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The Control of Rate and Timing of Spikes in the Deep Cerebellar
The Control of Rate and Timing of Spikes in the Deep Cerebellar

Dynamics and Synchronization of Motifs of Neuronal Populations in the Presence
Dynamics and Synchronization of Motifs of Neuronal Populations in the Presence

... cortex (striate), up to extrastriate cortical cells. In the first layer, the receptive field of a photoreceptor neuron corresponds to the region in which light alters the firing response of that cell. For the ganglion cells in the retina, the receptive field encompasses the sensitive areas of their ...
Vasopressin Receptors of the Vasopressor (V,)
Vasopressin Receptors of the Vasopressor (V,)

... the dorsal motor nucleus of the vagus nerve, respectively (Dorsa et al., 1983; Dreifuss et al., 1988; Tribollet et al., 1988). Using brain-stem slices, we have shown that vagal motoneurons are directly depolarized by oxytocin and that this effect is mediated by oxytocin receptors (Charpak et al., 19 ...
Intrinsic laminar lattice connections in primate visual cortex
Intrinsic laminar lattice connections in primate visual cortex

... of 4C. At further distances from the injection site, the labeled band in 4B typically narrows and remains within the athalamic zone of 4B proper (see Fig. IB). The wide HRP band is prominent only when layer 4B itself is involved in the injection. Otherwise, if the injection is restricted to layers 1 ...
Pearson SA, Mouihate A, Pittman QJ, Whelan PJ
Pearson SA, Mouihate A, Pittman QJ, Whelan PJ

... The development of motor networks in the spinal cord is partly activity-dependent. We have observed receptor-mediated excitatory effects of two peptides, arginine vasopressin (AVP) and oxytocin (OXT), on motor network activity in the neonate. With the use of an en bloc in vitro preparation of mouse ...
Impact of acute inflammation on spinal motoneuron synaptic
Impact of acute inflammation on spinal motoneuron synaptic

... band of 38 kDa on immunoblotting, corresponding to the protein P38 as described previously [15,16]. The immunolabeling pattern observed here was similar to that in other studies of mouse neurons, providing a characteristic punctate labeling [17,18]. The antibody against glial fibrillary acidic prote ...
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PDF

... band of 38 kDa on immunoblotting, corresponding to the protein P38 as described previously [15,16]. The immunolabeling pattern observed here was similar to that in other studies of mouse neurons, providing a characteristic punctate labeling [17,18]. The antibody against glial fibrillary acidic prote ...
Jesús Pujol Martí  Neural map organization and development in the lateral-line system
Jesús Pujol Martí Neural map organization and development in the lateral-line system

... the communication between sensory organs and the brain. In most sensory systems, neurons project from the sensory receptors to the brain in a spatially ordered manner forming neural maps that encode stimuli attributes, such as identity or position. The formation of such precise patterns of connectiv ...
Coincidence Detection or Temporal Integration?
Coincidence Detection or Temporal Integration?

... however, and did not reconstruct the SII neuronal recording sites with respect to the cortical layers. Cutaneous stimulation. We have shown previously that thalamic and cortical neurons that are sensitive to hair movements can be activated by computer-controlled airjets (Johnson and Alloway, 1994, 1 ...
Distinct Representations and Theta Dynamics in Dorsal and Ventral
Distinct Representations and Theta Dynamics in Dorsal and Ventral

... ⬎80% of the maze area, were classified as putative interneurons. Other cells were classified as pyramidal cells (supplemental Fig. 2 A, available at www.jneurosci.org as supplemental material). No attempt was made to distinguish among the large family of interneurons (Freund and Buzsáki, 1996). The ...
Probabilistic models for spike trains of single neurons
Probabilistic models for spike trains of single neurons

Structure and Function in the Inferior Olivary Nucleus
Structure and Function in the Inferior Olivary Nucleus

... Abstract   The   inferior   olivary   nucleus   is   the   source   of   the   climbing   fibres,   one   of   the   two   major   afferent   pathways   into   the   cerebellum.   This   thesis   is   concerned   with  aspects  of  the  cel ...
Zn2 Slows Down CaV3.3 Gating Kinetics: Implications for
Zn2 Slows Down CaV3.3 Gating Kinetics: Implications for

... 1999), carrying more slowly inactivating currents such as those recorded in nRT cells (Huguenard and Prince 1992). As these different isoforms have specific kinetic properties, neuron behavior will depend on the type of T-current it expresses. Specifically, because slow inactivating CaV3.3 channels ...
Synaptic Integration of Olfactory Information in Mouse Anterior
Synaptic Integration of Olfactory Information in Mouse Anterior

... partially overlap in their central targets (Zou et al., 2001). Immediate-early gene (IEG) studies show that odorants likely to activate separate populations of mitral cells activate distinct but partially overlapping regions of the olfactory cortex (Illig and Haberly, 2003; Zou et al., 2005). Moreov ...
Fig. 1
Fig. 1

