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pdf slides
pdf slides

... Linkage Analysis • Key to linkage analysis: – The smaller the amount of recombination observed between genes, i.e. the more tightly linked they are, the closer we could infer that they lie on a chromosome. ...
Gene Cloning Technology
Gene Cloning Technology

... The frequency with which this particular sequence of 6 base pairs will occur in a very large DNA molecule can be calculated on the basis of: the probability of occurrence of any specified base at each position: ...
Gene Cloning Technology
Gene Cloning Technology

... The frequency with which this particular sequence of 6 base pairs will occur in a very large DNA molecule can be calculated on the basis of: the probability of occurrence of any specified base at each position: ...
Transcription &amp
Transcription &

Cell
Cell

... DNA, usually in the form of a single circular-shaped piece The liquid interior of the cell is called the cytoplasm Prokaryotes divide, and thus reproduce, by simple mitosis DNA not associated extensively with protein. During cell division chromosome compacted into nucleoids. In bacteria no distinct ...
Antibiotics and resistance
Antibiotics and resistance

... • It is the matting of two bacterial cells during which DNA is transferred from the donor (male) to the recipient cell (female). • The mating process is controlled by F plasmid. • The mating process is mediated by the sex pilus. ...
10.6AC The Pattern - Texarkana Independent School District
10.6AC The Pattern - Texarkana Independent School District

... 2. The chain above represents three codons. Which of the following changes would be expected in the amino acid chain if the mutation shown above occurred? (a) The amino acid sequence would be shorter than expected. (b) The identity of one amino acid would change. (c) The amino acid sequence would r ...
Chapter 17- Transcription and Translation
Chapter 17- Transcription and Translation

... C) What is an activator protein (specific transcription factor)? D) What region of the DNA do the activator proteins bind to? E) How is the binding of transcription factors and activator proteins impacted by the how tightly DNA is bound to histones (level of DNA packing)? ...
Niemann Pick LAB
Niemann Pick LAB

... 2) what are the risks of future children in the family developing the disease ? ...
Bacterial Transformation with Recombinant DNA
Bacterial Transformation with Recombinant DNA

... molecule (or gene) is said to be cloned if it is contained in a vector DNA molecule from which the cloned DNA can be readily isolated. There are different types of cloning vectors such as plasmids, phage, and cosmids. In this lab we will use plasmid vectors. Plasmids Plasmids are small circular DNA ...
Exam 3 Key Fa08
Exam 3 Key Fa08

... 17. Name one protein involved in the separation of the DNA strands for replication and briefly give its function. (1 pt) [helicase – separates strand / single-stranded binding proteins – keep DNA from reconnecting / topoisomerase – releases strain on DNA by cutting, unwinding and reattaching] Sectio ...
The Genetics of Microorganisms
The Genetics of Microorganisms

... with complementary sections of the same tRNA strand • At these points the molecule bends back upon itself into several hairpin loops, giving the molecule a cloverleaf structure that then folds into a complex, 3-D helix • Bottom loop of the cloverleaf exposes a triplet (the anticodon) that designates ...
Midterm#1 comments#2 Overview- chapter 6 Crossing-over
Midterm#1 comments#2 Overview- chapter 6 Crossing-over

... • No loss of genetic material, just formation of new chromatids • Parental chromatids are noncrossover products • Recombinant chromatids are always products of crossing-over ...
DNA and Genes student
DNA and Genes student

... single base is added or deleted from DNA. • A frameshift mutation shifts the reading of codons by one base. • This mutation would cause nearly every amino acid in the protein after the deletion to be changed. ...
DNA Technology
DNA Technology

... manages to get inside a bacterial cell, this sequence ensures that it will be replicated. ...
PAN Shen Quan
PAN Shen Quan

... As a natural genetic engineer of plants, Agrobacterium tumefaciens can deliver T-DNA into different eukaryotes, including plant, yeast, fungal and human cells. This DNA transfer represents the only known example of interkingdom transfer of genetic information. We adopt a molecular genetic approach t ...
biotechnology
biotechnology

... The bands of DNA traveled to the bottom of the gel, is this side positive or negative on the electrode? Why? The negative pole is located closest to the wells. The positive pole is located furtherst from the wells. DNA is negatively charged. What suspect should be questioned further about the crime? ...
Materials and methods (Supplement)
Materials and methods (Supplement)

... mechanism (Fig. 2D, type I) [17] (Supplement Fig. 2A). However, additional short sequences were present in the footprint sequences of the plasmid DNA after excision. These additional sequences can be categorized as two types. Type II has short direct repeats, as exemplified by clone 2b, as well as b ...
1 Chapter 13: DNA, RNA, and Proteins Section 1: The Structure of
1 Chapter 13: DNA, RNA, and Proteins Section 1: The Structure of

... a. At replication fork new nucleotides are added to each side b. Original 2 strands serve as template for 2 new strands ...
Strawberry DNA extraction:
Strawberry DNA extraction:

... Today we will isolate DNA from strawberry cell. Ripe fruit is a good material for isolating plant DNA since the cell walls are already weakened by the ripening process. Commercial strawberries 8 sets of each type of chromosome (this is called octoploid). Wild strawberries have only 2 sets of chromos ...
Honors Biology Midterm Study Guide Chapter 1 and 2: The Science
Honors Biology Midterm Study Guide Chapter 1 and 2: The Science

... 5. Human hair is made of protein.  Explain how the processes of DNA replication/transcription/translation, cell cycle with Meiosis all can  lead to two people having different colored hair.  6. Explain the differences between chromosomal and gene mutations and their significance on the resulting pro ...
Biosafety and recombinant DNA technology
Biosafety and recombinant DNA technology

... • Such vectors lack certain virus replication genes and are propagated in cell lines that complement the defect. • Stocks of such vectors may be contaminated with replication-competent viruses, generated by rare spontaneous recombination events in the propagating cell lines, or may derive from insuf ...
Genetic variability
Genetic variability

...  each gamete formed receives randomly 1 ch. of the homologous pair of chromosomes - paternal (CHp) or maternal (CHm) ...
Genetics and Heredity
Genetics and Heredity

... and yellow paints blend to make green. What would happen if this was the case? ...
Gene expression
Gene expression

... NORMAL ENTRY TO/EXIT FROM CELL CYCLE ...
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Cre-Lox recombination



In the field of genetics, Cre-Lox recombination is known as a site-specific recombinase technology, and is widely used to carry out deletions, insertions, translocations and inversions at specific sites in the DNA of cells. It allows the DNA modification to be targeted to a specific cell type or be triggered by a specific external stimulus. It is implemented both in eukaryotic and prokaryotic systems.The system consists of a single enzyme, Cre recombinase, that recombines a pair of short target sequences called the Lox sequences. This system can be implemented without inserting any extra supporting proteins or sequences. The Cre enzyme and the original Lox site called the LoxP sequence are derived from bacteriophage P1.Placing Lox sequences appropriately allows genes to be activated, repressed, or exchanged for other genes. At a DNA level many types of manipulations can be carried out. The activity of the Cre enzyme can be controlled so that it is expressed in a particular cell type or triggered by an external stimulus like a chemical signal or a heat shock. These targeted DNA changes are useful in cell lineage tracing and when mutants are lethal if expressed globally.The Cre-Lox system is very similar in action and in usage to the FLP-FRT recombination system.
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