S3 Text.
... would warrant further investigation. Comparing the main results obtained from our expression variability analysis with those obtained with CV on the human embryo data set. In order to investigate the impact of the statistic used to study expression variability, we repeated our analyses using the CV ...
... would warrant further investigation. Comparing the main results obtained from our expression variability analysis with those obtained with CV on the human embryo data set. In order to investigate the impact of the statistic used to study expression variability, we repeated our analyses using the CV ...
Summary and Discussion English
... Conservation of genomic integrity is essential for correct expression of the genome and for the faithful transmission of genetic information to the next generations. However, all living organisms are continuously exposed to a variety of endogenous and environmental DNA-damaging agents, which threat ...
... Conservation of genomic integrity is essential for correct expression of the genome and for the faithful transmission of genetic information to the next generations. However, all living organisms are continuously exposed to a variety of endogenous and environmental DNA-damaging agents, which threat ...
Molecular and cellular basis of calpainopathy
... investigated, it has been determined that several affect the ability of CAPN3 to bind to titin (the relationship between CAPN3 and titin will be discussed elsewhere in this article) [24,25]. It is likely that additional mutations that impair CAPN3/substrate interactions will be identified, although ...
... investigated, it has been determined that several affect the ability of CAPN3 to bind to titin (the relationship between CAPN3 and titin will be discussed elsewhere in this article) [24,25]. It is likely that additional mutations that impair CAPN3/substrate interactions will be identified, although ...
Goldmine: Integrating information to place sets of genomic ranges
... for any set of query ranges using Goldmine. Summarization and plotting of context proportions across the range set is also demonstrated. A list of variable-size genomic ranges representing regions with changes in DNA methylation is used as an example. This query range set can be interchanged for any ...
... for any set of query ranges using Goldmine. Summarization and plotting of context proportions across the range set is also demonstrated. A list of variable-size genomic ranges representing regions with changes in DNA methylation is used as an example. This query range set can be interchanged for any ...
2012-04-16_Geuvadis_Analysis_CRG_Marc
... if a read locates within the boundary of the annotated mature miRNA (plus / minus 3 nts) it is annotated as such ...
... if a read locates within the boundary of the annotated mature miRNA (plus / minus 3 nts) it is annotated as such ...
Cancer Prone Disease Section Familial Juvenile Polyposis Syndrome in Oncology and Haematology
... Genes involved and proteins ...
... Genes involved and proteins ...
Plasmid Sex Introduction .....In most bacteria there are several
... Restriction modification systems play a role in transformation as well as in conjugation. However, it is thought that since these modification systems generate both DNA ends and smaller fragments, restriction modification may actually increase the chance of recombination with incorporated fragments. ...
... Restriction modification systems play a role in transformation as well as in conjugation. However, it is thought that since these modification systems generate both DNA ends and smaller fragments, restriction modification may actually increase the chance of recombination with incorporated fragments. ...
Mutator Transposon in Maize and MULEs in the Plant Genome
... the a1-mum2 allele and one copy of MuDR, from 10%–20% of progeny contain more than one copy of Mu1 or MuDR[11] and many experiments conformed that the existing Mu insertion segregate in a Mendelian fasion. These experiments reveal that new germinal insertions must happen without the loss of the exis ...
... the a1-mum2 allele and one copy of MuDR, from 10%–20% of progeny contain more than one copy of Mu1 or MuDR[11] and many experiments conformed that the existing Mu insertion segregate in a Mendelian fasion. These experiments reveal that new germinal insertions must happen without the loss of the exis ...
Gene silencing in mammalian cells and the spread of DNA
... Aprt promoter and the methylation center is methylated on approximately 25% of alleles, and that this level persisted even when the cells were subcloned (Turker et al., 1989). These observations can best be explained by assuming that methylation for CpG sites on a given allele can be either gained o ...
... Aprt promoter and the methylation center is methylated on approximately 25% of alleles, and that this level persisted even when the cells were subcloned (Turker et al., 1989). These observations can best be explained by assuming that methylation for CpG sites on a given allele can be either gained o ...
Adrenal Carcinoma - LNMI - cleare
... sometimes are called neuroendocrine carcinomas. Recognition of ...
