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Target-specific differences in somatodendritic morphology of layer V
Target-specific differences in somatodendritic morphology of layer V

... Dendritic geometry has been shown to be a critical determinant of information processing and neuronal computation. However, it is not known whether cortical projection neurons that target different subcortical nuclei have distinct dendritic morphologies. In this study, fast blue retrograde tracing i ...
Circadian and histaminergic regulation of the sleep
Circadian and histaminergic regulation of the sleep

... histamine into the basal forebrain region caused a significant increase in the high θ- and γrange power throughout infusion period, but the δ-wave activity during non-rapid eye movement slow-wave sleep remained similar to those of the control. We conclude from our data that the circadian process may ...
Cellular, synaptic and network effects of neuromodulation
Cellular, synaptic and network effects of neuromodulation

... potentials, and the bottom neuron was firing in bursts of action potentials separated by long interburst intervals. When we consider that biological neurons may display eight, ten, or more different voltage-dependent currents, and that the subunit composition of each channel type can regulate its ki ...
the mirror-neuron system - UCSF Center for Integrative Neuroscience
the mirror-neuron system - UCSF Center for Integrative Neuroscience

... which respond to the presentation of an object, and mirror neurons, which respond when the monkey sees object-directed action (Rizzolatti & Luppino 2001). In order to be triggered by visual stimuli, mirror neurons require an interaction between a biological effector (hand or mouth) and an object. Th ...
the mirror-neuron system - Psychology and Neuroscience
the mirror-neuron system - Psychology and Neuroscience

... which respond to the presentation of an object, and mirror neurons, which respond when the monkey sees object-directed action (Rizzolatti & Luppino 2001). In order to be triggered by visual stimuli, mirror neurons require an interaction between a biological effector (hand or mouth) and an object. Th ...
Brainstem (II)
Brainstem (II)

... -- silent during sleep, active during wakefulness -- form part of the ascending reticular activating system - Reticular formation in the lateral part of medulla -- send fibers to spinal cord - Solitary nucleus and dorsal motor nucleus of vagus ...
Spatial Responsiveness of Monkey Hippocampal Neurons to
Spatial Responsiveness of Monkey Hippocampal Neurons to

... experimenter. The range that the monkey could see was restricted to about 280” from the center by attaching opaque acrylic plates at the sides of its face. Usually each object was presented by the experimenter putting it on the stage behind the window for about 2.0 seconds. The distance between the ...
Full PDF
Full PDF

... survival-related stress responses to external inputs are dependent upon hypocretinergic actions, localized stressors may require only brain stem centers for the generation of a response (128). Accordingly, Furlong et al. (56) found that “Stress responses to inputs coming from lower CNS levels may no ...
Chapter 13 *Lecture PowerPoint  The Spinal Cord,
Chapter 13 *Lecture PowerPoint The Spinal Cord,

... – Site of information processing, synaptic integration • White matter—abundantly myelinated axons – Carry signals from one part of the CNS to another ...
Grasping the Intentions of Others with One`s Own Mirror Neuron
Grasping the Intentions of Others with One`s Own Mirror Neuron

... away? The aim of the present study is to investigate the neural basis of intention understanding in this sense and, more specifically, the role played by the human mirror neuron system in this type of intention understanding. The term ‘‘intention’’ will be always used in this specific sense, to indica ...
Total Wiring Length Minimization of C. elegans Neural
Total Wiring Length Minimization of C. elegans Neural

... Depending on the function they perform in the body of the worm, neurons can be divided into three groups: motor neurons, sensory neurons and interneurons. The cells from the first group project their axons on muscles of the C. elegans and therefore control the movement of the worm. Sensory neurons h ...
chapt13_lectureS
chapt13_lectureS

... • ascending tracts carry sensory signals up the spinal cord • sensory signals travel across three neurons from origin in receptors to the destination in the sensory areas of the brain – first order neurons – detect stimulus and transmit signal to spinal cord or brainstem ...
highlighted topics - American Journal of Physiology
highlighted topics - American Journal of Physiology

... Endogenous, temperature-compensated circadian clocks have been localized to discrete sites within the nervous systems of a number of organisms. In mammals, the master circadian pacemaker is the bilaterally paired suprachiasmatic nucleus (SCN) in the anterior hypothalamus. The SCN is composed of mult ...
full text - TReAD Lab
full text - TReAD Lab

... Anatomical differences between the medial and lateral STN are substantial. For example, the medial tip of the STN has reciprocal projections with the primate limbic pallidum (ventral pallidum (VP) in rodents), whereas the lSTN preferentially interacts with the external pallidal segment (globus palli ...
Spinal cord and reflexes
Spinal cord and reflexes

...  Isolates CNS neural tissue from general circulation  Formed by network of tight junctions  Between endothelial cells of CNS capillaries  Lipid-soluble compounds (O2, CO2), steroids, and prostaglandins diffuse into interstitial fluid of brain and spinal cord  Astrocytes control blood–brain barr ...
Spinal cord and reflexes
Spinal cord and reflexes

