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17-Basal ganglion
17-Basal ganglion

14.10 Insight 775 Gilbert
14.10 Insight 775 Gilbert

... Poggio et al.5 on visual hyperacuity. Poggio et al.5 proposed a threelayers feedforward network (Fig. 2b), the input layer of which consists of a small number of gaussian filters (receptive fields) that transform any input pattern into a vector of activity levels by convolving the input with the cor ...
extrasynaptic glutamate does not reach the postsynaptic density
extrasynaptic glutamate does not reach the postsynaptic density

... density (PSD) and activates only extrasynaptic receptors, modulating the excitability of the neurons. The inhibition of excitability of the CA1 neurons by Glu can be related at least partially to the activation of metabotropic (mGlu) receptors. According to Garaschuk et al. [20], ACPD, selective ago ...
A1 - 58 - University of Pittsburgh
A1 - 58 - University of Pittsburgh

... When the action potentials arrive at the muscle cell, they must first bridge the synapse between neuron and muscle cell via acetylcholine, the same neurotransmitter that allowed the signal to jump between neurons. When acetylcholine reaches the cell membrane of the muscle, it binds to post-synaptic ...
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Opposite Functions of Histamine H1 and H2 Receptors and H3

... the recording electrode (Zhou and Hablitz 1996). After electrophysiological recordings, brain slices were fixed in 4% paraformaldehyde in 0.1 M phosphate buffer (PB) at 4°C overnight. Without resectioning, slices were then processed for visualization of neurobiotin-filled neurons. Endogenous peroxid ...
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10-Sensation of Taste lecture

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Integrated model of visual processing

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Receptive Fields and Binaural Interactions for Virtual

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Visual signals in the dorsolateral pontine nucleus of the alert

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From view cells and place cells to cognitive map learning

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choosing the greater of two goods: neural currencies for valuation

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Morphological and F`unctional Identifications of Catfish Retinal

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... does not affect sympathetic activity or blood pressure, raises some question about the nature of this synaptic driving input in this species (Sun and Guyenet 1987; Trzebski and Baradziej 1992). However, bilateral microinjections of the synaptic blocker, cobalt chloride, into the RVLM of cats markedl ...
Computational cognitive neuroscience: 10. Prefrontal Cortex (PFC)
Computational cognitive neuroscience: 10. Prefrontal Cortex (PFC)

... • Recall from the Learning Chapter that the NMDA channel requires the neuron to be sufficiently depolarized to remove the Mg+ (magnesium) ions that otherwise block the channel. This activity-dependent nature of the NMDA channel makes it ideally suited to providing a "switched" or dynamically gated f ...
Mechanisms of Magnetic Stimulation of Central Nervous System
Mechanisms of Magnetic Stimulation of Central Nervous System

... by the size of the gradient of the induced electric field and the passive space constant in the axon fiber (l). Thus, for an axon fiber with spatially homogenous passive parameters, the major factor determining the shape of the membrane potential change, and thus the location of AP initiation during ...
A cellular mechanism for cortical associations: an organizing
A cellular mechanism for cortical associations: an organizing

... recordings from soma (blue) and dendritic tree (black and red). (Right, top) Simulated distal excitatory postsynaptic potential (EPSP) with dendritic current injection (Istim, red) causes no dendritic spike (red) and has virtually no impact at the cell body (blue). (Right, middle) A somatic action p ...
The Neural Basis of the Object Concept in Ambiguous and
The Neural Basis of the Object Concept in Ambiguous and

... Schillen and König (1994) investigate the synchronization properties of an oscillator network for a stimulus that is uniform in one feature dimension (orientation), but differs in two others (features dimensions chosen are orientation, disparity and color). It turned out that the oscillators receiv ...
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Stimulus (physiology)



In physiology, a stimulus (plural stimuli) is a detectable change in the internal or external environment. The ability of an organism or organ to respond to external stimuli is called sensitivity. When a stimulus is applied to a sensory receptor, it normally elicits or influences a reflex via stimulus transduction. These sensory receptors can receive information from outside the body, as in touch receptors found in the skin or light receptors in the eye, as well as from inside the body, as in chemoreceptors and mechanorceptors. An internal stimulus is often the first component of a homeostatic control system. External stimuli are capable of producing systemic responses throughout the body, as in the fight-or-flight response. In order for a stimulus to be detected with high probability, its level must exceed the absolute threshold; if a signal does reach threshold, the information is transmitted to the central nervous system (CNS), where it is integrated and a decision on how to react is made. Although stimuli commonly cause the body to respond, it is the CNS that finally determines whether a signal causes a reaction or not.
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