Article A Distinct Mitochondrial Genome with DUI
... the male genome by a female one erasing all previous records of the “divergent” genome (Hoeh et al. 1996; Zouros 2013); 2/ a recent separation of “divergent” and “normal” lineages, implying a DUI origin event particular to A. islandica, and therefore the occurrence of several independent DUI origins ...
... the male genome by a female one erasing all previous records of the “divergent” genome (Hoeh et al. 1996; Zouros 2013); 2/ a recent separation of “divergent” and “normal” lineages, implying a DUI origin event particular to A. islandica, and therefore the occurrence of several independent DUI origins ...
NQO1 Pro187Ser polymorphism confers to the susceptibility of
... Cancer is a major public health problem worldwide and one of the leading causes of death [1]. The newly diagnosed and death for prostate cancer (PCa) were 217,730 and 32,050 respectively in USA [2]. However, PCa is a complex process and its exact mechanism has not yet been fully elucidated. Genetic ...
... Cancer is a major public health problem worldwide and one of the leading causes of death [1]. The newly diagnosed and death for prostate cancer (PCa) were 217,730 and 32,050 respectively in USA [2]. However, PCa is a complex process and its exact mechanism has not yet been fully elucidated. Genetic ...
Transgenerational epigenetics in the germline cycle
... Although the definition of epigenetics has undergone some restriction, what is currently classified as ‘epigenetic research’ has exploded in the last decade. In the face of such expansion, it is probably useful to consider two main mechanistic components that have to exist in any epigenetic process: ...
... Although the definition of epigenetics has undergone some restriction, what is currently classified as ‘epigenetic research’ has exploded in the last decade. In the face of such expansion, it is probably useful to consider two main mechanistic components that have to exist in any epigenetic process: ...
Ion AmpliSeq RNA Panels—quantitative targeted gene expression
... their samples. Additional ready-to-use panels are available, targeting both cancer and apoptosis pathways. After sequencing the RNA-derived amplicons on the Ion Torrent™ sequencing platform, the number of reads mapped to each gene corresponds to the abundance of the assayed gene in the test sample. ...
... their samples. Additional ready-to-use panels are available, targeting both cancer and apoptosis pathways. After sequencing the RNA-derived amplicons on the Ion Torrent™ sequencing platform, the number of reads mapped to each gene corresponds to the abundance of the assayed gene in the test sample. ...
A global view of pleiotropy and phenotypically derived gene function
... functional category. Thus, clustering mutants with a wide range of pleiotropies by phenotype profile successfully groups genes with common biological functions. The fact that both condition-specific and highly pleiotropic genes can be grouped by common phenotype profiles into gene sets that show signifi ...
... functional category. Thus, clustering mutants with a wide range of pleiotropies by phenotype profile successfully groups genes with common biological functions. The fact that both condition-specific and highly pleiotropic genes can be grouped by common phenotype profiles into gene sets that show signifi ...
19.1 CONSTITUTIVE, INDUCIBLE AND REPRESSIBLE GENE
... This leads to diauxic pattern of growth in laboratory media containing both sugars. The Lac promoter is intrinsically "weak" because of a poor match to consensus sequence of the sigma factor. This is important for positive regulation by CAP. The mechanism by which glucose regulates adenyl cyclase ac ...
... This leads to diauxic pattern of growth in laboratory media containing both sugars. The Lac promoter is intrinsically "weak" because of a poor match to consensus sequence of the sigma factor. This is important for positive regulation by CAP. The mechanism by which glucose regulates adenyl cyclase ac ...
Genome Biology and Evolution
... Monophlebidae. Further analyses should be done to determine whether other Flavobacteria that have been previously obtained from insects of the family Coccidae and Lecanodiaspididae whose 16S rRNA sequences are phylogenetically related to Walczuchella monophlebidarum (Rosenblueth et al. 2012) could b ...
... Monophlebidae. Further analyses should be done to determine whether other Flavobacteria that have been previously obtained from insects of the family Coccidae and Lecanodiaspididae whose 16S rRNA sequences are phylogenetically related to Walczuchella monophlebidarum (Rosenblueth et al. 2012) could b ...
Tobacco Packet-2014
... 4. __Tar__________________—thick, sticky fluid formed when tobacco burns that irritates respiratory tissues and is a major cause of cancer 5. __Carbon Monoxide_____—poisonous odorless, tasteless gas that interferes with the blood’s oxygen-carrying ability 6. __Emphysema__________—a chronic obstructi ...
