NEUROTRANSMITTERS AND RECEPTORS AS THE TARGETS FOR ADDICTION TREATMENT: A
... Addiction is an important health problem which is characterized by a chronic relapsing disease with implications in social and economic life. Addiction research begins with the neurotransmitters and their mechanisms by which drugs acts and shows their effects. In this review we have presented an ove ...
... Addiction is an important health problem which is characterized by a chronic relapsing disease with implications in social and economic life. Addiction research begins with the neurotransmitters and their mechanisms by which drugs acts and shows their effects. In this review we have presented an ove ...
DRUGS AFFECTING THE RESPIRATORY SYSTEM
... Involves combined use of antihistamines, nasal decongestants, antitussives, and expectorants Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
... Involves combined use of antihistamines, nasal decongestants, antitussives, and expectorants Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
Pharmacology - Shelbye's CSON Notes Blog
... – Opiod means they act like an opiate – Opiates are from poppy seeds ...
... – Opiod means they act like an opiate – Opiates are from poppy seeds ...
Selective Serotonin-Reuptake Inhibitors
... craving and attenuating the withdrawal symptom of nicotine in tobacco. The side effect of this drug include dry mouth, sweat in, nervousness, tremor, very low incidence of sexual dysfunction, and increase the risk of seizure at high doses. 2. Mirtazapine This drug enhance serotonin and norepinephrin ...
... craving and attenuating the withdrawal symptom of nicotine in tobacco. The side effect of this drug include dry mouth, sweat in, nervousness, tremor, very low incidence of sexual dysfunction, and increase the risk of seizure at high doses. 2. Mirtazapine This drug enhance serotonin and norepinephrin ...
Early treatment of psychosis
... gain (especially clozapine, olanzapine and risperidone), potential for type II diabetes • Efficacy of all drugs similar except for clozapine and olanzapine. But they have better efficacy but worse metabolic effects. • Have high affinity for 5HT2, 1-adrenergic receptors, varied affinity for DA rece ...
... gain (especially clozapine, olanzapine and risperidone), potential for type II diabetes • Efficacy of all drugs similar except for clozapine and olanzapine. But they have better efficacy but worse metabolic effects. • Have high affinity for 5HT2, 1-adrenergic receptors, varied affinity for DA rece ...
Session 14 Pharmacodynamics
... High efficiency coupling may also result from spare receptors. Receptors may be considered spare when the maximal response is elicited by an agonist at a concentration that does not produce full occupancy of the available receptors. Spare receptors are not different from “nonspare” receptors. They a ...
... High efficiency coupling may also result from spare receptors. Receptors may be considered spare when the maximal response is elicited by an agonist at a concentration that does not produce full occupancy of the available receptors. Spare receptors are not different from “nonspare” receptors. They a ...
Pharmacology and Pharmacokinetics of Alcohol and Opioids
... NMDA receptors potentially leading to increased withdrawal symptoms of both alcohol and opiates. ...
... NMDA receptors potentially leading to increased withdrawal symptoms of both alcohol and opiates. ...
Opioid Antagonist Therapy
... Those highly motivated to abstain from all opioids Those who failed agonist therapy Th h f il d i h Those using opioids irregularly Short history of opioid abuse Those wanting to discontinue agonist therapy and are ...
... Those highly motivated to abstain from all opioids Those who failed agonist therapy Th h f il d i h Those using opioids irregularly Short history of opioid abuse Those wanting to discontinue agonist therapy and are ...
Hallucinogens
... • no actions on 5-HT2A serotonin receptors (principal molecular target for classical hallucinogens) • structurally distinct from DMT, psilocybin, mescaline and synthetic hallucinogens such as LSD and ketamines ...
... • no actions on 5-HT2A serotonin receptors (principal molecular target for classical hallucinogens) • structurally distinct from DMT, psilocybin, mescaline and synthetic hallucinogens such as LSD and ketamines ...
Lecture 15- Nervous systems (continued), Sensory and motor
... • True or False: The concentrations shown in this diagram are correct ...
... • True or False: The concentrations shown in this diagram are correct ...
The Autonomic Nervous System
... • are located primarily on presynaptic nerve endings. • The stimulation of α2 receptor causes inhibition of further release of norepinephrine. • α2 Receptors are also found on presynpatic parasympathetic neurons. Norepinephrine can diffuse and interact with these receptors, inhibiting acetylcholine ...
... • are located primarily on presynaptic nerve endings. • The stimulation of α2 receptor causes inhibition of further release of norepinephrine. • α2 Receptors are also found on presynpatic parasympathetic neurons. Norepinephrine can diffuse and interact with these receptors, inhibiting acetylcholine ...
Drug Intoxication and Withdrawal - CA
... DA and NE reuptake inhibitor, nicotinic antagonist Chemically similar to stimulants Antidepressant, no wt gain or sexual dysfunction Abused intranasally; high similar to cocaine, but less intense • Seizure with high doses (>600 mg/d) • WD rare; anxiety, lethargy, irritability • Tx: gradual taper ...
