publication
... genes. All the active genes have at least three exons. Two introns are found in the erythroid globin genes and MB; although they differ dramatically in size, they are in homologous locations (Figure 3). Furthermore, even more distantly related globin genes, such as CYGB and NGB in vertebrates and pl ...
... genes. All the active genes have at least three exons. Two introns are found in the erythroid globin genes and MB; although they differ dramatically in size, they are in homologous locations (Figure 3). Furthermore, even more distantly related globin genes, such as CYGB and NGB in vertebrates and pl ...
Molecular studies of major depressive disorder
... that these conditions may be aetiologically related and perhaps share common inherited risk factors.14 The apparently clear contribution of inherited factors to MDD led to early optimism among the psychiatric genetics research community that loci involved in aetiology would be identified with ease. ...
... that these conditions may be aetiologically related and perhaps share common inherited risk factors.14 The apparently clear contribution of inherited factors to MDD led to early optimism among the psychiatric genetics research community that loci involved in aetiology would be identified with ease. ...
CRUK/MRC Oxford Institute for Radiation Oncology
... and telomeres. Failure of these responses causes genomic instability and cancer. Research at the CRUK/MRC Oxford Institute for Radiation Oncology brings together scientists working on different but complementary elements that impact on DNA damage responses; these range from studies on telomeres and ...
... and telomeres. Failure of these responses causes genomic instability and cancer. Research at the CRUK/MRC Oxford Institute for Radiation Oncology brings together scientists working on different but complementary elements that impact on DNA damage responses; these range from studies on telomeres and ...
The Complete Mitochondrial DNA (mtDNA) of the Donkey and
... common chimpanzee, showed that the relative evolutionary rate of individual peptide-coding genes varies among different species-pairs and modes of comparison. The findings show that the superimposition of sequence data ...
... common chimpanzee, showed that the relative evolutionary rate of individual peptide-coding genes varies among different species-pairs and modes of comparison. The findings show that the superimposition of sequence data ...
Andreas Mock Cancer Research UK Cambridge Institute, University
... than a ‘hard’ threshold ττ. However, this hard threshold does not reflect the underlying continuous co-expression measure and leads to a significant loss of information. As a consequence, Horvath and colleagues introduced a new framework for weighted gene co-expression analysis (WGCNA)5. At its core ...
... than a ‘hard’ threshold ττ. However, this hard threshold does not reflect the underlying continuous co-expression measure and leads to a significant loss of information. As a consequence, Horvath and colleagues introduced a new framework for weighted gene co-expression analysis (WGCNA)5. At its core ...
CCO Brochure 4 pages:Layout 1
... a. Although the sensitivity of MRI is excellent, it is less than 100%. Therefore, women who opt for screening should strongly consider other risk-reducing measures (e.g., chemoprevention and/or oophorectomy) and must be able to accept some risk.1 b. The benefits of MRI screening for women at high ris ...
... a. Although the sensitivity of MRI is excellent, it is less than 100%. Therefore, women who opt for screening should strongly consider other risk-reducing measures (e.g., chemoprevention and/or oophorectomy) and must be able to accept some risk.1 b. The benefits of MRI screening for women at high ris ...
Spatially ordered transcription of regulatory DNA in
... change as development proceeds (Fig. 4). Probes spanning the whole iab region (from +58 to +150 kb) hybridize strongly to transcripts in PS13-15. When the germ band is extended both ectoderm and mesoderm show expression (Fig. 4C,E). Later, the signal is particularly strong in the ventral nerve cord, ...
... change as development proceeds (Fig. 4). Probes spanning the whole iab region (from +58 to +150 kb) hybridize strongly to transcripts in PS13-15. When the germ band is extended both ectoderm and mesoderm show expression (Fig. 4C,E). Later, the signal is particularly strong in the ventral nerve cord, ...
