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Involvement of Polyamine Catabolism in the Regulation of Glucose
Involvement of Polyamine Catabolism in the Regulation of Glucose

... regulation of glucose, energy and lipid metabolism was investigated using transgenic mice overexpressing or deficient for SSAT. The characterization of SSAT mice revealed that these mice exhibited severely reduced whole body WAT mass, elevated energy expenditure, high insulin sensitivity, a low tiss ...
Major roles of isocitrate lyase and malate synthase in
Major roles of isocitrate lyase and malate synthase in

... inoculated onto wheat seedlings and leaves were unable to induce necrotic lesions on either tissue, indicating that this gene is essential for virulence on wheat. The biological reason for this phenotype is that the mls1-deficient strain has dramatically decreased spore germination and a reduction i ...
Distinct C-terminal Amino Acid Sequence Motifs Serve
Distinct C-terminal Amino Acid Sequence Motifs Serve

Molecular Neurobiology - Universidad Autónoma de Madrid
Molecular Neurobiology - Universidad Autónoma de Madrid

... tau kinase is GSK3 and we have studied the effect of a overexpression of GSK3 not only on tau phosphorylation but also on adult neurogenesis taking place at dentate gyrus, since that neurogenesis has been related to the acquisition of episodic memory, a process that is impaired in Alzheimer disease ...
Engineering the pentose phosphate pathway of
Engineering the pentose phosphate pathway of

... it is unable to utilise the 5-carbon sugars D-xylose and L-arabinose present in plant biomass. In this study, one key metabolic step of the catabolic D-xylose pathway in recombinant D-xylose-utilising S. cerevisiae strains was studied. This step, carried out by xylulokinase (XK), was shown to be rat ...
Mechanisms of animal diapause: recent
Mechanisms of animal diapause: recent

... these marks is dramatically different compared with the same histone/chromatin signatures in animals that did not transit through dauer development (75). Curiously, levels of both acetylated and methylated H3K4, histone modifications that are generally associated with euchromatin, are significantly ...
Regulation of Starch Synthesis in Cassava Yona Baguma
Regulation of Starch Synthesis in Cassava Yona Baguma

... of PP2A, did not, suggesting that sugar and ABA signaling pathways converge at the PP1 level downstream of the sugar signaling pathway. Chloramphenicol, which specifically inhibits plastid de novo protein synthesis, with or without sucrose, blocked sbe expression but cycloheximide, a cytosolic de no ...
Effect of Aminoguanidine (Inducible Nitric Oxide Synthase Inhibitor
Effect of Aminoguanidine (Inducible Nitric Oxide Synthase Inhibitor

... species, for example rat and human PDK2 proteins share greater than 95% identity in their primary amino acids sequence. The total number of amino acid residues varies among different PDK isomers, for example PDK1 has 436 residues, PDK2 and PDK4 have 407 residues and PDK3 has 406 residues [35]. The G ...
Carbon–hydrogen bond activation of chloroalkanes by a rhodium
Carbon–hydrogen bond activation of chloroalkanes by a rhodium

... Cp or Cp* metal complexes [2–4]. More recently, however, the analogous trispyrazolylborate complexes [5] have been shown to also activate a variety of C–H bonds in aliphatic and aromatic hydrocarbons [6–11]. Despite these many investigations, there are only a few examples that look at the activation ...
Acetyl CoA - WordPress.com
Acetyl CoA - WordPress.com

... this reaction is catalyzed by pyruvate dehydrogenase the NAD+ required for this reaction and for the oxidation of glyceraldehyde 3 phosphate is regenerated when NADH ultimately transfers its electrons to O2 through the electron transport chain in mitochondria In the overall reaction, the carboxyl gr ...
David Gilbert - National e
David Gilbert - National e

... Many receptors that activate ERK also elevate cAMP levels leading to activation of PKA. PKA inhibits Raf-1 and blocks ERK activation ...
Boundless Study Slides
Boundless Study Slides

... acetate derived from carbohydrates, fats, and proteins into carbon dioxide • complex A structure consisting of a central atom, molecule, or protein weakly connected to surrounding atoms, molecules, or proteins. • deamination The removal of an amino group from a compound. • disaccharide A sugar, such ...
Comparative analysis of cytosolic and mitochondrial ATP synthesis
Comparative analysis of cytosolic and mitochondrial ATP synthesis

