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... predicted 1,021,611 orthologs using stringent sequence similarity criteria. For each pair of plant species, we determined sets of conserved synteny blocks using strand orientation and physical mapping. Gene ontology (GO) annotations are added for each gene. Plant Orthology Browser (POB) includes thr ...
... predicted 1,021,611 orthologs using stringent sequence similarity criteria. For each pair of plant species, we determined sets of conserved synteny blocks using strand orientation and physical mapping. Gene ontology (GO) annotations are added for each gene. Plant Orthology Browser (POB) includes thr ...
Comparison between Human and Mouse genomes
... Automated partial DNA sequencing was conducted on more than 600 randomly selected human brain complementary DNA (cDNA) clones to generate expressed sequence tags (ESTs). ESTs have applications in the discovery of new human genes, mapping of the human genome, and identification of coding regions in g ...
... Automated partial DNA sequencing was conducted on more than 600 randomly selected human brain complementary DNA (cDNA) clones to generate expressed sequence tags (ESTs). ESTs have applications in the discovery of new human genes, mapping of the human genome, and identification of coding regions in g ...
A rough guide to Drosophila mating schemes (light version 2.1) 1
... powerful "boundary object" linking genetics to other biological disciplines [4]. Thus, fly genetics was systematically applied to the study of development, physiology and behaviour, generating new understanding of the principal genetic and molecular mechanisms underpinning biology, many being conser ...
... powerful "boundary object" linking genetics to other biological disciplines [4]. Thus, fly genetics was systematically applied to the study of development, physiology and behaviour, generating new understanding of the principal genetic and molecular mechanisms underpinning biology, many being conser ...
Correlation between sequence divergence and polymorphism
... Charlottesville, VA 22904-4328, USA Full list of author information is available at the end of the article ...
... Charlottesville, VA 22904-4328, USA Full list of author information is available at the end of the article ...
cis667-10
... to another location It can also move from one chromosome to another We call these movements genome rearrangments ...
... to another location It can also move from one chromosome to another We call these movements genome rearrangments ...
Cloning and Genetic Analysis of Six Pyrroloquinoline
... to oxidize glucose to gluconate (Goosen et al., 1987). These mutants were used for cloning four genes involved in PQQ biosynthesis. DNA sequence analysis failed to give clues to the nature of putative biosynthesis enzymes (Goosen et al., 1989). In some facultative methylotrophic bacteria such as M. ...
... to oxidize glucose to gluconate (Goosen et al., 1987). These mutants were used for cloning four genes involved in PQQ biosynthesis. DNA sequence analysis failed to give clues to the nature of putative biosynthesis enzymes (Goosen et al., 1989). In some facultative methylotrophic bacteria such as M. ...
Rider BRIDGE 2001-2002
... Would a limb form if you implanted an FGF bead in the flank of a snake embryo? Why, why not? Would it be a forelimb or hindlimb? why? " Yes, a limb bud would form...downstream of Hox genes is FGF. This doesn't happen in a normal snake because it doesn't express the proper Hox genes in the proper l ...
... Would a limb form if you implanted an FGF bead in the flank of a snake embryo? Why, why not? Would it be a forelimb or hindlimb? why? " Yes, a limb bud would form...downstream of Hox genes is FGF. This doesn't happen in a normal snake because it doesn't express the proper Hox genes in the proper l ...
MGI-Guidelines for Nomenclature of Genes, Genetic Markers
... Southern blot, but is principally based on sequence comparisons. 2.6.1 Families Identified by Hybridization Historically, many gene families have been identified as fragments detected by hybridization to the same probe but which map to different loci. These family members may be functional genes or ...
... Southern blot, but is principally based on sequence comparisons. 2.6.1 Families Identified by Hybridization Historically, many gene families have been identified as fragments detected by hybridization to the same probe but which map to different loci. These family members may be functional genes or ...
NIH Public Access - International Stem Cell Corporation
... lines (11 samples), 41 primary cell lines (41 samples), and 20 tissue types (67 samples), as well as samples of differentiated hESC lines and mixtures of known ratios of a sample with a known duplication with a sample without that duplication (Table S1). Copy number variants for all samples were ide ...
