General - Bioinformatics Research Group at SRI International
... X = total number of reactions in P Y = enzymes catalyzing number of reactions for which there is evidence in O Z = number of Y reactions that are used in other pathways in O ...
... X = total number of reactions in P Y = enzymes catalyzing number of reactions for which there is evidence in O Z = number of Y reactions that are used in other pathways in O ...
Functional Analysis of A Novel Splicing Mutation in The Mutase
... The human MCM enzyme is encoded by the mutase gene (MUT), mapped to chromosome 6p12.3, that is composed of 13 exons. The MUT open reading frame consists of 2.7 kb, which encods 750 amino acids. The leader sequence, which consists of the first 32 residues, directs the precursor proapoenzyme into the ...
... The human MCM enzyme is encoded by the mutase gene (MUT), mapped to chromosome 6p12.3, that is composed of 13 exons. The MUT open reading frame consists of 2.7 kb, which encods 750 amino acids. The leader sequence, which consists of the first 32 residues, directs the precursor proapoenzyme into the ...
Real time PCR or Quantitative PCR
... quantifying transgenic contaminants with herbicide resistance in conventional rape seed. ● Cancer or disease detection ○ Multiplex real-time reverse transcriptase PCR is an applicable method for the detection, identification, and quantification HBV, HCV and HIV-1 ○ Bernard and Wittwer (2002) used re ...
... quantifying transgenic contaminants with herbicide resistance in conventional rape seed. ● Cancer or disease detection ○ Multiplex real-time reverse transcriptase PCR is an applicable method for the detection, identification, and quantification HBV, HCV and HIV-1 ○ Bernard and Wittwer (2002) used re ...
Finding Clusters of Positive and Negative Coregulated Genes in
... They transform the gene expression data in a binned matrix with pairwise changing tendencies for all conditions. For the decision if a gene is up- or downregulated or not differentially expressed, the user has to choose an arbitrary normalisation threshold. The outcome of the clustering is depending ...
... They transform the gene expression data in a binned matrix with pairwise changing tendencies for all conditions. For the decision if a gene is up- or downregulated or not differentially expressed, the user has to choose an arbitrary normalisation threshold. The outcome of the clustering is depending ...
Cytogenetics
... a tumour suppressor gene, at 5q21 deletion, related to 85% of C-R cancer, due to mutation b) Hereditary nonpolyposis colon cancer (HNPCC) genes in DNA mis-match repair, at 2q15-21, related to 1-5% of C-R cancer, due to genomic instability ...
... a tumour suppressor gene, at 5q21 deletion, related to 85% of C-R cancer, due to mutation b) Hereditary nonpolyposis colon cancer (HNPCC) genes in DNA mis-match repair, at 2q15-21, related to 1-5% of C-R cancer, due to genomic instability ...
Paralogous gene conversion, allelic divergence of attacin genes
... BmNPV infection and thus indicating their potential role in the antiviral immune response (Sagisaka et al., 2010). Therefore, an attempt has been made to study the differential expression of attacin gene in BmNPV resistance. In addition to that the organization of paralogous attacin genes, their tis ...
... BmNPV infection and thus indicating their potential role in the antiviral immune response (Sagisaka et al., 2010). Therefore, an attempt has been made to study the differential expression of attacin gene in BmNPV resistance. In addition to that the organization of paralogous attacin genes, their tis ...
SB2. Students will analyze how biological traits are passed on to
... help find and fix mutations • Although, sometimes these enzymes don’t work and the mutation is not fixed – The DNA site for the production of that enzyme has been damaged by the mutation ...
... help find and fix mutations • Although, sometimes these enzymes don’t work and the mutation is not fixed – The DNA site for the production of that enzyme has been damaged by the mutation ...
Gene Expression Profiles and Microarray Data Analysis - BIDD
... • Compare samples from healthy and sick host to find gene-disease connection • Analyze samples to differentiate sick and healthy, disease subtypes, drug response groups • Probe samples, including human pathogens, for disease detection ...
... • Compare samples from healthy and sick host to find gene-disease connection • Analyze samples to differentiate sick and healthy, disease subtypes, drug response groups • Probe samples, including human pathogens, for disease detection ...
Immunogenetics
... to abandon the one gene- one polypeptide theory and propose that two genes code for a single polypeptide? ...
... to abandon the one gene- one polypeptide theory and propose that two genes code for a single polypeptide? ...
Failures in Mitochondrial tRNA and tRNA Metabolism
... ardiovascular disease is the leading cause of death in America and the world. In particular, hypertension affects ⬇1 billion individuals worldwide and 130 million in China.1 The etiology of cardiovascular disease is not well understood because of the multifactorial causes. Cardiovascular disease can ...
