Schizophrenia and the supersensitive synapse
... the ‘supersensitive synapse’. Outline of the integrated model The chain of events starts with a nonspecific injury. This can be a gene mutation leading to hypofunction or hyperfunction of a protein. It can be the result of chemicals, toxins, drugs, infectious agents, hypoxia or direct trauma. The or ...
... the ‘supersensitive synapse’. Outline of the integrated model The chain of events starts with a nonspecific injury. This can be a gene mutation leading to hypofunction or hyperfunction of a protein. It can be the result of chemicals, toxins, drugs, infectious agents, hypoxia or direct trauma. The or ...
May 2015 ToxTidbits - Maryland Poison Center
... synthe c cannabinoid compounds that have been studied have nonselec ve affinity for and agonist ac on at cannabinoid receptors CB1 and CB2. This is similar to delta-9-tetrahydrocannabinol (THC), the psychoac ve cannabinoid in cannabis plants. However, there are important differences. THC is a par al ...
... synthe c cannabinoid compounds that have been studied have nonselec ve affinity for and agonist ac on at cannabinoid receptors CB1 and CB2. This is similar to delta-9-tetrahydrocannabinol (THC), the psychoac ve cannabinoid in cannabis plants. However, there are important differences. THC is a par al ...
New Insights for Drug Design from the X
... areas in TM regions and the involvement of the ELs. A current challenge is how to use this structural information for the rational design of novel potent and selective ligands. For example, new chemotypes were discovered as antagonists of various GPCRs by subjecting chemical libraries to in silico d ...
... areas in TM regions and the involvement of the ELs. A current challenge is how to use this structural information for the rational design of novel potent and selective ligands. For example, new chemotypes were discovered as antagonists of various GPCRs by subjecting chemical libraries to in silico d ...
ANS - Anesthesiology, Pharmacology and Therapeutics
... Critical chemical centres in acetylcholine are the positive Nitrogen and the carbonyl oxygen (-C=O). Those with an ester (acid + alcohol) linkage, such as ACh and methacholine MCh (methacholine = acetylbetamethylacetylcholine) are metabolized by acetylcholinesterase (AChE). It might be surprising th ...
... Critical chemical centres in acetylcholine are the positive Nitrogen and the carbonyl oxygen (-C=O). Those with an ester (acid + alcohol) linkage, such as ACh and methacholine MCh (methacholine = acetylbetamethylacetylcholine) are metabolized by acetylcholinesterase (AChE). It might be surprising th ...
Orciprenaline Sulphate
... This medication should be taken 3 times a day, by mouth. It may take a few hours before the full benefit of the drug takes effect. ...
... This medication should be taken 3 times a day, by mouth. It may take a few hours before the full benefit of the drug takes effect. ...
Allosteric Modulation: a Novel Approach to Drug Discovery
... only been able to discover competitive compounds. These molecules must interact with the highlyconserved endogenous ligand binding site, often resulting in a limited set of pharmacophores all with similar side effect profiles. Allosteric modulators offer a promising way to revisit these targets, pro ...
... only been able to discover competitive compounds. These molecules must interact with the highlyconserved endogenous ligand binding site, often resulting in a limited set of pharmacophores all with similar side effect profiles. Allosteric modulators offer a promising way to revisit these targets, pro ...
cAlnOfficial Journalofthe c.AmericanHeart cjlssociation
... traditional pharmacologic models and modern biochemical techniques have documented the existence of distinct dopamine receptor subtypes that mediate these responses. Appreciation of the structure-activity requirements of these receptors has led to the synthesis of drugs that may have a profound infl ...
... traditional pharmacologic models and modern biochemical techniques have documented the existence of distinct dopamine receptor subtypes that mediate these responses. Appreciation of the structure-activity requirements of these receptors has led to the synthesis of drugs that may have a profound infl ...
3rd year antidepressant part 22011-09
... Side effects similar to SSRI drugs but may be withdrawal manifestations on discontinuation may need dosage tapering ...
... Side effects similar to SSRI drugs but may be withdrawal manifestations on discontinuation may need dosage tapering ...
