Expression of the LXR Protein in Human Atherosclerotic Lesions
... Key Words: LXR␣ 䡲 atherosclerosis 䡲 macrophages 䡲 monoclonal antibody iver X–activated receptor ␣ (LXR␣; NR1H3) is a member of the nuclear receptor superfamily that forms a functional heterodimer with retinoid X receptors (RXRs).1,2 LXR␣/RXRs heterodimers bind to DR-4 –type sequence elements known a ...
... Key Words: LXR␣ 䡲 atherosclerosis 䡲 macrophages 䡲 monoclonal antibody iver X–activated receptor ␣ (LXR␣; NR1H3) is a member of the nuclear receptor superfamily that forms a functional heterodimer with retinoid X receptors (RXRs).1,2 LXR␣/RXRs heterodimers bind to DR-4 –type sequence elements known a ...
The regulation of leukemia inhibitory factor
... processes including inducing differentiation of leukemia cell, inflammatory response, neuronal development, embryonic implantation, stem cell self-renewal and cancer progression, etc. LIF exerts its biological functions mainly through the activation and regulation of JAK/STAT3, AKT, EKR1/2 and mTOR ...
... processes including inducing differentiation of leukemia cell, inflammatory response, neuronal development, embryonic implantation, stem cell self-renewal and cancer progression, etc. LIF exerts its biological functions mainly through the activation and regulation of JAK/STAT3, AKT, EKR1/2 and mTOR ...
Studying Protein Flexibility in a Statistical Framework: Tools and
... Subunit motions are classified differently as allosteric, non-allosteric, or unclassifiable. Finally, large protein motions which cannot easily be classified as subunit motions are classified as complex movements. For example, the order-to-disorder transition that the headpiece domain undergoes when ...
... Subunit motions are classified differently as allosteric, non-allosteric, or unclassifiable. Finally, large protein motions which cannot easily be classified as subunit motions are classified as complex movements. For example, the order-to-disorder transition that the headpiece domain undergoes when ...
Yeast ING Protein Yeast Protein Human Ortholog Description of
... of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; ac ...
... of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; ac ...
Dietary protein for athletes - Inside Outside Wellness Center
... of opinion exists than between those who establish recommendations and the athletes themselves, particularly strength- and (or) power-training athletes. The published standards for dietary guidelines — the Dietary Reference Intakes (DRIs), assert that although protein is an essential nutrient, it is ...
... of opinion exists than between those who establish recommendations and the athletes themselves, particularly strength- and (or) power-training athletes. The published standards for dietary guidelines — the Dietary Reference Intakes (DRIs), assert that although protein is an essential nutrient, it is ...
lec 7 Metabolism of purine nucleotides
... Uric acid is the end product of purine metabolism in human. ...
... Uric acid is the end product of purine metabolism in human. ...
Lecture 2 - cholesterol _CVS block
... Most important animal steroid Mainitains membrane fluidity Has an insulating effect on nerve fibres Cholesterol is the parent molecule for – Bile acids and bile salts – Steroid hormones and – vitamin D3 ...
... Most important animal steroid Mainitains membrane fluidity Has an insulating effect on nerve fibres Cholesterol is the parent molecule for – Bile acids and bile salts – Steroid hormones and – vitamin D3 ...
Structural Basis of Biological Nitrogen Fixation
... the Fe protein are related by a molecular 2-fold rotation axis that passes through the 4Fe-4S cluster, which is located at the subunit-subunit interface. The 4Fe-4S cluster is symmetrically coordinated by the thiol groups of Cys97 and Cys132 from each subunit.41 In addition to the cluster, there are ...
... the Fe protein are related by a molecular 2-fold rotation axis that passes through the 4Fe-4S cluster, which is located at the subunit-subunit interface. The 4Fe-4S cluster is symmetrically coordinated by the thiol groups of Cys97 and Cys132 from each subunit.41 In addition to the cluster, there are ...
Modular Architecture of Metabolic Pathways Revealed by
... ABSTRACT: The metabolic network is both a network of chemical reactions and a network of enzymes that catalyze reactions. Toward better understanding of this duality in the evolution of the metabolic network, we developed a method to extract conserved sequences of reactions called reaction modules f ...
... ABSTRACT: The metabolic network is both a network of chemical reactions and a network of enzymes that catalyze reactions. Toward better understanding of this duality in the evolution of the metabolic network, we developed a method to extract conserved sequences of reactions called reaction modules f ...
Full-Text PDF
... proteins. This capacity of PHB has been well established experimentally. Seebach et al. [38] have found that the triolide of R-3HB forms crown ester complexes with alkali metals; Burger and Seebach [39] have shown that oligomers of R-3HB transport alkali and alkaline earth salts across methylene chl ...
