Evidence That the Human X Chromosome Is Enriched for Male
... a female-benefit /male-detriment allele might spread, were it X linked, and hence is a force leading to enrichment on the X chromosome of female-specific genes (after a modifier has suppressed the genes’ expression in males). However, this force will be counterbalanced by the greater relative ease o ...
... a female-benefit /male-detriment allele might spread, were it X linked, and hence is a force leading to enrichment on the X chromosome of female-specific genes (after a modifier has suppressed the genes’ expression in males). However, this force will be counterbalanced by the greater relative ease o ...
Th17/Treg ratio derived using DNA methylation asthmatic response
... Reagents (GPRs) with unlabelled probes that target specific genes of interest (www.nanostring.com/elements/). 100 ng of each RNA sample is added to the TagSet in hybridization buffer and incubated at 65°C for 16 hours. The TagSet consists of a reporter tag and capture tag that hybridize to the user ...
... Reagents (GPRs) with unlabelled probes that target specific genes of interest (www.nanostring.com/elements/). 100 ng of each RNA sample is added to the TagSet in hybridization buffer and incubated at 65°C for 16 hours. The TagSet consists of a reporter tag and capture tag that hybridize to the user ...
Name
... The genetic information (DNA) in our cells plays a major role in how our body works. Spelling mistakes often happen when this information is being transcribed. When these spelling mistakes occur on uncoded genes, there aren't any consequences. In a few rare cases, however, a spelling mistake – or mu ...
... The genetic information (DNA) in our cells plays a major role in how our body works. Spelling mistakes often happen when this information is being transcribed. When these spelling mistakes occur on uncoded genes, there aren't any consequences. In a few rare cases, however, a spelling mistake – or mu ...
Identification of the Minus-Dominance Gene Ortholog in
... RWP12 is located at the N terminus; the initial methionine is set at the seventh residue of the multiple alignment. Since it seemed likely that the RWP-RK domain should extend farther into the 59-region, the DNA sequence neighboring RWP12 was analyzed by GENSCAN (Burge and Karlin 1997) with the ‘‘or ...
... RWP12 is located at the N terminus; the initial methionine is set at the seventh residue of the multiple alignment. Since it seemed likely that the RWP-RK domain should extend farther into the 59-region, the DNA sequence neighboring RWP12 was analyzed by GENSCAN (Burge and Karlin 1997) with the ‘‘or ...
The constitution and the control of the ovarian
... arrested at the diplotene stage. One main factor involved in ultimate stage of ovarian follicle formation is FIGLA, a germ cell-specific bHLH transcription factor (Fig. 1). Female mice lacking Figla are sterile due to the absence of follicles and oocytes (Soyal et al., 2000). The defect appears afte ...
... arrested at the diplotene stage. One main factor involved in ultimate stage of ovarian follicle formation is FIGLA, a germ cell-specific bHLH transcription factor (Fig. 1). Female mice lacking Figla are sterile due to the absence of follicles and oocytes (Soyal et al., 2000). The defect appears afte ...
Hybrid Plasmids Containing the Pyruvate
... the Ipd region in which no useful restriction sites had been found in previous analyses (Fig. 2). The sources of the sub-cloned fragments and the corresponding vectors used to construct the new plasmids are summarized in Fig. 3. Nutritional and enzymological studies. Nutritional studies with the del ...
... the Ipd region in which no useful restriction sites had been found in previous analyses (Fig. 2). The sources of the sub-cloned fragments and the corresponding vectors used to construct the new plasmids are summarized in Fig. 3. Nutritional and enzymological studies. Nutritional studies with the del ...
BaseSpace Knowledge Network
... Somatic mutations are acquired genetic alterations in somatic tissue that are not transmitted to offspring. These mutations can be linked to a specific condition or be the underlying cause for cancer (driver mutation). Evidence-based summaries for somatic alterations are harvested from publications, ...
... Somatic mutations are acquired genetic alterations in somatic tissue that are not transmitted to offspring. These mutations can be linked to a specific condition or be the underlying cause for cancer (driver mutation). Evidence-based summaries for somatic alterations are harvested from publications, ...
Patterns of Heredity
... The genetic information (DNA) in our cells plays a major role in how our body works. Spelling mistakes often happen when this information is being transcribed. When these spelling mistakes occur on uncoded genes, there aren't any consequences. In a few rare cases, however, a spelling mistake – or mu ...
... The genetic information (DNA) in our cells plays a major role in how our body works. Spelling mistakes often happen when this information is being transcribed. When these spelling mistakes occur on uncoded genes, there aren't any consequences. In a few rare cases, however, a spelling mistake – or mu ...
