![figure 1 - Proceedings of the Royal Society B](http://s1.studyres.com/store/data/014127601_1-709a38204806e1caa96d5d5726db3bdd-300x300.png)
figure 1 - Proceedings of the Royal Society B
... Anabolic processes use energy to construct the molecular components of cells, whereas catabolic processes break down molecules to regulate their turnover and to harvest energy and recycle nutrients. During favourable environmental conditions (e.g. nutrient abundance), metabolic regulation favours an ...
... Anabolic processes use energy to construct the molecular components of cells, whereas catabolic processes break down molecules to regulate their turnover and to harvest energy and recycle nutrients. During favourable environmental conditions (e.g. nutrient abundance), metabolic regulation favours an ...
the scf ubiquitin ligase: insights into a molecular machine
... (LRR)), the domain is an arc-shaped α–β-repeat structure that is also found in many protein-binding contexts, including the extracellular-binding domain of certain surface receptors11,12. In most cases, FBLs also seem to involve substrate phosphorylation for their interaction, but this does not seem ...
... (LRR)), the domain is an arc-shaped α–β-repeat structure that is also found in many protein-binding contexts, including the extracellular-binding domain of certain surface receptors11,12. In most cases, FBLs also seem to involve substrate phosphorylation for their interaction, but this does not seem ...
Microtubule Associated Protein 1b (MAP1B) Is a Marker of the
... PP2A, respectively [12–18]. Homozygous constitutive MAP1B knockout mice displayed striking developmental defects in the brain, including the absence of the corpus callosum, a reduced number of large myelinated axons and myelinization defects in peripheral nerves [16]. However these mice displayed on ...
... PP2A, respectively [12–18]. Homozygous constitutive MAP1B knockout mice displayed striking developmental defects in the brain, including the absence of the corpus callosum, a reduced number of large myelinated axons and myelinization defects in peripheral nerves [16]. However these mice displayed on ...
The presence of monoglucosylated N196
... It introduces diversity into a biological system because of its inherent structural heterogeneity, and thus plays critical roles during a variety of cellular processes, such as protein folding, protein–protein interaction, immune response and responses to pathogens [2–4]. More than half of all eukar ...
... It introduces diversity into a biological system because of its inherent structural heterogeneity, and thus plays critical roles during a variety of cellular processes, such as protein folding, protein–protein interaction, immune response and responses to pathogens [2–4]. More than half of all eukar ...
Protein Targeting to the Nuclear Pore. What Can
... of membrane-bound organelles or compartments found in the cytoplasm, with each type carrying out an essential function for the cell. The spatial separation of proteins and biochemical pathways typical of the various types of organelles requires selective targeting apparatuses. Because each type of o ...
... of membrane-bound organelles or compartments found in the cytoplasm, with each type carrying out an essential function for the cell. The spatial separation of proteins and biochemical pathways typical of the various types of organelles requires selective targeting apparatuses. Because each type of o ...
intact-protein based sample preparation strategies for
... to disaggregate the tissue by treatment with collagenase or by other means, followed by a separate analysis of specific cell populations of interest. This traditional approach is still widely relied upon, particularly when large numbers of cells are needed. An elegant approach to reduce cellular het ...
... to disaggregate the tissue by treatment with collagenase or by other means, followed by a separate analysis of specific cell populations of interest. This traditional approach is still widely relied upon, particularly when large numbers of cells are needed. An elegant approach to reduce cellular het ...
Protein Arginine Methylation in Candida albicans: Role
... similar to that of a mammalian small-molecule methyltransferase that targets guanidinoacetate (29), more closely related genes are found in fungal and plant genomes but are absent in animals. S. cerevisiae shares different subsets of PRMT genes with other fungi, including Schizosaccharomyces pombe, ...
... similar to that of a mammalian small-molecule methyltransferase that targets guanidinoacetate (29), more closely related genes are found in fungal and plant genomes but are absent in animals. S. cerevisiae shares different subsets of PRMT genes with other fungi, including Schizosaccharomyces pombe, ...
Novel Inhibitory Action of Tunicamycin Homologues Suggests a
... cone-mediated axonal elongation. Elucidation of biological roles for palmitoylation in growth cone functions, or in other cellular processes, has been hindered by the lack of an inhibitor that would permit direct experimental manipulation of this modification in intact cells. The nucleoside antibiot ...