... lines (11 samples), 41 primary cell lines (41 samples), and 20 tissue types (67 samples), as well as samples of differentiated hESC lines and mixtures of known ratios of a sample with a known duplication with a sample without that duplication (Table S1). Copy number variants for all samples were ide ...
Genome-Wide Analysis of Core Cell Cycle Genes in
... (one gene predicted as two) or fused (two genes predicted as one) genes, to completely missed or nonexistent predicted genes (Rouzé et al., 1999). In addition, no general and well-defined prediction protocol is used by the different annotation centers, which results in the generation of redundant, n ...
... (one gene predicted as two) or fused (two genes predicted as one) genes, to completely missed or nonexistent predicted genes (Rouzé et al., 1999). In addition, no general and well-defined prediction protocol is used by the different annotation centers, which results in the generation of redundant, n ...
Comparative analysis of peanut NBS‐LRR gene clusters suggests
... present in plant genomes as multigene families, often in complex clusters. Clusters of R genes have been reported in several legumes such as soybean, Lotus, Medicago and Phaseolus (Ameline-Torregrosa et al., 2008; Innes et al., 2008; Sato et al., 2008; David et al., 2009). Early exploration of the h ...
... present in plant genomes as multigene families, often in complex clusters. Clusters of R genes have been reported in several legumes such as soybean, Lotus, Medicago and Phaseolus (Ameline-Torregrosa et al., 2008; Innes et al., 2008; Sato et al., 2008; David et al., 2009). Early exploration of the h ...
Studies of codon usage and tRNA genes of 18 unicellular organisms
... The 18 organisms are as follows: yeast S. cerevisiae, Aquifex aeolicus, Archaeoglobus fulgidus, B. subtilis, Borrelia burgdorferi, Chlamydia trachomatis, E. coli, Haemophilus influenzae, Helicobacter pylori, Methanococcus jannaschii, Methanobacterium thermoautotrophicum, Mycobacterium tuberculosis, ...
... The 18 organisms are as follows: yeast S. cerevisiae, Aquifex aeolicus, Archaeoglobus fulgidus, B. subtilis, Borrelia burgdorferi, Chlamydia trachomatis, E. coli, Haemophilus influenzae, Helicobacter pylori, Methanococcus jannaschii, Methanobacterium thermoautotrophicum, Mycobacterium tuberculosis, ...
Gene expression patterns in human placenta
... involved in glucose metabolism including aldolase, enolase and GPI. Unlike other organs, both placenta and lung have primary roles in oxygen exchange (20), and the relatively high expression of HIF2␣ in these organs may be associated with a common response to hypoxia. Several genes involved in growt ...
... involved in glucose metabolism including aldolase, enolase and GPI. Unlike other organs, both placenta and lung have primary roles in oxygen exchange (20), and the relatively high expression of HIF2␣ in these organs may be associated with a common response to hypoxia. Several genes involved in growt ...
DNA Methylation Analysis
... Database9 (Genome Build 36). Additional markers provide increased resolution focused on 144 established cancer genes that have shown differential methylation patterns. To ensure the most important loci were represented, Illumina designed markers to cover nearly 1,000 cancer-related genes described i ...
... Database9 (Genome Build 36). Additional markers provide increased resolution focused on 144 established cancer genes that have shown differential methylation patterns. To ensure the most important loci were represented, Illumina designed markers to cover nearly 1,000 cancer-related genes described i ...
Not now, but soon: Justification for continued research on CRISPR
... most efficient piece of genome editing technology available. CRISPR-Cas9 can create double- stranded breaks in DNA at precise locations within an organism’s genome, allowing genes to be added and deleted from that spot with better accuracy and more precision than ever before. CRISPR-Cas9 has opened ...
... most efficient piece of genome editing technology available. CRISPR-Cas9 can create double- stranded breaks in DNA at precise locations within an organism’s genome, allowing genes to be added and deleted from that spot with better accuracy and more precision than ever before. CRISPR-Cas9 has opened ...
