show - FACETS Project
... This report is dedicated to the study of nonlinear bidimensional neuron models, which from a mathematical point of view are hybrid dynamical systems, i.e. whose dynamics is defined by a continuous-time dynamical system modelling the subthreshold behavior of the neuron, coupled with a discrete dynami ...
... This report is dedicated to the study of nonlinear bidimensional neuron models, which from a mathematical point of view are hybrid dynamical systems, i.e. whose dynamics is defined by a continuous-time dynamical system modelling the subthreshold behavior of the neuron, coupled with a discrete dynami ...
Neocortical Very Fast Oscillations (Ripples, 80–200 Hz) During
... Grenier, François, Igor Timofeev, and Mircea Steriade. Neocortical very fast oscillations (ripples, 80 –200 Hz) during seizures: intracellular correlates. J Neurophysiol 89: 841– 852, 2003; 10.1152/jn.00420.2002. Multi-site field potential and intracellular recordings from various neocortical areas ...
... Grenier, François, Igor Timofeev, and Mircea Steriade. Neocortical very fast oscillations (ripples, 80 –200 Hz) during seizures: intracellular correlates. J Neurophysiol 89: 841– 852, 2003; 10.1152/jn.00420.2002. Multi-site field potential and intracellular recordings from various neocortical areas ...
Choice Coding in Frontal Cortex during Stimulus
... choices, the animal may learn to make a specific response when a specific pair of pictures is presented (a stimulus–response association). Reward-predictive neural activity could then reflect an AO association, indicating knowledge of the reward that is associated with that response. A second proble ...
... choices, the animal may learn to make a specific response when a specific pair of pictures is presented (a stimulus–response association). Reward-predictive neural activity could then reflect an AO association, indicating knowledge of the reward that is associated with that response. A second proble ...
hanPNAS11
... retrograde axonal tracing by injecting rhodamine-conjugated latex microspheres (LMS) into the pons of Tbr1+/+ and Tbr1−/− newborn mice. Analysis was carried out after 18–24 h of survival to allow for transport of the tracer, a time frame that is limited by the perinatal lethality of the Tbr1−/− (22) ...
... retrograde axonal tracing by injecting rhodamine-conjugated latex microspheres (LMS) into the pons of Tbr1+/+ and Tbr1−/− newborn mice. Analysis was carried out after 18–24 h of survival to allow for transport of the tracer, a time frame that is limited by the perinatal lethality of the Tbr1−/− (22) ...
Columnar Organization of Dendrites and Axons of Single and
... boutons per unit axonal length was also highest there. Electron microscopy combined with GABA postimmunogold labeling revealed that most (⬎90%) of the synaptic contacts were established on dendritic spines and shafts of excitatory neurons in layers 4 and 2/3. The largely columnar organization of den ...
... boutons per unit axonal length was also highest there. Electron microscopy combined with GABA postimmunogold labeling revealed that most (⬎90%) of the synaptic contacts were established on dendritic spines and shafts of excitatory neurons in layers 4 and 2/3. The largely columnar organization of den ...
Dendritic Morphology of Pyramidal Neurons in the
... narrowed and then tapered off and could be found within the 120-mm section thickness. To avoid sampling neurons from different cortical layers, an ongoing tally of average soma depth was recorded, and neurons were selected within a range that spanned across cortical layer III (mean soma depth for ar ...
... narrowed and then tapered off and could be found within the 120-mm section thickness. To avoid sampling neurons from different cortical layers, an ongoing tally of average soma depth was recorded, and neurons were selected within a range that spanned across cortical layer III (mean soma depth for ar ...
Early Neuronal Loss and Axonal/Presynaptic Damage is Associated
... events in the subiculum of APP751SwedLondon/PS1M146L mice, a transgenic model that displays neuronal vulnerability at early ages in hippocampus and entorhinal cortex. Our results indicate that the subiculum is the earliest affected region in the hippocampus, showing a selective early loss of both p ...
... events in the subiculum of APP751SwedLondon/PS1M146L mice, a transgenic model that displays neuronal vulnerability at early ages in hippocampus and entorhinal cortex. Our results indicate that the subiculum is the earliest affected region in the hippocampus, showing a selective early loss of both p ...
Corina Wirth and Hans
... The local field potential (LFP) at each electrode was recorded against the bath electrode. To improve the signal-to-noise ratio, the traces were averaged (n ⫽ 15–20). Because spike activity can be detected with MEA electrodes at distances of ⱕ100 m (Egert et al. 2002), we assume that each electrode ...
... The local field potential (LFP) at each electrode was recorded against the bath electrode. To improve the signal-to-noise ratio, the traces were averaged (n ⫽ 15–20). Because spike activity can be detected with MEA electrodes at distances of ⱕ100 m (Egert et al. 2002), we assume that each electrode ...
