GKunz_EPCIS
... • Conclusion: small changes to opioid drugs can create profound changes in biological activity. This conclusion is not only relevant to opioid receptors but is really representative of the development of agonists and antagonists of all receptors. (It is this exquisitely stereospecific binding of lig ...
... • Conclusion: small changes to opioid drugs can create profound changes in biological activity. This conclusion is not only relevant to opioid receptors but is really representative of the development of agonists and antagonists of all receptors. (It is this exquisitely stereospecific binding of lig ...
Examining Pharmaceutical Claims of Unlimited Scope
... • Conclusion: small changes to opioid drugs can create profound changes in biological activity. This conclusion is not only relevant to opioid receptors but is really representative of the development of agonists and antagonists of all receptors. (It is this exquisitely stereospecific binding of lig ...
... • Conclusion: small changes to opioid drugs can create profound changes in biological activity. This conclusion is not only relevant to opioid receptors but is really representative of the development of agonists and antagonists of all receptors. (It is this exquisitely stereospecific binding of lig ...
Continuing evolution of the drug discovery process in
... chemical diversity available. These were then optimized by medicinal chemists to produce candidates, which were passed to development and eventually into the market. However, this approach at that time suffered from lack of sufficient molecules with high enough structural diversity, and the common u ...
... chemical diversity available. These were then optimized by medicinal chemists to produce candidates, which were passed to development and eventually into the market. However, this approach at that time suffered from lack of sufficient molecules with high enough structural diversity, and the common u ...
Pharmacology lecture 1 Dr. Sameer Al
... Pharmacological action of serotonin: 1- CVS: - On heart : serotonin has small +ve inotropic and +ve chronotropic effect on the heart. Elevated plasma level of serotonin in carcinoid syndrome lead to pathogenic endocardial changes. - On blood vessels : serotonin produces triphasic response which inc ...
... Pharmacological action of serotonin: 1- CVS: - On heart : serotonin has small +ve inotropic and +ve chronotropic effect on the heart. Elevated plasma level of serotonin in carcinoid syndrome lead to pathogenic endocardial changes. - On blood vessels : serotonin produces triphasic response which inc ...
HYPERTENSIN PHL315
... It is not used widely It is a logical choice for emergencies (hypertensive crisis) where you want to reduce blood pressure quickly (by reducing CO and TPR at the same time) • Useful in pre ecclampsia of pregnancy • In treatmeant of pheochromocytoma before surgery. ...
... It is not used widely It is a logical choice for emergencies (hypertensive crisis) where you want to reduce blood pressure quickly (by reducing CO and TPR at the same time) • Useful in pre ecclampsia of pregnancy • In treatmeant of pheochromocytoma before surgery. ...
PowerPoint - Pitt Honors Human Physiology
... enzyme found in the retina; this cross reactivity is thought to be the basis for abnormalities related to color vision observed with higher doses or plasma levels. • In addition to human corpus cavernosum smooth muscle, PDE5 is also found in lower concentrations in other tissues including platelets, ...
... enzyme found in the retina; this cross reactivity is thought to be the basis for abnormalities related to color vision observed with higher doses or plasma levels. • In addition to human corpus cavernosum smooth muscle, PDE5 is also found in lower concentrations in other tissues including platelets, ...
Document
... dipole interaction between a hydrogen atom and an electronegative atom, such as oxygen, nitrogen, or fluorine. The hydrogen bond is extremely strong because oxygen, nitrogen, and fluorine are extremely good at attracting the relative positive charge of hydrogen, resulting in an extreme dipole situatio ...
... dipole interaction between a hydrogen atom and an electronegative atom, such as oxygen, nitrogen, or fluorine. The hydrogen bond is extremely strong because oxygen, nitrogen, and fluorine are extremely good at attracting the relative positive charge of hydrogen, resulting in an extreme dipole situatio ...
drugs affecting the autonomic nervous system
... Adrenergic receptor: The nt noradrenaline binds only to the adrenergic receptor. These receptors are found in the sns and the drugs that mimic the action of noradrenalin and bind to these receptors are called adrenergic drugs / adrenergic agonists. These drugs will result in increased heart rate, in ...
... Adrenergic receptor: The nt noradrenaline binds only to the adrenergic receptor. These receptors are found in the sns and the drugs that mimic the action of noradrenalin and bind to these receptors are called adrenergic drugs / adrenergic agonists. These drugs will result in increased heart rate, in ...
Effects of clozapine and typical antipsychotic drugs on
... plasma 5-hydroxyindoleacetic acid (5-HIAA) levels and plasma 5-HT turnover. Design: Prospective, crosssectional study open to medication and blinded to biochemical analyses. Participants: Healthy control subjects (n = 24) and 46 inpatients and outpatients meeting the DSM-IV criteria for schizophreni ...
... plasma 5-hydroxyindoleacetic acid (5-HIAA) levels and plasma 5-HT turnover. Design: Prospective, crosssectional study open to medication and blinded to biochemical analyses. Participants: Healthy control subjects (n = 24) and 46 inpatients and outpatients meeting the DSM-IV criteria for schizophreni ...
pharmalogical emergencies
... Drug Induced Weight Gain Drug induced dysphoria, negative syndrome like symptoms • Drug related anticholinergic side effects • Drug induced cardiac complication- QTc prolongation ...