... 4. __Tar__________________—thick, sticky fluid formed when tobacco burns that irritates respiratory tissues and is a major cause of cancer 5. __Carbon Monoxide_____—poisonous odorless, tasteless gas that interferes with the blood’s oxygen-carrying ability 6. __Emphysema__________—a chronic obstructi ...
is involved in hair formation and spermatogenesis in mice gene
... been reported in which mammalian homologs of developmentally important Drosophila genes perform similar functions and participate in similar pathways as their fly relatives. As the organ separating the animal body from its environment, skin/skin appendages in both flies and mice carry out essential ...
... been reported in which mammalian homologs of developmentally important Drosophila genes perform similar functions and participate in similar pathways as their fly relatives. As the organ separating the animal body from its environment, skin/skin appendages in both flies and mice carry out essential ...
upstream sequence of a differentiation
... 1986, 1989). Several other cultured rabbit cell types including esophageal epithelial cells, kidney epithelial cells, mesothelial cells and fibroblasts do not synthesize K3. Therefore a panel of cultured cells, all of the same rabbit origin, is available, and is ideally suited for studying the tissu ...
... 1986, 1989). Several other cultured rabbit cell types including esophageal epithelial cells, kidney epithelial cells, mesothelial cells and fibroblasts do not synthesize K3. Therefore a panel of cultured cells, all of the same rabbit origin, is available, and is ideally suited for studying the tissu ...
Evolutionary Genomics of Fast Evolving Tunicates
... process of genome reduction could have been caused in part by the elimination of genes (like notochord genes and Hox genes, as described in the previous section), this was not the only or even the main cause, since this genome contains about 18,000 predicted genes. Instead, genome compaction, namely ...
... process of genome reduction could have been caused in part by the elimination of genes (like notochord genes and Hox genes, as described in the previous section), this was not the only or even the main cause, since this genome contains about 18,000 predicted genes. Instead, genome compaction, namely ...
Effects of adenovirus delivered Flt
... the ARE as a dimer. Although small Maf proteins have been proposed to represent the dimerizing partners for Nrf2 in the activation complex, this has not been conclusively demonstrated. The molecular mechanisms controlling the ARE-mediated transcription by the MAP kinase and PI3 kinase pathways rema ...
... the ARE as a dimer. Although small Maf proteins have been proposed to represent the dimerizing partners for Nrf2 in the activation complex, this has not been conclusively demonstrated. The molecular mechanisms controlling the ARE-mediated transcription by the MAP kinase and PI3 kinase pathways rema ...
Rapid detection of multidrug-resistant tuberculosis
... eye, and stored using any simple word-processing programme. Strain-typing itself does not provide direct information about drug susceptibility, but a register of spoligotypes from known MDR isolates may be particularly useful in providing early warning of possible infection with these strains. Whils ...
... eye, and stored using any simple word-processing programme. Strain-typing itself does not provide direct information about drug susceptibility, but a register of spoligotypes from known MDR isolates may be particularly useful in providing early warning of possible infection with these strains. Whils ...
Familial spontaneous pneumothorax and mutation CASE STUDY
... phenotype has previously been reported in association with mutations on exon 4 [5] and exons 9 and 12 [6]. It is possible that these regions (and exon 10) encode functional domains particularly relevant to lung development. It is interesting to note that, among patients with mutations in the exon 11 ...
... phenotype has previously been reported in association with mutations on exon 4 [5] and exons 9 and 12 [6]. It is possible that these regions (and exon 10) encode functional domains particularly relevant to lung development. It is interesting to note that, among patients with mutations in the exon 11 ...
Short Tandem Repeat Polymorphism and Cancer Risk: Influence of
... in CA repeats between the two methods, including 5 samples with two-repeat difference, 3 with three-repeat difference, 3 with four-repeat difference, and 1 with fiverepeat difference. Of the 12 samples that had the same allelic difference in CA repeats, only 8 had exactly the same number of repeats ...
... in CA repeats between the two methods, including 5 samples with two-repeat difference, 3 with three-repeat difference, 3 with four-repeat difference, and 1 with fiverepeat difference. Of the 12 samples that had the same allelic difference in CA repeats, only 8 had exactly the same number of repeats ...
