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Motor activity induced by disinhibition of the primary motor cortex of
Motor activity induced by disinhibition of the primary motor cortex of

... Application of a GABAA 0,-aminobutyric acid-A) receptor antagonist through a microdialysis probe into the forelimb primary motor cortex of ketamine-anesthetized rats induced electromyographic activity in the contralateral forelimb. This activity consisted of spontaneous forelimb movements with a fre ...
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... bridging disciplines and introducing theoretical ideas and methods to neuroscience research. This concept of combining theoretical and experimental approaches has proven highly successful and nowadays plays a pivotal role in the modern neurosciences. Research in neural coding covers neural represent ...
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... The cerebellum plays an important role in motor learning and control, and when the cerebellum is damaged, failure of motor control (ataxia) and impairment of motor adaptation are observed. Recent experiments have shown that the cerebellum is involved in cognitive functions as well. (*3) Synaptic pla ...
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Synaptic plasticity: taming the beast

... ron is effectively summed into a relatively constant input current. In response to such input, a neuron will fire in much the same way as it would in response to the injection of the equivalent constant current through an electrode, by firing rapidly and regularly. In such a situation, the neuron ac ...
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Neuroscience 7b – Cortical Motor Function

... movement unless the stimuli is very intense (much more so than in M1). This are of the brain prepares M1 for the motor act. It does this by facilitating multiple columns in M1. These neurones are more easily stimulated by impulses from other parts of the brain and are close to the threshold level ne ...
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Distribution of GABA‐like immunoreactivity in the rat amygdaloid

... GABA-Li material. However, the pattern and location of The distribution of GABA-like immunoreactivity in the the neurons varied, as did their shapes, the density of their amygdaloid complex has been studied by using specific distribution, and the intensity of the staining in the anti-GABA antibodies ...
KKDP5: The effects of chronic changes to the functioning of the
KKDP5: The effects of chronic changes to the functioning of the

... substantia nigra, but only after we have lost about 60% of them would we start to show motor symptoms like those of Parkinson’s disease. Although Parkinson’s disease is progressive, the rate at which its symptoms worsen is variable, and only rarely is progression so rapid that a person becomes disab ...
Spinal Cord - Welcome to Study Windsor
Spinal Cord - Welcome to Study Windsor

... What is Pain?  “An unpleasant sensory & emotional experience associated with ...
Neural correlates of decision processes
Neural correlates of decision processes

... to predict which eye movements were initiated from the activity of the neurons, and the time at which they were initiated. The authors performed an analysis in which average responses were constructed from random samples of all of the trials from all of the neurons. The difference in the amount of n ...
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Synaptic gating



Synaptic gating is the ability of neural circuits to gate inputs by either suppressing or facilitating specific synaptic activity. Selective inhibition of certain synapses has been studied thoroughly (see Gate theory of pain), and recent studies have supported the existence of permissively gated synaptic transmission. In general, synaptic gating involves a mechanism of central control over neuronal output. It includes a sort of gatekeeper neuron, which has the ability to influence transmission of information to selected targets independently of the parts of the synapse upon which it exerts its action (see also neuromodulation).Bistable neurons have the ability to oscillate between a hyperpolarized (down state) and a depolarized (up state) resting membrane potential without firing an action potential. These neurons can thus be referred to as up/down neurons. According to one model, this ability is linked to the presence of NMDA and AMPA glutamate receptors. External stimulation of the NMDA receptors is responsible for moving the neuron from the down state to the up state, while the stimulation of AMPA receptors allows the neuron to reach and surpass the threshold potential. Neurons that have this bistable ability have the potential to be gated because outside gatekeeper neurons can modulate the membrane potential of the gated neuron by selectively shifting them from the up state to the down state. Such mechanisms have been observed in the nucleus accumbens, with gatekeepers originating in the cortex, thalamus and basal ganglia.
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