RESEARCH NOTES
... If mutations conferring resistance to FPA and to MBC affect the components of spore excision, N. tetrasperma should provide a sensitive system for detecting such mutations. Such mutants could provide information on the part played by cytoskeletal elements during development. The strains used were N. ...
... If mutations conferring resistance to FPA and to MBC affect the components of spore excision, N. tetrasperma should provide a sensitive system for detecting such mutations. Such mutants could provide information on the part played by cytoskeletal elements during development. The strains used were N. ...
Cystic Fibrosis: Correlations between Genotype and Phenotype
... Cystic fibrosis is a clinical entity with multiple representations. Despite acquired knowledge, there is still unknown information about this disease. We tried to define the relationship between classes of mutations and clinical manifestations. We also tried to structure clinical manifestations depe ...
... Cystic fibrosis is a clinical entity with multiple representations. Despite acquired knowledge, there is still unknown information about this disease. We tried to define the relationship between classes of mutations and clinical manifestations. We also tried to structure clinical manifestations depe ...
"What is a gene, in the post-ENCODE era?"
... The concept of the “gene” has evolved and become more complex since it was first proposed (see timeline in Fig. 1, accompanying poster). There are various definitions of the term, although common initial descriptions include the ability to determine a particular characteristic of an organism and the ...
... The concept of the “gene” has evolved and become more complex since it was first proposed (see timeline in Fig. 1, accompanying poster). There are various definitions of the term, although common initial descriptions include the ability to determine a particular characteristic of an organism and the ...
Chapter 1 Gene targeting, principles,and practice in mammalian cells
... - sequence variation between two homologous elements can affect recombination frequency - DNA mismatch repair is involved in repairing the mismatches and heterologies ---> lower the recombination ---> recombination of non-isogenic vectors are elevated to the levels of isogenic vectors in ...
... - sequence variation between two homologous elements can affect recombination frequency - DNA mismatch repair is involved in repairing the mismatches and heterologies ---> lower the recombination ---> recombination of non-isogenic vectors are elevated to the levels of isogenic vectors in ...
Draft-press-release-for-SA-press
... The coelacanth genome has also allowed scientists to test other long-debated questions. For example, coelacanths possess some features that look oddly similar to those seen only in animals that dwell on land, including “lobed” fins, which resemble the limbs of four-legged land animals (known as tet ...
... The coelacanth genome has also allowed scientists to test other long-debated questions. For example, coelacanths possess some features that look oddly similar to those seen only in animals that dwell on land, including “lobed” fins, which resemble the limbs of four-legged land animals (known as tet ...
x`*z`* _ _
... Law, C.W., et al., voom: Precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biol, 2014. 15(2): p. ...
... Law, C.W., et al., voom: Precision weights unlock linear model analysis tools for RNA-seq read counts. Genome Biol, 2014. 15(2): p. ...
Leapfrogging: primordial germ cell transplantation
... alleles. F0 animals were crossed with animals from a homozygous albino (tyr −/−) population that we previously established. Since the albino phenotype is only observed in homozygous tyr-deficient (null) offspring, scoring of the F1 animals for this phenotype effectively assayed the rate of mutant al ...
... alleles. F0 animals were crossed with animals from a homozygous albino (tyr −/−) population that we previously established. Since the albino phenotype is only observed in homozygous tyr-deficient (null) offspring, scoring of the F1 animals for this phenotype effectively assayed the rate of mutant al ...
The dual nature of homologous recombination in plants
... caused by both cell-external and internal factors: ionizing radiation is an example of an external factor, DNA replication across a nick is an internal factor, whereas reactive oxygen species can accumulate in plant cells as a consequence of pathogen attack and/or of intrinsic metabolic activities. ...
... caused by both cell-external and internal factors: ionizing radiation is an example of an external factor, DNA replication across a nick is an internal factor, whereas reactive oxygen species can accumulate in plant cells as a consequence of pathogen attack and/or of intrinsic metabolic activities. ...
What is a gene, post-ENCODE? History and updated definition
... The concept of the “gene” has evolved and become more complex since it was first proposed (see timeline in Fig. 1, accompanying poster). There are various definitions of the term, although common initial descriptions include the ability to determine a particular characteristic of an organism and the ...
