One vitellogenin gene in an ocean of many: The molecular ecology
... sampling strategy, could be discerned at the levels of clade and order. The most widely sampled forms of aquaglyceroporin were aqp3, -7, -9 and -10, with aqp3 on a sister branch to aqp9, and aqp7 clustering with aqp10 (Figure S6). In each subclass, the sarcopterygian aquaglyceroporins were robustly ...
... sampling strategy, could be discerned at the levels of clade and order. The most widely sampled forms of aquaglyceroporin were aqp3, -7, -9 and -10, with aqp3 on a sister branch to aqp9, and aqp7 clustering with aqp10 (Figure S6). In each subclass, the sarcopterygian aquaglyceroporins were robustly ...
1 - bioRxiv
... percentage of cells carrying a wild-type clotting factor allele, manifestation of the disease may occur 4-7. Several X-linked disorders affect the red blood cell fraction, which can result in lethal anemias. Xlinked hemolytic anemia (OMIM: 305900) is caused by mutations in the G6PD gene, which is es ...
... percentage of cells carrying a wild-type clotting factor allele, manifestation of the disease may occur 4-7. Several X-linked disorders affect the red blood cell fraction, which can result in lethal anemias. Xlinked hemolytic anemia (OMIM: 305900) is caused by mutations in the G6PD gene, which is es ...
Package `GOFunction`
... folder. This table contains seven columns: goid, name, refnum (the number of the reference genes in a GO term), interestnum (the number of the interesting genes in a GO term), pvalue, adjustp (the corrected p value by the fdr control), FinalResults. The "FinalResults" contains three types: (1) "Loca ...
... folder. This table contains seven columns: goid, name, refnum (the number of the reference genes in a GO term), interestnum (the number of the interesting genes in a GO term), pvalue, adjustp (the corrected p value by the fdr control), FinalResults. The "FinalResults" contains three types: (1) "Loca ...
Contrasting Effects of ENU Induced Embryonic Lethal Mutations of
... alleles causing either embryonic lethality at approximately day 9 in utero, qk lethal-1 (qk l-1), qk kt1, qk k2, and qk kt3 (Shedlovsky et al., 1988; Justice and Bode, 1986, 1988), or dysmyelination in the central nervous system (CNS) and peripheral nervous system (PNS), resulting in a quaking pheno ...
... alleles causing either embryonic lethality at approximately day 9 in utero, qk lethal-1 (qk l-1), qk kt1, qk k2, and qk kt3 (Shedlovsky et al., 1988; Justice and Bode, 1986, 1988), or dysmyelination in the central nervous system (CNS) and peripheral nervous system (PNS), resulting in a quaking pheno ...
Jounral of Bacteriology
... ionization–time of flight mass spectrometry analysis revealed expression of the antibiotic lipopeptide products surfactin, fengycin, and bacillomycin D. The fengycin (fen) and the surfactin (srf) operons were organized and located as in B. subtilis 168. A large 37.2-kb antibiotic DNA island containi ...
... ionization–time of flight mass spectrometry analysis revealed expression of the antibiotic lipopeptide products surfactin, fengycin, and bacillomycin D. The fengycin (fen) and the surfactin (srf) operons were organized and located as in B. subtilis 168. A large 37.2-kb antibiotic DNA island containi ...
Mutations in SIN4 and RGR1 Cause Constitutive Expression of MAL
... the maltose-binding sensor. Alternatively, other positive or negative regulators may be involved but may not have been identified as yet because they are encoded by repeated or essential genes. To identify possible additional players involved in regulating MAL gene expression, we designed a sensitiv ...
... the maltose-binding sensor. Alternatively, other positive or negative regulators may be involved but may not have been identified as yet because they are encoded by repeated or essential genes. To identify possible additional players involved in regulating MAL gene expression, we designed a sensitiv ...