... proteins. This capacity of PHB has been well established experimentally. Seebach et al. [38] have found that the triolide of R-3HB forms crown ester complexes with alkali metals; Burger and Seebach [39] have shown that oligomers of R-3HB transport alkali and alkaline earth salts across methylene chl ...
tRNA-derived short RNAs bind to Saccharomyces cerevisiae
... are highly stable, and therefore their rapid turnover would not be beneficial for the cell. Nevertheless, if tRNA is unable to accurately and efficiently play its role in protein synthesis by correctly charging its cognate amino acid or to perform other additional functions, its presence may be harm ...
... are highly stable, and therefore their rapid turnover would not be beneficial for the cell. Nevertheless, if tRNA is unable to accurately and efficiently play its role in protein synthesis by correctly charging its cognate amino acid or to perform other additional functions, its presence may be harm ...
P6060Datasheet-Lot0151208
... Recognition Determinants: The minimal recognition motif for phosphorylation by CaMKII is RXXS/T. A more recent report suggests the presence of positive determinants at the -5, -2 and +1 positions in addition to the -3R. Thus, CaMKII preferentially phosphorylates substrates with motifs: HydXRXXS/T an ...
... Recognition Determinants: The minimal recognition motif for phosphorylation by CaMKII is RXXS/T. A more recent report suggests the presence of positive determinants at the -5, -2 and +1 positions in addition to the -3R. Thus, CaMKII preferentially phosphorylates substrates with motifs: HydXRXXS/T an ...
The role of c-di-GMP signaling in an Aeromonas veronii biovar
... screening system (PhP-AE), which is based on the kinetics of fermentation of 11 reagents especially selected to discriminate between individual Aeromonas strains (Möllby et al., 1993; Kuhn et al., 1997). The isolates were distributed over a large number of common (192) and single PhP types. Eightee ...
... screening system (PhP-AE), which is based on the kinetics of fermentation of 11 reagents especially selected to discriminate between individual Aeromonas strains (Möllby et al., 1993; Kuhn et al., 1997). The isolates were distributed over a large number of common (192) and single PhP types. Eightee ...
What is Xtend - Bodybuilding.com Forums
... alanine and glutamine, and modulators of protein synthesis, is governed by their availability. Research suggests that first and foremost the BCAA are used for the synthesis of protein structures (Layman, 2003). Research on leucine shows that once the minimum requirement of leucine for protein synthe ...
... alanine and glutamine, and modulators of protein synthesis, is governed by their availability. Research suggests that first and foremost the BCAA are used for the synthesis of protein structures (Layman, 2003). Research on leucine shows that once the minimum requirement of leucine for protein synthe ...
Proteomic analyses of Oryza sativa mature pollen reveal novel
... pollen-stigma [2–4]. The importance of tip-focused intracellular Ca21 and tip plasma membrane-localized Rop1 GTPase in polar establishment of pollen tubes and tube growth is well understood [5, 6], but little biochemical and molecular genetic information exists on pollen functions. Some recent studi ...
... pollen-stigma [2–4]. The importance of tip-focused intracellular Ca21 and tip plasma membrane-localized Rop1 GTPase in polar establishment of pollen tubes and tube growth is well understood [5, 6], but little biochemical and molecular genetic information exists on pollen functions. Some recent studi ...
Peer-reviewed Article PDF
... for protozoan cells proliferation and considered as essential nutrients for the protozoan parasites. For example, Neurospora crassa mutants lacking ODC activity cannot grow unless putrescine, spermidine or spermines were added to the growing media [12,13]. The protozoan pathogens, Trypanosomatids de ...
... for protozoan cells proliferation and considered as essential nutrients for the protozoan parasites. For example, Neurospora crassa mutants lacking ODC activity cannot grow unless putrescine, spermidine or spermines were added to the growing media [12,13]. The protozoan pathogens, Trypanosomatids de ...
ARF-Aux/IAA interactions through domain III/IV are not strictly
... expression in a strongly auxin-dependent manner, as described previously.11 In contrast, transfection with effector genes encoding ARF5 or ARF7 CTD truncations (5D5M and 7D7M) restored reporter gene expression, but the restoration in expression was not fully dependent on auxin. Nevertheless, additio ...
... expression in a strongly auxin-dependent manner, as described previously.11 In contrast, transfection with effector genes encoding ARF5 or ARF7 CTD truncations (5D5M and 7D7M) restored reporter gene expression, but the restoration in expression was not fully dependent on auxin. Nevertheless, additio ...
Identification of a Protein with Antioxidant Activity that is Important for
... barley lipid transfer protein (LTP1) in Swiss-Prot/TrEMBL protein databases (Figure 4b). Thus, the 10 kDa protein was identified as barley LTP1. Its mature peptide is 91 amino acids in length and contains 8 cysteine residues, nearly 9% of the whole protein (Figure 4b), demonstrating that it is indee ...
