Rapid divergence and diversification of mammalian duplicate gene
... observation is that subfunctionalization may be more common in duplicate genes produced by whole genome duplication events [18, 35], which our study does not examine. Another possibility is that the stringency of our subfunctionalization classification resulted in an underestimation of such cases. B ...
... observation is that subfunctionalization may be more common in duplicate genes produced by whole genome duplication events [18, 35], which our study does not examine. Another possibility is that the stringency of our subfunctionalization classification resulted in an underestimation of such cases. B ...
Nomenclature I
... while following the rules described previously, e.g., ACH for “achondroplasia.” It is usual for this symbol to change when the gene product or function is identified; however, if there is no additional information derived from the cloned gene, the disease symbol, e.g., ACH, will be maintained. If an ...
... while following the rules described previously, e.g., ACH for “achondroplasia.” It is usual for this symbol to change when the gene product or function is identified; however, if there is no additional information derived from the cloned gene, the disease symbol, e.g., ACH, will be maintained. If an ...
Lessons from the hemoglobinopathies
... Bert Callewaert, MD, PhD – Center for Medical Genetics – Ghent University Hospital ...
... Bert Callewaert, MD, PhD – Center for Medical Genetics – Ghent University Hospital ...
The Schistosoma gene discovery program: state of the art
... members [19,30±34]. In all of these studies, the authors report that the great majority of the selected cDNA clones (between 30 to >60%) consists of transcripts that could not be identi®ed by matches to any DNA or protein sequences deposited in public databases and hence may represent Schistosoma-sp ...
... members [19,30±34]. In all of these studies, the authors report that the great majority of the selected cDNA clones (between 30 to >60%) consists of transcripts that could not be identi®ed by matches to any DNA or protein sequences deposited in public databases and hence may represent Schistosoma-sp ...
Rachel Coleman
... Real-time Quantitative PCR (RQ-PCR) on cDNA Common exon 12 mutations only Common forward primer/mutation specific reverse primers MGB probe Commercial NPM1+ plasmid standards Results normalised to ABL1 gene ...
... Real-time Quantitative PCR (RQ-PCR) on cDNA Common exon 12 mutations only Common forward primer/mutation specific reverse primers MGB probe Commercial NPM1+ plasmid standards Results normalised to ABL1 gene ...
Reactome Functional Interaction (FI) Network
... • rare for a single tumor to have multiple genes altered in the same pathway. ...
... • rare for a single tumor to have multiple genes altered in the same pathway. ...
Background and Overview of Comparative Genomics
... may be employed in linkage mapping in closely related species (for example, cattle microsatellites have been valuable for constructing a sheep linkage map; Broad and others 1998), they are not likely to recognize homologous sequences between more distantly related species. The most useful markers fo ...
... may be employed in linkage mapping in closely related species (for example, cattle microsatellites have been valuable for constructing a sheep linkage map; Broad and others 1998), they are not likely to recognize homologous sequences between more distantly related species. The most useful markers fo ...
Evidence for massive gene exchange between archaeal and
... uncharacterized owing to the lack of experimental data on these organisms. Several of them, however, form highly conserved families that, on the basis of the observed patterns of amino acid residue conservation, could be ...
... uncharacterized owing to the lack of experimental data on these organisms. Several of them, however, form highly conserved families that, on the basis of the observed patterns of amino acid residue conservation, could be ...
A global view of pleiotropy and phenotypically
... functional category. Thus, clustering mutants with a wide range of pleiotropies by phenotype profile successfully groups genes with common biological functions. The fact that both condition-specific and highly pleiotropic genes can be grouped by common phenotype profiles into gene sets that show sig ...
... functional category. Thus, clustering mutants with a wide range of pleiotropies by phenotype profile successfully groups genes with common biological functions. The fact that both condition-specific and highly pleiotropic genes can be grouped by common phenotype profiles into gene sets that show sig ...
Abstract
... the racial disparity has not narrowed. Even the improved healthcare, socio-economic/lifestyle factors does not seem to benefit this disparity greatly. Thus, it is evocative that certain biological factors may hold crucial links, therefore necessitating emerging biomarkers for valuable risk stratific ...