... The concept of the “gene” has evolved and become more complex since it was first proposed (see timeline in Fig. 1, accompanying poster). There are various definitions of the term, although common initial descriptions include the ability to determine a particular characteristic of an organism and the ...
What is a gene, post-ENCODE? History and updated
... The concept of the “gene” has evolved and become more complex since it was first proposed (see timeline in Fig. 1, accompanying poster). There are various definitions of the term, although common initial descriptions include the ability to determine a particular characteristic of an organism and the ...
... The concept of the “gene” has evolved and become more complex since it was first proposed (see timeline in Fig. 1, accompanying poster). There are various definitions of the term, although common initial descriptions include the ability to determine a particular characteristic of an organism and the ...
Role of PTEN/PI3K pathway in endothelial cells
... Tie2CrePtenflox/flox mice by null mutation of p110γ or p85α p85α is the most abundantly expressed regulatory subunit of the class IA PI3Ks that are activated following RTK engagement by VGFs. p110γ is the catalytic subunit of the sole class IB PI3K that is activated by the βγ subunit of Gproteins and ...
... Tie2CrePtenflox/flox mice by null mutation of p110γ or p85α p85α is the most abundantly expressed regulatory subunit of the class IA PI3Ks that are activated following RTK engagement by VGFs. p110γ is the catalytic subunit of the sole class IB PI3K that is activated by the βγ subunit of Gproteins and ...
Caspary T, Cleary MA, Baker CC, Guan XJ, Tilghman SM. Mol Cell Biol. 1998 Jun;18(6):3466-74. Multiple mechanisms of imprinting on distal mouse chromosome 7.
... the tendency of imprinted genes to exist in chromosomal clusters suggests long-range regulation through shared regulatory elements. We characterize a 800-kb region on the distal end of mouse chromosome 7 that contains a cluster of four maternally expressed genes, H19, Mash2, Kvlqt1, and p57Kip2, as ...
... the tendency of imprinted genes to exist in chromosomal clusters suggests long-range regulation through shared regulatory elements. We characterize a 800-kb region on the distal end of mouse chromosome 7 that contains a cluster of four maternally expressed genes, H19, Mash2, Kvlqt1, and p57Kip2, as ...
L-Lysin-Production with Corynebacterium glutamicum
... The leading position among the bacterial amino acid producers is occupied by Corynebacterium glutamicum. It belongs to the order Corynebacteriales, which is a clade within the Actinobacteria including Mycobacterium and Nocardia species. These Grampositive bacteria are characterized by a periplasmic ...
... The leading position among the bacterial amino acid producers is occupied by Corynebacterium glutamicum. It belongs to the order Corynebacteriales, which is a clade within the Actinobacteria including Mycobacterium and Nocardia species. These Grampositive bacteria are characterized by a periplasmic ...
Sex Chromosomes and Sex
... 1) For oogenesis to occur, expression of both alleles of several loci may be important. 2) Individuals with a single X chromosome or with a deletion of one of several different regions of the X chromosome have accelerated regression of the ovarian follicles and thus, gonadal dysgenesis and infertili ...
... 1) For oogenesis to occur, expression of both alleles of several loci may be important. 2) Individuals with a single X chromosome or with a deletion of one of several different regions of the X chromosome have accelerated regression of the ovarian follicles and thus, gonadal dysgenesis and infertili ...
Gene Section MUC17 (mucin 17, cell surface associated) in Oncology and Haematology
... has part of a new mucin called MUC17. Indeed, in 2002, driven with the hypothesis that the 177 bp tandem repeated sequences were part of a new unidentified mucin, Gum et al. screened the public GenBankTM database and the proprietary Lifeseq Gold ...
... has part of a new mucin called MUC17. Indeed, in 2002, driven with the hypothesis that the 177 bp tandem repeated sequences were part of a new unidentified mucin, Gum et al. screened the public GenBankTM database and the proprietary Lifeseq Gold ...