Gene Section KLK4 (kallikrein-related peptidase 4) Atlas of Genetics and Cytogenetics
... Hormone dependent cancer. Disease Kallikrein 4 has been reported to be more highly expressed in cancerous than benign prostate tissues at both the mRNA and protein levels. For example, a tissue microarray study carried out on 42 benign and 207 malignant prostate tissues found that KLK4 was more high ...
... Hormone dependent cancer. Disease Kallikrein 4 has been reported to be more highly expressed in cancerous than benign prostate tissues at both the mRNA and protein levels. For example, a tissue microarray study carried out on 42 benign and 207 malignant prostate tissues found that KLK4 was more high ...
An assessment of chromosomal alterations detected by
... and structural chromosomal abnormalities by karyotypic ...
... and structural chromosomal abnormalities by karyotypic ...
IAP workshop, Ghent, Sept.
... mixed-model approach used here for association mapping analysis with Kinship matrix included are more appropriate than other recent methods in identifying cis-regulated genes ( p-values more reliable). Each step’s statistical method is controlled in a more accurate way to specify statistical signi ...
... mixed-model approach used here for association mapping analysis with Kinship matrix included are more appropriate than other recent methods in identifying cis-regulated genes ( p-values more reliable). Each step’s statistical method is controlled in a more accurate way to specify statistical signi ...
founders effect in québec - French
... red scaly skin patches, complete deafness, poor absorption of food in the gut and other problems. It has been traced to families from Kamouraska in eastern Quebec who share a common ancestor. 28 Disorders with higher frequency in French Canadians Tyrosinaemia type I (hepatorenal tyrosinaemia) This a ...
... red scaly skin patches, complete deafness, poor absorption of food in the gut and other problems. It has been traced to families from Kamouraska in eastern Quebec who share a common ancestor. 28 Disorders with higher frequency in French Canadians Tyrosinaemia type I (hepatorenal tyrosinaemia) This a ...
Ch 21 C ppt - Houston ISD
... • It also suggests that the gene’s products are concentrated at the future anterior end. • This is a specific version of a general gradient hypothesis, in which gradients of morphogens establish an embryo’s axes and other features. ...
... • It also suggests that the gene’s products are concentrated at the future anterior end. • This is a specific version of a general gradient hypothesis, in which gradients of morphogens establish an embryo’s axes and other features. ...
Genome-wide DNA replication profile for
... expression and replication timing was further analyzed using logistic regression, which is a statistical method used if there are only two potential outcomes for one of the two variables (in this case, a gene is either expressed or not expressed). The resulting logistic regression curve (thick line) ...
... expression and replication timing was further analyzed using logistic regression, which is a statistical method used if there are only two potential outcomes for one of the two variables (in this case, a gene is either expressed or not expressed). The resulting logistic regression curve (thick line) ...
MS Word document - Sequence Ontology
... 1. Assumption that a transcript is part of a gene is flawed because of polycistronic transcripts. What is a polycistronic_mRNA? 2. There are issues related to ‘time’ that cause problems in the transitivity of the parts of transcripts. There is a time difference between primary and processed transcri ...
... 1. Assumption that a transcript is part of a gene is flawed because of polycistronic transcripts. What is a polycistronic_mRNA? 2. There are issues related to ‘time’ that cause problems in the transitivity of the parts of transcripts. There is a time difference between primary and processed transcri ...
Börjeson–Forssman–Lehmann syndrome: defining
... affected individuals of the pedigree. It is obvious that the inclusion of marker data would also help in the interpretation of cases described earlier, where one affected female with BFLS of feeble-minded parents had been presented [16]. Finally, the large fleshy ears and the prominent supraocular r ...
... affected individuals of the pedigree. It is obvious that the inclusion of marker data would also help in the interpretation of cases described earlier, where one affected female with BFLS of feeble-minded parents had been presented [16]. Finally, the large fleshy ears and the prominent supraocular r ...
Imprinted Genes and Human Disease
... of mutations of imprinted genes. We ask whether we should expect that imprinted genes are particularly fragile. That is, are they more likely to undergo mutation and/or are mutations of imprinted genes particularly likely to result in human disease? In general we consider how the field of evolutiona ...