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... same part of the world. Darker skin offered some protection from the sun and is associated with tropical parts of the world, while lighter skin is associated with higher latitudes, where less sun protection was needed. Biologists tell us that there are no physical characteristics that divide peopl ...
... same part of the world. Darker skin offered some protection from the sun and is associated with tropical parts of the world, while lighter skin is associated with higher latitudes, where less sun protection was needed. Biologists tell us that there are no physical characteristics that divide peopl ...
Chapter 2
... superior olive (MSO; Fig. 2.10) and the lateral superior olivary nuclei (LSO; Chapter 4). Smaller inputs originate in the medial nucleus of the trapezoid body and from periolivary nuclei, including the superior paraolivary nucleus, and the lateral and ventromedial nuclei of the trapezoid body. The l ...
... superior olive (MSO; Fig. 2.10) and the lateral superior olivary nuclei (LSO; Chapter 4). Smaller inputs originate in the medial nucleus of the trapezoid body and from periolivary nuclei, including the superior paraolivary nucleus, and the lateral and ventromedial nuclei of the trapezoid body. The l ...
UNC-119 suppresses axon branching
... terminated (axons and branches failed to reach the dorsal nerve cord). Finally, we noted if there were supernumerary growth cones extending directly from DD cell bodies. UNC-119 immunocytochemistry To determine where the UNC-119 protein was located, we generated antibodies against UNC-119. The DNA e ...
... terminated (axons and branches failed to reach the dorsal nerve cord). Finally, we noted if there were supernumerary growth cones extending directly from DD cell bodies. UNC-119 immunocytochemistry To determine where the UNC-119 protein was located, we generated antibodies against UNC-119. The DNA e ...
multiple reward signals in the brain
... concerns the presence and values of rewards, their predictability and accessibility, and the numerous methods and costs associated with attaining them. Various experimental approaches including brain lesions, psychopharmacology, electrical self-stimulation and the administration of addictive drugs, ...
... concerns the presence and values of rewards, their predictability and accessibility, and the numerous methods and costs associated with attaining them. Various experimental approaches including brain lesions, psychopharmacology, electrical self-stimulation and the administration of addictive drugs, ...
Activity in the Lateral Prefrontal Cortex Reflects Multiple Steps of
... ning of multistep behaviors? More specifically, does the activity of PFC neurons during the process of planning reflect the multiple movements required during future actions or the individual future events that occur as a result of the actions? To answer this question, we examined neuronal activity ...
... ning of multistep behaviors? More specifically, does the activity of PFC neurons during the process of planning reflect the multiple movements required during future actions or the individual future events that occur as a result of the actions? To answer this question, we examined neuronal activity ...
9 Propagated Signaling: The Action Potential
... The voltage clamp intervenes in this process by simultaneously withdrawing positive charges from the cell and depositing them in the external solution. By generating a current that is equal and opposite to the ionic current, the voltage-clamp circuit automatically prevents the ionic current from cha ...
... The voltage clamp intervenes in this process by simultaneously withdrawing positive charges from the cell and depositing them in the external solution. By generating a current that is equal and opposite to the ionic current, the voltage-clamp circuit automatically prevents the ionic current from cha ...
A Functional Role for Intra-Axonal Protein Synthesis during Axonal
... Figure 1. Rapidly growing axons of conditioned DRG neurons contain ribosomal protein L4. Four days after sciatic nerve crush, conditioned L4 –5 DRG neurons were dissociated and cultured on coated coverslips for 22 hr in medium containing Ara-C and DRB. The long processes extended by these DRG neuron ...
... Figure 1. Rapidly growing axons of conditioned DRG neurons contain ribosomal protein L4. Four days after sciatic nerve crush, conditioned L4 –5 DRG neurons were dissociated and cultured on coated coverslips for 22 hr in medium containing Ara-C and DRB. The long processes extended by these DRG neuron ...
Ventral Premotor and Inferior Parietal Cortices
... Both monkeys were trained to perform a motor task (Fig. 1A) consisting of 2 different conditions. The first part of the task was identical in the 2 conditions: starting from a fixed position (Fig. 1A, left), the monkey was required to reach and grasp a piece of food (target) using a precision grip (Fi ...
... Both monkeys were trained to perform a motor task (Fig. 1A) consisting of 2 different conditions. The first part of the task was identical in the 2 conditions: starting from a fixed position (Fig. 1A, left), the monkey was required to reach and grasp a piece of food (target) using a precision grip (Fi ...
DOES ISCHEMIA CAUSE ACUTE NEURONAL DAMAGE BY CONVERTING THE NA /K
... The gray matter of the higher brain undergoes spreading depolarization in response to ischemia, which increases metabolic demand and so promotes acute neuronal injury. The molecular mechanism linking ischemic failure of the Na+/K+ pump to the subsequent onset of a large inward current in neurons has ...
