Drugs Of Abuse: A Pharmacological Perspective
... • Marijuana is considered a mild hallucinogen • Schedule 1 despite “medical marijuana” in some states • New data on possible withdrawal syndrome in chronic users ...
... • Marijuana is considered a mild hallucinogen • Schedule 1 despite “medical marijuana” in some states • New data on possible withdrawal syndrome in chronic users ...
Major Depression PPT
... Fig. 1. Survival analysis of weeks to major depressive episode relapse (MDE): comparing patients with unipolar major depressive disorder who recovered from ...
... Fig. 1. Survival analysis of weeks to major depressive episode relapse (MDE): comparing patients with unipolar major depressive disorder who recovered from ...
OPIOID ANALGESICS
... MOA OF MORPHINE Certain opioid receptors are located on primary afferent and spinal cord pain transmission neurons(ascending pathways) and on neurons in the midbrain and medulla(descending pathways) that ...
... MOA OF MORPHINE Certain opioid receptors are located on primary afferent and spinal cord pain transmission neurons(ascending pathways) and on neurons in the midbrain and medulla(descending pathways) that ...
Hallucinogens - WordPress.com
... Abraham et al, (1996): “any agent that causes alterations in perception, cognition, and mood as its primary psychobiological action in the presence of an otherwise clear sensorium” ...
... Abraham et al, (1996): “any agent that causes alterations in perception, cognition, and mood as its primary psychobiological action in the presence of an otherwise clear sensorium” ...
Neurotransmitters
... Abraham et al, (1996): “any agent that causes alterations in perception, cognition, and mood as its primary psychobiological action in the presence of an otherwise clear sensorium” ...
... Abraham et al, (1996): “any agent that causes alterations in perception, cognition, and mood as its primary psychobiological action in the presence of an otherwise clear sensorium” ...
4th Lecture 1433
... Partial agonist “Drug with intermediate level of efficacy, such that even when 100% of the receptors are occupied, the tissue response is submaximal” exhibits similar potency (EC50), but lower efficacy (Emax) produces concentration-effect curves that resemble those observed with full agonists ...
... Partial agonist “Drug with intermediate level of efficacy, such that even when 100% of the receptors are occupied, the tissue response is submaximal” exhibits similar potency (EC50), but lower efficacy (Emax) produces concentration-effect curves that resemble those observed with full agonists ...
Autonomic NS I - joshcorwin.com
... the cholinergic receptors. These include cholinesterase inhibitors (donepezil); they increase ACH release (cisapride and Reglan). Viagra is included in this group. Direct Cholinergic Agonists (Choline Esters and Plant Alkaloids) The choline esters include ACH and Carbachol. These activate both nicot ...
... the cholinergic receptors. These include cholinesterase inhibitors (donepezil); they increase ACH release (cisapride and Reglan). Viagra is included in this group. Direct Cholinergic Agonists (Choline Esters and Plant Alkaloids) The choline esters include ACH and Carbachol. These activate both nicot ...
Pharmacology Ch 9 110-126 Cholinergic Pharmacology
... 2. Neostigmine – carbamic ester blocks AChE but also activates nicotinic AChRs at NMJ (irreversible) 3. Physostigmine – carbamic ester that is fairly irreversible ...
... 2. Neostigmine – carbamic ester blocks AChE but also activates nicotinic AChRs at NMJ (irreversible) 3. Physostigmine – carbamic ester that is fairly irreversible ...
Chapter 16 Cholinesterase Inhibitors
... (may be severe) that cannot be explained by structural or chemical abnormalities May occur with diarrhea, constipation, or both Considered IBS when symptoms have been present for 12 weeks over the past year ...
... (may be severe) that cannot be explained by structural or chemical abnormalities May occur with diarrhea, constipation, or both Considered IBS when symptoms have been present for 12 weeks over the past year ...
Popular Links - UNC School of Medicine
... • More likely to occur with short t½ life agents (paroxetine warning) • May be due to sudden decrease in available synaptic 5-HT in face of down-regulated receptors • Onset 24-72 hours and lasts up to 7-14 days • Symptoms: dizziness, nausea, lethargy, headache, parasthesia ...
... • More likely to occur with short t½ life agents (paroxetine warning) • May be due to sudden decrease in available synaptic 5-HT in face of down-regulated receptors • Onset 24-72 hours and lasts up to 7-14 days • Symptoms: dizziness, nausea, lethargy, headache, parasthesia ...
DENS 211 4th Lecture
... Partial agonist “Drug with intermediate level of efficacy, such that even when 100% of the receptors are occupied, the tissue response is submaximal” exhibits similar potency (EC50), but lower efficacy (Emax) produce concentration-effect curves that resemble those observed with full agonists i ...
... Partial agonist “Drug with intermediate level of efficacy, such that even when 100% of the receptors are occupied, the tissue response is submaximal” exhibits similar potency (EC50), but lower efficacy (Emax) produce concentration-effect curves that resemble those observed with full agonists i ...
Al Tmimi - Cardiovascular active medications tekst
... Drug-receptors interaction Drug receptors are macromolecules that interact with a drug to mediate characteristic intercellular changes The study of the relationship between a drug’s dose, tissue concentration, and elapsed time is called Pharmacokinetics (how a body affects a drug). While the study o ...
... Drug-receptors interaction Drug receptors are macromolecules that interact with a drug to mediate characteristic intercellular changes The study of the relationship between a drug’s dose, tissue concentration, and elapsed time is called Pharmacokinetics (how a body affects a drug). While the study o ...
