RiboT
... • Ribosome with inseparable subunits (RiboT) are able to substain the expression of entire bacterial genome • RiboT can be used for studying in cells mutations of functionally crucial rRNA residues that are dominantly lethal • Future prospects of engineering ribosomes capable of programmed polymeriz ...
... • Ribosome with inseparable subunits (RiboT) are able to substain the expression of entire bacterial genome • RiboT can be used for studying in cells mutations of functionally crucial rRNA residues that are dominantly lethal • Future prospects of engineering ribosomes capable of programmed polymeriz ...
nar-02451-data-e-201
... not extract gene expression information from such sentences. Additionally, we provide links to Expression Atlas, OMIM Gene Map, ArrayExpress, OMIM and GEO for more information about gene expression. Moreover, we extracted associations between gene methylation and disease progression such as “gene m ...
... not extract gene expression information from such sentences. Additionally, we provide links to Expression Atlas, OMIM Gene Map, ArrayExpress, OMIM and GEO for more information about gene expression. Moreover, we extracted associations between gene methylation and disease progression such as “gene m ...
Toxicity Mechanisms Identification via Gene Set
... predictive models to provide toxicological information that transcends the limits of traditional toxicity assessment approach.1,2 The advances in high-throughput toxicogenomics technologies, which allow for globally concurrent monitoring of cellular responses of numerous transcripts, proteins, or me ...
... predictive models to provide toxicological information that transcends the limits of traditional toxicity assessment approach.1,2 The advances in high-throughput toxicogenomics technologies, which allow for globally concurrent monitoring of cellular responses of numerous transcripts, proteins, or me ...
No Slide Title
... • Use in prognosis: e.g. tumors with high S phase fraction detected by flow cytometry have poorer prognosis • Use in predicting responsiveness to a particular type of therapy: e.g. high S phase fraction and loss of p53 will make cells more suceptible to DNA damaging agents ...
... • Use in prognosis: e.g. tumors with high S phase fraction detected by flow cytometry have poorer prognosis • Use in predicting responsiveness to a particular type of therapy: e.g. high S phase fraction and loss of p53 will make cells more suceptible to DNA damaging agents ...
CapeTownGenomes
... New sequencing technologies provide better representation of the genome (by removing cloning steps) and deeper coverage but are harder to assemble because of the short-read lengths. People now talk about the ‘accessible’ genome for a species. This simply means the output from a reasonably deep s ...
... New sequencing technologies provide better representation of the genome (by removing cloning steps) and deeper coverage but are harder to assemble because of the short-read lengths. People now talk about the ‘accessible’ genome for a species. This simply means the output from a reasonably deep s ...
PDF - Blood Journal
... without protein-coding potential, referred to as noncoding RNAs (ncRNAs). Studies of these RNAs have provided new insights into the development of virtually all mammalian tissues and opened up new fields of biology. It is now known that a class of ncRNAs termed microRNAs exerts diverse roles in norma ...
... without protein-coding potential, referred to as noncoding RNAs (ncRNAs). Studies of these RNAs have provided new insights into the development of virtually all mammalian tissues and opened up new fields of biology. It is now known that a class of ncRNAs termed microRNAs exerts diverse roles in norma ...
Functions of DNA methylation: islands, start sites, gene bodies and
... beginning to be appreciated. Furthermore, although there is abundant evidence that methylated CGIs at TSSs are associated with some silent genes, the timing of de novo methylation with respect to gene silencing is now beginning to be elucidated. The function of DNA methylation is intrinsically linke ...
... beginning to be appreciated. Furthermore, although there is abundant evidence that methylated CGIs at TSSs are associated with some silent genes, the timing of de novo methylation with respect to gene silencing is now beginning to be elucidated. The function of DNA methylation is intrinsically linke ...
12859_2006_1447_MOESM4_ESM
... Submission of the gene DDR1 yielded 8 splice variants. No sequence querying capabilities were available. The database can be downloaded in whole for highthroughput analysis. The EBI’s Alternative Splicing Database (ASD; http://www.ebi.ac.uk/asd/ ) Project is composed of 3 databases: AltSplice, AltEx ...
