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Peroxisome proliferator-activated receptor-γ (PPAR
Peroxisome proliferator-activated receptor-γ (PPAR

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Ch 2 The Biological Basis of Behavior
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Efferent connections of the parabigeminal nucleus to the amygdala
Efferent connections of the parabigeminal nucleus to the amygdala

... there is a point-to-point multineuronal chain: SC – Pbg – Am. This characteristic labeling in Pbg was first demonstrated by Graybiel (1978) in the cat (see her “band” in Fig. 6B, Graybiel, 1978). Otherwise, the ipsilaterally projecting Pbg neurons in the cat have a broader distribution (Graybiel, 19 ...
Neurons, Brain Chemistry, and Neurotransmission
Neurons, Brain Chemistry, and Neurotransmission

... synaptic cleft. An average neuron forms approximately 1,000 synapses with other neurons. It has been estimated that there are more synapses in the human brain than there are stars in our galaxy. Furthermore, synaptic connections are not static. Neurons form new synapses or strengthen synaptic connec ...
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Synaptic gating



Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation).Bistable neurons have the ability to oscillate between a hyperpolarized (down state) and a depolarized (up state) resting membrane potential without firing an action potential. These neurons can thus be referred to as up/down neurons. According to one model, this ability is linked to the presence of NMDA and AMPA glutamate receptors. External stimulation of the NMDA receptors is responsible for moving the neuron from the down state to the up state, while the stimulation of AMPA receptors allows the neuron to reach and surpass the threshold potential. Neurons that have this bistable ability have the potential to be gated because outside gatekeeper neurons can modulate the membrane potential of the gated neuron by selectively shifting them from the up state to the down state. Such mechanisms have been observed in the nucleus accumbens, with gatekeepers originating in the cortex, thalamus and basal ganglia.
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