Allelic Frequencies of Hla-A, Hla-B and Hla
... tumors stage I and II, but not III and IV. These data suggest that HLADRB1*08 is a marker to be considered in the outcome of patients with ACT, since patients with stages I and II disease have longer survival. This study sought to investigate the contribution of HLA genes with adrenocortical cancer ...
... tumors stage I and II, but not III and IV. These data suggest that HLADRB1*08 is a marker to be considered in the outcome of patients with ACT, since patients with stages I and II disease have longer survival. This study sought to investigate the contribution of HLA genes with adrenocortical cancer ...
Gene Section FANCD2 (Fanconi anemia, complementation group D2) Atlas of Genetics and Cytogenetics
... Disease Fanconi anaemia is a chromosome instability syndrome/cancer prone disease (at risk of leukaemia and squamous cell carcinoma). Prognosis Fanconi anaemia's prognosis is poor; mean survival is 20 years: patients die of bone marrow failure (infections, haemorrhages), leukaemia, or solid cancer. ...
... Disease Fanconi anaemia is a chromosome instability syndrome/cancer prone disease (at risk of leukaemia and squamous cell carcinoma). Prognosis Fanconi anaemia's prognosis is poor; mean survival is 20 years: patients die of bone marrow failure (infections, haemorrhages), leukaemia, or solid cancer. ...
Genes involved in ovulation rate and litter size in sheep
... The domesticated sheep, Ovis aries, has 54 chromosomes containing genetic material in the form of deoxyribonucleic acid (DNA). A locus, or loci in plural, is a specific location for a gene on a chromosome. The corresponding loci in a chromosome pair may contain similar or slightly different segments ...
... The domesticated sheep, Ovis aries, has 54 chromosomes containing genetic material in the form of deoxyribonucleic acid (DNA). A locus, or loci in plural, is a specific location for a gene on a chromosome. The corresponding loci in a chromosome pair may contain similar or slightly different segments ...
Female Sterile Mutations on the Second Chromosome of
... be grouped in several classes. On the one hand, all cells involved in oogenesis require thenormal complement of household genesthat allow those cells to grow and divide. They also require some more specialized gene functions which are also expressed in other tissues. Because of their pleiotropic eff ...
... be grouped in several classes. On the one hand, all cells involved in oogenesis require thenormal complement of household genesthat allow those cells to grow and divide. They also require some more specialized gene functions which are also expressed in other tissues. Because of their pleiotropic eff ...
Microarray expression data
... * the SVM is used then to recognize and classify the genes in the data set to the established groups on the basis of their expression * the SVM can also identify genes in the training set that are outliers or that have been previously assigned to the incorrect class * an application of potentially g ...
... * the SVM is used then to recognize and classify the genes in the data set to the established groups on the basis of their expression * the SVM can also identify genes in the training set that are outliers or that have been previously assigned to the incorrect class * an application of potentially g ...
Genome Evolution in an Insect Cell: Distinct
... recently found to be just 19.9% GC, making this psyllid symbiont the most AT-rich bacterial genome yet characterized (Clark et al., 2001). Analysis of six kilobases of Blochmannia sequences (unpubl. data) corroborates earlier evidence of low GC content for this bacterial genome (⬃30% GC; Dasch, 1975 ...
... recently found to be just 19.9% GC, making this psyllid symbiont the most AT-rich bacterial genome yet characterized (Clark et al., 2001). Analysis of six kilobases of Blochmannia sequences (unpubl. data) corroborates earlier evidence of low GC content for this bacterial genome (⬃30% GC; Dasch, 1975 ...
Copy number variants and genetic traits: closer to the resolution of
... to several megabases of DNA per event, adding up to a significant fraction of the genome57–59. The discovery of extensive copy number variation in the genomes of normal individuals provides new hypotheses to account for the phenotypic variability among inherited (Mendelian and polygenic) disorders a ...
... to several megabases of DNA per event, adding up to a significant fraction of the genome57–59. The discovery of extensive copy number variation in the genomes of normal individuals provides new hypotheses to account for the phenotypic variability among inherited (Mendelian and polygenic) disorders a ...
Role of mutator alleles in adaptive evolution
... The evolution of a population can be very different when adapting to a new environment if adaptation is limited by mutation availability. Mutator genotypes generate adaptive mutations efficiently. Therefore we suggest that a transient increase in mutator frequencies should be a common event in natur ...
... The evolution of a population can be very different when adapting to a new environment if adaptation is limited by mutation availability. Mutator genotypes generate adaptive mutations efficiently. Therefore we suggest that a transient increase in mutator frequencies should be a common event in natur ...
Cluster analysis
... A reliable and precise classification of tumours is essential for successful diagnosis and treatment of cancer. Current methods for classifying human malignancies rely on a variety of morphological, clinical, and molecular variables. In spite of recent progress, there are still uncertainties in diag ...
... A reliable and precise classification of tumours is essential for successful diagnosis and treatment of cancer. Current methods for classifying human malignancies rely on a variety of morphological, clinical, and molecular variables. In spite of recent progress, there are still uncertainties in diag ...
Chapter 11 Mutation: The Source of Genetic Variation
... Chemical mutagens: Base analogs Base modifiers Intercalating agents ...
... Chemical mutagens: Base analogs Base modifiers Intercalating agents ...
Novel Roles for Selected Genes in Meiotic DNA Processing
... Figure 2. Assessment of YGL250W, SOH1, and BRE5 (A) Schematic representation of Chromosome II from the diploid W303 background which consists of two LYS2 heteroalleles (lys2–59ndeI and lys2– 39ndeI). These were used to measure meiotic gene conversion (see Materials and Methods). (B) Spot test of w ...
