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THE THREE-DIMENSIONAL STRUCTURE OF PROTEINS
... can theoretically assume countless different conformations, and as a result the unfolded state of a protein is characterized by a high degree of conformational entropy. This entropy, and the hydrogen-bonding interactions of many groups in the polypeptide chain with solvent (water), tend to maintain ...
... can theoretically assume countless different conformations, and as a result the unfolded state of a protein is characterized by a high degree of conformational entropy. This entropy, and the hydrogen-bonding interactions of many groups in the polypeptide chain with solvent (water), tend to maintain ...
International Journal on New Trends in Education and Their
... S: tRNAs remains in the protein structure along with amino acids. Even though the pre-service teacher knows that the duty of tRNA in protein synthesis is to bring amino acids, he/she still thinks that as a result of protein synthesis, tRNA and amino acids merge and become a part of the protein struc ...
... S: tRNAs remains in the protein structure along with amino acids. Even though the pre-service teacher knows that the duty of tRNA in protein synthesis is to bring amino acids, he/she still thinks that as a result of protein synthesis, tRNA and amino acids merge and become a part of the protein struc ...
Renin Precursor Synthesis and Renin
... plasma it does not bind to other proteins. This facilitates its enzymatic activity in mouse plasma, but does not offer an explanation for the highmolecular-weight forms. In order to mimic complex-formation of renin with plasma proteins 1251-labelled pure submaxillary mol. wt. 40000 renin was mixed w ...
... plasma it does not bind to other proteins. This facilitates its enzymatic activity in mouse plasma, but does not offer an explanation for the highmolecular-weight forms. In order to mimic complex-formation of renin with plasma proteins 1251-labelled pure submaxillary mol. wt. 40000 renin was mixed w ...
characterization of proteins from the cytoskeleton of giardia lamblia
... species are competent to co-assemble. To explain structural diversity of microtubules in vivo, one possibility is that assembly is specifically modified by other proteins associated with tubulin. Accessory proteins might exert an effect in a number of ways: by direct structural interactions with tub ...
... species are competent to co-assemble. To explain structural diversity of microtubules in vivo, one possibility is that assembly is specifically modified by other proteins associated with tubulin. Accessory proteins might exert an effect in a number of ways: by direct structural interactions with tub ...
De Novo Pyrimidine Nucleotide Synthesis Mainly
... to the Nucleobase:Cation Symporter1 (NCS1) family of transport proteins, also known as purine-related transporters (Saier et al., 2009; www.tcdb.org). The closest Arabidopsis homolog to this protein is encoded by At5g03555. The deduced amino acid sequence exhibits 23% identity and 43% similarity to ...
... to the Nucleobase:Cation Symporter1 (NCS1) family of transport proteins, also known as purine-related transporters (Saier et al., 2009; www.tcdb.org). The closest Arabidopsis homolog to this protein is encoded by At5g03555. The deduced amino acid sequence exhibits 23% identity and 43% similarity to ...
A metaproteomic assessment of winter and summer
... Rhodobacterales clades of Alphaproteobacteria, as well as many lineages of Gammaproteobacteria. The metaproteome data were used to elucidate the main metabolic and energy generation pathways and transport processes occurring at the microbial level in each season. In summer, autotrophic carbon assimi ...
... Rhodobacterales clades of Alphaproteobacteria, as well as many lineages of Gammaproteobacteria. The metaproteome data were used to elucidate the main metabolic and energy generation pathways and transport processes occurring at the microbial level in each season. In summer, autotrophic carbon assimi ...
Metabolic Pathway Flux Enhancement by Synthetic
... with long flexible synthetic linkers to colocalize enzymes in engineered metabolic pathways. While this approach currently lacks the ability to precisely control the three-dimensional positioning of recruited enzymes, it has the advantage that each protein–protein interaction domain should be capabl ...
... with long flexible synthetic linkers to colocalize enzymes in engineered metabolic pathways. While this approach currently lacks the ability to precisely control the three-dimensional positioning of recruited enzymes, it has the advantage that each protein–protein interaction domain should be capabl ...
Host cell protein analysis by mass spectrometry and its application
... Case: Exchange of the depth filter in the manufacturing process ELISA results showed comparable levels of HCP in the drug substance batches before and after the filter change ...
... Case: Exchange of the depth filter in the manufacturing process ELISA results showed comparable levels of HCP in the drug substance batches before and after the filter change ...
Brucella Quorum Sensing: much more than
... long chain AHLs limits their diffusion and increases their interaction with bacterial membranes, which lowers their presence in the culture medium (Pearson et al., 1999; Schaefer et al., 2002); (ii) in vitro AHL production does not correlate with in vivo production, as seen in P. aeruginosa (Ericks ...
... long chain AHLs limits their diffusion and increases their interaction with bacterial membranes, which lowers their presence in the culture medium (Pearson et al., 1999; Schaefer et al., 2002); (ii) in vitro AHL production does not correlate with in vivo production, as seen in P. aeruginosa (Ericks ...
