2000 Genome Biology paper
... shifted to see the inversions better. This pattern is consistent with the occurrence a small number of inversions around the origin and terminus in the two lineages since their divergence from a common ancestor (see Figure 4). (d) V. cholerae chrI versus V. cholerae chrI, self-alignment. Only recent ...
... shifted to see the inversions better. This pattern is consistent with the occurrence a small number of inversions around the origin and terminus in the two lineages since their divergence from a common ancestor (see Figure 4). (d) V. cholerae chrI versus V. cholerae chrI, self-alignment. Only recent ...
Newton E. Morton - The American Society of Human Genetics
... differ among populations or over time. If S is the fraction of survivors, then we expect –logeS = A+BF, where 0≤F≤1 is a set of inbreeding values, B is a corresponding effect of inbreeding, and A measures the amount of expressed damage when F = 0. An estimate of B/A with an unusually high value woul ...
... differ among populations or over time. If S is the fraction of survivors, then we expect –logeS = A+BF, where 0≤F≤1 is a set of inbreeding values, B is a corresponding effect of inbreeding, and A measures the amount of expressed damage when F = 0. An estimate of B/A with an unusually high value woul ...
A Unified Statistical Framework for RNA Sequence Data from
... collected from tissues. This bulk RNA-seq data provides reliable measurements of gene expression levels throughout the genome for bulk samples. With sufficient sequencing depth, even weakly expressed transcripts can be accurately captured by RNA-seq data. This technology has led to breakthroughs in ...
... collected from tissues. This bulk RNA-seq data provides reliable measurements of gene expression levels throughout the genome for bulk samples. With sufficient sequencing depth, even weakly expressed transcripts can be accurately captured by RNA-seq data. This technology has led to breakthroughs in ...
Using bacterial biosensors to understand the genetic basis for
... • Screening using sub-MIC preservatives identified biosensors with altered light expression in both planktonic and agar growth. ...
... • Screening using sub-MIC preservatives identified biosensors with altered light expression in both planktonic and agar growth. ...
Fully automated pipeline for detection of sex linked genes using
... Background: Sex chromosomes present a genomic region which to some extent, differs between the genders of a single species. Reliable high-throughput methods for detection of sex chromosomes specific markers are needed, especially in species where genome information is limited. Next generation sequen ...
... Background: Sex chromosomes present a genomic region which to some extent, differs between the genders of a single species. Reliable high-throughput methods for detection of sex chromosomes specific markers are needed, especially in species where genome information is limited. Next generation sequen ...
Musil et al - Merit Research Journals
... importance of both genes. The discrepancy among these studies may be caused by several factors. First of all, these four works differ in size of patient groups. Whereas our work covers the group of 20 living patients and Skinner’s study works with 29 patients, Jeanpierre’s study ) is much wider deal ...
... importance of both genes. The discrepancy among these studies may be caused by several factors. First of all, these four works differ in size of patient groups. Whereas our work covers the group of 20 living patients and Skinner’s study works with 29 patients, Jeanpierre’s study ) is much wider deal ...
pdf file - Department of Statistics
... Example 3: Genetic dissection of transcriptional regulation. In linkage analysis the goal is to find a statistically significant association between a phenotype and a marker locus. In a recent study, Brem et al. (2002) cross two strains of yeast that show much differential gene expression. In 40 of ...
... Example 3: Genetic dissection of transcriptional regulation. In linkage analysis the goal is to find a statistically significant association between a phenotype and a marker locus. In a recent study, Brem et al. (2002) cross two strains of yeast that show much differential gene expression. In 40 of ...
Secondary Leukemia Associated With The Anti-Cancer Agent
... required [49–51]. The hypersensitive sites for DNase I are also present in the BCRs of other transcription genes including AF9, AF4, RUNX1, ETO, and RARA. Cowell showed, using RNA-FISH analysis, that topoisomerase IIb is corecruited with components of the NHEJ machinery, which induces dynamic close ...
... required [49–51]. The hypersensitive sites for DNase I are also present in the BCRs of other transcription genes including AF9, AF4, RUNX1, ETO, and RARA. Cowell showed, using RNA-FISH analysis, that topoisomerase IIb is corecruited with components of the NHEJ machinery, which induces dynamic close ...
A Yale geneticist and a Chinese lab are creating the Amazon.com of
... Humans and mice share about which has funded part of Xu’s research. The project 99 percent of their genes. is also funding other scientists to knock out 8,500 genes in mouse stem cells using more-conventional with a disabled gene simply by mating two specially technologies; its goal is to make a com ...
... Humans and mice share about which has funded part of Xu’s research. The project 99 percent of their genes. is also funding other scientists to knock out 8,500 genes in mouse stem cells using more-conventional with a disabled gene simply by mating two specially technologies; its goal is to make a com ...
