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... having evolved one from another through gene duplication. Paralogs are separated by a gene duplication event. • Each specific gene family member (e.g. a specific gene in human) is an ortholog of the same family member in another species (e.g. mouse). Both evolved from an ancestral globin gene. Ortho ...
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...  If you have t/t, e.g., will have function, but not if have T/t or T/T  LOF for all but homozygous recessive o Sometimes need proteins to work as dimers  Homo/heterodimers  If have protein that functions as dimer, and mutation alters one of the proteins’ shape, could screw up the function  Bein ...
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Point mutation



A point mutation, or single base modification, is a type of mutation that causes a single nucleotide base change, insertion, or deletion of the genetic material, DNA or RNA. The term frameshift mutation indicates the addition or deletion of a base pair. A point mutant is an individual that is affected by a point mutation.Repeat induced point mutations are recurring point mutations, discussed below.
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