07 Adrenoceptor-antagonist
... migraine, cirrhosis with varices, and congestive heart failure), it should not be assumed that all members of this class of drugs are interchangeable; the appropriate drug should be selected from those that have documented efficacy for the disease • For example in heart failure clinical trials have ...
... migraine, cirrhosis with varices, and congestive heart failure), it should not be assumed that all members of this class of drugs are interchangeable; the appropriate drug should be selected from those that have documented efficacy for the disease • For example in heart failure clinical trials have ...
Lester-BMB170C
... Cells made a commitment, more than a billion yr ago, to use high-energy phosphate bonds for energy storage. Therefore cells contain a high internal phosphate concentration. But Ca phosphate is insoluble near neutral pH. Therefore cells cannot have appreciable concentration of Ca2+; they typically ma ...
... Cells made a commitment, more than a billion yr ago, to use high-energy phosphate bonds for energy storage. Therefore cells contain a high internal phosphate concentration. But Ca phosphate is insoluble near neutral pH. Therefore cells cannot have appreciable concentration of Ca2+; they typically ma ...
Lecture 7 - Antidepressants new 11-12
... Augmenter drugs Some antidepressants work better in some patients when used in combination with another drug. This "augmenter" drugs include: ...
... Augmenter drugs Some antidepressants work better in some patients when used in combination with another drug. This "augmenter" drugs include: ...
Antidepressant Agents
... • TCA should be used with caution in manicdepressive patients, since they may unmask manic behavior • TCA have narrow therapeutic index. Depressed patients with suicidal intents should be given limited quantities of these drugs. ...
... • TCA should be used with caution in manicdepressive patients, since they may unmask manic behavior • TCA have narrow therapeutic index. Depressed patients with suicidal intents should be given limited quantities of these drugs. ...
Dose-Response Concept
... concentration and/or duration of the chemical at the target organ are diminished. Ex. Metabolism is increased – Excretion is increased, therefore half-life is decreased Receptor antagonism occurs when two chemicals that bind to the same receptor produce less of an effect when given together than the ...
... concentration and/or duration of the chemical at the target organ are diminished. Ex. Metabolism is increased – Excretion is increased, therefore half-life is decreased Receptor antagonism occurs when two chemicals that bind to the same receptor produce less of an effect when given together than the ...
chronic pain
... unchanged by the kidneys. Side effects, though rare, may include GI upset and sedation. NMDA receptor antagonists are used as adjunctive drugs (i.e. in combination with other analgesics) to improve the control of pain. Intense and/or chronic painful stimuli result in changes in the central nervous s ...
... unchanged by the kidneys. Side effects, though rare, may include GI upset and sedation. NMDA receptor antagonists are used as adjunctive drugs (i.e. in combination with other analgesics) to improve the control of pain. Intense and/or chronic painful stimuli result in changes in the central nervous s ...
drugs acting on the respiratory system bronchial asthma
... Anorexia, nausea vomiting, abdominal discomfort, headache, anxiety, insomnia, seizures, arrhythmias. Theophylline is now largely reserved for patients in whom symptoms remain poorly controlled despite the combination of regular treatment with an inhaled anti- inflammatory agent and as needed use of ...
... Anorexia, nausea vomiting, abdominal discomfort, headache, anxiety, insomnia, seizures, arrhythmias. Theophylline is now largely reserved for patients in whom symptoms remain poorly controlled despite the combination of regular treatment with an inhaled anti- inflammatory agent and as needed use of ...
NV and antidiarrheal drugs
... Alters fat absorption resulting in the formation of gall bladder sludge and stones Hyper or hypoglycemia (insulin-glucagon disturbance) Hypothyroidism Bradycardia ...
... Alters fat absorption resulting in the formation of gall bladder sludge and stones Hyper or hypoglycemia (insulin-glucagon disturbance) Hypothyroidism Bradycardia ...
Document
... Chronic bronchitis is defined in clinical terms as a cough with sputum production on most days for 3 months of a year, for 2 consecutive years.[6] Chronic bronchitis is hallmarked by the increased number (hyperplasia) and increased size (hypertrophy) of the mucus-secreting (goblet) cells of the airw ...
... Chronic bronchitis is defined in clinical terms as a cough with sputum production on most days for 3 months of a year, for 2 consecutive years.[6] Chronic bronchitis is hallmarked by the increased number (hyperplasia) and increased size (hypertrophy) of the mucus-secreting (goblet) cells of the airw ...
LÉČIVA OVLIVŇUJÍCÍ CHOLINERGNÍ RECEPTORY
... - the heart rate may be slow initially or following a low dose (less than 0.5 mg) (result of central vagal stimulation + block of presynaptic M-autoreceptor inhibitory effects); as the muscarinic (M2) receptors on the SA node are blocked by higher concentrations of atropine, tachycardia results - at ...
... - the heart rate may be slow initially or following a low dose (less than 0.5 mg) (result of central vagal stimulation + block of presynaptic M-autoreceptor inhibitory effects); as the muscarinic (M2) receptors on the SA node are blocked by higher concentrations of atropine, tachycardia results - at ...
PHARMACOLOGY AND PHARMACEUTICAL INDUSTRY
... battery of simple in-vivo tests for various CNS activities. It has screened about 4000 plants, several thousand synthetic compounds and over 500 marine products. A protocol has been standardized to study effects on cognitive behaviour of the rhesus monkey. A primate model of anxiety has been develop ...
