Highly Enantioselective Cyclocarbonylation of Allylic
... Recently, we have achieved high enantioselectivity in a number of Rh-BICP and Ru-BICP catalyzed asymmetric hydrogenation reactions.7 These results demonstrated that the BICP ligand is an excellent chiral motif for group VIII transition metal-catalyzed reactions. To optimize the steric and electronic ...
... Recently, we have achieved high enantioselectivity in a number of Rh-BICP and Ru-BICP catalyzed asymmetric hydrogenation reactions.7 These results demonstrated that the BICP ligand is an excellent chiral motif for group VIII transition metal-catalyzed reactions. To optimize the steric and electronic ...
Text - Enlighten: Publications
... Ar ¼ 2,6-Me2-C6H3; ArF ¼ 3,5-(CF3)2-C6H3) have been studied by Cu K-edge X-ray absorption spectroscopy, as well as single- and multi-reference computational methods (DFT, TD-DFT, CASSCF, MRCI, and OVB). The study was extended to a range of both known and theoretical compounds bearing 2p-element dono ...
... Ar ¼ 2,6-Me2-C6H3; ArF ¼ 3,5-(CF3)2-C6H3) have been studied by Cu K-edge X-ray absorption spectroscopy, as well as single- and multi-reference computational methods (DFT, TD-DFT, CASSCF, MRCI, and OVB). The study was extended to a range of both known and theoretical compounds bearing 2p-element dono ...
Visible light photooxidation of nitrate: the dawn of
... these findings, we suggest that the reaction proceeds via a singlet excited state as depicted in Scheme 1. Having demonstrated the pathway for photocatalytic NO3 generation, we selected the well-studied reaction of NO3 with diphenylacetylene (2) yielding benzil (3) and benzophenone (4) to explore ...
... these findings, we suggest that the reaction proceeds via a singlet excited state as depicted in Scheme 1. Having demonstrated the pathway for photocatalytic NO3 generation, we selected the well-studied reaction of NO3 with diphenylacetylene (2) yielding benzil (3) and benzophenone (4) to explore ...
8fd26191dcc2fe1
... Alkyl Halides • Alkyl halides are organic molecules containing a halogen atom bonded to an sp3 hybridized carbon atom. • Alkyl halides are classified as primary (1°), secondary (2°), or tertiary (3°), depending on the number of carbons bonded to the carbon with the halogen atom. ...
... Alkyl Halides • Alkyl halides are organic molecules containing a halogen atom bonded to an sp3 hybridized carbon atom. • Alkyl halides are classified as primary (1°), secondary (2°), or tertiary (3°), depending on the number of carbons bonded to the carbon with the halogen atom. ...
LECTURE 7 REDUCTIVE ELIMINATIONSa
... • Retention of stereochemistry at carbon is a characteristic feature of this group of reactions. • Since there are several mechanisms for oxidative addition the principle of microscopic reversibility (which holds that a reversible reaction proceeds by the same mechanism in both forward and reverse d ...
... • Retention of stereochemistry at carbon is a characteristic feature of this group of reactions. • Since there are several mechanisms for oxidative addition the principle of microscopic reversibility (which holds that a reversible reaction proceeds by the same mechanism in both forward and reverse d ...
Exam #3
... (12 pts) Bromoetherification, the addition of the elements Br and OR to a double bond, is a common method for constructing rings containing oxygen atoms. Draw a stepwise mechanism for the following INTRAMOLECULAR bromoetherification reaction. Hint: the mechanism is analogous to that of bromohydrin f ...
... (12 pts) Bromoetherification, the addition of the elements Br and OR to a double bond, is a common method for constructing rings containing oxygen atoms. Draw a stepwise mechanism for the following INTRAMOLECULAR bromoetherification reaction. Hint: the mechanism is analogous to that of bromohydrin f ...
Green synthesis of 2-amino-7-hydroxy-4-aryl-4H
... 1. Curini, M.; Cravotto, G.; Epofano, F.; Giannone, G. Curr. Med. Chem. 2006, 13, 199–222. 2. Litvinov, Y. M.; Shestopalov, A. M. Adv. Heterocycl. Chem. 2011, 103, 175–260. 3. Desimone, R. W.; Currie, K. S.; Mitchell, S. A.; Darrow, J. W.; Pippin, D. A. Comb. Chem. High T. Scr. 2004, ...
... 1. Curini, M.; Cravotto, G.; Epofano, F.; Giannone, G. Curr. Med. Chem. 2006, 13, 199–222. 2. Litvinov, Y. M.; Shestopalov, A. M. Adv. Heterocycl. Chem. 2011, 103, 175–260. 3. Desimone, R. W.; Currie, K. S.; Mitchell, S. A.; Darrow, J. W.; Pippin, D. A. Comb. Chem. High T. Scr. 2004, ...
Ir-catalysed formation of C− F bonds. From allylic alcohols to α
... mixture of 5 : 1. Less water failed to dissolve SelectF, and more water increased by-product (3a) formation. The catalyst loading could be lowered to 1 mol% (Table 2, entry 1). At acidic pH, higher amounts of unwanted ketone 3a are obtained and the reaction is complete in a shorter time (15 min) (Ta ...