The Bacillus subtilis clpC operon encodes DNA
... frames (Ogasawara et al., 1994). We recently showed that the six genes are cotranscribed as an operon, preceded by two promoters. One resembles promoters recognized by the vegetative RNA polymerase EoA. The other promoter was shown to be stress-inducible and dependent upon aB, the general stress a-f ...
... frames (Ogasawara et al., 1994). We recently showed that the six genes are cotranscribed as an operon, preceded by two promoters. One resembles promoters recognized by the vegetative RNA polymerase EoA. The other promoter was shown to be stress-inducible and dependent upon aB, the general stress a-f ...
The Importance of the TSHR-gene in Domestic Chicken Hanna Johnsen
... “domesticated phenotype”, seen in all domesticated animal species (Jensen, 2006). Traits of this domesticated phenotype include behavioral changes such as reduced fear response, increased sociability and reduced anti-predator response. Changes in appearance such as altered fur and plumage colors, bo ...
... “domesticated phenotype”, seen in all domesticated animal species (Jensen, 2006). Traits of this domesticated phenotype include behavioral changes such as reduced fear response, increased sociability and reduced anti-predator response. Changes in appearance such as altered fur and plumage colors, bo ...
pistilata
... a, Wild-type flower consisting of four sepals, four petals, six stamens and two fused carpels. b, sep1 sep2 sep3 triple mutant flower in which the four petals and six stamens are replaced by sepaloid organs and carpels are replaced by a new flower that repeats this same phenotype. In addition, there ...
... a, Wild-type flower consisting of four sepals, four petals, six stamens and two fused carpels. b, sep1 sep2 sep3 triple mutant flower in which the four petals and six stamens are replaced by sepaloid organs and carpels are replaced by a new flower that repeats this same phenotype. In addition, there ...
A novel arginine substitution mutation in 1A domain and a novel 27
... region have been reported.26–29 The proband of family B carries a novel duplication insertion of 27 nucleotides (1222ins27). This type of mutation is unique for a number of different reasons. Firstly, in-frame insertion or deletion mutations are extremely rare in keratin diseases (table 2), and this ...
... region have been reported.26–29 The proband of family B carries a novel duplication insertion of 27 nucleotides (1222ins27). This type of mutation is unique for a number of different reasons. Firstly, in-frame insertion or deletion mutations are extremely rare in keratin diseases (table 2), and this ...
the human y chromosome, in the light of evolution
... within this year. So far, 21 distinct genes or gene families that are expressed in healthy tissues have been identified in the human NRY. These group into three salient classes — classes 1, 2 and 3 — largely on the basis of expression profile and homology to the X. The eight known class 1 genes are ...
... within this year. So far, 21 distinct genes or gene families that are expressed in healthy tissues have been identified in the human NRY. These group into three salient classes — classes 1, 2 and 3 — largely on the basis of expression profile and homology to the X. The eight known class 1 genes are ...
DNA methylation involved in proline accumulation in - Funpec-RP
... (Siripornadulsil et al., 2002; Verbruggen and Hermans, 2008). Recent findings have suggested that proline may also play a role in flowering and development both as a metabolite and a signal molecule (Mattioli et al., 2009). In any case, proline clearly plays crucial roles not only in drought toleran ...
... (Siripornadulsil et al., 2002; Verbruggen and Hermans, 2008). Recent findings have suggested that proline may also play a role in flowering and development both as a metabolite and a signal molecule (Mattioli et al., 2009). In any case, proline clearly plays crucial roles not only in drought toleran ...
Gene Section MYB (v-myb myeloblastosis viral oncogene homolog (avian))
... leukaemic transformation. However, MYB also activates a number of haemopoietic-specific genes. ...
... leukaemic transformation. However, MYB also activates a number of haemopoietic-specific genes. ...
The molecular genetics of head development in Drosophila
... 'cephalization' occurred when several of the anteriormost trunk segments became incorporated into the beginnings of a clearly recognizable head region. This process is already evident in certain annelid embryos (e.g. the polychaete Nereis) in which the head includes regions called the prostomium (an ...
... 'cephalization' occurred when several of the anteriormost trunk segments became incorporated into the beginnings of a clearly recognizable head region. This process is already evident in certain annelid embryos (e.g. the polychaete Nereis) in which the head includes regions called the prostomium (an ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.