... the racial disparity has not narrowed. Even the improved healthcare, socio-economic/lifestyle factors does not seem to benefit this disparity greatly. Thus, it is evocative that certain biological factors may hold crucial links, therefore necessitating emerging biomarkers for valuable risk stratific ...
Severe oligozoospermia resulting from deletions
... chromosomes. We conclude that the deletions of the AZF region are the cause of oligozoospermia in these two men. The Y-DNA tests described above were all done on blood, a conventional and readily accessible source of DNA for genetic testing. However, our finding of AZFregion deletions in leucocytes ...
... chromosomes. We conclude that the deletions of the AZF region are the cause of oligozoospermia in these two men. The Y-DNA tests described above were all done on blood, a conventional and readily accessible source of DNA for genetic testing. However, our finding of AZFregion deletions in leucocytes ...
Sex-linked dosage-sensitive modifiers as imprinting
... Many modifiers of variegating position-effects (Locke et al. 1988), as well as modifiers of other phenotypes in Drosophila (Rabinow and Birchler, 1989), are responsive to gene dosage. Locke et al. (1988) have described a number of modifying genes that affect white-mottled and yellow variegation. The ...
... Many modifiers of variegating position-effects (Locke et al. 1988), as well as modifiers of other phenotypes in Drosophila (Rabinow and Birchler, 1989), are responsive to gene dosage. Locke et al. (1988) have described a number of modifying genes that affect white-mottled and yellow variegation. The ...
Export To Word
... They will "read" and "write" a message. They will also participate in "cloning" a plasmid. In this lesson, students will learn the effect of DNA mutations on protein formation and phenotype. The students will convert a DNA sequence to an amino acid sequence and use color-by-number pictures to show t ...
... They will "read" and "write" a message. They will also participate in "cloning" a plasmid. In this lesson, students will learn the effect of DNA mutations on protein formation and phenotype. The students will convert a DNA sequence to an amino acid sequence and use color-by-number pictures to show t ...
R i
... The -1496C allele contains a weak p50/p65 site (–1495 to –1508; R i =3.3 bits) that is abolished (R i < 0) in the G variant. These alleles each also contain p50 homodimer binding sites on opposite strands; however, the C allele is predicted to bind with 1.6 fold difference). The higher CYP2D6 activ ...
... The -1496C allele contains a weak p50/p65 site (–1495 to –1508; R i =3.3 bits) that is abolished (R i < 0) in the G variant. These alleles each also contain p50 homodimer binding sites on opposite strands; however, the C allele is predicted to bind with 1.6 fold difference). The higher CYP2D6 activ ...
Extensive post-transcriptional regulation of miRNAs within
... biological functions including cell proliferation, apoptosis and differentiation. Consequently it is not surprising that disruption of miRNA synthesis plays an important role in various human diseases including cancer. The biogenesis of miRNAs lends itself to regulation at several stages, from trans ...
... biological functions including cell proliferation, apoptosis and differentiation. Consequently it is not surprising that disruption of miRNA synthesis plays an important role in various human diseases including cancer. The biogenesis of miRNAs lends itself to regulation at several stages, from trans ...
Two Cyp19 (P450 Aromatase) Genes on Duplicated Zebrafish
... branched as expected from the known evolutionary relationships of the species. All fish Cyp19 genes clustered together on the same branch, suggesting that they were all orthologs of the single mammalian Cyp19 gene. The fish branch, however, bifurcated into two subbranches with a high bootstrap value ...
... branched as expected from the known evolutionary relationships of the species. All fish Cyp19 genes clustered together on the same branch, suggesting that they were all orthologs of the single mammalian Cyp19 gene. The fish branch, however, bifurcated into two subbranches with a high bootstrap value ...
Patterns of Heredity Note Packet
... The genetic information (DNA) in our cells plays a major role in how our body works. Spelling mistakes often happen when this information is being transcribed. When these spelling mistakes occur on uncoded genes, there aren't any consequences. In a few rare cases, however, a spelling mistake – or mu ...
... The genetic information (DNA) in our cells plays a major role in how our body works. Spelling mistakes often happen when this information is being transcribed. When these spelling mistakes occur on uncoded genes, there aren't any consequences. In a few rare cases, however, a spelling mistake – or mu ...