...  Isolates CNS neural tissue from general circulation  Formed by network of tight junctions  Between endothelial cells of CNS capillaries  Lipid-soluble compounds (O2, CO2), steroids, and prostaglandins diffuse into interstitial fluid of brain and spinal cord  Astrocytes control blood–brain barr ...
Somatosensory Cortical Activity in Relation to Arm Posture
Somatosensory Cortical Activity in Relation to Arm Posture

... postures. Unit discharge was related to parameters defining the posture of the arm by multiple linear regression techniques. 2. Two monkeys were trained to grasp a manipulandum presented at locations distributed throughout their workspace. The discharge of single units in SI was recorded for 3 s whi ...
Columnar Organization of Dendrites and Axons of Single and
Columnar Organization of Dendrites and Axons of Single and

... Germany) fitted with 2.5⫻ plan /0.075 NA and 40⫻-W/0.80 objectives) with the pial surface pointing to the front and the hippocampus to the right. The barrel field was visualized at low magnification under bright-field illumination and can be identified in layer 4 as evenly spaced dark structures. Ba ...
Reward and Aversion
Reward and Aversion

... distinct components of wanting and liking, which can be separately identified and behaviorally manipulated, and that DA mediates the wanting but not the liking component of reward. According to this incentive salience hypothesis, the function of DA is not to mediate the pleasure of unconditioned inc ...
Cicc4e_02-FINAL_PPT
Cicc4e_02-FINAL_PPT

... What are the nervous system, neurons, and nerves, and how do they relate to one another? How do neurons use neurotransmitters to communicate with each other and with the body? How do the brain and spinal cord interact, and what are some misconceptions about the brain, and what is neuroplasticity? Ho ...
Mirror Neurons in a New World Monkey, Common Marmoset
Mirror Neurons in a New World Monkey, Common Marmoset

... ventral premotor cortex (PMv), where mirror neurons have been reported in macaques, is difficult to identify in marmosets, since no sulcal landmarks exist in the frontal cortex. We addressed this problem using “in vivo” connection imaging methods. That is, we first identified cells responsive to oth ...
Thalamic POm projections to the dorsolateral striatum of rats
Thalamic POm projections to the dorsolateral striatum of rats

... results (Mowery et al. 2011). After recording neuronal responses to controlled whisker stimulation, the tracer was iontophoretically deposited (Fig. 2D’) from the same pipette while it was positioned at the recording site. Occasionally, the recording-deposit site was marked by a small amount of necr ...
Activity of Ventral Medial Thalamic Neurons during
Activity of Ventral Medial Thalamic Neurons during

... reflect abnormal oscillations in corticothalamic networks. Although it was suggested that basal ganglia could modulate, via their feedback circuits to the cerebral cortex, the occurrence of SWDs, the cellular and network mechanisms underlying such a subcortical control of absence seizures remain unk ...
Clones in the chick diencephalon contain multiple
Clones in the chick diencephalon contain multiple

... 1994; Rubenstein and Puelles, 1994), similar to the correlation noted in the hindbrain. Short-term lineal relationships in the diencephalon have been analyzed using the method of single cell microinjection of a fluorescent dye (Figdor and Stern, 1993). The results indicated that the morphological ne ...
Slide 1
Slide 1

... • We have learned that some forms of CNS damage can be repaired. This is called Neuroplasticity, the ability to constantly change both the structure and function of the cell involved in trauma ...
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Circumventricular organs

Circumventricular organs (CVOs) are structures in the brain that are characterized by their extensive vasculature and lack of a normal blood brain barrier (BBB). The CVOs allow for the linkage between the central nervous system and peripheral blood flow; additionally they are an integral part of neuroendocrine function. The lack of a blood brain barrier allows the CVOs to act as an alternative route for peptides and hormones in the neural tissue to the peripheral blood stream, while still protecting it from toxic substances. CVOs can be classified into (a) sensory and (b) secretory organs. The sensory organs include the area postrema (AP), the subfornical organ (SFO) and the vascular organ of lamina terminalis. They have the ability to sense plasma molecules and then pass that information into other regions of the brain. Through this, they provide direct information to the autonomic nervous system from the systemic circulation. The secretory organs include the subcommissural organ (SCO), the posterior pituitary, the pineal gland, the median eminence and the intermediate lobe of the pituitary gland. These organs are responsible for secreting hormones and glycoproteins into the peripheral vascular system using feedback from both the brain environment and external stimuli.All of the circumventricular organs, besides the SCO, contain extensive vasculature and fenestrated capillaries which leads to a ‘leaky’ BBB at the site of the organs. Furthermore, all CVOs contain neural tissue, allowing them to play a role in the neuroendocrine system. It is highly debated if the choroid plexus can be included as a CVO. It has a high concentration of fenestrated capillaries, but its lack of neural tissue and its primary role of producing cerebrospinal fluid (CSF) usually excludes the choroid plexus from the CVO classification.Research has also linked CVOs to body fluid regulation, cardiovascular functions, immune responses, thirst, feeding behavior and reproductive behavior.
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