... sometimes are called neuroendocrine carcinomas. Recognition of ...
notes
... The time-scale of evolution Think of the 3.5 billion years that makes the history of life on earth as stretching for a single year. On the first of January, there is nothing more than primitive bacteria, and this remains the case for the next eight months. Multicellular eukaryotic life appears in ea ...
... The time-scale of evolution Think of the 3.5 billion years that makes the history of life on earth as stretching for a single year. On the first of January, there is nothing more than primitive bacteria, and this remains the case for the next eight months. Multicellular eukaryotic life appears in ea ...
Reaching new heights: insights into the genetics of human stature
... Height is a trait that has long fascinated scientists. It is among the most visible of human characteristics, is easily and accurately measured and is highly heritable. In many countries, the average height of the population has increased substantially over the past few generations. For example, Dut ...
... Height is a trait that has long fascinated scientists. It is among the most visible of human characteristics, is easily and accurately measured and is highly heritable. In many countries, the average height of the population has increased substantially over the past few generations. For example, Dut ...
PAG 2012 - Illumina
... From SNP discovery to SNP associations: Using next-generation sequencing and custom arrays to create a high density genetic linkage map for the Silver Lipped Pearl Oyster, ...
... From SNP discovery to SNP associations: Using next-generation sequencing and custom arrays to create a high density genetic linkage map for the Silver Lipped Pearl Oyster, ...
Mining Phenotypes and Informative Genes from Gene Expression
... cannot handle the heavy noise well in the gene expression data. Although some approaches [16] filter out genes for partition samples, the gene filtering processes are non-invertible. The deterministic filtering will cause samples to be grouped based on the local decisions. Sub-space clustering have ...
... cannot handle the heavy noise well in the gene expression data. Although some approaches [16] filter out genes for partition samples, the gene filtering processes are non-invertible. The deterministic filtering will cause samples to be grouped based on the local decisions. Sub-space clustering have ...
Retrovirus Integration Database (RID): a public database for
... sites based on genes, the PubMed ID of one or two specific publications, or a sample name or a tissue type to narrow the query. The “ADVANCED QUERIES” section can be used to find integrations that have been reported in the same genes across multiple studies. The results of any search can be exported ...
... sites based on genes, the PubMed ID of one or two specific publications, or a sample name or a tissue type to narrow the query. The “ADVANCED QUERIES” section can be used to find integrations that have been reported in the same genes across multiple studies. The results of any search can be exported ...
horiuchi - Genetics
... The failure of the phoRc and phoB mutations to complement implies that there is only a single positive control gene (phoB) for AP synthesis. An alternate hypothesis that one of the mutations has a polar effect on a second cistron is unlikely. By this hypothesis, one of the mutations is a nonsense mu ...
... The failure of the phoRc and phoB mutations to complement implies that there is only a single positive control gene (phoB) for AP synthesis. An alternate hypothesis that one of the mutations has a polar effect on a second cistron is unlikely. By this hypothesis, one of the mutations is a nonsense mu ...
De novo DNA cytosine methyltransferase activities in
... (previously termed MTasen, n stands for N-terminal disruption) is a partial loss-of-function mutation, which results in reduction of methyl cytosine to 30% of the normal level in homozygous embryos and midgestation lethality (Li et al., 1992). The Dnmts allele (previously termed MTases, s stands for ...
... (previously termed MTasen, n stands for N-terminal disruption) is a partial loss-of-function mutation, which results in reduction of methyl cytosine to 30% of the normal level in homozygous embryos and midgestation lethality (Li et al., 1992). The Dnmts allele (previously termed MTases, s stands for ...
Chromosome Structure Variations
... stage, and sometimes pairing occurs between the similar but not identical copies of a tandem duplication. If a crossover occurs within the mispaired copies, one of the ...
... stage, and sometimes pairing occurs between the similar but not identical copies of a tandem duplication. If a crossover occurs within the mispaired copies, one of the ...
Patterns of Inheritance
... At the level of the organism, the phenotype, the effects of one allele (the dominant form) may mask those of the other (recessive form) allele. Mendel repeated this type of experiment for other traits (outlined in Fig. 6.10, p. 179). He calculated the ratio of dominant to recessive forms for each tr ...
... At the level of the organism, the phenotype, the effects of one allele (the dominant form) may mask those of the other (recessive form) allele. Mendel repeated this type of experiment for other traits (outlined in Fig. 6.10, p. 179). He calculated the ratio of dominant to recessive forms for each tr ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.