... diseases [20], however its importance in neuron differentiation remains mostly unknown. Since Hsp90 is expressed preferentially in neurons in the nervous system from late embryonic differentiation stages [18], and local stability and degradation mechanisms are responsible for neuronal polarity estab ...
Modulation of Inhibitory Synaptic Potentials in the Piriform Cortex
Modulation of Inhibitory Synaptic Potentials in the Piriform Cortex

... fibers in layer Ia and association/intrinsic fibers in layer Ib. A simple model of piriform cortex as an associative memory was used to analyze how suppression of inhibitory synaptic transmission influenced performance of the network. Levels of suppression of excitatory synaptic transmission were se ...
Open-loop organization of thalamic reticular nucleus and dorsal
Open-loop organization of thalamic reticular nucleus and dorsal

... two to five action potentials. Previous experimental and computational work has established that bursts are a reliable way to send a high-efficacy signal to a postsynaptic target and are likely a more suitable mode for signal detection than spikes in tonic mode (Denning and Reinagel 2005; Goense et ...
Pierre Berthet Computational Modeling of the Basal Ganglia – Functional Pathways
Pierre Berthet Computational Modeling of the Basal Ganglia – Functional Pathways

... a great role to play in the realisation of such AI. It is a challenge as well for society and ethics, as it needs to be decided how this knowledge can be used, and how far the society is willing to change, in the face of the coming discoveries. The brain, and especially the human brain, is a complex ...
neural projections from nucleus accumbens to globus pallidus
neural projections from nucleus accumbens to globus pallidus

Excitatory and Inhibitory Vestibular Pathways to the Extraocular
Excitatory and Inhibitory Vestibular Pathways to the Extraocular

... possibly because this order exhibits robust oculomotor performance with eye movements comparable with those observed in mammals (Easter 1972; Pastor et al. 1992; Schairer and Bennett 1986). In the goldfish, neurons within the vestibular complex, notably the anterior, descending, and tangential octav ...
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PDF Format

... animals, remained to be explored by comparing the electrical ...
jneurosci.org - INI Institute of Neuroinformatics
jneurosci.org - INI Institute of Neuroinformatics

... by convolving the bouton locations with a spherical Gaussian kernel of width (or SD) h (Scott, 1992). Each local maximum of the density landscape is a peak of a mountain and the set of boutons forming the mountain defines the cluster. To determine which boutons belong to the mountain, boutons are mo ...
Activity Regulates the Synaptic Localization of the NMDA Receptor
Activity Regulates the Synaptic Localization of the NMDA Receptor

... compared to the 3- or 4 week APV-treated neurons (Figures 1E and 1F). In fact, the number of NR1 clusters now appeared to be lower than in a 4 week untreated culture, presumably due to the enhanced activity through the increased number of synaptic NMDA receptor clusters resulting from the initial AP ...
Learning-related postburst afterhyperpolarization reduction in CA1
Learning-related postburst afterhyperpolarization reduction in CA1

... again demonstrated ex vivo. This reproducible AHP reduction in CA1 neurons after hippocampus-dependent learning establishes it as a cellular hallmark of learning-related intrinsic plasticity. Thus, the question remains, how is PKA recruited to cause or maintain this cellular feature of learning? PKA ...
The occipitoparietal pathway of the macaque monkey: comparison
The occipitoparietal pathway of the macaque monkey: comparison

... The dendritic morphology of pyramidal cells located at the base of layer III in the primary visual area (V1), the second visual area (V2), the middle temporal area (MT), the ventral portion of the lateral intraparietal area (LIPv) and in the portion of cytoarchitectonic area 7a within the anterior b ...
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Pre-Bötzinger complex



The pre-Bötzinger complex (preBötC) is a cluster of interneurons in the ventrolateral medulla of the brainstem. This complex has been proven to be essential for the generation of respiratory rhythm in mammals. The exact mechanism of the rhythm generation and transmission to motor nuclei remains controversial and the topic of much present research.Several synthetic compounds have been shown to act on neurons specific to the preBötC, most being selective agonists or antagonists to receptor subtypes on neurons in the vicinity. Since many of these neurons express GABA, glutamate, serotonin and adenosine receptors, chemicals custom tailored to bind at these sites are most effective at altering respiratory rhythm.Adenosine modulates the preBötC output via activation of the A1 and A2A receptor subtypes. An adenosine A1 receptor agonist has been shown to depress preBötC rhythmogenesis independent of the neurotransmitters GABA and glycine in ""in vitro"" preparations from 0-7 day old mice. Another synthetic drug specific to the adenosine A2A receptor subtype is CGS-21680 that has been shown to cause apneas in 14-21 day old rat pups in vivo. For this reason, it has been used as a model to study pathological conditions such as apnea of prematurity and SIDS in neonatal infants.
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