... cone-mediated axonal elongation. Elucidation of biological roles for palmitoylation in growth cone functions, or in other cellular processes, has been hindered by the lack of an inhibitor that would permit direct experimental manipulation of this modification in intact cells. The nucleoside antibiot ...
pdf - The Elf Lab
... our theory. For instance, when cells are starved for an amino acid, the missense error rates at codons read by isoacceptors for which the charg- ...
... our theory. For instance, when cells are starved for an amino acid, the missense error rates at codons read by isoacceptors for which the charg- ...
Functional Anthology of Intrinsic Disorder. 1. Biological Processes
... view of intrinsic disorder.6 More detailed analysis of extended disordered proteins/regions revealed that they can be further divided into two groups, random coil-like and pre-molten globule-like conformations.7 Recently, more than 150 proteins have been identified as containing functional disordere ...
... view of intrinsic disorder.6 More detailed analysis of extended disordered proteins/regions revealed that they can be further divided into two groups, random coil-like and pre-molten globule-like conformations.7 Recently, more than 150 proteins have been identified as containing functional disordere ...
The structural biology of the amyloid precursor protein
... It currently affects about 1 million patients in Germany and about 25 million patients worldwide. The type one transmembrane amyloid precursor protein (APP) and its processing by a series of proteolytic cleavages are generally believed to be causative to the disease (Thinakaran and Koo, 2008). APP i ...
... It currently affects about 1 million patients in Germany and about 25 million patients worldwide. The type one transmembrane amyloid precursor protein (APP) and its processing by a series of proteolytic cleavages are generally believed to be causative to the disease (Thinakaran and Koo, 2008). APP i ...
Bacteriophage EMS9: Preliminary Genomic Description
... listed first, followed by the position (in base pairs) where the ORF occurs, the DNA strand on which the information is encoded and finally, the nature of the predicted protein is listed. Certain of the ORFs listed encode proteins that are predicted to function in a variety of processes important fo ...
... listed first, followed by the position (in base pairs) where the ORF occurs, the DNA strand on which the information is encoded and finally, the nature of the predicted protein is listed. Certain of the ORFs listed encode proteins that are predicted to function in a variety of processes important fo ...
Two dileucine motifs mediate late endosomal/lysosomal targeting of
... DXXLL-type dileucine signals recruit GGA proteins (Golgilocalized, γ -ear-containing, Arf-binding proteins), a different class of monomeric clathrin adaptors functioning at the TGN [13]. Lysosomal membrane proteins can travel from the TGN via a direct route to endosomes and from there to lysosomes, ...
... DXXLL-type dileucine signals recruit GGA proteins (Golgilocalized, γ -ear-containing, Arf-binding proteins), a different class of monomeric clathrin adaptors functioning at the TGN [13]. Lysosomal membrane proteins can travel from the TGN via a direct route to endosomes and from there to lysosomes, ...
Disulfide formation in plant storage vacuoles permits assembly
... During endosperm development in the castor oil seed of Ricinus communis, lipids and proteins accumulate in oil bodies and protein storage vacuoles (PSV), respectively. The most abundant of the storage proteins, which provide an early source of amino acids to fuel post-germinative growth, are the 11S ...
... During endosperm development in the castor oil seed of Ricinus communis, lipids and proteins accumulate in oil bodies and protein storage vacuoles (PSV), respectively. The most abundant of the storage proteins, which provide an early source of amino acids to fuel post-germinative growth, are the 11S ...
`slow-twitch type` mitochondria, but does not
... than the wild-type fast-twitch muscles. This effect was attributed mainly to the increased fractional volume of mitochondria in PV– ⁄ – fast-twitch muscle, extensor digitorum longus, similar to levels observed in the slowtwitch muscle, soleus. Quantitative analysis of selected mitochondrial proteins ...
... than the wild-type fast-twitch muscles. This effect was attributed mainly to the increased fractional volume of mitochondria in PV– ⁄ – fast-twitch muscle, extensor digitorum longus, similar to levels observed in the slowtwitch muscle, soleus. Quantitative analysis of selected mitochondrial proteins ...
Montbeliarde : Bred for the French cheese Industry
... solidifies, curdles or coagulates into cheese through the action of rennet. Several types of casein exist but Kappa casein is definitely one of the most important for cheese making. Kappa Casein There are several forms of kappa casein – A, B and E – that are associated with milk protein and quality. ...
... solidifies, curdles or coagulates into cheese through the action of rennet. Several types of casein exist but Kappa casein is definitely one of the most important for cheese making. Kappa Casein There are several forms of kappa casein – A, B and E – that are associated with milk protein and quality. ...