Masters_Thesis_Final - JScholarship
... genome is inactive, 9.9% has low sensitivity and forms weaker sites and only about 0.1% of the genome is hypersensitive in nature. ...
... genome is inactive, 9.9% has low sensitivity and forms weaker sites and only about 0.1% of the genome is hypersensitive in nature. ...
Quantitative and Single-Gene Perspectives on the Study of Behavior
... The clearest contribution single-gene mutants have made is in the realm of identifying individual genes that are central to behavioral mechanisms, pointing the way to the unraveling of the cellular mechanisms. Perhaps the best example of this strategy can be seen in studies of the circadian clock. T ...
... The clearest contribution single-gene mutants have made is in the realm of identifying individual genes that are central to behavioral mechanisms, pointing the way to the unraveling of the cellular mechanisms. Perhaps the best example of this strategy can be seen in studies of the circadian clock. T ...
Altering gene expression by aminocoumarins: the role of DNA
... genes and their sensitivity to supercoiling. Of note, homologues of FIS and H-NS are lacking in Firmicutes such as Staphylococci or Streptococci, and much less is known about the role of supercoiling in these organisms. The results obtained in S. pneumoniae indicate that the genome of this organism ...
... genes and their sensitivity to supercoiling. Of note, homologues of FIS and H-NS are lacking in Firmicutes such as Staphylococci or Streptococci, and much less is known about the role of supercoiling in these organisms. The results obtained in S. pneumoniae indicate that the genome of this organism ...
Title: Genes in the Postgenomic Era Authors: Paul E. Griffiths and
... yielded twenty-six example, of which sixteen restricted exons to coding sequences3, five permitted them in untranslated regions of the gene (UTRs)4 and five were unclear on the point. The difference is significant. On the traditional definition it would makes no sense to distinguish exons in the unt ...
... yielded twenty-six example, of which sixteen restricted exons to coding sequences3, five permitted them in untranslated regions of the gene (UTRs)4 and five were unclear on the point. The difference is significant. On the traditional definition it would makes no sense to distinguish exons in the unt ...
- Wiley Online Library
... Frankel et al., 2011; Montavon et al., 2011; Visser et al., 2012). Traditionally, the study of cis-regulation was tackled with functional analyses of individual cis-regulatory elements (mostly enhancers). Over many years, these analyses have shed light on the logic of cis-regulation (Istrail and Dav ...
... Frankel et al., 2011; Montavon et al., 2011; Visser et al., 2012). Traditionally, the study of cis-regulation was tackled with functional analyses of individual cis-regulatory elements (mostly enhancers). Over many years, these analyses have shed light on the logic of cis-regulation (Istrail and Dav ...
Constitutive Mutations of the Saccharomyces
... considerably from inducible alleles in their C-terminal domain, with many of the alterations clustered and common to both alleles. The 27 alterations from residues 238-461 of Ma143-C protein are sufficient for constitutivity, but the minimal number of alterations needed for the constitutive phenotyp ...
... considerably from inducible alleles in their C-terminal domain, with many of the alterations clustered and common to both alleles. The 27 alterations from residues 238-461 of Ma143-C protein are sufficient for constitutivity, but the minimal number of alterations needed for the constitutive phenotyp ...
Ascidian embryogenesis and the origins of the chordate body plan
... of transgcnic DNA and RNA into de\ eloping embryos. hlosaic incorporation is not ~1prohlcm in this system because of the small number of clca\~ges involved in the formation of adwnccd-stage embryos. ‘liansgenesis has been wed to characterize &rcgulatory I)NA elements that mediate tissue-specific and ...
... of transgcnic DNA and RNA into de\ eloping embryos. hlosaic incorporation is not ~1prohlcm in this system because of the small number of clca\~ges involved in the formation of adwnccd-stage embryos. ‘liansgenesis has been wed to characterize &rcgulatory I)NA elements that mediate tissue-specific and ...
MOLLECULAR BIOLOGY COURSE
... Mitochondria are complex organelles that convert energy from food into a form that the cell can use. They have their own genetic material, separate from the DNA in the nucleus, and can make copies of themselves. ...
... Mitochondria are complex organelles that convert energy from food into a form that the cell can use. They have their own genetic material, separate from the DNA in the nucleus, and can make copies of themselves. ...
nar-02451-data-e-201
... not extract gene expression information from such sentences. Additionally, we provide links to Expression Atlas, OMIM Gene Map, ArrayExpress, OMIM and GEO for more information about gene expression. Moreover, we extracted associations between gene methylation and disease progression such as “gene m ...
... not extract gene expression information from such sentences. Additionally, we provide links to Expression Atlas, OMIM Gene Map, ArrayExpress, OMIM and GEO for more information about gene expression. Moreover, we extracted associations between gene methylation and disease progression such as “gene m ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.