA plays a role in various higher functions in the brai ...
Dual single unit recording in Globus Pallidus (GP) and Subthalamic
... Q175 knock in mouse models demonstrate age-dependent alterations in firing activity of downstream nuclei within the IP; namely an increase in mean firing rate of D2 MSNinnervated globus pallidus (GP) neurons and a corresponding decrease in the mean firing rate of pallidal-innervated subthalamic nucl ...
... Q175 knock in mouse models demonstrate age-dependent alterations in firing activity of downstream nuclei within the IP; namely an increase in mean firing rate of D2 MSNinnervated globus pallidus (GP) neurons and a corresponding decrease in the mean firing rate of pallidal-innervated subthalamic nucl ...
identification of cell types in brain slices of the inferior colliculus
... AbstractÐDifferent type neurons in the inferior colliculus may have different functions. Recent intracellular studies of the inferior colliculus suggest that intrinsic electrical properties contribute to discharge patterns, but the intrinsic discharge patterns have not been fully characterized in th ...
... AbstractÐDifferent type neurons in the inferior colliculus may have different functions. Recent intracellular studies of the inferior colliculus suggest that intrinsic electrical properties contribute to discharge patterns, but the intrinsic discharge patterns have not been fully characterized in th ...
Update on models of basal ganglia function and dysfunction
... behaving primates, a direct role of the basal ganglia in motor control is often taken for granted. However, the finding that the timing of changes in neuronal activity in the basal ganglia in relation to movement onset lags that in cortex in reaction time tasks [33,34] and that lesions of the basal g ...
... behaving primates, a direct role of the basal ganglia in motor control is often taken for granted. However, the finding that the timing of changes in neuronal activity in the basal ganglia in relation to movement onset lags that in cortex in reaction time tasks [33,34] and that lesions of the basal g ...
Neurodevelopmental mechanisms of schizophrenia: understanding
... young adulthood, especially by examining possible convergence of promising SZ genetic susceptibility factors at the functional levels in vivo. The extraordinary advances in the field over the past 1–2 years enable us to provide an overview of these issues. In particular, we focus on the significance ...
... young adulthood, especially by examining possible convergence of promising SZ genetic susceptibility factors at the functional levels in vivo. The extraordinary advances in the field over the past 1–2 years enable us to provide an overview of these issues. In particular, we focus on the significance ...
The contribution of intrinsic membrane dynamics to fast network
... 100 –200 Hz sharp-wave ripples) single cortical neurons typically fire irregularly at rates that are much lower than the oscillation frequency. Recent computational studies have provided a mathematical description of such fast oscillations, using the leaky integrate-and-fire (LIF) neuron model. Here ...
... 100 –200 Hz sharp-wave ripples) single cortical neurons typically fire irregularly at rates that are much lower than the oscillation frequency. Recent computational studies have provided a mathematical description of such fast oscillations, using the leaky integrate-and-fire (LIF) neuron model. Here ...
The Familial Dysautonomia disease gene, Ikbkap/Elp1, is required
... callosum and the lateral amygdaloid nucleus in the CKO brain were significantly reduced, while the hippocampus was relatively enlarged with respect to the reduced hemisphere (Table 2), which we attribute to the absence of Cre expression in the hippocampus (Fig.1g and S1a,b). Given the critical role ...
... callosum and the lateral amygdaloid nucleus in the CKO brain were significantly reduced, while the hippocampus was relatively enlarged with respect to the reduced hemisphere (Table 2), which we attribute to the absence of Cre expression in the hippocampus (Fig.1g and S1a,b). Given the critical role ...
RHS 332-chap 2 part
... Basal nuclei set organism’s level of responsiveness to stimuli. Extrapyramidal disorders are associated with basal nuclei pathology: Negative symptoms of underresponsiveness: Akinesias i.e. Parkinson disease ...
... Basal nuclei set organism’s level of responsiveness to stimuli. Extrapyramidal disorders are associated with basal nuclei pathology: Negative symptoms of underresponsiveness: Akinesias i.e. Parkinson disease ...
LAB: Nerve Reflexes
... of little more than two neurons that communicate across a single synapse. A reflex is a relatively simple motor response that does not involve a large number of interneurons (or association neurons). The simplest version is a mono-synaptic reflex that uses one sensory and one motor neuron (for examp ...
... of little more than two neurons that communicate across a single synapse. A reflex is a relatively simple motor response that does not involve a large number of interneurons (or association neurons). The simplest version is a mono-synaptic reflex that uses one sensory and one motor neuron (for examp ...
Neuropeptide-Mediated Facilitation and Inhibition of Sensory Inputs
... was separated into three pools with Vaseline barriers. The caudal pool contained the tail fin. Neuromodulators were added to this pool to modulate sensory inputs evoked by tail fin stimulation. The middle pool contained high divalent cation or low calcium Ringer to block polysynaptic transmission an ...
... was separated into three pools with Vaseline barriers. The caudal pool contained the tail fin. Neuromodulators were added to this pool to modulate sensory inputs evoked by tail fin stimulation. The middle pool contained high divalent cation or low calcium Ringer to block polysynaptic transmission an ...
The mirror mechanism: recent findings and perspectives
... motor act, but not in the precise movements necessary to achieve the goal. Although some other specific visual characteristics have been already observed in the early studies on mirror neurons, these characteristics have been recently re-investigated and will be dealt with below. An important aspect ...
... motor act, but not in the precise movements necessary to achieve the goal. Although some other specific visual characteristics have been already observed in the early studies on mirror neurons, these characteristics have been recently re-investigated and will be dealt with below. An important aspect ...
Molecular neuroscience
Molecular neuroscience is a branch of neuroscience that observes concepts in molecular biology applied to the nervous systems of animals. The scope of this subject primarily pertains to a reductionist view of neuroscience, considering topics such as molecular neuroanatomy, mechanisms of molecular signaling in the nervous system, the effects of genetics on neuronal development, and the molecular basis for neuroplasticity and neurodegenerative diseases. As with molecular biology, molecular neuroscience is a relatively new field that is considerably dynamic.