... Submission of the gene DDR1 yielded 8 splice variants. No sequence querying capabilities were available. The database can be downloaded in whole for highthroughput analysis. The EBI’s Alternative Splicing Database (ASD; http://www.ebi.ac.uk/asd/ ) Project is composed of 3 databases: AltSplice, AltEx ...
the lkb1 tumor suppressor - E
... neoplasia directly by controlling cell growth, either by regulating proliferation or by promoting cell death. Although multiple gatekeeper genes have been identified, only one gatekeeper is thought to be active in a given cell type and inactivation of this gatekeeper is rate limiting for tumor devel ...
... neoplasia directly by controlling cell growth, either by regulating proliferation or by promoting cell death. Although multiple gatekeeper genes have been identified, only one gatekeeper is thought to be active in a given cell type and inactivation of this gatekeeper is rate limiting for tumor devel ...
Developmental Biology BY1101 P. Murphy Lecture 10 Master
... •And chromosomal arrangement of the genes is conserved. •They have also conserved the order and relative position along the AP axis of the embryo where they are expressed and function (colinearity) The genes are in fact so closely similar that the mouse version of one gene has been transferred to th ...
... •And chromosomal arrangement of the genes is conserved. •They have also conserved the order and relative position along the AP axis of the embryo where they are expressed and function (colinearity) The genes are in fact so closely similar that the mouse version of one gene has been transferred to th ...
reported several instances of so-called " complex genes ", whose
... two different pairs of M- and R-genes makes these cases distinct, and, at the same time, invalidates the view that their occurrence is a matter of chance. One is led to the conclusion that linkage, in the usual sense, is not involved here at all, but, rather, that two complex gene molecules exist: t ...
... two different pairs of M- and R-genes makes these cases distinct, and, at the same time, invalidates the view that their occurrence is a matter of chance. One is led to the conclusion that linkage, in the usual sense, is not involved here at all, but, rather, that two complex gene molecules exist: t ...
Computational Biology
... (e.g. level of conservation of amino acids) of individual genes/proteins. Genetic distance is defined as # mismatches / # matches. Sequence conservation depends on physico-chemical properties of amino acids (and genome context such as G+C content). ...
... (e.g. level of conservation of amino acids) of individual genes/proteins. Genetic distance is defined as # mismatches / # matches. Sequence conservation depends on physico-chemical properties of amino acids (and genome context such as G+C content). ...
Ramamoorthy, Krithika : Critical Review of Methods available for Microarray Data Analysis
... approximately equal amounts of control and experimental samples bound, while the red or green spots have increased levels of the experimental and control sample respectively. Black spots correspond to genes that are not differentially expressed, while red spots indicate upregulation of the gene (in ...
... approximately equal amounts of control and experimental samples bound, while the red or green spots have increased levels of the experimental and control sample respectively. Black spots correspond to genes that are not differentially expressed, while red spots indicate upregulation of the gene (in ...
Fatty Acids - Mayo Clinic
... HIV-1 RNA quantitation is performed by PCR using the Roche Amplicor System. Plasma is chemically extracted and the viral RNA is precipitated with isopropanol. A known amount of a standard synthetic RNA molecule is added to each specimen to permit quantitation of HIV RNA by a comparison of resulting ...
... HIV-1 RNA quantitation is performed by PCR using the Roche Amplicor System. Plasma is chemically extracted and the viral RNA is precipitated with isopropanol. A known amount of a standard synthetic RNA molecule is added to each specimen to permit quantitation of HIV RNA by a comparison of resulting ...
X inactivation Xplained
... repeat-rich core, to which Xist localizes [39]. In differentiated mouse ES cells, Xist forms a repressive compartment from which the transcription machinery is excluded as a first step in X inactivation [40]. This compartment initially does not contain genes and is also not sufficient for gene si ...
... repeat-rich core, to which Xist localizes [39]. In differentiated mouse ES cells, Xist forms a repressive compartment from which the transcription machinery is excluded as a first step in X inactivation [40]. This compartment initially does not contain genes and is also not sufficient for gene si ...
Limitations of Pseudogenes in Identifying Gene Losses
... high-quality genome sequences has also allowed researchers to discover genes lost during evolution, where sequences are not necessarily shared between species. These changes may also have played important roles in adaptive evolution. Gene loss is a ubiquitous phenomenon across all sequenced genomes, ...
