Hypoglossal Nerve Response to 5-HT3 Drugs Injected into the XII
... 320-390g were used. All procedures were approved by the Institutional Animal Care and Use Committee of the University of Pennsylvania. ...
... 320-390g were used. All procedures were approved by the Institutional Animal Care and Use Committee of the University of Pennsylvania. ...
呼吸系统用药(汤慧芳2015V2)
... β2-AR agonists • Short-acting β2-adrenergic receptor agonists(SABAs) • 1. Albuterol (Salbuterol 沙丁胺醇 ) ...
... β2-AR agonists • Short-acting β2-adrenergic receptor agonists(SABAs) • 1. Albuterol (Salbuterol 沙丁胺醇 ) ...
Morphine
... 2- non-opioids, e.g. nonsteroidal anti-inflammatory drugs (NSAIDs). 3- Co-analgesics or adjuvants : are drugs that have a primary indication other than pain but are analgesic in some conditions. For example, antidepressants and anticonvulsants also act to reduce nociceptive processing in neuropathic ...
... 2- non-opioids, e.g. nonsteroidal anti-inflammatory drugs (NSAIDs). 3- Co-analgesics or adjuvants : are drugs that have a primary indication other than pain but are analgesic in some conditions. For example, antidepressants and anticonvulsants also act to reduce nociceptive processing in neuropathic ...
Terms and symbols - Guide to Pharmacology
... ligands bind are referred to collectively as the recognition site(s) of the receptor. Those at which the endogenous agonist binds are termed primary or orthosteric sites whereas other ligands may act through allosteric sites (see Table 1). III. Use of Drugs in Definition of Receptors or of Signaling ...
... ligands bind are referred to collectively as the recognition site(s) of the receptor. Those at which the endogenous agonist binds are termed primary or orthosteric sites whereas other ligands may act through allosteric sites (see Table 1). III. Use of Drugs in Definition of Receptors or of Signaling ...
Inhaled Adrenergic Bronchodilators: Historical
... Isoproterenol (isoprenaline). Isoproterenol has an isopropyl group attached to the terminal nitrogen, giving it a larger group at this site and, in keeping with the keyhole theory of -2 specificity, shifts its activity from ␣ to largely  stimulation. Since the catechol nucleus remains the same as ...
... Isoproterenol (isoprenaline). Isoproterenol has an isopropyl group attached to the terminal nitrogen, giving it a larger group at this site and, in keeping with the keyhole theory of -2 specificity, shifts its activity from ␣ to largely  stimulation. Since the catechol nucleus remains the same as ...
Midterm review - February 26, 2004
... Lipophilic drugs tend to have large volumes of distribution which means they tend to exert their effects quickly and then redistribute into fat (ie propofol). As a consequence, they stick around and slowly leach out of the fat into the plasma. This may or may not be significant enough to cause linge ...
... Lipophilic drugs tend to have large volumes of distribution which means they tend to exert their effects quickly and then redistribute into fat (ie propofol). As a consequence, they stick around and slowly leach out of the fat into the plasma. This may or may not be significant enough to cause linge ...
Developmental Neurotoxicity from Environmental Chemical Exposures
... • Continuous terbutaline exposure for 2 weeks: RR=2.0 • Male twins with no other affected siblings: RR=4.4 ...
... • Continuous terbutaline exposure for 2 weeks: RR=2.0 • Male twins with no other affected siblings: RR=4.4 ...
Midterm review - February 26, 2004
... Lipophilic drugs tend to have large volumes of distribution which means they tend to exert their effects quickly and then redistribute into fat (ie propofol). As a consequence, they stick around and slowly leach out of the fat into the plasma. This may or may not be significant enough to cause linge ...
... Lipophilic drugs tend to have large volumes of distribution which means they tend to exert their effects quickly and then redistribute into fat (ie propofol). As a consequence, they stick around and slowly leach out of the fat into the plasma. This may or may not be significant enough to cause linge ...
delta receptor
... The mu-receptor opens up the ion channel allowing K+ to flow out of the cell causing hyperpolarization of the membrane potential. This hyperpolarization causes it to become extremely difficult for an action potential to be reached and therefore the firing of the neuron become far less frequent and t ...
... The mu-receptor opens up the ion channel allowing K+ to flow out of the cell causing hyperpolarization of the membrane potential. This hyperpolarization causes it to become extremely difficult for an action potential to be reached and therefore the firing of the neuron become far less frequent and t ...
CARDIOVASCULAR PHARMACOLOGY
... PCT – Carbonic Anhydrase Inhibitors = weak diuretic d/t predominant effect on NaHCO3 ...
... PCT – Carbonic Anhydrase Inhibitors = weak diuretic d/t predominant effect on NaHCO3 ...
6-作用于神经系统的药物
... puberty (青春期), fall ill rarely after 40 years old. The causes of illness are not clear, probably owing to genetic factors and environmental factors together. Schizophrenia can be divided into 2 types: TypeⅠ and TypeⅡ. hallucination(幻觉), delusion(妄想) ...
... puberty (青春期), fall ill rarely after 40 years old. The causes of illness are not clear, probably owing to genetic factors and environmental factors together. Schizophrenia can be divided into 2 types: TypeⅠ and TypeⅡ. hallucination(幻觉), delusion(妄想) ...
Side effects
... Cause more cardiac stimulation (mediated by a β1 receptor), they should be reserved for special situation. - Epinephrine: very effective, rapidly acting bronchodilator especially preferable for the relief of acute attack of bronchial asthma. - Administered by inhalation or subcutaneously. Side effec ...
