Pharmacology/Therapeutics II Block I Lectures
... a failed homicide as psychiatric care or police intervention may be required. A patient may be unwilling or unable to relate the quantity, identity, exposure route, or dosing time of the agent. Thus, supportive care is often the mainstay of management unless a toxicological syndrome that has an anti ...
... a failed homicide as psychiatric care or police intervention may be required. A patient may be unwilling or unable to relate the quantity, identity, exposure route, or dosing time of the agent. Thus, supportive care is often the mainstay of management unless a toxicological syndrome that has an anti ...
Respiratory Pharmacology Week 4
... or β-adrenergic receptors. • Blood vessels: α1 couples to Gq, which results in increased intracellular Ca2+ which results in smooth muscle contraction. α2, on the other hand, couples to Gi, which causes a decrease of cAMP activity, resulting in e.g. smooth muscle contraction. • Heart/Lung: β recepto ...
... or β-adrenergic receptors. • Blood vessels: α1 couples to Gq, which results in increased intracellular Ca2+ which results in smooth muscle contraction. α2, on the other hand, couples to Gi, which causes a decrease of cAMP activity, resulting in e.g. smooth muscle contraction. • Heart/Lung: β recepto ...
Long-Term Effects of Olanzapine, Risperidone, and Quetiapine on
... common sites of action of both typical and atypical antipsychotics, although the physiological consequences of these molecular changes remain incompletely defined. In contrast, typical neuroleptics, but not clozapine, also increased D2 receptor binding and expression in rat and monkey CPu (Lidow and ...
... common sites of action of both typical and atypical antipsychotics, although the physiological consequences of these molecular changes remain incompletely defined. In contrast, typical neuroleptics, but not clozapine, also increased D2 receptor binding and expression in rat and monkey CPu (Lidow and ...
GRADED DOSE RESPONSE CURVE An all-or-non
... 2.The potency = The concentration of drug required to produce a specified response The smaller the EC50 , the greater the potency of the agonist i.e. the lower C needed to elicit the maximum biological response. 3. Compare the relative potency and efficacy of drugs that produce the same effect. ...
... 2.The potency = The concentration of drug required to produce a specified response The smaller the EC50 , the greater the potency of the agonist i.e. the lower C needed to elicit the maximum biological response. 3. Compare the relative potency and efficacy of drugs that produce the same effect. ...
IN-SILICO PROTEIN LIGAND INTERACTION STUDY OF TYPICAL ANTIPSYCHOTIC DRUGS
... primarily used to manage psychosis (including delusions or hallucinations, as well as disordered thought), particularly in schizophrenia and bipolar disorder, and is increasingly being used in the management of non-psychotic disorders. A first generation of antipsychotics, known as typical antipsych ...
... primarily used to manage psychosis (including delusions or hallucinations, as well as disordered thought), particularly in schizophrenia and bipolar disorder, and is increasingly being used in the management of non-psychotic disorders. A first generation of antipsychotics, known as typical antipsych ...
I. Morphine
... – Used orally to relieve mild to moderate pain, it is weak analgesic; often combined with Paracetamol. – Has a low addiction potential – The most common adverse effects are: dizziness, drowsiness, and nausea and vomiting. – CNS depression is additive with other CNS depressants (alcohol and sedatives ...
... – Used orally to relieve mild to moderate pain, it is weak analgesic; often combined with Paracetamol. – Has a low addiction potential – The most common adverse effects are: dizziness, drowsiness, and nausea and vomiting. – CNS depression is additive with other CNS depressants (alcohol and sedatives ...
Receptors as Drug Targets
... • Receptors become sensititized on long term exposure to antagonists • Cell synthesises more receptors to compensate for blocked receptors • Cells become more sensitive to natural messenger • Can result in tolerance and dependence • Increased doses of antagonist are required to achieve same effect ( ...
... • Receptors become sensititized on long term exposure to antagonists • Cell synthesises more receptors to compensate for blocked receptors • Cells become more sensitive to natural messenger • Can result in tolerance and dependence • Increased doses of antagonist are required to achieve same effect ( ...
Heel 2
... antagonizes the muscarinic effects central and peripheral. 2-Cholmesterases reactivators (oximes) as Pralidoxime (PAM), diacetyl monoxime (DAM). They combine with the poison in blood and may dephosphorylate the enzyme if given early before aging of the enzyme. They reverse muscle weakness and are us ...
... antagonizes the muscarinic effects central and peripheral. 2-Cholmesterases reactivators (oximes) as Pralidoxime (PAM), diacetyl monoxime (DAM). They combine with the poison in blood and may dephosphorylate the enzyme if given early before aging of the enzyme. They reverse muscle weakness and are us ...
Intra-articular injection of morphine: may it play a role? Serbülent
... pain was partly the result of increased endogenous surgery, the opioid receptor antagonists naloxone opioid function, naloxone or naloxone methiodide or peripherally restricted naloxone methiodide were was administered. Both opioid receptor antagonists administered, and pain was assessed. Levels of ...
... pain was partly the result of increased endogenous surgery, the opioid receptor antagonists naloxone opioid function, naloxone or naloxone methiodide or peripherally restricted naloxone methiodide were was administered. Both opioid receptor antagonists administered, and pain was assessed. Levels of ...
What lessons can we learn from 20 years of chemokine receptor drug discovery?
... • CCR2, CCR5 and CXCR4 form homo and heterodimers, and oligomers • Heterodimers shown to exhibit negative agonist binding cooperativity as a result of allosteric modulation • Selective antagonists show partial inhibition of signalling through g the other receptor p in cells coexpressing p g both CCR ...
... • CCR2, CCR5 and CXCR4 form homo and heterodimers, and oligomers • Heterodimers shown to exhibit negative agonist binding cooperativity as a result of allosteric modulation • Selective antagonists show partial inhibition of signalling through g the other receptor p in cells coexpressing p g both CCR ...