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... catalytically-competent orientation. The crystal structure of MTG revealed that this triad is not conserved; rather, it was proposed that MTG uses a cysteine protease-like mechanism in which Asp255 plays the role of the histidine residue in factor XIII-like TGases [15]. Of the two, MTG is more robus ...
... catalytically-competent orientation. The crystal structure of MTG revealed that this triad is not conserved; rather, it was proposed that MTG uses a cysteine protease-like mechanism in which Asp255 plays the role of the histidine residue in factor XIII-like TGases [15]. Of the two, MTG is more robus ...
Supp Mat - Columbia University
... concentration of 450 mM. The aa-tRNA was recovered by ethanol precipitation. To estimate the aminoacylation efficiencies, analytical scale aminoacylations were performed concurrently under the same conditions outlined above with the exception that [32P]-labeled tRNA was used11. After acidic quenchin ...
... concentration of 450 mM. The aa-tRNA was recovered by ethanol precipitation. To estimate the aminoacylation efficiencies, analytical scale aminoacylations were performed concurrently under the same conditions outlined above with the exception that [32P]-labeled tRNA was used11. After acidic quenchin ...
Selection at the Wobble Position of Codons Read by the Same tRNA
... carried out with the iterative use of the program FASTA (Pearson and Lipman 1988) set to standard parameters; a dedicated C language program was employed to conduct pairwise homology searches and to eliminate all the sequences having nucleotide sequence similarity scores with other yeast genes highe ...
... carried out with the iterative use of the program FASTA (Pearson and Lipman 1988) set to standard parameters; a dedicated C language program was employed to conduct pairwise homology searches and to eliminate all the sequences having nucleotide sequence similarity scores with other yeast genes highe ...
paper describing HSSP
... values for single residues, pairs of residues, short oligopeptides or short sequence patterns. Both kinds of methods are severely limited by the size of the database in which one performs searches or from which one derives structural preferences. For example, in order to have on the average 5 occurr ...
... values for single residues, pairs of residues, short oligopeptides or short sequence patterns. Both kinds of methods are severely limited by the size of the database in which one performs searches or from which one derives structural preferences. For example, in order to have on the average 5 occurr ...
Bacterial hemoglobins and flavohemoglobins: versatile proteins and
... muscle tissues (myoglobin), where they donate oxygen to the respiring cells. Very recently, two hexacoordinate Hbs have been discovered in mammals : a Hb present preferentially in the brain called neuroglobin, and an ubiquitously expressed Hb designated histoglobin or, alternatively, cytoglobin [3^5 ...
... muscle tissues (myoglobin), where they donate oxygen to the respiring cells. Very recently, two hexacoordinate Hbs have been discovered in mammals : a Hb present preferentially in the brain called neuroglobin, and an ubiquitously expressed Hb designated histoglobin or, alternatively, cytoglobin [3^5 ...
mammalian hibernation: biochemical adaptation
... mammals arise from two main effects of cold on metabolic systems that have been optimized over millions of years of mammalian evolution for function within a narrow temperature window. The first is the differential effect of temperature change on the rates of thousands of cellular reactions that can ...
... mammals arise from two main effects of cold on metabolic systems that have been optimized over millions of years of mammalian evolution for function within a narrow temperature window. The first is the differential effect of temperature change on the rates of thousands of cellular reactions that can ...
Origin and Evolution of a New Gene Descended From alcohol
... from that of other Drosophila Adh genes (SULLIVAN et al. 1990). However, some aspects of the data are incompatible with a simple pseudogene hypothesis. Though putatively nonfunctional (at least in terms of proteincoding capacity), this gene hasevolvedonlyslightly more quickly than Adh-2 and Adh-1 (S ...
... from that of other Drosophila Adh genes (SULLIVAN et al. 1990). However, some aspects of the data are incompatible with a simple pseudogene hypothesis. Though putatively nonfunctional (at least in terms of proteincoding capacity), this gene hasevolvedonlyslightly more quickly than Adh-2 and Adh-1 (S ...
Translocation Arrest by Reversible Folding of a Precursor Protein
... made use of the following observation. Import and processing of a fusion protein between a mitochondrial presequence (amino acid residues 1-22 of cytochrome oxidase subunit IV) and dihydrofolate reductase (DHFR) t was found to be inhibited after binding of the folate antagonist methotrexate to the D ...
... made use of the following observation. Import and processing of a fusion protein between a mitochondrial presequence (amino acid residues 1-22 of cytochrome oxidase subunit IV) and dihydrofolate reductase (DHFR) t was found to be inhibited after binding of the folate antagonist methotrexate to the D ...
Regulation of the heat stress response in Arabidopsis by
... To get insights into the protein kinases regulated in response to heat stress, we performed in-gel kinase assays of protein extracts from Arabidopsis leaves before and after exposure to heat stress (Fig. 1). Detached leaves were incubated in pre-heated (37 ◦ C) liquid medium and then placed at 37 ◦ ...