PowerPoint - 埼玉医科大学総合医療センター 内分泌・糖尿病内科
... of heterozygosity at 16p (in 8 of 33 patients for whom data were available [24%]). The most frequent mutation identified by means of whole-genome sequencing was in ARMC5, located at 16p11.2. ARMC5 mutations were detected in tumors obtained from 18 of 33 patients (55%). In all cases, both alleles of ...
... of heterozygosity at 16p (in 8 of 33 patients for whom data were available [24%]). The most frequent mutation identified by means of whole-genome sequencing was in ARMC5, located at 16p11.2. ARMC5 mutations were detected in tumors obtained from 18 of 33 patients (55%). In all cases, both alleles of ...
reviews - Department of Genetics
... determine whether mutant heterozygotes are affected. Expressivity describes the extent to which particular structures or processes are affected by a particular genotype. The trait might be enhanced or reduced; it might even be suppressed so that mutants seem to be almost normal. The action of geneti ...
... determine whether mutant heterozygotes are affected. Expressivity describes the extent to which particular structures or processes are affected by a particular genotype. The trait might be enhanced or reduced; it might even be suppressed so that mutants seem to be almost normal. The action of geneti ...
1. Project summary
... The specificity of the axonal damage in HSP apparently contrasts with the wide distribution and range of functions carried out by the few gene products known to cause the clinical phenotypes. However, we think to envisage two possible pathogenetic mechanisms. The mitochondrial way seems to affect ne ...
... The specificity of the axonal damage in HSP apparently contrasts with the wide distribution and range of functions carried out by the few gene products known to cause the clinical phenotypes. However, we think to envisage two possible pathogenetic mechanisms. The mitochondrial way seems to affect ne ...
Homologous and Nonhomologous Rearrangements: Interactions
... Taking homologies into account in the chromosomal rearrangement process requires some knowledge regarding sequence repeats on the chromosome. A naive approach would be to compute a complete alignment search of the genome on itself and then to proceed to the rearrangements if any. However, searching ...
... Taking homologies into account in the chromosomal rearrangement process requires some knowledge regarding sequence repeats on the chromosome. A naive approach would be to compute a complete alignment search of the genome on itself and then to proceed to the rearrangements if any. However, searching ...
Against the Central Dogma
... then create cDNA from the extracted RNA. (The DiseaseRelated Human LncProfiler does not come with the cDNA synthesis reagents). There is no tailing and tagging step involved in the Disease-Related Human LncProfiler kit, which decreases the time involved in creating the cDNA used in the qPCR reaction ...
... then create cDNA from the extracted RNA. (The DiseaseRelated Human LncProfiler does not come with the cDNA synthesis reagents). There is no tailing and tagging step involved in the Disease-Related Human LncProfiler kit, which decreases the time involved in creating the cDNA used in the qPCR reaction ...
Polymorphic miRNA-mediated gene regulation: contribution to
... genetics, especially for traits of medical or agronomic importance. The vast majority of causal mutations identified to date alter the primary sequence and hence the structure of proteins. They are either missense or nonsense mutations, insertion–deletions in the open reading frame, or mutations cau ...
... genetics, especially for traits of medical or agronomic importance. The vast majority of causal mutations identified to date alter the primary sequence and hence the structure of proteins. They are either missense or nonsense mutations, insertion–deletions in the open reading frame, or mutations cau ...
The genomic rate of adaptive evolution
... In 1991, McDonald and Kreitman (MK) proposed a test of the neutral theory of molecular evolution, which has become the basis of several methods to estimate the proportion of substitutions that are fixed by positive selection rather than by genetic drift. The test compares the amount of variation wit ...
... In 1991, McDonald and Kreitman (MK) proposed a test of the neutral theory of molecular evolution, which has become the basis of several methods to estimate the proportion of substitutions that are fixed by positive selection rather than by genetic drift. The test compares the amount of variation wit ...
An Introduction to Genetic Analysis Chapter 20 Transposable
... he looked for rare wild-type Wx recombinants by staining the pollen with KI-I2 reagent, which stains Wx pollen black and wx pollen red. By counting the frequency of Wx pollen grains in each kind of heterozygote, Nelson was able to do fine-structure recombination mapping of the waxy gene. He showed t ...
