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... Careful endonuclease selection is thus an important factor in determining the success of transgene stabilization. Modern fullgenomic sequencing technologies will likely assist the search for suitable endonucleases and allow for screening of mutations in loci that could be affected by endonuclease ac ...
... Careful endonuclease selection is thus an important factor in determining the success of transgene stabilization. Modern fullgenomic sequencing technologies will likely assist the search for suitable endonucleases and allow for screening of mutations in loci that could be affected by endonuclease ac ...
Rare genomic changes and mitochondrial sequences
... have also proven to be phylogenetically informative within some groups, such as ticks (Murrell et al., 2003) and spiders (Masta and Boore, 2008). Besides potentially providing new types of genome structure characters for making phylogenetic inferences, mitochondrial genomes provide a rich source of ...
... have also proven to be phylogenetically informative within some groups, such as ticks (Murrell et al., 2003) and spiders (Masta and Boore, 2008). Besides potentially providing new types of genome structure characters for making phylogenetic inferences, mitochondrial genomes provide a rich source of ...
Section D - Prokaryotic and Eukaryotic Chromosome Structure
... eukaryotic cells without the use of ...
... eukaryotic cells without the use of ...
WheatNet: A genome-scale functional network for hexaploid bread
... genome-scale network, which facilitates the prediction of novel candidate genes for a trait, can be constructed. Network-based predictions have been useful in the model plant Arabidopsis thaliana (Lee et al., 2010). However, such a predictive gene network is not yet available for bread wheat, Tritic ...
... genome-scale network, which facilitates the prediction of novel candidate genes for a trait, can be constructed. Network-based predictions have been useful in the model plant Arabidopsis thaliana (Lee et al., 2010). However, such a predictive gene network is not yet available for bread wheat, Tritic ...
Molecular genetics of Rett syndrome and clinical
... imprinted or undergo inactivation on the X chromosome). There is a tight correlation in various cell types between methylation and silencing as well as nonmethylation and expression for some genes that are regulated in a tissue-speci®c manner, such as leukosialin (CD43) [43]. Although the cause-and- ...
... imprinted or undergo inactivation on the X chromosome). There is a tight correlation in various cell types between methylation and silencing as well as nonmethylation and expression for some genes that are regulated in a tissue-speci®c manner, such as leukosialin (CD43) [43]. Although the cause-and- ...
209 Original Scientific Article THE INFLUENCE OF
... embryos into the nucleus at the 8-cell stage (4, 9). At the 16-cell stage, DNMT1 enzymes are localized only in the cytoplasm. The timing of the DNMT1 migration into the nucleus coincides with the major genome activation, suggesting that the DNMT3a and DNMT3b genes are activated at the same time. DNM ...
... embryos into the nucleus at the 8-cell stage (4, 9). At the 16-cell stage, DNMT1 enzymes are localized only in the cytoplasm. The timing of the DNMT1 migration into the nucleus coincides with the major genome activation, suggesting that the DNMT3a and DNMT3b genes are activated at the same time. DNM ...
Molecular mechanisms of the origin of micronuclei
... (i.e. the lagging chromatid, the chromatin bridge or the interphase buds). For example, the lagging chromatid most likely generates the micronuclei with lamina and with relaxed chromatin, whereas the chromatin bridge tends to generate the micronuclei without lamina and with condensed chromatin (38). ...
... (i.e. the lagging chromatid, the chromatin bridge or the interphase buds). For example, the lagging chromatid most likely generates the micronuclei with lamina and with relaxed chromatin, whereas the chromatin bridge tends to generate the micronuclei without lamina and with condensed chromatin (38). ...
Epidermolysis Bullosa Letalis - Center for Arab Genomic Studies
... dermoepidermal adhesion zone, with at least six different genes being involved in the pathogenesis of junctional epidermolysis bullosa. Herlitz junctional epidermolysis bullosa has been shown to be associated with mutations in one of the 3 laminin-5 genes (LAMB3, LAMA3, LAMC2), resulting in prematur ...
... dermoepidermal adhesion zone, with at least six different genes being involved in the pathogenesis of junctional epidermolysis bullosa. Herlitz junctional epidermolysis bullosa has been shown to be associated with mutations in one of the 3 laminin-5 genes (LAMB3, LAMA3, LAMC2), resulting in prematur ...
Developmental, transcriptome, and genetic alterations associated
... Seedlessness is a relevant trait in grapevine cultivars intended for fresh consumption or raisin production. Previous DNA marker analysis indicated that Corinto bianco (CB) is a parthenocarpic somatic variant of the seeded cultivar Pedro Ximenes (PX). This study compared both variant lines to determ ...
... Seedlessness is a relevant trait in grapevine cultivars intended for fresh consumption or raisin production. Previous DNA marker analysis indicated that Corinto bianco (CB) is a parthenocarpic somatic variant of the seeded cultivar Pedro Ximenes (PX). This study compared both variant lines to determ ...