... battery of simple in-vivo tests for various CNS activities. It has screened about 4000 plants, several thousand synthetic compounds and over 500 marine products. A protocol has been standardized to study effects on cognitive behaviour of the rhesus monkey. A primate model of anxiety has been develop ...
5-hydroxytryptamine1a-like receptor activation in the bed nucleus of
... neurons was mediated by activation of 5-HT1A-like receptors. This was confirmed by the blockade of both 5-HTHyp and 5-CTHyp by the specific 5-HT1A receptor antagonist N-[2-[4-(2methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate salt (WAY100635 200nM). Furthermore, an in ...
... neurons was mediated by activation of 5-HT1A-like receptors. This was confirmed by the blockade of both 5-HTHyp and 5-CTHyp by the specific 5-HT1A receptor antagonist N-[2-[4-(2methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate salt (WAY100635 200nM). Furthermore, an in ...
Anglická výuka
... placebo (circa 20% vs 50%) poor adherence leads to relapse and high costs to individuals, families, carers and society stopping medication is the most powerful predictor of relapse ...
... placebo (circa 20% vs 50%) poor adherence leads to relapse and high costs to individuals, families, carers and society stopping medication is the most powerful predictor of relapse ...
16ppt
... Classically, depression was attributed to a deficiency in the neurotransmitters serotonin, ...
... Classically, depression was attributed to a deficiency in the neurotransmitters serotonin, ...
Drug Targets
... probable, and therefore only occurs rarely. • Before conversion into the products C + D, the collision complex A-B has to pass through a transition state, the formation of which usually requires a large amount of activation energy, Ea. Since only a few A–B complexes can produce this amount of energy ...
... probable, and therefore only occurs rarely. • Before conversion into the products C + D, the collision complex A-B has to pass through a transition state, the formation of which usually requires a large amount of activation energy, Ea. Since only a few A–B complexes can produce this amount of energy ...
Adrenergic Agonists
... Dopamine dilates renal and splanchnic arterioles by activating dopaminergic receptors, thus increasing blood flow to the kidneys and other viscera (see Figure 6.12). These receptors are not affected by α or β-blocking drugs. Therefore, dopamine is clinically useful in the treatment of shock, in whic ...
... Dopamine dilates renal and splanchnic arterioles by activating dopaminergic receptors, thus increasing blood flow to the kidneys and other viscera (see Figure 6.12). These receptors are not affected by α or β-blocking drugs. Therefore, dopamine is clinically useful in the treatment of shock, in whic ...
Obesity Pharmacotherapy - The 6th Arab Diabetes Forum In
... patients with Prader-Willi syndrome Ecopipam, a dopamine (D1) receptor antagonist, was originally developed as atreatment for schizophrenia. It has recently been withdrawn from clinical trials with regard to treatment of obesity. ...
... patients with Prader-Willi syndrome Ecopipam, a dopamine (D1) receptor antagonist, was originally developed as atreatment for schizophrenia. It has recently been withdrawn from clinical trials with regard to treatment of obesity. ...
Alpha Receptors, Beta Receptors, Kappa Receptors
... • The tobacco plant is native to the Americas • Europeans discovered it on their trips to the Americas and brought it back to Portugal and Spain in the 16th century; they viewed it as a miracle cure for everything from headaches to dysentery. As tobacco use spread, health concerns increased, and by ...
... • The tobacco plant is native to the Americas • Europeans discovered it on their trips to the Americas and brought it back to Portugal and Spain in the 16th century; they viewed it as a miracle cure for everything from headaches to dysentery. As tobacco use spread, health concerns increased, and by ...
The substituted amphetamines 3,4
... The abilities of the substituted amphetamines 3,4-methylenedioxymethamphetamine (MDMA), methamphetamine, p-chloroamphetamine(PCA) and fenfluramine to induce synaptosomal [3H]serotonin (5-HT) release were compared using a novel microassaysystem. The rank order of release potencies was found to be (+) ...
... The abilities of the substituted amphetamines 3,4-methylenedioxymethamphetamine (MDMA), methamphetamine, p-chloroamphetamine(PCA) and fenfluramine to induce synaptosomal [3H]serotonin (5-HT) release were compared using a novel microassaysystem. The rank order of release potencies was found to be (+) ...
Adverse reactions
... • Five dopaminergic systems or pathways are important for understanding schizophrenia and the mechanism of action of antipsychotic drugs: 1) Mesolimbic-mesocortical pathway: the one most closely related to behavior and psychosis 2) Nigrostriatal pathway: it is involved in the coordination of volunta ...
... • Five dopaminergic systems or pathways are important for understanding schizophrenia and the mechanism of action of antipsychotic drugs: 1) Mesolimbic-mesocortical pathway: the one most closely related to behavior and psychosis 2) Nigrostriatal pathway: it is involved in the coordination of volunta ...
Adverse reactions
... • Five dopaminergic systems or pathways are important for understanding schizophrenia and the mechanism of action of antipsychotic drugs: 1) Mesolimbic-mesocortical pathway: the one most closely related to behavior and psychosis 2) Nigrostriatal pathway: it is involved in the coordination of volunta ...
... • Five dopaminergic systems or pathways are important for understanding schizophrenia and the mechanism of action of antipsychotic drugs: 1) Mesolimbic-mesocortical pathway: the one most closely related to behavior and psychosis 2) Nigrostriatal pathway: it is involved in the coordination of volunta ...