... he looked for rare wild-type Wx recombinants by staining the pollen with KI-I2 reagent, which stains Wx pollen black and wx pollen red. By counting the frequency of Wx pollen grains in each kind of heterozygote, Nelson was able to do fine-structure recombination mapping of the waxy gene. He showed t ...
Prospective diagnostic analysis of copy number variants using SNP
... Received 11 December 2012; revised 23 February 2013; accepted 28 March 2013 ...
... Received 11 December 2012; revised 23 February 2013; accepted 28 March 2013 ...
Evolutionary analysis of the female
... of mRNAs6 in avian genomes should render gene transpositions rare in birds. Only one out of the 46 NRW genes was multi-copy, HINTW, as evidenced by unusually high sequence coverage resulting from collapsed mapping of slightly divergent copies. HINTW is the only ampliconic gene found on avian W chrom ...
... of mRNAs6 in avian genomes should render gene transpositions rare in birds. Only one out of the 46 NRW genes was multi-copy, HINTW, as evidenced by unusually high sequence coverage resulting from collapsed mapping of slightly divergent copies. HINTW is the only ampliconic gene found on avian W chrom ...
REPORT OF CONSENSUS MEETING ON THE MANAGEMENT OF
... proven strategy to deal with this. It was essential that we did not increase anxiety in women who were not themselves alarmed. Most women who were referred because of anxiety could be effectively reassured, including those at increased risk, but reassurance itself was not enough to quell the anxieti ...
... proven strategy to deal with this. It was essential that we did not increase anxiety in women who were not themselves alarmed. Most women who were referred because of anxiety could be effectively reassured, including those at increased risk, but reassurance itself was not enough to quell the anxieti ...
thesis - Tel Archives ouvertes
... infertility phenotype. At the fundamental level this project open a way for basic science research, may help to identify factors involved in important processes during human spermatogenesis, allowing the fine dissection of these mechanisms. Deciphering such mechanisms will be highly relevant from th ...
... infertility phenotype. At the fundamental level this project open a way for basic science research, may help to identify factors involved in important processes during human spermatogenesis, allowing the fine dissection of these mechanisms. Deciphering such mechanisms will be highly relevant from th ...
Hyper-eccentric structural genes in the mitochondrial genome of the
... pattern is generally conserved among the diplonemid species studied to date (Marande and Burger 2007; Kiethega et al. 2011); the number of modules and fragmented positions found in cox1 are generally the same among four diplonemid species sequenced to date. Each module is independently transcribed, ...
... pattern is generally conserved among the diplonemid species studied to date (Marande and Burger 2007; Kiethega et al. 2011); the number of modules and fragmented positions found in cox1 are generally the same among four diplonemid species sequenced to date. Each module is independently transcribed, ...
PDF - Blood Journal
... indicated the pufferfish (Fugu rubripes and the closely related Spheroides nephelus) as an ideal species for just this task because it has a relatively compact genome of 400 Mb, approximately 7.5 times smaller than the human genome.1,2 Nevertheless, the Fugu genome contains a complement of genes sim ...
... indicated the pufferfish (Fugu rubripes and the closely related Spheroides nephelus) as an ideal species for just this task because it has a relatively compact genome of 400 Mb, approximately 7.5 times smaller than the human genome.1,2 Nevertheless, the Fugu genome contains a complement of genes sim ...
LINKAGE - TYPES OF LINKAGE AND ESTIMATION OF LINKAGE
... traits is inherited as such by the young one. Incomplete Linkage The genes distantly located in the chromosome show incomplete linkage because they have a chance of separation by crossing over and of going into different gametes and offspring. Importance of linkage in breeding When there is a close ...
... traits is inherited as such by the young one. Incomplete Linkage The genes distantly located in the chromosome show incomplete linkage because they have a chance of separation by crossing over and of going into different gametes and offspring. Importance of linkage in breeding When there is a close ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.