Antiemetic drugs
... synapses. Due to multiple cholinergic effects and the advent of less toxic agents, it is now seldom used. B. The acetylcholinesterase inhibitor: – Intravenous neostigmine can be used in the treatment of acute large bowel distention . – Cholinergic effects include excessive salivation, nausea, vomiti ...
... synapses. Due to multiple cholinergic effects and the advent of less toxic agents, it is now seldom used. B. The acetylcholinesterase inhibitor: – Intravenous neostigmine can be used in the treatment of acute large bowel distention . – Cholinergic effects include excessive salivation, nausea, vomiti ...
VRX-03011, a novel 5-HT4 agonist, enhances memory and
... and memory. This limitation is compounded by some previously developed 5-HT4 receptor agonists producing adverse drug reactions in gastrointestinal functions (Briejer et al., 2001; Wooltorton, 2004). Thus, a partial 5-HT4 agonist that more selectively modulates ACh output during mnemonic conditions ...
... and memory. This limitation is compounded by some previously developed 5-HT4 receptor agonists producing adverse drug reactions in gastrointestinal functions (Briejer et al., 2001; Wooltorton, 2004). Thus, a partial 5-HT4 agonist that more selectively modulates ACh output during mnemonic conditions ...
Subtype-selective GABAA receptor mimetics—novel
... of GABAA receptors enabling the pharmacological separation of different benzodiazepine effects. GABAA receptors are heteropentameric chloride channels assembled from a repertoire of α, β, γ, δ, ɛ, θ, π, and ρ subunits [14]. Benzodiazepine-sensitive GABAA receptors, which make up the majority of GABA ...
... of GABAA receptors enabling the pharmacological separation of different benzodiazepine effects. GABAA receptors are heteropentameric chloride channels assembled from a repertoire of α, β, γ, δ, ɛ, θ, π, and ρ subunits [14]. Benzodiazepine-sensitive GABAA receptors, which make up the majority of GABA ...
Large Receptor Reserve for Cannabinoid Actions in the Central
... significant inhibition of radiotracer binding in the mouse brains, except at very high doses (10 mg/kg or greater, i.v.). By contrast, the CB1 antagonist SR 141716A (10 mg/kg, i.p.), completely abolished specific [131I]AM 281 binding. These experiments suggest that behavioral effects of cannabinoids ...
... significant inhibition of radiotracer binding in the mouse brains, except at very high doses (10 mg/kg or greater, i.v.). By contrast, the CB1 antagonist SR 141716A (10 mg/kg, i.p.), completely abolished specific [131I]AM 281 binding. These experiments suggest that behavioral effects of cannabinoids ...
Introduction of two new anaesthetic agents
... • a2-adrenoceptors: are found in both the central and peripheral nervous system. They are found both pre- and postsynaptically and serve to produce inhibitory functions. • -Presynaptic a2 receptors inhibit the release of noradrenaline and thus serve as an important receptor in the negative feedback ...
... • a2-adrenoceptors: are found in both the central and peripheral nervous system. They are found both pre- and postsynaptically and serve to produce inhibitory functions. • -Presynaptic a2 receptors inhibit the release of noradrenaline and thus serve as an important receptor in the negative feedback ...
Anti-psychotics
... o Atypical APDs (esp. ziprasidone): significant risk of QT prolongation o Overall: ~2x increased risk of sudden cardiac death with both typical and atypical (dose-dependent) Endocrine Effects: o Hyperprolactinemia: manifest as amenorrhea, galactorrhea, infertility, impotence ...
... o Atypical APDs (esp. ziprasidone): significant risk of QT prolongation o Overall: ~2x increased risk of sudden cardiac death with both typical and atypical (dose-dependent) Endocrine Effects: o Hyperprolactinemia: manifest as amenorrhea, galactorrhea, infertility, impotence ...
Psychopharmacology
... Given the structural diversity of the members of each class, they may not resemble each other in terms of their pharmacokinetics, metabolism or toxicity. However, most have an action on the metabolism and at the receptor for monoamine neurotransmitters: Norepinephrine Serotonin Dopamine ...
... Given the structural diversity of the members of each class, they may not resemble each other in terms of their pharmacokinetics, metabolism or toxicity. However, most have an action on the metabolism and at the receptor for monoamine neurotransmitters: Norepinephrine Serotonin Dopamine ...