... Drug Induced Weight Gain Drug induced dysphoria, negative syndrome like symptoms • Drug related anticholinergic side effects • Drug induced cardiac complication- QTc prolongation ...
new-ff-Benzodiazepines-
... 2. They are used as sleep inducers, selective AED (triazolam) and muscle relaxants. 3. They cause transient analgesia (I.V. diazepam). 4. Combination of benzodiazepines with CNS depressants can produce true surgical anesthesia. Benzodiazepines are ideal anxiolytics due to: Devoid of the side effec ...
... 2. They are used as sleep inducers, selective AED (triazolam) and muscle relaxants. 3. They cause transient analgesia (I.V. diazepam). 4. Combination of benzodiazepines with CNS depressants can produce true surgical anesthesia. Benzodiazepines are ideal anxiolytics due to: Devoid of the side effec ...
Analgesics Power Point - IHMC Public Cmaps (3)
... chemoreceptor trigger zone causes nausea and vomiting – Unpleasant side effect, but not life threatening ...
... chemoreceptor trigger zone causes nausea and vomiting – Unpleasant side effect, but not life threatening ...
OPIOID ANALGESICS
... chemoreceptor trigger zone causes nausea and vomiting – Unpleasant side effect, but not life threatening ...
... chemoreceptor trigger zone causes nausea and vomiting – Unpleasant side effect, but not life threatening ...
PXR (N-16): sc-9690
... interacting with specific intracellular receptors to regulate gene expression. This superfamily of receptors includes both steroid and nonsteroid receptors. Like many nonsteroid hormone receptors, PXR (Pregnane X Receptor) binds as a heterodimer with RXR to a DNA sequence typical of a nonsteroid hor ...
... interacting with specific intracellular receptors to regulate gene expression. This superfamily of receptors includes both steroid and nonsteroid receptors. Like many nonsteroid hormone receptors, PXR (Pregnane X Receptor) binds as a heterodimer with RXR to a DNA sequence typical of a nonsteroid hor ...
Narcotic analgesics
... synthetics drugs with similar pharmacologic properties. These drugs produce analgesia and sedation while reducing anxiety and fear. Narcotic effects are produced in combination with opiate receptors at deep levels of the brain (thalamus, hypothalamus, limbic system). Opioid receptors are grouped int ...
... synthetics drugs with similar pharmacologic properties. These drugs produce analgesia and sedation while reducing anxiety and fear. Narcotic effects are produced in combination with opiate receptors at deep levels of the brain (thalamus, hypothalamus, limbic system). Opioid receptors are grouped int ...
Conventional Drugs
... the antihistamine drug is able to block histamine receptors effectively, but not 100%. There is also a small but finite blocking effect on cholinergic receptors too. In practice, this type of antihistamine will reduce the histamine-related allergic symptoms, but also cause anticholinergic adverse dr ...
... the antihistamine drug is able to block histamine receptors effectively, but not 100%. There is also a small but finite blocking effect on cholinergic receptors too. In practice, this type of antihistamine will reduce the histamine-related allergic symptoms, but also cause anticholinergic adverse dr ...
I. Adrenergic Nervous System: Overview
... Normally, when a person is in a serene, unstimulated state, the "firing" of neurons in the locus ceruleus is minimal. A novel stimulus (which could include a perception of danger or an environmental stressor signal such as elevated sound levels or over-illumination), once perceived, is relayed from ...
... Normally, when a person is in a serene, unstimulated state, the "firing" of neurons in the locus ceruleus is minimal. A novel stimulus (which could include a perception of danger or an environmental stressor signal such as elevated sound levels or over-illumination), once perceived, is relayed from ...
OPIOID ANALGESICS
... chemoreceptor trigger zone causes nausea and vomiting – Unpleasant side effect, but not life threatening ...
... chemoreceptor trigger zone causes nausea and vomiting – Unpleasant side effect, but not life threatening ...
Mechanism of Actions of Antidepressants: Beyond the Receptors
... behavioral effects (other than side effects). Substantial improvement in depressive symptoms occurs only if the drugs are taken at adequate dosage and with adequate frequency and permanence. However, it may not be necessary to maintain constant therapeutic serum levels for efficacy (25,26). Therefor ...
... behavioral effects (other than side effects). Substantial improvement in depressive symptoms occurs only if the drugs are taken at adequate dosage and with adequate frequency and permanence. However, it may not be necessary to maintain constant therapeutic serum levels for efficacy (25,26). Therefor ...
1-Antipsychotic drug..
... divided into two groups: The typical = 1st generation and the atypical = 2nd generation antipsychotics Atypical drugs are preferred as a first line treatment because they: 1- have fewer side effects 2- have additional benefits for the ...
... divided into two groups: The typical = 1st generation and the atypical = 2nd generation antipsychotics Atypical drugs are preferred as a first line treatment because they: 1- have fewer side effects 2- have additional benefits for the ...
Pharmacology of the autonomic nervous system for dental students
... blockers are (β1 and β2 blockers): propranolol, pindolol, oxprenolol. Pindolol and oxprenolol have intrinsic sympathomimetic activity (ISA). ISA positive drugs enhance the resting work but they decrease the frequency and contractility of the heart upon sympathetic stimulation. The advantage of the s ...
... blockers are (β1 and β2 blockers): propranolol, pindolol, oxprenolol. Pindolol and oxprenolol have intrinsic sympathomimetic activity (ISA). ISA positive drugs enhance the resting work but they decrease the frequency and contractility of the heart upon sympathetic stimulation. The advantage of the s ...