Interactive Visualization of Gene Regulatory Networks with
... for visualization of gene regulatory networks. Gene regulatory networks can be represented by graphs, in which nodes represent genes, and edges represent interactions between a gene product (a regulator protein) and its target genes. The nodes have several attributes, such as position on the chromos ...
... for visualization of gene regulatory networks. Gene regulatory networks can be represented by graphs, in which nodes represent genes, and edges represent interactions between a gene product (a regulator protein) and its target genes. The nodes have several attributes, such as position on the chromos ...
Linkage Mapping in Drosophila written by JD Hendrix
... develop into pupae. The outer skin, or cuticle, hardens and becomes more translucent as the pupa matures. During this time, most of the larval body is replaced by the growth of specialized cells located on the ventral surface of the organism. These cells, located in regions called imaginal disks, de ...
... develop into pupae. The outer skin, or cuticle, hardens and becomes more translucent as the pupa matures. During this time, most of the larval body is replaced by the growth of specialized cells located on the ventral surface of the organism. These cells, located in regions called imaginal disks, de ...
Conservation and Coevolution in the Scale
... highly connected (Barabasi and Albert 1999). At the genomic level, gene duplication is thought to underlie the phenomenon of preferential attachment (Rzhetsky and Gomez 2001; Bhan, Galas, and Dewey 2002; Barabasi and Oltvai 2004). Existing highly connected nodes (i.e., genes or proteins) are more li ...
... highly connected (Barabasi and Albert 1999). At the genomic level, gene duplication is thought to underlie the phenomenon of preferential attachment (Rzhetsky and Gomez 2001; Bhan, Galas, and Dewey 2002; Barabasi and Oltvai 2004). Existing highly connected nodes (i.e., genes or proteins) are more li ...
Inferences About the Distribution of Dominance
... evolution of, dominance. A deleterious allele may be recessive because a single copy of a functioning allele may be sufficient to meet the needs of the organism, or it may be partially recessive or dominant if two functional alleles are required for full function. In some cases, a mutated allele can ...
... evolution of, dominance. A deleterious allele may be recessive because a single copy of a functioning allele may be sufficient to meet the needs of the organism, or it may be partially recessive or dominant if two functional alleles are required for full function. In some cases, a mutated allele can ...
Coordinated repression and activation of two
... somatic and visceral muscles (Giesen et al., 1997; Murawsky et al., 2001). We confirmed this observation and, in addition, found that Futsch is also misexpressed in the cardiac mesoderm (supplementary material Fig. S2), suggesting that ttk might be expressed at subdetectable levels in the heart and/ ...
... somatic and visceral muscles (Giesen et al., 1997; Murawsky et al., 2001). We confirmed this observation and, in addition, found that Futsch is also misexpressed in the cardiac mesoderm (supplementary material Fig. S2), suggesting that ttk might be expressed at subdetectable levels in the heart and/ ...
PDF
... assumed to exist in these taxa, but have not yet been characterised adequately. Identical colours are used for genes that can be assigned unique homologues (orthologues) within the clusters of different taxa. Similar but non-identical colours are used for genes where orthology relationships are uncl ...
... assumed to exist in these taxa, but have not yet been characterised adequately. Identical colours are used for genes that can be assigned unique homologues (orthologues) within the clusters of different taxa. Similar but non-identical colours are used for genes where orthology relationships are uncl ...
Package `TCGAbiolinks`
... 0.3.0), stats, utils, igraph, selectr, supraHex, S4Vectors, ComplexHeatmap (>= 1.10.2), R.utils, SummarizedExperiment (>= 1.4.0), genefilter, ConsensusClusterPlus, readr, RColorBrewer, doParallel, dplyr, clusterProfiler, pathview, parallel, tools, xml2, httr (>= 1.2.1), matlab, circlize, ggrepel (>= ...
... 0.3.0), stats, utils, igraph, selectr, supraHex, S4Vectors, ComplexHeatmap (>= 1.10.2), R.utils, SummarizedExperiment (>= 1.4.0), genefilter, ConsensusClusterPlus, readr, RColorBrewer, doParallel, dplyr, clusterProfiler, pathview, parallel, tools, xml2, httr (>= 1.2.1), matlab, circlize, ggrepel (>= ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.