Using Risk-based Sampling to Enrich Cohorts for Endpoints, Genes
... We now consider a pure interaction scenario, where E doubles risk but only for those who carry one or two copies of the variant allele, and genotype does not affect risk in the absence of exposure. Figure 2A shows results based on comparing a saturated model for joint effects with a model with just ...
... We now consider a pure interaction scenario, where E doubles risk but only for those who carry one or two copies of the variant allele, and genotype does not affect risk in the absence of exposure. Figure 2A shows results based on comparing a saturated model for joint effects with a model with just ...
1 Combining Gene Expression with Marker Genotypes in Poultry
... microarray experiments were carried out on the founder lines of the study. The underlying idea was that genes that were differentially expressed between the founder lines AND were located in the areas of the QTL that were found in the cross resulting from these lines, would be prime positional candi ...
... microarray experiments were carried out on the founder lines of the study. The underlying idea was that genes that were differentially expressed between the founder lines AND were located in the areas of the QTL that were found in the cross resulting from these lines, would be prime positional candi ...
A virulence-associated gene microarray: a tool for
... An oligonucleotide probe microarray for investigation of the evolution of epidemic Staphylococcus aureus strains has been constructed. The array comprises 383 probes based on virulence-associated genes present in four key strains. Twelve strains including seven for which the complete chromosomal nuc ...
... An oligonucleotide probe microarray for investigation of the evolution of epidemic Staphylococcus aureus strains has been constructed. The array comprises 383 probes based on virulence-associated genes present in four key strains. Twelve strains including seven for which the complete chromosomal nuc ...
Condition-dependent mutation rates and sexual selection
... the daughters were screened for recessive lethals on the paternally inherited X chromosome. Females maintained on a low-quality diet transmitted significantly more (!30%) sex-linked recessive lethals to their offspring than did females reared on a high-quality diet (Agrawal & Wang, 2008). Together, ...
... the daughters were screened for recessive lethals on the paternally inherited X chromosome. Females maintained on a low-quality diet transmitted significantly more (!30%) sex-linked recessive lethals to their offspring than did females reared on a high-quality diet (Agrawal & Wang, 2008). Together, ...
A rough guide to Drosophila mating schemes (version 1.2) 1
... GENETICS is the approach to identify the gene(s) that are responsible for a particular biological process or function in an organism. In Drosophila this is usually performed through using unbiased large-scale LOF or GOF screens to identify genes that can disturb the process/function in question (Fig ...
... GENETICS is the approach to identify the gene(s) that are responsible for a particular biological process or function in an organism. In Drosophila this is usually performed through using unbiased large-scale LOF or GOF screens to identify genes that can disturb the process/function in question (Fig ...
Rate Asymmetry After Genome Duplication Causes Substantial
... topologies among neighbor-joining (NJ) trees drawn from different loci and suggested that this conflict was the result of ‘‘asynchronous functional divergence’’ of duplicated genes (Langkjaer, R. B., P. F. Cliften, M. Johnston, and J. Piskur. 2003. Yeast genome duplication was followed by asynchrono ...
... topologies among neighbor-joining (NJ) trees drawn from different loci and suggested that this conflict was the result of ‘‘asynchronous functional divergence’’ of duplicated genes (Langkjaer, R. B., P. F. Cliften, M. Johnston, and J. Piskur. 2003. Yeast genome duplication was followed by asynchrono ...
Saccharopolyspora erythraea that are involved
... lying between eryAZ and eryK had an EryB phenotype. The EryC mutants, on the other hand, accumulate 3-aL-mycarosyl-erythronolide B, and convert erythromycin D (or later intermediates) to erythromycin A. These mutants cannot synthesize desosamine and/or are unable to attach it the macrolactone ring. ...
... lying between eryAZ and eryK had an EryB phenotype. The EryC mutants, on the other hand, accumulate 3-aL-mycarosyl-erythronolide B, and convert erythromycin D (or later intermediates) to erythromycin A. These mutants cannot synthesize desosamine and/or are unable to attach it the macrolactone ring. ...
Full text - PAHdb - McGill University
... repositories of the vast wealth of data being gathered about individual genes and the genomes they inhabit. PAHdb is one such legacy and resource. PAHdb (http://www.pahdb.mcgill.ca) is an online relational locus-specific knowledgebase [Scriver et al., 2000] originating in, and still serving, the PAH ...
... repositories of the vast wealth of data being gathered about individual genes and the genomes they inhabit. PAHdb is one such legacy and resource. PAHdb (http://www.pahdb.mcgill.ca) is an online relational locus-specific knowledgebase [Scriver et al., 2000] originating in, and still serving, the PAH ...
Questions - nslc.wustl.edu
... chromosome also carry one normal chromosome 14 and two normal chromosomes 21. Usually the complementary translocation chromosome, which would carry the short arms of 14 and 21, is not present. When the phenotypically normal parents of translocation Down's children are examined, generally one parent ...
... chromosome also carry one normal chromosome 14 and two normal chromosomes 21. Usually the complementary translocation chromosome, which would carry the short arms of 14 and 21, is not present. When the phenotypically normal parents of translocation Down's children are examined, generally one parent ...
15_detaillectout
... o Individuals with hemophilia have prolonged bleeding because a firm clot forms slowly. o Bleeding in muscles and joints can be painful and can lead to serious damage. ...
... o Individuals with hemophilia have prolonged bleeding because a firm clot forms slowly. o Bleeding in muscles and joints can be painful and can lead to serious damage. ...
Major influence of repetitive elements on disease
... highly homologous LCR sequences. In terms of nonrecurrent CNVs, NHEJ (among other molecular mechanisms [3]) generally occurs between sequences with a degree of homology lower than that observed between distinct LCRs. The diversity of breakpoint junctions of non-recurrent variants renders the establi ...