Histamine - heartha..
... H1 antagonists include both first-generation and second-generation compounds Both categories of agents are orally active and are metabolized by the liver using the cytochrome P450 drug-metabolizing system The average duration of pharmacological action is about 4-6 hours Meclizine (Antivert) ...
... H1 antagonists include both first-generation and second-generation compounds Both categories of agents are orally active and are metabolized by the liver using the cytochrome P450 drug-metabolizing system The average duration of pharmacological action is about 4-6 hours Meclizine (Antivert) ...
Opiates
... receptors, produced in the cell bodies of C fibres in the dorsal root ganglion, and transported both centrally and peripherally, become functional in the periphery. A number of clinical studies have demonstrated this action, but the efficacy of peripheral opioids after inflammation is much less than the ...
... receptors, produced in the cell bodies of C fibres in the dorsal root ganglion, and transported both centrally and peripherally, become functional in the periphery. A number of clinical studies have demonstrated this action, but the efficacy of peripheral opioids after inflammation is much less than the ...
Clinical uses Chronic Hypertension
... human liver and decreased glucose release (β2receptor blockade) • Therefore, β-blockers should be used with caution in type I diabetic patients ...
... human liver and decreased glucose release (β2receptor blockade) • Therefore, β-blockers should be used with caution in type I diabetic patients ...
Steroids: Estrogen and Progestin
... •PR-A strongly inhibits this action of PR-B •Upon binding progesterone, the heat-shock proteins dissociate, and the receptors are phosphorylated and subsequently form dimers (homo- and hetero-) that bind with high selectivity to progesterone response elements located on target genes ...
... •PR-A strongly inhibits this action of PR-B •Upon binding progesterone, the heat-shock proteins dissociate, and the receptors are phosphorylated and subsequently form dimers (homo- and hetero-) that bind with high selectivity to progesterone response elements located on target genes ...
Autonomic Nervous System
... •Muscarinic agonist = cholinergic agent •Causes receptor activation •The prototype is Bethanechol/ Urecholine •Reversibly binds to muscarinic cholingeric receptors •Relief of urinary retention postoperatively and post-partum ...
... •Muscarinic agonist = cholinergic agent •Causes receptor activation •The prototype is Bethanechol/ Urecholine •Reversibly binds to muscarinic cholingeric receptors •Relief of urinary retention postoperatively and post-partum ...
07 Rhinitis & cough
... o Non-pharmacological therapy – Avoidance of irritants/ allergen – Dusting/vacuuming; washing of bed sheets – Intake of fluids ...
... o Non-pharmacological therapy – Avoidance of irritants/ allergen – Dusting/vacuuming; washing of bed sheets – Intake of fluids ...
Structural analysis of histamine receptors and its application in drug
... histamine receptors is not available. On the other hand, homology models can be built by using the experimental 3D structure of a sequentially related protein, and the sequence alignment of the target and the template proteins. Structure-based methods can be used effectively in several stages of dru ...
... histamine receptors is not available. On the other hand, homology models can be built by using the experimental 3D structure of a sequentially related protein, and the sequence alignment of the target and the template proteins. Structure-based methods can be used effectively in several stages of dru ...
Press Releases - Guy Griebel Homepage
... of leukaemia, whereas all of the mice in the placebo group developed fatal disease. Moreover, spleen weights and WBC counts were also significantly lower in the treated mice. Both of these studies strongly support the idea that FLT3 is potentially a good drug target in AML. PKC412 and CT53518 are no ...
... of leukaemia, whereas all of the mice in the placebo group developed fatal disease. Moreover, spleen weights and WBC counts were also significantly lower in the treated mice. Both of these studies strongly support the idea that FLT3 is potentially a good drug target in AML. PKC412 and CT53518 are no ...
lec#6 ANS - DENTISTRY 2012
... ISA (Intrinsic Sympathomimetic Activity) Some β-blockers have ISA (act as partial agonists) which is weak as compared to their β-blocking activity. Such blockers would be advantageous in patients with heart failure and bradycardia β-blockers with ISA are rarely used because they increase risk after ...
... ISA (Intrinsic Sympathomimetic Activity) Some β-blockers have ISA (act as partial agonists) which is weak as compared to their β-blocking activity. Such blockers would be advantageous in patients with heart failure and bradycardia β-blockers with ISA are rarely used because they increase risk after ...
Lecture presentation - TMA Department Sites
... Nausea, dry mouth, vomiting, diarrhea, cramps, ischemic colitis ...
... Nausea, dry mouth, vomiting, diarrhea, cramps, ischemic colitis ...
XML - Student Journals @ McMaster University
... characterized by recurrent seizures that cause changes in attention or behaviour1. Epileptic seizures occur due to abnormal, excessive, and hyper-synchronous neuronal activity in the brain2. Currently, antiepileptic drugs are ineffective for 30% of all epileptic patients and most only provide short- ...
... characterized by recurrent seizures that cause changes in attention or behaviour1. Epileptic seizures occur due to abnormal, excessive, and hyper-synchronous neuronal activity in the brain2. Currently, antiepileptic drugs are ineffective for 30% of all epileptic patients and most only provide short- ...
Dopamine D1-like Receptors and Reward-related
... the arguments for this idea are not straightforward, but involve a number of other subsidiary assumptions (70). Because of the need for these assumptions, our interpretation of the evidence may appear complex, and other interpretations may appear more straightforward and equally plausible. One of th ...
... the arguments for this idea are not straightforward, but involve a number of other subsidiary assumptions (70). Because of the need for these assumptions, our interpretation of the evidence may appear complex, and other interpretations may appear more straightforward and equally plausible. One of th ...