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12 transgenic mice
12 transgenic mice

... Overexpression of growth hormone produces giant mice An example of this technology was a early experiment performed with with growth hormone gene cloned into the metallothionine promoter. This promoter targets expression to the liver or any cell in the presence of heavy metal (zinc). The normal pro ...
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... 1. The division of a eukaryote cell, producing two daughter cells with the same number of chromosomes is known as ___________ . A) meiosis B) binary fission C) mitosis D) cytokinesis 2. Prokaryotes, such as bacteria, divide by a process called A) meiosis. B) binary fission. C) mitosis. D) cytokinesi ...
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... 2. Mix the salt, water, and Dawn detergent in a glass or small bowl. Set the mixture aside. This is your extraction liquid. 3. Line the funnel with the cheesecloth, and put the funnel's tube into the glass. 4. Put the strawberries in the plastic bag and push out all the extra air. Seal it tightly. 5 ...
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Epigenetics in stem-cell differentiation

Embryonic stem cells are capable of self-renewing and differentiating to the desired fate depending on its position within the body. Stem cell homeostasis is maintained through epigenetic mechanisms that are highly dynamic in regulating the chromatin structure as well as specific gene transcription programs. Epigenetics has been used to refer to changes in gene expression, which are heritable through modifications not affecting the DNA sequence.The mammalian epigenome undergoes global remodeling during early stem cell development that requires commitment of cells to be restricted to the desired lineage. There has been multiple evidence suggesting that the maintenance of the lineage commitment of stem cells are controlled by epigenetic mechanisms such as DNA methylation, histone modifications and regulation of ATP-dependent remolding of chromatin structure. Based on the histone code hypothesis, distinct covalent histone modifications can lead to functionally distinct chromatin structures that influence the fate of the cell.This regulation of chromatin through epigenetic modifications is a molecular mechanism that will determine whether the cell will continue to differentiate into the desired fate. A research study performed by Lee et al. examined the effects of epigenetic modifications on the chromatin structure and the modulation of these epigenetic markers during stem cell differentiation through in vitro differentiation of murine embryonic stem (ES) cells.
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