Diplosporous development in Boehmeria tricuspis: Insights
... molecular basis of apomictic development in B. tricuspis, we sequenced and compared transcriptomic profiles of the flowers of sexual and apomictic plants at four key developmental stages. A total of 283,341 unique transcripts were obtained from 1,463 million high-quality paired-end reads. In total, ...
... molecular basis of apomictic development in B. tricuspis, we sequenced and compared transcriptomic profiles of the flowers of sexual and apomictic plants at four key developmental stages. A total of 283,341 unique transcripts were obtained from 1,463 million high-quality paired-end reads. In total, ...
Primary ciliary dyskinesia: genes, candidate genes
... even if heterozygous. On the other hand, mutations in other genes may not affect ciliary function at all, perhaps due to the redundancy of functions of common gene families such as dyneins. In any case, the low incidence of KS and PCD suggests that perhaps mutations in only a small number of these g ...
... even if heterozygous. On the other hand, mutations in other genes may not affect ciliary function at all, perhaps due to the redundancy of functions of common gene families such as dyneins. In any case, the low incidence of KS and PCD suggests that perhaps mutations in only a small number of these g ...
Downloaded - Journal of Medical Genetics
... (III.1, III.5, III.16, IV.1, IV.3, and IV.4) presented with dental alterations at onset and at present they do not show deafness (table 1). In this family, bone alterations appeared when dental and auditory problems were already evident. At the beginning, after the first biopsy examination, PDB coul ...
... (III.1, III.5, III.16, IV.1, IV.3, and IV.4) presented with dental alterations at onset and at present they do not show deafness (table 1). In this family, bone alterations appeared when dental and auditory problems were already evident. At the beginning, after the first biopsy examination, PDB coul ...
A Molecular Genetic Study of Factor XI Deficiency
... frequency of at least 4.3% .' It also occurs much less commonly in non-Jewish populations.' The disorder, first described by Rosenthal et al? is inherited as an autosomal incompletely recessive trait. Homozygous and heterozygous patients are identified by a severe or partial deficiency of factor XI, ...
... frequency of at least 4.3% .' It also occurs much less commonly in non-Jewish populations.' The disorder, first described by Rosenthal et al? is inherited as an autosomal incompletely recessive trait. Homozygous and heterozygous patients are identified by a severe or partial deficiency of factor XI, ...
Familial expansile osteolysis in a large Spanish kindred resulting
... (III.1, III.5, III.16, IV.1, IV.3, and IV.4) presented with dental alterations at onset and at present they do not show deafness (table 1). In this family, bone alterations appeared when dental and auditory problems were already evident. At the beginning, after the first biopsy examination, PDB coul ...
... (III.1, III.5, III.16, IV.1, IV.3, and IV.4) presented with dental alterations at onset and at present they do not show deafness (table 1). In this family, bone alterations appeared when dental and auditory problems were already evident. At the beginning, after the first biopsy examination, PDB coul ...
Ensembl Genome Browser - molecularevolution.org
... “Instant” refresh of selected set Flexible output to HTML table, FASTA, CSV, TSV, Excel … All Ensembl genes on chromosome 5 in GTF format, etc… ...
... “Instant” refresh of selected set Flexible output to HTML table, FASTA, CSV, TSV, Excel … All Ensembl genes on chromosome 5 in GTF format, etc… ...
Special Feature —Manipulating Genes to Understand
... A number of retroviral vectors are available that allow genes to be inserted and packaged into viral particles.1516 These viral particles can be used to infect a wide range of cell types, including embryos. Infection can occur through direct exposure to retroviral particles or by cocultivation with ...
... A number of retroviral vectors are available that allow genes to be inserted and packaged into viral particles.1516 These viral particles can be used to infect a wide range of cell types, including embryos. Infection can occur through direct exposure to retroviral particles or by cocultivation with ...
Chapter 10
... genomes represent a colossal amount of sequence data available for analysis and comparison. In addition to the genome sequences, methods are also available for identifying which genes in the genome are transcribed in particular tissue types, at specific times in development, or at different stages o ...
... genomes represent a colossal amount of sequence data available for analysis and comparison. In addition to the genome sequences, methods are also available for identifying which genes in the genome are transcribed in particular tissue types, at specific times in development, or at different stages o ...
The mitochondrial genome of the soybean cyst nematode
... tend to have slightly lower T-contents, with a range of 27% (Trichinella spiralis) to 44% (Agamermis sp.). A comparison with other pseudocoelomates (from the phyla Acanthocephala and Rotifera) indicates that they also have elevated Tcontents (Table 1). A high T-content appears to be a feature of pse ...
... tend to have slightly lower T-contents, with a range of 27% (Trichinella spiralis) to 44% (Agamermis sp.). A comparison with other pseudocoelomates (from the phyla Acanthocephala and Rotifera) indicates that they also have elevated Tcontents (Table 1). A high T-content appears to be a feature of pse ...
Unearthing the Roles of Imprinted Genes in the Placenta
... differentiate into specific cells and tissues [17]. Epigenetics can be defined as the heritable changes in gene expression that are not caused by the changes in DNA sequence [18]. The best studied epigenetic mechanisms are DNA methylation and histone post-translational modifications, which interact wit ...