... mixture of 5 : 1. Less water failed to dissolve SelectF, and more water increased by-product (3a) formation. The catalyst loading could be lowered to 1 mol% (Table 2, entry 1). At acidic pH, higher amounts of unwanted ketone 3a are obtained and the reaction is complete in a shorter time (15 min) (Ta ...
Process for preparing polycarbonates
... carbonate block portion of the products since the theo retical'50 percent CO2 reaction in the products is nor ...
... carbonate block portion of the products since the theo retical'50 percent CO2 reaction in the products is nor ...
ether - HCC Southeast Commons
... Practice Problem: Why do you suppose only symmetrical ethers are prepared by the sulfuric acid-catalyzed dehydration procedure? What product(s) would you expect if ethanol and 1-propanol were allowed to react together? In what ratio would the products be formed if the two alcohols were of equal rea ...
... Practice Problem: Why do you suppose only symmetrical ethers are prepared by the sulfuric acid-catalyzed dehydration procedure? What product(s) would you expect if ethanol and 1-propanol were allowed to react together? In what ratio would the products be formed if the two alcohols were of equal rea ...
A mechanistic approach to solvolysis of n-caproyl chloride (n
... INTRODUCTION The solvolytic reactions of organic acid chlorides can be divided from mechanistic point of view into two main types, unimolecular (SN1 type of Ingold)1 and Bimolecular. In the case of bimolecular mechanism, two different points of view prevail. They are either an S N2 mechanism or an A ...
... INTRODUCTION The solvolytic reactions of organic acid chlorides can be divided from mechanistic point of view into two main types, unimolecular (SN1 type of Ingold)1 and Bimolecular. In the case of bimolecular mechanism, two different points of view prevail. They are either an S N2 mechanism or an A ...
chm238f02.exam2
... (c) Which reagent(s) would you use if you wanted to substitute the alcohol with bromide in the same position and with inversion of configuration, without any rearrangement. ...
... (c) Which reagent(s) would you use if you wanted to substitute the alcohol with bromide in the same position and with inversion of configuration, without any rearrangement. ...
Manganese-Catalyzed Carbonylation of Alkyl Iodides
... Arynes are highly strained and reactive species that undergo a range of synthetically useful transformations when generated and used in situ, hence a number of methods for their formation have been developed. 1' 2 Although highly reactive in solution, arynes can be stabilized by electron rich metal ...
... Arynes are highly strained and reactive species that undergo a range of synthetically useful transformations when generated and used in situ, hence a number of methods for their formation have been developed. 1' 2 Although highly reactive in solution, arynes can be stabilized by electron rich metal ...
Metal-catalysed approaches to amide bond formation
... bonds. Nucleophilic attack of the amine onto the ester then proceeds via a six-membered (path A) or four-membered (path B) transition state. ...
... bonds. Nucleophilic attack of the amine onto the ester then proceeds via a six-membered (path A) or four-membered (path B) transition state. ...
msc_pre_chemistry_pap1_bl2
... and rotationally related. The eg orbitals get separated by 10Dq. Hence, orbital momentum due to the dx2-y2 orbital electron gets quenched, and the spin-only formula should apply. It can be seen that the orbital angular momentum formula should be important for the high spin d1, d2, d6 and d7 ion comp ...
... and rotationally related. The eg orbitals get separated by 10Dq. Hence, orbital momentum due to the dx2-y2 orbital electron gets quenched, and the spin-only formula should apply. It can be seen that the orbital angular momentum formula should be important for the high spin d1, d2, d6 and d7 ion comp ...
Woodward–Hoffmann rules
The Woodward–Hoffmann rules, devised by Robert Burns Woodward and Roald Hoffmann, are a set of rules in organic chemistry predicting the barrier heights of pericyclic reactions based upon conservation of orbital symmetry. The Woodward–Hoffmann rules can be applied to understand electrocyclic reactions, cycloadditions (including cheletropic reactions), sigmatropic reactions, and group transfer reactions. Reactions are classified as allowed if the electronic barrier is low, and forbidden if the barrier is high. Forbidden reactions can still take place but require significantly more energy.The Woodward–Hoffmann rules were first formulated to explain the striking stereospecificity of electrocyclic reactions under thermal and photochemical control. Thermolysis of the substituted cyclobutene trans-1,2,3,4-tetramethylcyclobutene (1) gave only one diastereomer, the (E,E)-3,4-dimethyl-2,4-hexadiene (2) as shown below; the (Z,Z) and the (E,Z) diastereomers were not detected in the reaction. Similarly, thermolysis of cis-1,2,3,4-tetramethylcyclobutene (3) gave only the (E,Z) diastereomer (4).Due to their elegance and simplicity, the Woodward–Hoffmann rules are credited with first exemplifying the power of molecular orbital theory to experimental chemists. Hoffmann was awarded the 1981 Nobel Prize in Chemistry for this work, shared with Kenichi Fukui who developed a similar model using frontier molecular orbital (FMO) theory; because Woodward had died two years before, he was not eligible to win what would have been his second Nobel Prize for Chemistry.