Symbiotic DNA in eukaryotic genomes
... dispersing themselves among the chromosomes, and increasing their likelihood of infecting new sexual lineages. In a cross between individuals with and without a mobile element, the element is inherited by 50-100% of the offspring, depending on the efficiency of its intragenomic replication. A mobile ...
... dispersing themselves among the chromosomes, and increasing their likelihood of infecting new sexual lineages. In a cross between individuals with and without a mobile element, the element is inherited by 50-100% of the offspring, depending on the efficiency of its intragenomic replication. A mobile ...
list of publications
... homologues are highly conserved, and a substantial number of papers describe fertilized zygote, ultimately results in a myriad of cells with different structures their mode of action, it remains unknown how any of these proteins recognizes and functions. The basis of this diversity is differential g ...
... homologues are highly conserved, and a substantial number of papers describe fertilized zygote, ultimately results in a myriad of cells with different structures their mode of action, it remains unknown how any of these proteins recognizes and functions. The basis of this diversity is differential g ...
as a PDF
... Down syndrome. Atrioventricular canal defects are one of the most frequent CHDs that occur with trisomy 21. Therefore, these defects may result from a different genetic mechanism than those that occur without a recognised chromosomal genetic syndrome. The child with atrial septal defect and patent d ...
... Down syndrome. Atrioventricular canal defects are one of the most frequent CHDs that occur with trisomy 21. Therefore, these defects may result from a different genetic mechanism than those that occur without a recognised chromosomal genetic syndrome. The child with atrial septal defect and patent d ...
Familial Malignant Melanoma Approved by the Cancer.Net Editorial
... these genes gives a person an increased risk of melanoma. However, alterations in these two genes only account for a small percentage of familial melanoma. CDKN2A is unusual because it affects two separate proteins that have different functions; one is called p16, and one is called p14ARF. Both CDKN ...
... these genes gives a person an increased risk of melanoma. However, alterations in these two genes only account for a small percentage of familial melanoma. CDKN2A is unusual because it affects two separate proteins that have different functions; one is called p16, and one is called p14ARF. Both CDKN ...
Biol 1406 notes Ch 15 8thed
... Morgan reasoned that body color and wing shape are usually inherited together because the genes for these characters are on the same chromosome. The other two phenotypes (gray-vestigial and black-normal) were rarer than expected based on independent assortment (but totally unexpected from depend ...
... Morgan reasoned that body color and wing shape are usually inherited together because the genes for these characters are on the same chromosome. The other two phenotypes (gray-vestigial and black-normal) were rarer than expected based on independent assortment (but totally unexpected from depend ...
Embryo Genome Profiling by Single-Cell
... indication for PGD as well. Hence, genome-wide profiling of embryos with diagnosis of single gene disorders, HLA matching, sex, and aneuploidy provides an approach to PGD for mendelian disorder carriers, such as the carriers of -thalassemia. Traditionally, multiplex PCR has been used to detect the ...
... indication for PGD as well. Hence, genome-wide profiling of embryos with diagnosis of single gene disorders, HLA matching, sex, and aneuploidy provides an approach to PGD for mendelian disorder carriers, such as the carriers of -thalassemia. Traditionally, multiplex PCR has been used to detect the ...
Gene Section MINA (MYC induced nuclear antigen) Atlas of Genetics and Cytogenetics
... Structure: MINA is a member of the jumonji C (JmjC) protein family, and suspected to hydroxylate some proteins to control gene expression. Activation: The expression of mRNA is elevated by cMYC protein, and frequently increased in various types of cancers, including human colon cancer, esophageal sq ...
... Structure: MINA is a member of the jumonji C (JmjC) protein family, and suspected to hydroxylate some proteins to control gene expression. Activation: The expression of mRNA is elevated by cMYC protein, and frequently increased in various types of cancers, including human colon cancer, esophageal sq ...
A G to C mutation in the CRYGD gamma crystallin gene associated
... dominant congenital cataract in developing countries [5]. Two main approaches have been used to identify the causative mutations. Large families linkage analysis has been used to identify the chromosomal locus followed by screening of ...
... dominant congenital cataract in developing countries [5]. Two main approaches have been used to identify the causative mutations. Large families linkage analysis has been used to identify the chromosomal locus followed by screening of ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.