... The gray matter of the higher brain undergoes spreading depolarization in response to ischemia, which increases metabolic demand and so promotes acute neuronal injury. The molecular mechanism linking ischemic failure of the Na+/K+ pump to the subsequent onset of a large inward current in neurons has ...
Perception Spike Timing-Dependent Plasticity: From Synapse to
... In most in vitro studies of STDP, the induction protocol consists of relatively simple spike patterns with pre/post spikes paired at regular intervals. The advantage of this approach is that each induction pattern can be described by a small number of parameters, and the dependence of synaptic modif ...
... In most in vitro studies of STDP, the induction protocol consists of relatively simple spike patterns with pre/post spikes paired at regular intervals. The advantage of this approach is that each induction pattern can be described by a small number of parameters, and the dependence of synaptic modif ...
The peripheral nervous system-
... Thoenen, 1985). Thus, although the glial scar presents a physical environment that is not conducive to extensive axon growth, mature mammalian astrocytes may restrict axon regeneration by specific mechanisms that have yet to be fully described. Recent findings by Schwab and associates have indicated ...
... Thoenen, 1985). Thus, although the glial scar presents a physical environment that is not conducive to extensive axon growth, mature mammalian astrocytes may restrict axon regeneration by specific mechanisms that have yet to be fully described. Recent findings by Schwab and associates have indicated ...
Dissociation of Mnemonic Coding and Other Functional Neuronal
... 1975; Petrides and Iversen 1976). Electrophysiological studies in the PFCdl of monkeys have revealed delay-related neuronal activity during the performance of DR and delayed alternation (DA) tasks in manual (Carlson et al. 1990; Fuster 1973; Fuster and Alexander 1971; Kojima and GoldmanRakic 1984; K ...
... 1975; Petrides and Iversen 1976). Electrophysiological studies in the PFCdl of monkeys have revealed delay-related neuronal activity during the performance of DR and delayed alternation (DA) tasks in manual (Carlson et al. 1990; Fuster 1973; Fuster and Alexander 1971; Kojima and GoldmanRakic 1984; K ...
Spike Timing-Dependent Plasticity: From Synapse to Perception
... The simplest explanation for the post-pre LTD window is that the afterdepolarization associated with the AP causes a partial opening of NMDARs, resulting in a lowlevel Ca2⫹ influx required for LTD induction. However, such a simple model inevitably predicts the existence of a LTD window at positive ( ...
... The simplest explanation for the post-pre LTD window is that the afterdepolarization associated with the AP causes a partial opening of NMDARs, resulting in a lowlevel Ca2⫹ influx required for LTD induction. However, such a simple model inevitably predicts the existence of a LTD window at positive ( ...
Efferent connections of the parabigeminal nucleus to the amygdala
... The projection of Pbg to the Am is demonstrated in Figs. 1a, c, d. Fluoro-Gold (FG), one of the most effective fluorescent retrograde tracers, was stereotaxically injected in the central nucleus of the Am (Fig. 1a). After 4 days, the tracer was retrogradely transported to the cells of origin of the ...
... The projection of Pbg to the Am is demonstrated in Figs. 1a, c, d. Fluoro-Gold (FG), one of the most effective fluorescent retrograde tracers, was stereotaxically injected in the central nucleus of the Am (Fig. 1a). After 4 days, the tracer was retrogradely transported to the cells of origin of the ...
Morphological and F`unctional Identifications of Catfish Retinal
... Answering the first question involves the ability to predict the system response to any stimulus, and it is therefore usually carried out through the performance of suitable stimulus-response experiments. As this endeavor is directed to the discovery of the system function (in its processing of stim ...
... Answering the first question involves the ability to predict the system response to any stimulus, and it is therefore usually carried out through the performance of suitable stimulus-response experiments. As this endeavor is directed to the discovery of the system function (in its processing of stim ...
Glutamate Inhibits GABA Excitatory Activity in
... tional GABAA receptors. Most neurons also expressed glutamate receptors within the next 3 d (Chen et al., 1995; van den Pol et al., 1995). Studies in the hypothalamus (Chen et al., 1995) and other brain regions (Reynolds and Brien, 1992; Ben-Ari et al., 1994) suggest that GABAergic activity develops ...
... tional GABAA receptors. Most neurons also expressed glutamate receptors within the next 3 d (Chen et al., 1995; van den Pol et al., 1995). Studies in the hypothalamus (Chen et al., 1995) and other brain regions (Reynolds and Brien, 1992; Ben-Ari et al., 1994) suggest that GABAergic activity develops ...