Distinguishing Among Evolutionary Models for the Maintenance of
... duplicated (unequal crossing-over is a form of NAHR, albeit involving closely linked sequences). Bailey et al. (2003) found an enrichment of transposable elements at the junctions of interchromosomally duplicated sequences in humans, a pattern also recently found in Drosophila melanogaster (Fiston-L ...
... duplicated (unequal crossing-over is a form of NAHR, albeit involving closely linked sequences). Bailey et al. (2003) found an enrichment of transposable elements at the junctions of interchromosomally duplicated sequences in humans, a pattern also recently found in Drosophila melanogaster (Fiston-L ...
C. elegans Life Cycle
... Comprehensive example on use of genetics to probe a signaling pathway that helps control development of the hermaphrodite vulva Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display ...
... Comprehensive example on use of genetics to probe a signaling pathway that helps control development of the hermaphrodite vulva Copyright © The McGraw-Hill Companies, Inc. Permission required to reproduce or display ...
Genetic Approaches to Studying Genome Function
... SUPPRESSION: A given mutation (A) has a discrete phenotype that is not normal, i.e. not wild-type. The presence of the second mutation (B, the suppressor mutation) causes the AB double mutant to display a phenotype that is normal or near-normal. Thus, a suppressor mutation rescues or restores or re ...
... SUPPRESSION: A given mutation (A) has a discrete phenotype that is not normal, i.e. not wild-type. The presence of the second mutation (B, the suppressor mutation) causes the AB double mutant to display a phenotype that is normal or near-normal. Thus, a suppressor mutation rescues or restores or re ...
Polymorphisms in the pfcrt and pfmdr1 genes in Plasmodium
... have been associated with chloroquine resistance.10,16 The K76T mutation is strongly associated with the chloroquine resistance phenotypes in field and clinical studies.15-17 Mutation in codon 76 have been found in CQR P. falciparum strains all over the world and become the principal determinant of ...
... have been associated with chloroquine resistance.10,16 The K76T mutation is strongly associated with the chloroquine resistance phenotypes in field and clinical studies.15-17 Mutation in codon 76 have been found in CQR P. falciparum strains all over the world and become the principal determinant of ...
Exploring HLA Diversity in Brazil
... can find something new. We have genetic variation here that you do not find elsewhere, but most of the frequent variations found worldwide are also found in Brazil. Q: What is the focus of your current research studies? EC: We’re conducting two different research studies. The first study is an evalu ...
... can find something new. We have genetic variation here that you do not find elsewhere, but most of the frequent variations found worldwide are also found in Brazil. Q: What is the focus of your current research studies? EC: We’re conducting two different research studies. The first study is an evalu ...
The Chlamydomonas genome project: a decade on
... comprises up to thousands of stretches of sequence that are identical or nearly identical to each other. Repetitive sequences that are similar to each other comprise a repeat family; it is common to have thousands of different repeat families. The presence of many Mb of repetitive sequences greatly ...
... comprises up to thousands of stretches of sequence that are identical or nearly identical to each other. Repetitive sequences that are similar to each other comprise a repeat family; it is common to have thousands of different repeat families. The presence of many Mb of repetitive sequences greatly ...
Expression of pBLU
... If the agar plate also contains X-gal, the -galactosidase gene product will convert X-gal into Indo-Blu, our dye. E. coli colonies are usually white. Those producing Indo-Blu will be blue. The bacteria cannot move, so they will grow and divide in the same spot on the plate. Small numbers of bacteri ...
... If the agar plate also contains X-gal, the -galactosidase gene product will convert X-gal into Indo-Blu, our dye. E. coli colonies are usually white. Those producing Indo-Blu will be blue. The bacteria cannot move, so they will grow and divide in the same spot on the plate. Small numbers of bacteri ...
Teaching and Learning Genetics with Drosophila 4. Pattern of
... thorax are recessive to normal allele (law of dominance). b) Since there is no difference between the reciprocal crosses, it can be inferred that the gene(s) controlling these characters are not sex linked, that is, they are not on the X-chromosome. c) The data of F1 do not tell us whether these thr ...
... thorax are recessive to normal allele (law of dominance). b) Since there is no difference between the reciprocal crosses, it can be inferred that the gene(s) controlling these characters are not sex linked, that is, they are not on the X-chromosome. c) The data of F1 do not tell us whether these thr ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.