Escherichia coli rpoB Mutants Have Increased
... compare the evolvability—defined as the fitness increase realized by an evolving population initiated from a test genotype—of a series of Escherichia coli mutants on multiple timescales. Each mutant differs from a common progenitor strain by a mutation in the rpoB gene, which encodes the b subunit o ...
... compare the evolvability—defined as the fitness increase realized by an evolving population initiated from a test genotype—of a series of Escherichia coli mutants on multiple timescales. Each mutant differs from a common progenitor strain by a mutation in the rpoB gene, which encodes the b subunit o ...
lactase persistence: evidence for selection
... because it offers the same selective advantage. Mutations could arise in the same gene and give rise to the same trait because many nucleotides contribute to controlling the expression of a gene. Mutations in a different gene could also give rise to the same trait. The latter scenario is an example ...
... because it offers the same selective advantage. Mutations could arise in the same gene and give rise to the same trait because many nucleotides contribute to controlling the expression of a gene. Mutations in a different gene could also give rise to the same trait. The latter scenario is an example ...
Schizophrenia genetics: emerging themes for a complex disorder
... consortia detected incrementally more risk loci such that by the end of 2013 around 30 loci had been reported at genome-wide significance, albeit not always in samples that were well enough powered to give confidence in the findings. The largest single study prior to 2014 undertook a meta-analysis of n ...
... consortia detected incrementally more risk loci such that by the end of 2013 around 30 loci had been reported at genome-wide significance, albeit not always in samples that were well enough powered to give confidence in the findings. The largest single study prior to 2014 undertook a meta-analysis of n ...
Smchd1 regulates a subset of autosomal genes subject to
... Smchd1MommeD1/MommeD1 and Smchd1+/+, male and female embryos (n = 4 for each genotype and sex combination) at E9.5 (Figure 1, Additional files 1 and 2). Males and females were analyzed separately because the females are likely to have deregulated expression of autosomal genes as a secondary conseque ...
... Smchd1MommeD1/MommeD1 and Smchd1+/+, male and female embryos (n = 4 for each genotype and sex combination) at E9.5 (Figure 1, Additional files 1 and 2). Males and females were analyzed separately because the females are likely to have deregulated expression of autosomal genes as a secondary conseque ...
Amplification of AML1 on a duplicated chromosome 21 in
... This study presents a series of 20 patients with ALL, each with an abnormal marker chromosome of variable morphology, replacing one copy of a normal chromosome 21. The markers were composed entirely of chromosome 21 material, with multiple copies of the AML1 gene duplicated in tandem along their len ...
... This study presents a series of 20 patients with ALL, each with an abnormal marker chromosome of variable morphology, replacing one copy of a normal chromosome 21. The markers were composed entirely of chromosome 21 material, with multiple copies of the AML1 gene duplicated in tandem along their len ...
- NDLScholarship
... with cystic fibrosis. The isolation of the gene responsible for cystic fibrosis has opened up the reality of genetic screening. A simple test of a person's saliva, costing about the price of a newspaper, allows identification of carriers (people who have one healthy and one faulty copy of the gene)- ...
... with cystic fibrosis. The isolation of the gene responsible for cystic fibrosis has opened up the reality of genetic screening. A simple test of a person's saliva, costing about the price of a newspaper, allows identification of carriers (people who have one healthy and one faulty copy of the gene)- ...
lecture - Berkeley MCB
... expression profiling, that the polycomb group protein enhancer of zeste homolog 2 (EZH2) is overexpressed in hormone-refractory, metastatic prostate cancer. … Dysregulated expression of EZH2 may be involved in the progression of prostate cancer, as well as being a marker that distinguishes indolent ...
... expression profiling, that the polycomb group protein enhancer of zeste homolog 2 (EZH2) is overexpressed in hormone-refractory, metastatic prostate cancer. … Dysregulated expression of EZH2 may be involved in the progression of prostate cancer, as well as being a marker that distinguishes indolent ...
(XX) express twice as many genes as males (XY)?
... chromosome. X chromosome have genes for many characters unrelated to sex, whereas the Y chromosome mainly encodes genes related to sex determination • Human sex-linked genes follow the same pattern of inheritance as Morgan’s white-eye locus in Drosophila. – Fathers pass sex-linked alleles to all the ...
... chromosome. X chromosome have genes for many characters unrelated to sex, whereas the Y chromosome mainly encodes genes related to sex determination • Human sex-linked genes follow the same pattern of inheritance as Morgan’s white-eye locus in Drosophila. – Fathers pass sex-linked alleles to all the ...
letter Widespread aneuploidy revealed by DNA microarray expression profiling
... location, we noted an expres- Fig. 3 Selection for aneuploidy in rnr1∆ and rps24a∆/rps24a∆ mutants. a, Slow-growing rnr1∆ (sector 2) or sion bias in a 56-ORF region on rps24a∆/rps24a∆ (sector 4) cells or their isogenic parental wild-type cells (sectors 1 and 3) were streaked onto solid the right arm ...
... location, we noted an expres- Fig. 3 Selection for aneuploidy in rnr1∆ and rps24a∆/rps24a∆ mutants. a, Slow-growing rnr1∆ (sector 2) or sion bias in a 56-ORF region on rps24a∆/rps24a∆ (sector 4) cells or their isogenic parental wild-type cells (sectors 1 and 3) were streaked onto solid the right arm ...