... To get insights into the protein kinases regulated in response to heat stress, we performed in-gel kinase assays of protein extracts from Arabidopsis leaves before and after exposure to heat stress (Fig. 1). Detached leaves were incubated in pre-heated (37 ◦ C) liquid medium and then placed at 37 ◦ ...
167 renal and small intestinal sodium
... Magagnin et al. 1993; Markovich et al. 1993). At present, more detailed information about the N-glycosylation sites likely to be used is only available for the type II Na+/Pi symporter NaPi-2 from the rat. Site-directed mutagenesis has shown that amino acid residues Asn-298 and Asn-328 (located with ...
... Magagnin et al. 1993; Markovich et al. 1993). At present, more detailed information about the N-glycosylation sites likely to be used is only available for the type II Na+/Pi symporter NaPi-2 from the rat. Site-directed mutagenesis has shown that amino acid residues Asn-298 and Asn-328 (located with ...
Avian Infectious Bronchitis Virus (IBV) genesig Standard Kit
... Coronaviridae Family. This virus causes acute respiratory disease in chickens. This family of viruses has an exceptionally large genome of up to 31Kbp in length. Upon infection with IBV, the virion binds to the host cell via cell surface molecules. The virus is then introduced to the cell cytoplasm ...
... Coronaviridae Family. This virus causes acute respiratory disease in chickens. This family of viruses has an exceptionally large genome of up to 31Kbp in length. Upon infection with IBV, the virion binds to the host cell via cell surface molecules. The virus is then introduced to the cell cytoplasm ...
Protein Structure and Interactions
... folding of other proteins often by preventing aggregation of folding intermediates. Another important class of chaperones is ribonucleic acid (RNA) chaperones. RNA chaperones are proteins that facilitate conformational changes of RNA molecules to assist the assembly and disassembly of RNA–RNA and RN ...
... folding of other proteins often by preventing aggregation of folding intermediates. Another important class of chaperones is ribonucleic acid (RNA) chaperones. RNA chaperones are proteins that facilitate conformational changes of RNA molecules to assist the assembly and disassembly of RNA–RNA and RN ...
488KB - The Doudna Lab - University of California, Berkeley
... silencing complex23. Thus, in mammals this loop has functions even some cases, the loop also helps Dicer recognize and process diverse beyond binding dsRNA substrates and assisting their hydrolysis. In dsRNA substrates. contrast, the analogous loop in the RNase IIIb domain of Dicer is compact and st ...
... silencing complex23. Thus, in mammals this loop has functions even some cases, the loop also helps Dicer recognize and process diverse beyond binding dsRNA substrates and assisting their hydrolysis. In dsRNA substrates. contrast, the analogous loop in the RNase IIIb domain of Dicer is compact and st ...
Chapter 5 - Biology Junction
... Concept 5.1: Macromolecules are polymers, built from monomers • A polymer is a long molecule consisting of many similar building blocks • These small building-block molecules are called monomers • Three of the four classes of life’s organic molecules are polymers: – Carbohydrates – Proteins – Nucle ...
... Concept 5.1: Macromolecules are polymers, built from monomers • A polymer is a long molecule consisting of many similar building blocks • These small building-block molecules are called monomers • Three of the four classes of life’s organic molecules are polymers: – Carbohydrates – Proteins – Nucle ...
Chapter 5
... Concept 5.1: Macromolecules are polymers, built from monomers • A polymer is a long molecule consisting of many similar building blocks • These small building-block molecules are called monomers • Three of the four classes of life’s organic molecules are polymers: – Carbohydrates – Proteins – Nucle ...
... Concept 5.1: Macromolecules are polymers, built from monomers • A polymer is a long molecule consisting of many similar building blocks • These small building-block molecules are called monomers • Three of the four classes of life’s organic molecules are polymers: – Carbohydrates – Proteins – Nucle ...
Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. These products are often proteins, but in non-protein coding genes such as transfer RNA (tRNA) or small nuclear RNA (snRNA) genes, the product is a functional RNA.The process of gene expression is used by all known life - eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses - to generate the macromolecular machinery for life.Several steps in the gene expression process may be modulated, including the transcription, RNA splicing, translation, and post-translational modification of a protein. Gene regulation gives the cell control over structure and function, and is the basis for cellular differentiation, morphogenesis and the versatility and adaptability of any organism. Gene regulation may also serve as a substrate for evolutionary change, since control of the timing, location, and amount of gene expression can have a profound effect on the functions (actions) of the gene in a cell or in a multicellular organism.In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phenotype, i.e. observable trait. The genetic code stored in DNA is ""interpreted"" by gene expression, and the properties of the expression give rise to the organism's phenotype. Such phenotypes are often expressed by the synthesis of proteins that control the organism's shape, or that act as enzymes catalysing specific metabolic pathways characterising the organism.