... high-quality genome sequences has also allowed researchers to discover genes lost during evolution, where sequences are not necessarily shared between species. These changes may also have played important roles in adaptive evolution. Gene loss is a ubiquitous phenomenon across all sequenced genomes, ...
Caspary T, Cleary MA, Perlman EJ, Zhang P, Elledge SJ, and Tilghman SM. Genes Dev. 1999 Dec 1;13(23):3115-24. Oppositely imprinted genes p57Kip2 and Igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.
... Beckwith–Wiedemann syndrome (BWS) is a clinically variable disorder characterized by somatic overgrowth, macroglossia, abdominal wall defects, visceromegaly, and an increased susceptibility to childhood tumors. The disease has been linked to a large cluster of imprinted genes at human chromosome 11p ...
... Beckwith–Wiedemann syndrome (BWS) is a clinically variable disorder characterized by somatic overgrowth, macroglossia, abdominal wall defects, visceromegaly, and an increased susceptibility to childhood tumors. The disease has been linked to a large cluster of imprinted genes at human chromosome 11p ...
Validated preCRMs
... computational and experimental approaches (Collins et al. 2003). A particularly difficult challenge is identifying the cis-acting sequences, called cis-regulatory modules (CRMs), that are responsible for determining the amount, timing and tissue-specificity of gene expression. Unlike the situation f ...
... computational and experimental approaches (Collins et al. 2003). A particularly difficult challenge is identifying the cis-acting sequences, called cis-regulatory modules (CRMs), that are responsible for determining the amount, timing and tissue-specificity of gene expression. Unlike the situation f ...
Divergence Pattern of Duplicate Genes in Protein
... the evolutionary mechanisms of duplicate genes is, therefore, important for evolutionary genomics, functional genomics, and systems biology. Two models have been proposed to characterize the possible mechanisms of divergence of duplicate genes. First, the Dykhuizen-Hartl (Dykhuizen and Hartl 1980) m ...
... the evolutionary mechanisms of duplicate genes is, therefore, important for evolutionary genomics, functional genomics, and systems biology. Two models have been proposed to characterize the possible mechanisms of divergence of duplicate genes. First, the Dykhuizen-Hartl (Dykhuizen and Hartl 1980) m ...
Enhancers reside in a unique epigenetic environment during early
... The vast majority of enhancers at hypo-methylated loci are not active in any of the embryonic data sets analyzed if we use H3K27ac as a proxy of enhancer activity. To follow up on this observation, we defined two sets of enhancers based on their DNA methylation: hypo-enhancers (<25 % DNA methylation ...
... The vast majority of enhancers at hypo-methylated loci are not active in any of the embryonic data sets analyzed if we use H3K27ac as a proxy of enhancer activity. To follow up on this observation, we defined two sets of enhancers based on their DNA methylation: hypo-enhancers (<25 % DNA methylation ...
Beyond the Electrocardiogram: Mutations in Cardiac Ion Channel
... tachycardia-bradycardia syndrome, and AF.62 Unlike traditional channelopathies, HCN4 does not appear to manifest in primary ventricular arrhythmia. In 2014, Milano and colleagues18 showed that HCN4 may have a structural role in a family with SAN dysfunction, LVNC, and HCN4 mutation. There are two ma ...
... tachycardia-bradycardia syndrome, and AF.62 Unlike traditional channelopathies, HCN4 does not appear to manifest in primary ventricular arrhythmia. In 2014, Milano and colleagues18 showed that HCN4 may have a structural role in a family with SAN dysfunction, LVNC, and HCN4 mutation. There are two ma ...
Warren-Proposal-Mining-TF-Genes-Disease-2007-07
... One method for identifying disease-related genes involved clustering the diseases in OMIM, rather than the disease genes, using indices such as primary tissue involved, age of onset, primary etiology, episodic occurrence and their mode of inheritance. Similarity between two disease is the weighted c ...
... One method for identifying disease-related genes involved clustering the diseases in OMIM, rather than the disease genes, using indices such as primary tissue involved, age of onset, primary etiology, episodic occurrence and their mode of inheritance. Similarity between two disease is the weighted c ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.