... DA and NE reuptake inhibitor, nicotinic antagonist Chemically similar to stimulants Antidepressant, no wt gain or sexual dysfunction Abused intranasally; high similar to cocaine, but less intense • Seizure with high doses (>600 mg/d) • WD rare; anxiety, lethargy, irritability • Tx: gradual taper ...
8. Anti-cholinergics
... Is a rare but important cause of anesthetic morbidity and mortality. Occurs in susceptible individuals who undergoes general anesthesia with inhaled agents (halothene) and skeletal muscle relaxants( eg, succinylcholine). ...
... Is a rare but important cause of anesthetic morbidity and mortality. Occurs in susceptible individuals who undergoes general anesthesia with inhaled agents (halothene) and skeletal muscle relaxants( eg, succinylcholine). ...
Abstract
... receptor antagonists that block both AT1 and AT2 receptor subtypes (eg saralasin). AT1-selective antagonists have also been studied in this model, at pharmacologically relevant doses. The AT1 blocker eprosartan reduced sympathetically-stimulated increases in blood pressure to a greater extent than c ...
... receptor antagonists that block both AT1 and AT2 receptor subtypes (eg saralasin). AT1-selective antagonists have also been studied in this model, at pharmacologically relevant doses. The AT1 blocker eprosartan reduced sympathetically-stimulated increases in blood pressure to a greater extent than c ...
Short Note on Receptors
... intracellular as for hormone-receptors. Binding occurs as a result of noncovalent interaction between the receptor and its ligand, at locations called the binding site on the receptor. A receptor may contain one or more binding sites for different ligands. Binding to the active or orthostatic site o ...
... intracellular as for hormone-receptors. Binding occurs as a result of noncovalent interaction between the receptor and its ligand, at locations called the binding site on the receptor. A receptor may contain one or more binding sites for different ligands. Binding to the active or orthostatic site o ...
Hormone Receptors on the Plasma Membrane
... •Stereoselectivity – receptors should recognize only one of the naturally occurring optical isomers (+ or -, d or l, or S or R). •Agonist specificity – structurally related drugs should bind well, while physically dissimilar compounds should bind poorly. •Tissue specificity – binding should occur in ...
... •Stereoselectivity – receptors should recognize only one of the naturally occurring optical isomers (+ or -, d or l, or S or R). •Agonist specificity – structurally related drugs should bind well, while physically dissimilar compounds should bind poorly. •Tissue specificity – binding should occur in ...
N receptors
... JH, a 63-year-old architect, complains of urinary symptoms to his family physician. He has hypertension and the last 8 years, he has been adequately managed with a thiazide diuretic and an angiotensin-converting enzyme inhibitor. During the same period, JH developed the signs of benign prostatic hyp ...
... JH, a 63-year-old architect, complains of urinary symptoms to his family physician. He has hypertension and the last 8 years, he has been adequately managed with a thiazide diuretic and an angiotensin-converting enzyme inhibitor. During the same period, JH developed the signs of benign prostatic hyp ...
Depression
... norepinephrine causes an increase in extracellular amine levels. • Phenelzine is a none selective • Moclobemide is a reversible and selective inhibitor of MAO-A • Selegiline is a selective for MAO-B • Side effects: ...
... norepinephrine causes an increase in extracellular amine levels. • Phenelzine is a none selective • Moclobemide is a reversible and selective inhibitor of MAO-A • Selegiline is a selective for MAO-B • Side effects: ...
Adrenergic Agonists
... – leading to a hypersensitive response. • Epinephrine enhances cardiovascular actions in these patients. • The dose of epinephrine must be reduced. ...
... – leading to a hypersensitive response. • Epinephrine enhances cardiovascular actions in these patients. • The dose of epinephrine must be reduced. ...
Antipsychotics - 2011
... Mainstay of pharmacological treatment for schizophrenia and related disorders Diminish positive symptoms such as hallucinations, delusions, thought disorder Some impact on negative symptoms such as lack of motivation, blunted affect, cognitive impairment Important as a part of relapse prevention ...
... Mainstay of pharmacological treatment for schizophrenia and related disorders Diminish positive symptoms such as hallucinations, delusions, thought disorder Some impact on negative symptoms such as lack of motivation, blunted affect, cognitive impairment Important as a part of relapse prevention ...
Inotropes & Vasopressors
... Bronchodilatation + increased MV (small effect) Decreased cerebral BF + oxygen consumption Decreased hepatic, splanchnic + renal BF Decreased insulin secretion Administration - infusion ...
... Bronchodilatation + increased MV (small effect) Decreased cerebral BF + oxygen consumption Decreased hepatic, splanchnic + renal BF Decreased insulin secretion Administration - infusion ...