... differentiate into specific cells and tissues [17]. Epigenetics can be defined as the heritable changes in gene expression that are not caused by the changes in DNA sequence [18]. The best studied epigenetic mechanisms are DNA methylation and histone post-translational modifications, which interact wit ...
Supplementary Information (doc 408K)
... 5. Analysis of autosomal nonsynonymous variants predicted to be damaging We tested for enrichment of recessive genotypes in probands compared with parents for autosomal variants predicted to have a damaging effect on protein function. These variants included all loss-of-function point mutations (sto ...
... 5. Analysis of autosomal nonsynonymous variants predicted to be damaging We tested for enrichment of recessive genotypes in probands compared with parents for autosomal variants predicted to have a damaging effect on protein function. These variants included all loss-of-function point mutations (sto ...
Introduction - bei DuEPublico
... Hanahan and Weinberg [4] have summarized the capabilities a cell must acquire to become a cancer cell: 1) growth signal autonomy 2) evasion of apoptosis 3) insensitivity to antigrowth signals 4) sustained angiogenesis 5) limitless replicative potential and 6) capacity to invade tissue and grow at me ...
... Hanahan and Weinberg [4] have summarized the capabilities a cell must acquire to become a cancer cell: 1) growth signal autonomy 2) evasion of apoptosis 3) insensitivity to antigrowth signals 4) sustained angiogenesis 5) limitless replicative potential and 6) capacity to invade tissue and grow at me ...
Marfan syndrome
... encodes fibrillin-2 10. FBN2 has been genetically linked to a rare disorder that shares features ...
... encodes fibrillin-2 10. FBN2 has been genetically linked to a rare disorder that shares features ...
![[ 19] Saccharomyces Genome Database - SGD-Wiki](http://s1.studyres.com/store/data/012906934_1-a4c322e0bc64d409034f1882ecf44124-300x300.png)
[ 19] Saccharomyces Genome Database - SGD-Wiki
... about a locus includes the standard gene name, the systematic ORF name, and any aliases; Gene Ontology2'3 annotations describing the gene product's molecular functions, biological processes, and cellular components; additional brief information about the locus and gene product; phenotype information ...
... about a locus includes the standard gene name, the systematic ORF name, and any aliases; Gene Ontology2'3 annotations describing the gene product's molecular functions, biological processes, and cellular components; additional brief information about the locus and gene product; phenotype information ...
Saccharomyces Genome Database.
... about a locus includes the standard gene name, the systematic ORF name, and any aliases; Gene Ontology2'3 annotations describing the gene product's molecular functions, biological processes, and cellular components; additional brief information about the locus and gene product; phenotype information ...
... about a locus includes the standard gene name, the systematic ORF name, and any aliases; Gene Ontology2'3 annotations describing the gene product's molecular functions, biological processes, and cellular components; additional brief information about the locus and gene product; phenotype information ...
benfey_ch10
... Comparisons to identify regulatory elements Comparisons of genomes of different species can identify regulatory elements Change in intergenic regions and introns usually more rapid than in coding regions Nevertheless, regulatory elements tend to be ...
... Comparisons to identify regulatory elements Comparisons of genomes of different species can identify regulatory elements Change in intergenic regions and introns usually more rapid than in coding regions Nevertheless, regulatory elements tend to be ...
Epigenetic chromatin states uniquely define the developmental
... process that arises from a small pool of self-renewing hematopoietic stem cells (HSCs). Upon induction of differentiation, HSCs lose self-renewal ability and develop through a series of specialized progenitor cell types that possess restricted differentiation potential.1 Although several cell-intrin ...
... process that arises from a small pool of self-renewing hematopoietic stem cells (HSCs). Upon induction of differentiation, HSCs lose self-renewal ability and develop through a series of specialized progenitor cell types that possess restricted differentiation potential.1 Although several cell-intrin ...
08.seg_dup_els - NYU Computer Science
... hypothesis that recombination between homologous repeats from a family X, e.g., Alu or L1, contributes to the recent segmental duplication processes in mammalian genomes. The model reflects following intuitive observations: If some of the segmental duplication were caused by repeat recombination, th ...
... hypothesis that recombination between homologous repeats from a family X, e.g., Alu or L1, contributes to the recent segmental duplication processes in mammalian genomes. The model reflects following intuitive observations: If some of the segmental duplication were caused by repeat recombination, th ...
2001_butterfield_THE SUGARCANE GENOME
... marker order in grasses has been demonstrated over large chromosomal segments (Devos and Gale, 1997), several disease resistance genes are not well conserved and may prove difficult to identify through comparative analysis (Keller and Feuillet, 2000). In polyploids, study of single genes may be comp ...
... marker order in grasses has been demonstrated over large chromosomal segments (Devos and Gale, 1997), several disease resistance genes are not well conserved and may prove difficult to identify through comparative analysis (Keller and Feuillet, 2000). In polyploids, study of single genes may be comp ...
PDF
... examining how the networks specify these tissues at the level of their cis-regulatory architecture. We also found many interactions that had not been predicted by simple gene knockdown experiments, and we showed that a significant fraction of TF-DNA interactions make major contributions to the regul ...
... examining how the networks specify these tissues at the level of their cis-regulatory architecture. We also found many interactions that had not been predicted by simple gene knockdown experiments, and we showed that a significant fraction of TF-DNA interactions make major contributions to the regul ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.