... Other properties of this drug are less well characterized. Pharmacological studies have identified epinastine as a 5-HT2 antagonist, probably due to its structural resemblance to other guanidines which have been shown to be peripherally acting 5-HT2 antagonists [1]. Epinastine has been shown to bloc ...
Muscarinic AChR agonist
... NA eg DBH inhibitors, reserpine - depletes stores Drugs targeting reuptake at synapse eg cocaine, Tricyclic antidepressants ...
... NA eg DBH inhibitors, reserpine - depletes stores Drugs targeting reuptake at synapse eg cocaine, Tricyclic antidepressants ...
Opioids OD fact sheet
... Dextropropoxyphene: significant Na channel blocking effect ( long QRS, HB, arrhythmia), seizures if >1g, may require larger doses of naloxone, can cause death in <1hr Tramadol: µ-receptor and M1 action; inhibits reuptake of 5-HT and NAD, stimulate 5-HT release; toxic dose > 1.5g (>10mg/kg); 70-90% ...
... Dextropropoxyphene: significant Na channel blocking effect ( long QRS, HB, arrhythmia), seizures if >1g, may require larger doses of naloxone, can cause death in <1hr Tramadol: µ-receptor and M1 action; inhibits reuptake of 5-HT and NAD, stimulate 5-HT release; toxic dose > 1.5g (>10mg/kg); 70-90% ...
（3）
... -b2 AR agonists such as albuterol, metaproterenol and terbutaline are used. -The drugs are administered by inhalation and are absorbed slowly, limiting their systemic side effects, and b2 selectivity reduces cardiac stimulation. ...
... -b2 AR agonists such as albuterol, metaproterenol and terbutaline are used. -The drugs are administered by inhalation and are absorbed slowly, limiting their systemic side effects, and b2 selectivity reduces cardiac stimulation. ...
Noradrenergic Transmission
... Increase cardiac output (α2 block). Reflex tachycardia. Both drugs can precipitate arrhythmias and angina and are contra-indicated in : patients with decreased coronary perfusion. ...
... Increase cardiac output (α2 block). Reflex tachycardia. Both drugs can precipitate arrhythmias and angina and are contra-indicated in : patients with decreased coronary perfusion. ...
Motivation, Addiction & Eating
... weight faster. It releases fatty acids into blood and reduces feelings of hunger. – Studies show their bodies respond to food stimuli with increased insulin levels. ...
... weight faster. It releases fatty acids into blood and reduces feelings of hunger. – Studies show their bodies respond to food stimuli with increased insulin levels. ...
Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A
... ABBREVIATIONS: 5-HT, 5-hydroxytryptamine (serotonin); AA, arachidonic acid; BSA, bovine serum albumin; BAPTA, 1,2-bis(2-aminophenoxy)ethane-N,N,N9,N9-tetraacetic acid; [Ca21]i, intracellular calcium concentration; CHO, Chinese hamster ovary; DOI, (6)-1-(2,5-dimethoxy-4iodophenyl)-2-aminopropane; AM, ...
... ABBREVIATIONS: 5-HT, 5-hydroxytryptamine (serotonin); AA, arachidonic acid; BSA, bovine serum albumin; BAPTA, 1,2-bis(2-aminophenoxy)ethane-N,N,N9,N9-tetraacetic acid; [Ca21]i, intracellular calcium concentration; CHO, Chinese hamster ovary; DOI, (6)-1-(2,5-dimethoxy-4iodophenyl)-2-aminopropane; AM, ...
CNS pharmacology
... • It is a disease that affects men and women equally • It is a disease of the brain (disturbed thinking) • Has a gene=c component • Exact pathogenesis is unknown • It is now recognised as a bio ...
... • It is a disease that affects men and women equally • It is a disease of the brain (disturbed thinking) • Has a gene=c component • Exact pathogenesis is unknown • It is now recognised as a bio ...
Drugs affecting the Respiratory System
... less. No daily medication needed; treat with inhaled beta2 agonist Step 2-Mild persistent—symptoms >2/week but <1x/day or >2 nights/month. In those >5 years old, use inhaled corticosteroid, leukotriene modifier, Intal (cromolyn), or sustained ...
... less. No daily medication needed; treat with inhaled beta2 agonist Step 2-Mild persistent—symptoms >2/week but <1x/day or >2 nights/month. In those >5 years old, use inhaled corticosteroid, leukotriene modifier, Intal (cromolyn), or sustained ...
Caffeine
... Alkaloid found in the leaves of Erythroxylon coca. A shrub endogenous to the Andes. For more than 100 years it has been used a local anesthetic & to dilate the pupil in ophthalmology. Mechanism of action Blocks the uptake of DA, NE & 5HT. The reward effect of cocaine is due to the increase of DA con ...
... Alkaloid found in the leaves of Erythroxylon coca. A shrub endogenous to the Andes. For more than 100 years it has been used a local anesthetic & to dilate the pupil in ophthalmology. Mechanism of action Blocks the uptake of DA, NE & 5HT. The reward effect of cocaine is due to the increase of DA con ...
File
... Here, the antagonist binds to allosteric site on receptor that is different from the site that binds agonist molecules, leading to change in receptor binding or affinity to agonist with subsequent antagonism. The dose response curve of antagonist is similar to that of irreversible non-competitive an ...
... Here, the antagonist binds to allosteric site on receptor that is different from the site that binds agonist molecules, leading to change in receptor binding or affinity to agonist with subsequent antagonism. The dose response curve of antagonist is similar to that of irreversible non-competitive an ...
