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Honors Biology
Honors Biology

... d. In mice the gene for coat color has two forms. The allele for colored coat is dominant to the allele for albino. There are two forms for the gene controlling whiskers as well; straight is dominant to bent. Consider a cross between two mice heterozygous for both these genes. 22. Provide the chromo ...
Sunflower DNA extraction for RFLP and PCR
Sunflower DNA extraction for RFLP and PCR

... CTAB extraction buffer (1% CTAB, 0.7 M NaCl, 50 mM Tris-HCl pH 8.0, 20 mM EDTA pH 8.0, 0.5% PVP40, autoclaved and store at RT) preheated at 60°C and 1 uL βMercaptoethanol (0.1%-0.3%). 2. Put the 2.0 mL tube in 60-65°C water bath for 1.5 hr, mix gently by inverting the tubes for several times every 2 ...
Study Guide for Transcription.
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... RNA is much less stable than DNA --in RNA, U and G can base-pair. There are also other unusual pairings that occur in RNA but not in DNA --single stranded RNA has secondary structure: stem-loops form when bases pair up. Also, a pseudoknot forms when the bases of a loop pair with a different part of ...
Cloning and Sequencing
Cloning and Sequencing

... when designing primers Actually not a single primer for each but a mixture of primers (oligoprimers) if the sequence of the target is not known If amino acid sequence of gene product is used then degenerate primers must be used Initial forward primer is GABTATGTTGTTGARTCTTCWGG B=G/T/C R=G/A (purines ...
AP Biology Summer Homework Macromolecules WebQuest
AP Biology Summer Homework Macromolecules WebQuest

... 1. Proteins are chains of _______________________ linked by _______________________. 2. The 20 different amino acids used to make all proteins differ only in their _______________________. 3. A protein’s amino acid sequence determines its _______________________ and _______________________. 4. What ...
DNA Mutation
DNA Mutation

... capable of existing in two forms between which they interconvert. For example, guanine can exist in keto or enol forms. The keto form is favored but the enol form can occur by shifting a proton and some electrons; these forms are called tautomers or structural isomers. The various tautomer forms of ...
Simultanous isolation of RNA and DNA from one FFPE
Simultanous isolation of RNA and DNA from one FFPE

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UNIT 1: DNA and the Genome
UNIT 1: DNA and the Genome

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Genetic mechanisms
Genetic mechanisms

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Chap 11 – Regulation of Eukaryotic Gene Expression
Chap 11 – Regulation of Eukaryotic Gene Expression

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Genetic terms, punnett squares
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Conjugative plasmids are circular pieces of DNA that not only

... strains that lacked the plasmid, and conjugation was allowed to occur during growth on a plate overnight. The conjugation efficiency was determined by dividing the number of transconjugants (the recipient cells that incorporated the plasmid) by the total number of recipient cells. How was the number ...
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... Use the information and the diagram below to answer the following question(s). Part of the process of protein synthesis is shown below. The di erent structures in this process are ...
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Name Period Chapter 12 Genetics Lesson 1: The Genetic Code

... 4. Heterozygous refers to organism that has ______ __________________ _____________ for a trait. ( one brown and one blue eyed allele) Lesson 4: Chromosomes and Inheritance Chromosomes and inheritance: 1. Walter Sutton studied grasshoppers to discover how sex cells (eggs and sperm) form. 2. He hypot ...
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PCR: Polymerase Chain Reaction

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to accompany Holes` Essentials of Human Anatomy and Physiology
to accompany Holes` Essentials of Human Anatomy and Physiology

... chain (R group) • Amino acids are linked in a peptide bond joining the amino of one and carboxyl group of another amino acid ...
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Nucleic acid analogue



Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pucker-shaped pentose sugar, either ribose or deoxyribose, and one of four nucleobases.An analogue may have any of these altered. Typically the analogue nucleobases confer, among other things, different base pairing and base stacking properties. Examples include universal bases, which can pair with all four canonical bases, and phosphate-sugar backbone analogues such as PNA, which affect the properties of the chain (PNA can even form a triple helix).Nucleic acid analogues are also called Xeno Nucleic Acid and represent one of the main pillars of xenobiology, the design of new-to-nature forms of life based on alternative biochemistries.Artificial nucleic acids include peptide nucleic acid (PNA), Morpholino and locked nucleic acid (LNA), as well as glycol nucleic acid (GNA) and threose nucleic acid (TNA). Each of these is distinguished from naturally occurring DNA or RNA by changes to the backbone of the molecule.In May 2014, researchers announced that they had successfully introduced two new artificial nucleotides into bacterial DNA, and by including individual artificial nucleotides in the culture media, were able to passage the bacteria 24 times; they did not create mRNA or proteins able to use the artificial nucleotides. The artificial nucleotides featured 2 fused aromatic rings.
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