... highly homologous LCR sequences. In terms of nonrecurrent CNVs, NHEJ (among other molecular mechanisms [3]) generally occurs between sequences with a degree of homology lower than that observed between distinct LCRs. The diversity of breakpoint junctions of non-recurrent variants renders the establi ...
ppt檔案
... Mice from the lines that built larger nests raised more pups that lived to be 40 days old at lower temperatures Nest building is an important component of fitness, and its genetic basis allows it to be shaped by natural selection ...
... Mice from the lines that built larger nests raised more pups that lived to be 40 days old at lower temperatures Nest building is an important component of fitness, and its genetic basis allows it to be shaped by natural selection ...
ageing Powerpoint
... • For much of the evolutionary history of mankind, most people did not live to be that old. • The selective pressure to remove the Huntington's mutation is therefore weak • Giant conceptual leap... perhaps that is what ageing is, the result of late-acting deleterious mutations? ...
... • For much of the evolutionary history of mankind, most people did not live to be that old. • The selective pressure to remove the Huntington's mutation is therefore weak • Giant conceptual leap... perhaps that is what ageing is, the result of late-acting deleterious mutations? ...
draft - University of Michigan
... Theoretical (Charlesworth et al. 1987; Vicoso and Charlesworth 2006; Vicoso and Charlesworth 2009) and empirical (Khaitovich et al. 2005; Connallon 2007; Jaquiéry et al. 2012) studies have shown that X-linked (or Z-linked in ZW species) sequences can evolve more rapidly than sequences on autosomes i ...
... Theoretical (Charlesworth et al. 1987; Vicoso and Charlesworth 2006; Vicoso and Charlesworth 2009) and empirical (Khaitovich et al. 2005; Connallon 2007; Jaquiéry et al. 2012) studies have shown that X-linked (or Z-linked in ZW species) sequences can evolve more rapidly than sequences on autosomes i ...
A Missense Cystic Fibrosis Transmembrane
... clinical expression. The cloning of the CFTR gene and the identification of mutations in the gene, has promoted extensive research into the association between genotype and phenotype, which has contributed to our understanding the mechanisms of the remarkable clinical heterogeneity of CF. Previous s ...
... clinical expression. The cloning of the CFTR gene and the identification of mutations in the gene, has promoted extensive research into the association between genotype and phenotype, which has contributed to our understanding the mechanisms of the remarkable clinical heterogeneity of CF. Previous s ...
Real-time Quantification of HER2/neu Gene Amplification by
... PCR approaches published so far have used reference genes which are not localized on chromosome 17. Therefore it is not possible to distinguish whether a small region of the chromosome or the whole chromosome is amplified. But chromosome aneuploidy, including loss and gain of chromosome 17, is seen ...
... PCR approaches published so far have used reference genes which are not localized on chromosome 17. Therefore it is not possible to distinguish whether a small region of the chromosome or the whole chromosome is amplified. But chromosome aneuploidy, including loss and gain of chromosome 17, is seen ...
The role of variable DNA tandem repeats in bacterial adaptation
... regions, probably because they have a higher probability to rearrange and cause frameshift mutations in genes (Coenye & Vandamme, 2005; Ackermann & Chao, 2006; Orsi et al., 2010; Lin & Kussell, 2012). In contrast, SSRs whose unit size is a multiple of three nucleotides (3, 6, 9 …) are overrepresente ...
... regions, probably because they have a higher probability to rearrange and cause frameshift mutations in genes (Coenye & Vandamme, 2005; Ackermann & Chao, 2006; Orsi et al., 2010; Lin & Kussell, 2012). In contrast, SSRs whose unit size is a multiple of three nucleotides (3, 6, 9 …) are overrepresente ...
Sex Chromosome Dosage Effects On Gene Expression In
... throughout much of the animal kingdom. In all eutherian mammals, females carry two X-chromosomes, while males carry an X- and a Y-chromosome: presence of the Y-linked SRY gene determines a testicular gonadal phenotype, while its absence allows development of ovaries1. Sexual differentiation of the g ...
... throughout much of the animal kingdom. In all eutherian mammals, females carry two X-chromosomes, while males carry an X- and a Y-chromosome: presence of the Y-linked SRY gene determines a testicular gonadal phenotype, while its absence allows development of ovaries1. Sexual differentiation of the g ...
UCSC genome support forum
... 2. View this region in the Browser: 2.1. Navigate to http://genome.ucsc.edu/cgi-bin/hgGateway 2.2. Enter your assembly of choice and enter your coordinates in the “search term” box 2.3. Click the “submit” button 3. In the blue navigation bar at the top of the screen, click “View/DNA” 4. Click the “g ...
... 2. View this region in the Browser: 2.1. Navigate to http://genome.ucsc.edu/cgi-bin/hgGateway 2.2. Enter your assembly of choice and enter your coordinates in the “search term” box 2.3. Click the “submit” button 3. In the blue navigation bar at the top of the screen, click “View/DNA” 4. Click the “g ...
The genomic substrate for adaptive radiation in African cichlid fish
... produce a set of 40899 transcript models. The longest open reading frame in each of these models was BLAST-ed19 against the set of UniProt PE levels 1 and 2 protein sequences in order to classify the models according to their protein-coding potential. Data from the above two pipelines were filtered ...
... produce a set of 40899 transcript models. The longest open reading frame in each of these models was BLAST-ed19 against the set of UniProt PE levels 1 and 2 protein sequences in order to classify the models according to their protein-coding potential. Data from the above two pipelines were filtered ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.