... Figure 2. Assessment of YGL250W, SOH1, and BRE5 (A) Schematic representation of Chromosome II from the diploid W303 background which consists of two LYS2 heteroalleles (lys2–59ndeI and lys2– 39ndeI). These were used to measure meiotic gene conversion (see Materials and Methods). (B) Spot test of w ...
Shastry, B.S. 2002. SNP alleles in human disease and evolution
... genome, and they can be useful in association studies. However, they are less informative, in the sense that humans have relatively low nucleotide diversity compared with Drosophila and maize, than another type of marker called a microsatellite. Microsatellites are simple sequence repeats, the most ...
... genome, and they can be useful in association studies. However, they are less informative, in the sense that humans have relatively low nucleotide diversity compared with Drosophila and maize, than another type of marker called a microsatellite. Microsatellites are simple sequence repeats, the most ...
Chapter 1 A Perspective on Human Genetics
... Chemical mutagens: Base analogs Base modifiers Intercalating agents ...
... Chemical mutagens: Base analogs Base modifiers Intercalating agents ...
The Importance of Marine Genomics to Life
... nutrigenomics, which are sought to improve the human conditions. Among the objectives of the study of the human genes is to help the biologists to work out on the several different molecular interactions leading to the normal development of the organisms. The genetic sequence can also serve as a ref ...
... nutrigenomics, which are sought to improve the human conditions. Among the objectives of the study of the human genes is to help the biologists to work out on the several different molecular interactions leading to the normal development of the organisms. The genetic sequence can also serve as a ref ...
MOLECULAR STUDY OF IDIOPATHIC NEPHROTIC SYNDROME
... WARNING. The access to the contents of this doctoral thesis it is limited to the acceptance of the use conditions set by the following Creative Commons license: https://creativecommons.org/licenses/?lang=en ...
... WARNING. The access to the contents of this doctoral thesis it is limited to the acceptance of the use conditions set by the following Creative Commons license: https://creativecommons.org/licenses/?lang=en ...
LINEAR VERSUS NON-LINEAR: A PERSPECTIVE FROM HEALTH
... Radiocarcinogenesis is a complex process, and its progress should not be expected to be the same in all potential target organs. There seem to be some tissues at least where radiogenic damage is clearly "less repairable"; there also exist persons with various syndromes associated with diminished rep ...
... Radiocarcinogenesis is a complex process, and its progress should not be expected to be the same in all potential target organs. There seem to be some tissues at least where radiogenic damage is clearly "less repairable"; there also exist persons with various syndromes associated with diminished rep ...
From bedside to bench: how to analyze a splicing
... Over the last few years, many mutations routinely assumed to be missense, nonsense or even silent have been shown to also cause disease by affecting the premRNA processing of the genes in which they are found. Indeed, genetic analysis of mutations in and around 5’ and 3’ splice sites are responsible ...
... Over the last few years, many mutations routinely assumed to be missense, nonsense or even silent have been shown to also cause disease by affecting the premRNA processing of the genes in which they are found. Indeed, genetic analysis of mutations in and around 5’ and 3’ splice sites are responsible ...
GCAT-SEEK Workshop - Prokaryotic Genomics Module – Jeff
... Sequencing technologies, with the caveat that shorter reader lengths necessitate higher coverage levels. NextGen sequencing instruments generate massive amounts of sequence data, far more than what is needed for a single bacterial genome. Each run in the instrument also costs several thousand dollar ...
... Sequencing technologies, with the caveat that shorter reader lengths necessitate higher coverage levels. NextGen sequencing instruments generate massive amounts of sequence data, far more than what is needed for a single bacterial genome. Each run in the instrument also costs several thousand dollar ...
Mechanisms Underlying the Evolution and Maintenance of
... In this study, patterns of apicomplexan 18S gene evolution are reconciled with either the concerted evolution (Brown, Wensink, and Jordan 1972; Zimmer et al. 1980; Arnheim 1983) or birth-and-death evolution models (Hughes and Nei 1989; Ota and Nei 1994; Nei, Gu, and Sitnikova 1997; Gu and Nei 1999; ...
... In this study, patterns of apicomplexan 18S gene evolution are reconciled with either the concerted evolution (Brown, Wensink, and Jordan 1972; Zimmer et al. 1980; Arnheim 1983) or birth-and-death evolution models (Hughes and Nei 1989; Ota and Nei 1994; Nei, Gu, and Sitnikova 1997; Gu and Nei 1999; ...
The Genetic Control and Cytoplasmic Expression of "Inducibility" in
... when performed in the absence of inducerJ yields no trace of enzyme, at any time after mixing, although conjugation and ohromosome injection occur normally as shown by adequate controls involving other markers. The zygotes obtained in matings Band C are genetically identical, except that the wild ty ...
... when performed in the absence of inducerJ yields no trace of enzyme, at any time after mixing, although conjugation and ohromosome injection occur normally as shown by adequate controls involving other markers. The zygotes obtained in matings Band C are genetically identical, except that the wild ty ...
Nomenclature of Transposable Elements in Prokaryotes
... name such as IS2 is a generic term referring to all insertions that appear indistinguishable by hybridization, heteroduplexing, or restriction analysis, but which could have individual differences in base sequence and which might have undergone mutations or rearrangements in the laboratory (seeIV. E ...
... name such as IS2 is a generic term referring to all insertions that appear indistinguishable by hybridization, heteroduplexing, or restriction analysis, but which could have individual differences in base sequence and which might have undergone mutations or rearrangements in the laboratory (seeIV. E ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.