Gene Section MAPRE1 (Microtubule-associated protein, RP/EB family, member 1)
... applied when the protein was found to target to microtubule plus ends. ...
... applied when the protein was found to target to microtubule plus ends. ...
Lecture 6 and 7
... Internal standard to make sure that abundance is normalised and variation Is due to biological variation rather than gel-to-gel variation Oct 2011 SDMBT ...
... Internal standard to make sure that abundance is normalised and variation Is due to biological variation rather than gel-to-gel variation Oct 2011 SDMBT ...
Mapping allosteric connections from the receptor G proteins
... Ras, and a helical domain that buries the guanine nucleotidebinding pocket in the core of the protein. Switch I is a loop that forms one of the two linkers between these domains by connecting the ␣F-helix of the helical domain to the 2-strand of the GTPase domain (Fig. 1 A). Upon exchange of GDP fo ...
... Ras, and a helical domain that buries the guanine nucleotidebinding pocket in the core of the protein. Switch I is a loop that forms one of the two linkers between these domains by connecting the ␣F-helix of the helical domain to the 2-strand of the GTPase domain (Fig. 1 A). Upon exchange of GDP fo ...
Protein Folding and Expression
... Brevibacillus choshinensis is a gram-positive bacterium with exceptional capacity for heterologous protein expression. The Brevibacillus Expression System II enables highly efficient production of target protein in secreted form. This system allows high yield of active proteins and is wellsuited for ...
... Brevibacillus choshinensis is a gram-positive bacterium with exceptional capacity for heterologous protein expression. The Brevibacillus Expression System II enables highly efficient production of target protein in secreted form. This system allows high yield of active proteins and is wellsuited for ...
Human Diseases Associated with Form and Function of the Golgi
... Due to its central role in the secretory pathway, it is expected that any changes to the proteome of the Golgi complex would affect its homeostasis and consequently the flux of proteins trafficking through it. In recent years several diseases have been linked in various ways with trafficking at the ...
... Due to its central role in the secretory pathway, it is expected that any changes to the proteome of the Golgi complex would affect its homeostasis and consequently the flux of proteins trafficking through it. In recent years several diseases have been linked in various ways with trafficking at the ...
Precursor of human adenovirus core polypeptide Mu targets the
... where rRNA is synthesized, processed and incorporated into ribosomes (Pederson, 1998; Scheer & Hock, 1999). In adenovirus infection the formation of 18S and 28S rRNA is reduced (Castiglia & Flint, 1983) and late in infection the nucleoli are disrupted (Puvion-Dutilleul & Christensen, 1993). Our inte ...
... where rRNA is synthesized, processed and incorporated into ribosomes (Pederson, 1998; Scheer & Hock, 1999). In adenovirus infection the formation of 18S and 28S rRNA is reduced (Castiglia & Flint, 1983) and late in infection the nucleoli are disrupted (Puvion-Dutilleul & Christensen, 1993). Our inte ...
Protein (nutrient)
Proteins are essential nutrients for the human body. They are one of the building blocks of body tissue, and can also serve as a fuel source. As a fuel, proteins contain 4 kcal per gram, just like carbohydrates and unlike lipids, which contain 9 kcal per gram. The most important aspect and defining characteristic of protein from a nutritional standpoint is its amino acid composition.Proteins are polymer chains made of amino acids linked together by peptide bonds. During human digestion, proteins are broken down in the stomach to smaller polypeptide chains via hydrochloric acid and protease actions. This is crucial for the synthesis of the essential amino acids that cannot be biosynthesized by the body.There are nine essential amino acids which humans must obtain from their diet in order to prevent protein-energy malnutrition. They are phenylalanine, valine, threonine, tryptophan, methionine, leucine, isoleucine, lysine, and histidine. There are five dispensable amino acids which humans are able to synthesize in the body. These five are alanine, aspartic acid, asparagine, glutamic acid and serine. There are six conditionally essential amino acids whose synthesis can be limited under special pathophysiological conditions, such as prematurity in the infant or individuals in severe catabolic distress. These six are arginine, cysteine, glycine, glutamine, proline and tyrosine.Humans need the essential amino acids in certain ratios. Some protein sources contain amino acids in a more or less 'complete' sense. This has given rise to various ranking systems for protein sources, as described in the article.Animal sources of protein include meats, dairy products, fish and eggs. Vegan sources of protein include whole grains, pulses, legumes, soy, and nuts. Vegetarians and vegans can get enough essential amino acids by eating a variety of plant proteins. It is commonly believed that athletes should consume a higher-than-normal protein intake to maintain optimal physical performance.