Anxiety - Psychiatry Training
... • increased NE firing/activity produces anxiety state – stimulation of locus ceruleus; a2-antagonists (yohimbine/idazoxan) – plasma NE responses to stress higher in GAD vs controls (not all studies) ...
... • increased NE firing/activity produces anxiety state – stimulation of locus ceruleus; a2-antagonists (yohimbine/idazoxan) – plasma NE responses to stress higher in GAD vs controls (not all studies) ...
Demographic Differences in the Misuse and Abuse of Oxycodone
... 3. Ghafouri N, Darracq MA, Cantrell FL. Ondansetron-associated hypotension following pediatric self-poisoning. Pediatric emergency care. 2012;28:596-7. 4. Pillbox. Bethesda (MD): U S Department of Health and Human Services, National Institutes of Health; [cited 2014 Mar 10]. Available from: ...
... 3. Ghafouri N, Darracq MA, Cantrell FL. Ondansetron-associated hypotension following pediatric self-poisoning. Pediatric emergency care. 2012;28:596-7. 4. Pillbox. Bethesda (MD): U S Department of Health and Human Services, National Institutes of Health; [cited 2014 Mar 10]. Available from: ...
SECONDARY METABOLITES ISOLATED FROM PEROVSKIA
... atom types, number of chiral centers, and number of rings and chains (Gao, 2010). Based on the results of this investigation, it was determined that natural products are significantly more diverse than combinatorial compounds (Gao, 2010). Furthermore, natural products have superior drug-like propert ...
... atom types, number of chiral centers, and number of rings and chains (Gao, 2010). Based on the results of this investigation, it was determined that natural products are significantly more diverse than combinatorial compounds (Gao, 2010). Furthermore, natural products have superior drug-like propert ...
HST-151
... accounting for different levels of occupancy (i.e. the proportion of L2·nAChR in scheme 1) at equal agonist concentrations. The rate constants for channel opening and closing, α and ß, also depend on the particular ligand, so the time that the ligand-activated channel spends in the conducting state ...
... accounting for different levels of occupancy (i.e. the proportion of L2·nAChR in scheme 1) at equal agonist concentrations. The rate constants for channel opening and closing, α and ß, also depend on the particular ligand, so the time that the ligand-activated channel spends in the conducting state ...
Opioid Analgesics and Antagonists
... codeine.. It is well absorbed orally, , and it is metabolized in the liver. Propoxyphene can produce nausea, anorexia, and constipation. ...
... codeine.. It is well absorbed orally, , and it is metabolized in the liver. Propoxyphene can produce nausea, anorexia, and constipation. ...
Pharmacology of the Autonomic Nervous System
... Dopa decarboxylase (dopa to dopamine) is found in the cytoplasm of many nonneural as well as neural tissues and had been called "aromatic-L-amino acid decarboxylase" because of its broad substrate specificity. Peripheral (non-neuronal) dopa Figure 6: Metabolic pathway of decarboxylase can be inhibit ...
... Dopa decarboxylase (dopa to dopamine) is found in the cytoplasm of many nonneural as well as neural tissues and had been called "aromatic-L-amino acid decarboxylase" because of its broad substrate specificity. Peripheral (non-neuronal) dopa Figure 6: Metabolic pathway of decarboxylase can be inhibit ...
OPIATE ANALGESICS AND ANTAGONISTS
... • 2. Used orally to relieve mild to moderate pain, it is weak analgesic ;often combined with Paracetamol . • 3. Has a low addiction potential • 4. The most common adverse side effects are: dizziness, drowsiness, and nausea and vomiting. • 5. CNS depression is additive with other CNS depressants (alc ...
... • 2. Used orally to relieve mild to moderate pain, it is weak analgesic ;often combined with Paracetamol . • 3. Has a low addiction potential • 4. The most common adverse side effects are: dizziness, drowsiness, and nausea and vomiting. • 5. CNS depression is additive with other CNS depressants (alc ...
Yolande Knight serotonin syndrome presentation BASH meeting
... What explains the reports of serotonin syndrome in co-prescribed triptan and SSRI/SNRI? Some of the published case reports provided insufficient ...
... What explains the reports of serotonin syndrome in co-prescribed triptan and SSRI/SNRI? Some of the published case reports provided insufficient ...