10p proximal deletions from 10p11 and 10p12
... Each new version of the genome is often referred to as an ‘assembly’ or a ‘build’. Every few years a new assembly is released. The genetic information in this guide is based on the Genome Reference Consortium (GRC) human (h) genome assembly number 37 (GRCh37), which was released in 2009. Confusingly ...
... Each new version of the genome is often referred to as an ‘assembly’ or a ‘build’. Every few years a new assembly is released. The genetic information in this guide is based on the Genome Reference Consortium (GRC) human (h) genome assembly number 37 (GRCh37), which was released in 2009. Confusingly ...
Plant Molecular Biology
... data of J. Alan Downie (personal communication) for the translational stop of the nodA gene of R. leguminosarum. Hatched bars indicate fragments which were cloned in IncP vector pMP92 and arrows indicate the fragments which were cloned in front of lacZ in the IncQ transcriptional fusion vector pMP19 ...
... data of J. Alan Downie (personal communication) for the translational stop of the nodA gene of R. leguminosarum. Hatched bars indicate fragments which were cloned in IncP vector pMP92 and arrows indicate the fragments which were cloned in front of lacZ in the IncQ transcriptional fusion vector pMP19 ...
The Effects of Deleterious Mutations on Evolution at
... our work on this problem was helped by discussions with Nick Barton and with Jim, who had been thinking along similar lines. We called this effect “background selection” (a term also used by Birky and Walsh 1988) and showed that it provides an alternative to selective sweeps as a possible explanatio ...
... our work on this problem was helped by discussions with Nick Barton and with Jim, who had been thinking along similar lines. We called this effect “background selection” (a term also used by Birky and Walsh 1988) and showed that it provides an alternative to selective sweeps as a possible explanatio ...
Microdeletions on the long arm of the Y chromosome
... treated with ICSI. In effect, this approach treats the disorder with little knowledge of the possible consequences for the patient and/or their potential children.4 There is evidence that some cases of male infertility have an underlying genetic basis.6 Furthermore, severe male-factor infertility ha ...
... treated with ICSI. In effect, this approach treats the disorder with little knowledge of the possible consequences for the patient and/or their potential children.4 There is evidence that some cases of male infertility have an underlying genetic basis.6 Furthermore, severe male-factor infertility ha ...
bioinformatics review - e
... standard for the secondary analysis of high throughput experiments and a large number of tools have been developed for this purpose. We present a detailed comparison of 14 such tools using the following criteria: scope of the analysis, visualization capabilities, statistical model(s) used, correctio ...
... standard for the secondary analysis of high throughput experiments and a large number of tools have been developed for this purpose. We present a detailed comparison of 14 such tools using the following criteria: scope of the analysis, visualization capabilities, statistical model(s) used, correctio ...
New techniques that could make germline genetic
... Previous genetic-engineering technologies have tended to be species-specific; there have been lots of tools for manipulating E. coli and yeast, but they have often not been broadly applicable. This is another area where CRISPR excels; it can be used in organisms that have resisted previous attempts ...
... Previous genetic-engineering technologies have tended to be species-specific; there have been lots of tools for manipulating E. coli and yeast, but they have often not been broadly applicable. This is another area where CRISPR excels; it can be used in organisms that have resisted previous attempts ...
oculocutaneous albinism and analysis of tyrosinase gene in
... We developed two improved techniques for detecting tyrosinase mutations in type I-A OCA patients. One is allele-specific amplification based on the specific amplification of the target allele by a PCR with the normal and mutant allele-specific modified primers inhibiting unfavorable amplification. 1 ...
... We developed two improved techniques for detecting tyrosinase mutations in type I-A OCA patients. One is allele-specific amplification based on the specific amplification of the target allele by a PCR with the normal and mutant allele-specific modified primers inhibiting unfavorable amplification. 1 ...
NIH Public Access
... Rather, the FIS-PcG complex containing MEA itself seems to keep the silenced paternal MEA repressed [5••,6•,7•]. Disruption of the FIS-PcG complex causes loss of MEA imprinting as silencing of the paternal allele is released [5••,6•,7•]. In addition, MEA is physically associated with the MEA promote ...
... Rather, the FIS-PcG complex containing MEA itself seems to keep the silenced paternal MEA repressed [5••,6•,7•]. Disruption of the FIS-PcG complex causes loss of MEA imprinting as silencing of the paternal allele is released [5••,6•,7•]. In addition, MEA is physically associated with the MEA promote ...
The University of Chicago Genetic Services Laboratories
... dehydration, and failure to thrive. Although the majority of cases of neonatal diabetes involve isolated diabetes, many of the known monogenic causes are characterized by a variety of syndromic features. Molecular Genetics of Transient Neonatal Diabetes (TNDM) The most common cause of transient ne ...
... dehydration, and failure to thrive. Although the majority of cases of neonatal diabetes involve isolated diabetes, many of the known monogenic causes are characterized by a variety of syndromic features. Molecular Genetics of Transient Neonatal Diabetes (TNDM) The most common cause of transient ne ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.