... Suppression of ATP synthesis via glycolysis and oxidative phosphorylation (OxPhos) causes deregulation of transmembrane gradients for key ions including Na+ , K+ , and Ca2+ that are maintained by plasmalemmal and intracellular ATPases, the major consumers of ATP in neurons. ...
The mitochondrial carnitine/acylcarnitine carrier: Function
The mitochondrial carnitine/acylcarnitine carrier: Function

... Oxidation of fatty acids in mitochondria coupled to oxidative phosphorylation is the most important pathway for the production of metabolic energy during fasting. This process occurs in the mitochondrial matrix where the enzymes of fatty acid b-oxidation are located. Fatty acyl groups are transporte ...
The Role of Carbohydrate Response Element Binding Protein in
The Role of Carbohydrate Response Element Binding Protein in

... the pathogenesis of not only obesity-related diseases, but also fructose malabsorption. We have analyzed the role of carbohydrate response element binding protein (ChREBP) in the pathogenesis of metabolic diseases [14]. ChREBP is a glucose-activated transcription factor that regulates glucose and li ...
Biochemical, biophysical and interaction studies of the stress
Biochemical, biophysical and interaction studies of the stress

... advice on PhD related issues and CD experiments. Also I would like to thank Dr Marija Kristic Demonacos for her help when carrying out the molecular cloning aspect of this project and letting me work on her bench space, also providing me with an hSTRAP construct (pHA1-hSTRAP(1-440)) which was used i ...
Osmoadaptation mechanisms in prokaryotes
Osmoadaptation mechanisms in prokaryotes

... synthesize appropriate compatible solutes. In addition, a sudden dilution of the environment by rain or flooding triggers the release of compatible solutes [39]. It is, therefore, common to find high affinity transport systems in microorganisms that utilize these componds, as they allow them to adeq ...
Quality control in tRNA charging — editing of homocysteine
Quality control in tRNA charging — editing of homocysteine

... LysRS, ProRS, PheRS, and ThrRS are less accurate and have the ability to misactivate non-cognate amino acids (reaction 1). Misactivation occurs because there is a limited scope for structural variation among related amino acids. Pauling first recognized this problem in 1957, well before the mechanis ...
Full-Text PDF
Full-Text PDF

Methylobacterium extorquens AM1
Methylobacterium extorquens AM1

... intracellular metabolites by LC-MS. Sampling for metabolites was performed at three different timepoints during growth with 13C methanol and naturally labeled succinate. The first sample was collected in the middle of the first exponential growth phase, and the second sample was harvested just at th ...
- BioMedSearch
- BioMedSearch

De novo production of resveratrol from glucose or
De novo production of resveratrol from glucose or

... 2015). The preparations range widely in purity; some can contain as low as 50% of the active ingredient. The unpurified knotweed extracts, however, additionally contain emodin which has a laxative effect (Srinivas et al., 2007). Thus, there is market demand for lower cost and high purity resveratrol. ...
principles of metabolic regulation: glucose and glycogen
principles of metabolic regulation: glucose and glycogen

... Chapter 14 we discussed three possible fates for glucose 6-phosphate in a hepatocyte: passage into glycolysis for the production of ATP, passage into the pentose phosphate pathway for the production of NADPH and pentose phosphates, or hydrolysis to glucose and phosphate to replenish blood glucose. I ...
A chemogenomic analysis of the transmembrane binding cavity of
A chemogenomic analysis of the transmembrane binding cavity of

Interactions of TCA cycle enzymes and of the CcpA
Interactions of TCA cycle enzymes and of the CcpA

... Interaktion zwischen Mdh und Icd, welche ausschließlich durch die Substrate von Icd, die Kombination von Isocitrat, NADP+ und Mg2+, stimuliert wurde. Dieser stimulatorische Effekt ist hochspezifisch, da keine weiteren Metabolite und Kofaktoren von Icd und Mdh einen Einfluß auf die Interaktion von Md ...
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Biochemical cascade

A biochemical cascade (or a signaling pathway) is a series of chemical reactions which are initiated by a stimulus (first messenger) acting on a receptor that is transduced to the cell interior through second messengers (which amplify the initial signal) and ultimately to effector molecules, resulting in a cell response to the initial stimulus. At each step of the signaling cascade, various controlling factors are involved to regulate cellular actions, responding effectively to cues about their changing internal and external environments.
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