CHAPTER 9
... Acridine orange is a chemical that inhibits the replication of F factor DNA but does not affect the replication of chromosomal DNA, even if the chromosomal DNA contains an Hfr. Let’s suppose that you have an E. coli strain that is unable to metabolize lactose and has an F factor that carries a strep ...
... Acridine orange is a chemical that inhibits the replication of F factor DNA but does not affect the replication of chromosomal DNA, even if the chromosomal DNA contains an Hfr. Let’s suppose that you have an E. coli strain that is unable to metabolize lactose and has an F factor that carries a strep ...
Brooker Chapter 7 - Volunteer State Community College
... tumor and many cases of colon cancer have both copies of the IGF2 gene expressed (where only one, the father's, should be). Reduced methylation — and hence increased expression — of proto-oncogenes can lead to cancer, while increased methylation — and hence decreased expression — of tumor suppressor ...
... tumor and many cases of colon cancer have both copies of the IGF2 gene expressed (where only one, the father's, should be). Reduced methylation — and hence increased expression — of proto-oncogenes can lead to cancer, while increased methylation — and hence decreased expression — of tumor suppressor ...
Genome Evolution and Developmental Constraint in Caenorhabditis
... It has been hypothesized that evolutionary changes will be more frequent in later ontogeny than early ontogeny because of developmental constraint. To test this hypothesis, a genomewide examination of molecular evolution through ontogeny was carried out using comparative genomic data in Caenorhabdit ...
... It has been hypothesized that evolutionary changes will be more frequent in later ontogeny than early ontogeny because of developmental constraint. To test this hypothesis, a genomewide examination of molecular evolution through ontogeny was carried out using comparative genomic data in Caenorhabdit ...
pdf
... 1. The natural inducer (or antirepressor), is allolactose, an analog of lactose. It is made as a metabolic by-product of the reaction catalyzed by β-galactosidase. Usually this enzyme catalyzes the cleavage of lactose to galactose + glucose, but occasionally it will catalyze an isomerization to form ...
... 1. The natural inducer (or antirepressor), is allolactose, an analog of lactose. It is made as a metabolic by-product of the reaction catalyzed by β-galactosidase. Usually this enzyme catalyzes the cleavage of lactose to galactose + glucose, but occasionally it will catalyze an isomerization to form ...
Marfan syndrome in the third Millennium
... (Collod-Béroud et al., In preparation). No major rearrangements have been identified except for three cases of multi-exon deletions 35–36. Three categories of mutations have been described: 1) missense mutations, 2) small insertions or deletions, mutations causing premature termination of translatio ...
... (Collod-Béroud et al., In preparation). No major rearrangements have been identified except for three cases of multi-exon deletions 35–36. Three categories of mutations have been described: 1) missense mutations, 2) small insertions or deletions, mutations causing premature termination of translatio ...
The molecular basis of cytoplasmic male sterility and
... chloroplast genomes. Indeed, in all cases where a specific CMSassociated gene has been identified and shown via correlative or direct means to be responsible for CMS, the lesion has been in the mitochondrial genome (Fig. 2). However, because plant mitochondrial genomes are large (200–2400 kb), it is ...
... chloroplast genomes. Indeed, in all cases where a specific CMSassociated gene has been identified and shown via correlative or direct means to be responsible for CMS, the lesion has been in the mitochondrial genome (Fig. 2). However, because plant mitochondrial genomes are large (200–2400 kb), it is ...
Intervention strategies for mitochondrial disease
... recognized by the mitochondrial protein import machinery • Coupling the cargo to a delocalized lipophilic cation, leading to its accumulation in mitochondria (Several antioxidants have been successfully targeted using the cation ...
... recognized by the mitochondrial protein import machinery • Coupling the cargo to a delocalized lipophilic cation, leading to its accumulation in mitochondria (Several antioxidants have been successfully targeted using the cation ...
Slide 1
... Autosomal aneuploidy is not well tolerated in animals, and in mammals is detected mainly after spontaneous abortion. Aneuploidy is much better tolerated in plants. There are four main types of aneuploidy: – Nullisomy involves loss of 1 homologous chromosome pair (the cell is 2N - 2). – Monosomy inv ...
... Autosomal aneuploidy is not well tolerated in animals, and in mammals is detected mainly after spontaneous abortion. Aneuploidy is much better tolerated in plants. There are four main types of aneuploidy: – Nullisomy involves loss of 1 homologous chromosome pair (the cell is 2N - 2). – Monosomy inv ...
High mutation rates in human and ape pseudoautosomal genes
... Keywords: Pseudoautosomal region; Human; Orangutan; Substitution rate; Mutation rate ...
... Keywords: Pseudoautosomal region; Human; Orangutan; Substitution rate; Mutation rate ...
The Drosophila serum response factor homolog is required for formation of intervein tissue of the wing and is allelic to blistered. Development 122, 2589-2597. pdf
... and Cohen, 1993). The wing pouch is the oval domain that will give rise to the adult wing blade. The hinge is the proximal structures that fasten the wing blade to the body wall (Ng et al., 1995). (B) DSRF expression detected in a wing disc with a DSRF antiserum (brown peroxidase reaction product). ...
... and Cohen, 1993). The wing pouch is the oval domain that will give rise to the adult wing blade. The hinge is the proximal structures that fasten the wing blade to the body wall (Ng et al., 1995). (B) DSRF expression detected in a wing disc with a DSRF antiserum (brown peroxidase reaction product). ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.