... of mutations of imprinted genes. We ask whether we should expect that imprinted genes are particularly fragile. That is, are they more likely to undergo mutation and/or are mutations of imprinted genes particularly likely to result in human disease? In general we consider how the field of evolutiona ...
Gene Section FANCC (Fanconi anaemia complementation group C) Atlas of Genetics and Cytogenetics
... FACC is implicated in the FA complementation group C; it represents about 15% of FA cases. Disease Fanconi anaemia is a chromosome instability syndrome/cancer prone disease (at risk of leukaemia). Prognosis Fanconi anaemia's prognosis is poor; mean survival is 16 years: patients die of bone marrow f ...
... FACC is implicated in the FA complementation group C; it represents about 15% of FA cases. Disease Fanconi anaemia is a chromosome instability syndrome/cancer prone disease (at risk of leukaemia). Prognosis Fanconi anaemia's prognosis is poor; mean survival is 16 years: patients die of bone marrow f ...
Evaluation of the Y-Chromosome Structure
... Genomic studies undertaken by Skaletsky et al. (2003) provided evidence of an abundance of intrachromosomal recombination resulting in what was known as the non-recombining region, the NRY, being renamed to the male specific region, the MSY (Skaletsky et al. 2003). ...
... Genomic studies undertaken by Skaletsky et al. (2003) provided evidence of an abundance of intrachromosomal recombination resulting in what was known as the non-recombining region, the NRY, being renamed to the male specific region, the MSY (Skaletsky et al. 2003). ...
The Role of Nearly Neutral Mutations in the Evolution of Dynamical
... biology have pointed to the importance of selective neutrality. The neutral theory claims that the great majority of evolutionary changes are caused not by Darwinian selection but by random drift of selectively neutral or nearly neutral mutants. However, with a few exceptions neutrality has generall ...
... biology have pointed to the importance of selective neutrality. The neutral theory claims that the great majority of evolutionary changes are caused not by Darwinian selection but by random drift of selectively neutral or nearly neutral mutants. However, with a few exceptions neutrality has generall ...
Familial Mediterranean Fever (FMF)
... The chances of successful pregnancy outcome are actually better in women with FMF who are careful to take their colchicine. A comprehensive review of the medical literature on the use of colchicine during pregnancy may be found at http://www.amyloidosis.org.uk. This review is in the fever syndromes ...
... The chances of successful pregnancy outcome are actually better in women with FMF who are careful to take their colchicine. A comprehensive review of the medical literature on the use of colchicine during pregnancy may be found at http://www.amyloidosis.org.uk. This review is in the fever syndromes ...
Transvection, nuclear structure, and chromatin proteins.
... possible that transvection is not only nonessential, it is undesirable, and Drosophila has evolved mechanisms to prevent rampant communication between paired homologues. This view is consistent with the benign effects of rearrangements and predicts that transvection will not be apparent unless the b ...
... possible that transvection is not only nonessential, it is undesirable, and Drosophila has evolved mechanisms to prevent rampant communication between paired homologues. This view is consistent with the benign effects of rearrangements and predicts that transvection will not be apparent unless the b ...
Identification and Functional Analysis of Mutations in the Hepatocyte
... reporter gene. The mutant HNF-1a did not stimulate transcription of the ALB-luciferase reporter, whereas WTHNF-1a stimulated transcription and generated a significant increase in reporter gene activity (Fig. 2A). Increasing amounts of the Pro379fsdelCT-HNF-1a inhibited luciferase activity up to 53% ...
... reporter gene. The mutant HNF-1a did not stimulate transcription of the ALB-luciferase reporter, whereas WTHNF-1a stimulated transcription and generated a significant increase in reporter gene activity (Fig. 2A). Increasing amounts of the Pro379fsdelCT-HNF-1a inhibited luciferase activity up to 53% ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.