... barley lipid transfer protein (LTP1) in Swiss-Prot/TrEMBL protein databases (Figure 4b). Thus, the 10 kDa protein was identified as barley LTP1. Its mature peptide is 91 amino acids in length and contains 8 cysteine residues, nearly 9% of the whole protein (Figure 4b), demonstrating that it is indee ...
Phytochemistry
... phoresis at higher pH values. For the same reasons, and one species Amaranthus caudatus has been reported as possibly due to microheterogeneity in carbohydrate comcontaining a toxic agglutinin lacking serological specificity and not being inhibited by serum glycoproteins I-7]. position, the isoelect ...
... phoresis at higher pH values. For the same reasons, and one species Amaranthus caudatus has been reported as possibly due to microheterogeneity in carbohydrate comcontaining a toxic agglutinin lacking serological specificity and not being inhibited by serum glycoproteins I-7]. position, the isoelect ...
Amino Acid Residues Contributing to Function of
... Olfactory receptors (Ors) convert chemical signals—the binding of odors and pheromones—to electrical signals through the depolarization of olfactory sensory neurons. Vertebrates Ors are G-protein-coupled receptors, stimulated by odors to produce intracellular second messengers that gate ion channels ...
... Olfactory receptors (Ors) convert chemical signals—the binding of odors and pheromones—to electrical signals through the depolarization of olfactory sensory neurons. Vertebrates Ors are G-protein-coupled receptors, stimulated by odors to produce intracellular second messengers that gate ion channels ...
Transcriptional regulation of mammalian autophagy at a glance
... referred to as p53) has been described to inhibit mTORC1 and thus to activate autophagy, several studies have shown that cytoplasmic p53 is a potent inhibitor of autophagy. The mechanisms for this inhibition are largely unknown (Green and Kroemer, 2009); however, post-transcriptional downregulation ...
... referred to as p53) has been described to inhibit mTORC1 and thus to activate autophagy, several studies have shown that cytoplasmic p53 is a potent inhibitor of autophagy. The mechanisms for this inhibition are largely unknown (Green and Kroemer, 2009); however, post-transcriptional downregulation ...
Conservation of PHO pathway in ascomycetes and the role of Pho84
... structure and storage of cellular energy and is thus indispensable for survival of all living organisms. Hence, it is crucial for living organisms to maintain proper phosphate homeostasis, as any imbalance (hyper- or hypophosphatemia) will impact cellular processes, viz. cell differentiation and pro ...
... structure and storage of cellular energy and is thus indispensable for survival of all living organisms. Hence, it is crucial for living organisms to maintain proper phosphate homeostasis, as any imbalance (hyper- or hypophosphatemia) will impact cellular processes, viz. cell differentiation and pro ...
Capabilities and limitations of gel electrophoresis for elemental
... because of its excellent limits of detection, but also because it offers truly quantitative results. The availability of a real blank, the gel itself, is an important advantage. With it, a real procedural limit of detection (LoD) can, for example, be determined. The blank model can even be further r ...
... because of its excellent limits of detection, but also because it offers truly quantitative results. The availability of a real blank, the gel itself, is an important advantage. With it, a real procedural limit of detection (LoD) can, for example, be determined. The blank model can even be further r ...
Identification of enzymes involved in anaerobic benzene
... the culture was transferred from benzene to a different substrate, the community structure of benzene-, phenoland benzoate-grown cultures was assessed by T-RFLP analysis when approximately 25 mM ferrous iron was produced (Fig. S1). With all substrates, the analysis showed the same dominance of the P ...
... the culture was transferred from benzene to a different substrate, the community structure of benzene-, phenoland benzoate-grown cultures was assessed by T-RFLP analysis when approximately 25 mM ferrous iron was produced (Fig. S1). With all substrates, the analysis showed the same dominance of the P ...
Cyclic Adenosine Monophosphate Signaling Pathway
... BAECs treated with genistein, forskolin, or vehicle were scraped and collected in PBS supplemented with protease and phosphatase inhibitor cocktail. Cytoplasmic and nuclear proteins were harvested by sonication and centrifugation. The enzymatic activity of PKA in lysates was assessed by measuring ph ...
... BAECs treated with genistein, forskolin, or vehicle were scraped and collected in PBS supplemented with protease and phosphatase inhibitor cocktail. Cytoplasmic and nuclear proteins were harvested by sonication and centrifugation. The enzymatic activity of PKA in lysates was assessed by measuring ph ...
Paracrine signalling
Paracrine signaling is a form of cell-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior or differentiation of those cells. Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. Cells that produce paracrine factors secrete them into the immediate extracellular environment. Factors then travel to nearby cells in which the gradient of factor received determines the outcome. However, the exact distance that paracrine factors can travel is not certain.Although paracrine signaling elicits a diverse array of responses in the induced cells, most paracrine factors utilize a relatively streamlined set of receptors and pathways. In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. The highly conserved receptors and pathways can be organized into four major families based on similar structures: Fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective receptor initiates signal transduction cascades, eliciting different responses.