... Cause more cardiac stimulation (mediated by a β1 receptor), they should be reserved for special situation. - Epinephrine: very effective, rapidly acting bronchodilator especially preferable for the relief of acute attack of bronchial asthma. - Administered by inhalation or subcutaneously. Side effec ...
Serotonin Syndrome
... nervous system receptors. This drug utilization review identified Idaho Medicaid participants receiving both tramadol as well as an antidepressant over the same time period. Additional drugs that are known to cause serotonin syndrome are listed below. Patients experiencing serotonin syndrome need to ...
... nervous system receptors. This drug utilization review identified Idaho Medicaid participants receiving both tramadol as well as an antidepressant over the same time period. Additional drugs that are known to cause serotonin syndrome are listed below. Patients experiencing serotonin syndrome need to ...
united states securities and exchange commission - corporate
... “anticipates,” “estimates,” “intends,” “plans,” “potential” or similar expressions (including their use in the negative), or by discussions of future matters such as the development of product candidates or products, potential benefits of product candidates, the expected timing of data from clinical ...
... “anticipates,” “estimates,” “intends,” “plans,” “potential” or similar expressions (including their use in the negative), or by discussions of future matters such as the development of product candidates or products, potential benefits of product candidates, the expected timing of data from clinical ...
The Nemertine Toxin Anabaseine and Its Derivative DMXBA (GTS-21): Chemical and Pharmacological Properties
... have been described, the actual number of species in this inconspicuous phylum is likely to be several times this figure. Being soft-bodied and relatively vulnerable to predators, they contain integumentary toxins which serve as chemical defenses against predators [39,42,43,45,50]. The phylum is rou ...
... have been described, the actual number of species in this inconspicuous phylum is likely to be several times this figure. Being soft-bodied and relatively vulnerable to predators, they contain integumentary toxins which serve as chemical defenses against predators [39,42,43,45,50]. The phylum is rou ...
Pharmacologyonline 3: 7-22 (2011) Newsletter Tamboli et al.
... concentrations that had no effect alone, lobeline blocked nicotine-evoked DA release, indicating that it acts as an antagonist at nicotinic acetylcholine receptor (nAChR) [24]. Application of lobeline releases norepinephrine (NE) from the cytoplasm which may be due to the vesicular uptake inhibition ...
... concentrations that had no effect alone, lobeline blocked nicotine-evoked DA release, indicating that it acts as an antagonist at nicotinic acetylcholine receptor (nAChR) [24]. Application of lobeline releases norepinephrine (NE) from the cytoplasm which may be due to the vesicular uptake inhibition ...
Cimetidine - Clemson University
... • The rate but not the extent of absorption can be affected by food. • The drug distributes throughout body tissues. • 48% and 75% of an oral and IV dose, respectively, is excreted in the urine. • Half life is roughly 2 hours - with normal renal function. ...
... • The rate but not the extent of absorption can be affected by food. • The drug distributes throughout body tissues. • 48% and 75% of an oral and IV dose, respectively, is excreted in the urine. • Half life is roughly 2 hours - with normal renal function. ...
antidepressants_and_mode_stabilizing_drugs
... What are the possible mechanisms of depression? • Depression is associated with insufficient central release of NA and 5-HT. • Led to development of the Biogenic Amine Hypothesis. ...
... What are the possible mechanisms of depression? • Depression is associated with insufficient central release of NA and 5-HT. • Led to development of the Biogenic Amine Hypothesis. ...
narcotics - The Podiatry Institute
... caused by drugs with antagonist activity. Morphine-like narcotic agonists have activity at the mu and kappa receptors, and possibly at the delta receptor as wel1. Narcotic agonists include natllral occurring opium alkaloids (i.e., morphine and codeine), semisynthetic analogs (i.e., hydromorphone, ox ...
... caused by drugs with antagonist activity. Morphine-like narcotic agonists have activity at the mu and kappa receptors, and possibly at the delta receptor as wel1. Narcotic agonists include natllral occurring opium alkaloids (i.e., morphine and codeine), semisynthetic analogs (i.e., hydromorphone, ox ...
DRUG RECEPTOR AND PHARMCODYNAMICS
... Graded dose response means that a slight increase of drug should bring about a small increase in the response, for example, increase doses of histamine cause gradual contraction of the guinea-pig ileum. Very low doses of histamine have virtually no effect and responses can be observed, only beyond ...
... Graded dose response means that a slight increase of drug should bring about a small increase in the response, for example, increase doses of histamine cause gradual contraction of the guinea-pig ileum. Very low doses of histamine have virtually no effect and responses can be observed, only beyond ...
Psy 5260 – Summer I 2009 Week Seven Lecture Notes
... GABA analogue, increases GABA levels in brain Excellent pharmacokinetic profile: no binding to plasma proteins, not metabolized, excreted unchanged by kidneys, few pk drug interactions, half-life 5-7 hours Results of clinical studies suggest this agent is most effective as adjunctive med. In pts. re ...
... GABA analogue, increases GABA levels in brain Excellent pharmacokinetic profile: no binding to plasma proteins, not metabolized, excreted unchanged by kidneys, few pk drug interactions, half-life 5-7 hours Results of clinical studies suggest this agent is most effective as adjunctive med. In pts. re ...
Towards a Molecular Description of the GABA
... Major mammalian inhibitory neurotransmitter receptor Pentameric integral membrane protein containing an ion channel selective for chloride ions. ...
... Major mammalian inhibitory neurotransmitter receptor Pentameric integral membrane protein containing an ion channel selective for chloride ions. ...