Greedy Algorithms - University of Illinois at Urbana
... organelles by comparing mitochondrial genomes of the cabbage and turnip • 99% similarity between genes • These surprisingly identical gene sequences differed in gene order • This study helped pave the way to analyzing genome rearrangements in molecular evolution ...
... organelles by comparing mitochondrial genomes of the cabbage and turnip • 99% similarity between genes • These surprisingly identical gene sequences differed in gene order • This study helped pave the way to analyzing genome rearrangements in molecular evolution ...
Lessons from the hemoglobinopathies (Bert Callewaert)
... Bert Callewaert, MD, PhD – Center for Medical Genetics – Ghent University Hospital ...
... Bert Callewaert, MD, PhD – Center for Medical Genetics – Ghent University Hospital ...
GUEST COMMENTARY
... integration, Beckwith and Signer reasoned that FTSlac integration into a chromosomal gene would destroy that gene. Assuming that FTSlac integration was mutagenic, they could then direct integration into a particular gene by selecting simultaneously for Lac⫹ and loss of target gene function at high g ...
... integration, Beckwith and Signer reasoned that FTSlac integration into a chromosomal gene would destroy that gene. Assuming that FTSlac integration was mutagenic, they could then direct integration into a particular gene by selecting simultaneously for Lac⫹ and loss of target gene function at high g ...
Harvey ras (H-ras) Point Mutations Are Induced by 4
... DMBA, and the promoter, TPA (12, 13). Continuous exposure of squamous cells to DMBA and TPA induced H-ras mutations on chromosome 7 in greater than 90% of mice (14). H-ras appeared to be activated by specific mutations which can be affected by the initiating carcinogen (15). Since tumors do not deve ...
... DMBA, and the promoter, TPA (12, 13). Continuous exposure of squamous cells to DMBA and TPA induced H-ras mutations on chromosome 7 in greater than 90% of mice (14). H-ras appeared to be activated by specific mutations which can be affected by the initiating carcinogen (15). Since tumors do not deve ...
Lec 11 - Development of e
... controlled by a particular gene. Bateson and Punnett proposed the presence or absence theory. According to them, in a cross the character which dominates the other has a determiner, while, the recessive character has no such determiner. But all the theories were discarded by Morgan, who produced the ...
... controlled by a particular gene. Bateson and Punnett proposed the presence or absence theory. According to them, in a cross the character which dominates the other has a determiner, while, the recessive character has no such determiner. But all the theories were discarded by Morgan, who produced the ...
X-chromosome inactivation: molecular mechanism and genetic
... M., Tonlorenzi, R. and Willard, H. F. (1991). A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature 349, 38-44. Migeon, B. R. (1994). X-chromosome inactivation: molecular mechanisms and genetic consequences. Trends Genet 10, 230-235 ...
... M., Tonlorenzi, R. and Willard, H. F. (1991). A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature 349, 38-44. Migeon, B. R. (1994). X-chromosome inactivation: molecular mechanisms and genetic consequences. Trends Genet 10, 230-235 ...
Glycosylphosphatidyl inositol-anchored protein (GPI
... The elucidation of the genetic events underlying the initiation and progression of human thymoma has been hampered by limitations inherent in both in vitro and in vivo methods of study. The most significant limitation of in vitro-based systems is that there is no typical cell line for human thymoma. ...
... The elucidation of the genetic events underlying the initiation and progression of human thymoma has been hampered by limitations inherent in both in vitro and in vivo methods of study. The most significant limitation of in vitro-based systems is that there is no typical cell line for human thymoma. ...
Suppressors of Yeast Actin Mutations.
... HE eukaryotic cytoskeleton consists of a number of different filamentous structures; each type of filament consists of one ortwo major protein subunits along with an unknown number of minor components or attachments, sometimes called “associated” proteins. The function of theseelaborate filamentous ...
... HE eukaryotic cytoskeleton consists of a number of different filamentous structures; each type of filament consists of one ortwo major protein subunits along with an unknown number of minor components or attachments, sometimes called “associated” proteins. The function of theseelaborate filamentous ...
Interphase chromosome profiling (ICP)
... The patient is a 34 year old G0P0 referred for infertility evaluation. She reported an absence of natural menarche, but she was subsequently able to have menstrual cycles with oral contraceptive initiation. However, when she stopped the treatment, her amenorrhea returned. Past medical history is sig ...
... The patient is a 34 year old G0P0 referred for infertility evaluation. She reported an absence of natural menarche, but she was subsequently able to have menstrual cycles with oral contraceptive initiation. However, when she stopped the treatment, her amenorrhea returned. Past medical history is sig ...
Hemophilia
... When the father ihas a hemophilia, all of his daughters would be carriers, while none of his sons would have hemophilia. ...
... When the father ihas a hemophilia, all of his daughters would be carriers, while none of his sons would have hemophilia. ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.