... ardiovascular disease is the leading cause of death in America and the world. In particular, hypertension affects ⬇1 billion individuals worldwide and 130 million in China.1 The etiology of cardiovascular disease is not well understood because of the multifactorial causes. Cardiovascular disease can ...
W0=2, a stable aneuploid derivative of Candida
... unequal crossing over in the ribosomal DNA repeats, new chromosomal bands frequently appear in both the large and the small size ranges. Many of these are due to translocations (Thrash-Bingham & Gorman, 1992), but whether there are also deletions leading to aneuploid regions of the genome is not kno ...
... unequal crossing over in the ribosomal DNA repeats, new chromosomal bands frequently appear in both the large and the small size ranges. Many of these are due to translocations (Thrash-Bingham & Gorman, 1992), but whether there are also deletions leading to aneuploid regions of the genome is not kno ...
RNA Genes: Retroelements and Virally Retroposable microRNAs in
... transcribed by Pol III from the upstream section of Alu TE as miRNA promoters, suggesting that some interplay between miRNAs and TEs may act to the circuit on and off. The human miRNA gene cluster, including SINEs, miR-371, miR-372 and miR-373 in the down stream of C19MC, and the murine miR-290, miR ...
... transcribed by Pol III from the upstream section of Alu TE as miRNA promoters, suggesting that some interplay between miRNAs and TEs may act to the circuit on and off. The human miRNA gene cluster, including SINEs, miR-371, miR-372 and miR-373 in the down stream of C19MC, and the murine miR-290, miR ...
A Rare Cause of Polyuria and Polydipsia in a Patient With Cystic
... renal cysts of predominantly cortical distribution. The liver showed parenchymal heterogeneity. He was hospitalized and conservative therapy with nutritional management and oral bicarbonate supplementation were provided according to biochemical results. Liver function tests were all normal. Careful ...
... renal cysts of predominantly cortical distribution. The liver showed parenchymal heterogeneity. He was hospitalized and conservative therapy with nutritional management and oral bicarbonate supplementation were provided according to biochemical results. Liver function tests were all normal. Careful ...
tion on “Genetics” Informa TEACHING STAFF
... incomplete penetrance: (if you find any, please explain) ...
... incomplete penetrance: (if you find any, please explain) ...
Nucleotide substitutions and evolution of duplicate genes.
... copy, and changing the ith position in the label in each new node to be Yi. When the loop terminates d will be the dimension of the resulting cube. From the n-dimensional difference cube for a pair of codons it is clear there are n! unique paths, each of length n, between the two vertices for the co ...
... copy, and changing the ith position in the label in each new node to be Yi. When the loop terminates d will be the dimension of the resulting cube. From the n-dimensional difference cube for a pair of codons it is clear there are n! unique paths, each of length n, between the two vertices for the co ...
The Isolation of Mutagen-Sensitive nuv Mutants of
... alkylating agent MNNG and/or UV-irradiation (designated nuu mutants). Of these, 23 were selected for further characterization. All were markedly hypersensitive to both MNNG and the quasi-UVmimetic mutagen 4-NQO. The hypersensitive phenotype of each mutant was shown to result from mutation of a singl ...
... alkylating agent MNNG and/or UV-irradiation (designated nuu mutants). Of these, 23 were selected for further characterization. All were markedly hypersensitive to both MNNG and the quasi-UVmimetic mutagen 4-NQO. The hypersensitive phenotype of each mutant was shown to result from mutation of a singl ...
Supplementary Figures (doc 9746K)
... categories are junctions whose start and stop sites have been annotated in the Ensembl gene annotation. The only difference is that the new junction group uses different combinations of start and stop sites. The 3rd and 4th categories are junctions having new 3’ stop sites (acceptor site) or 5’ star ...
... categories are junctions whose start and stop sites have been annotated in the Ensembl gene annotation. The only difference is that the new junction group uses different combinations of start and stop sites. The 3rd and 4th categories are junctions having new 3’ stop sites (acceptor site) or 5’ star ...
View PDF - Molecular Systems Biology
... at single molecule resolution. They also introduce a novel statistical framework to interpret this type of data that explicitly models two sources of non-regulated noise, and apply these techniques to mESC in two different culture conditions, as well as a set of NPCs. They find that developmental pr ...
... at single molecule resolution. They also introduce a novel statistical framework to interpret this type of data that explicitly models two sources of non-regulated noise, and apply these techniques to mESC in two different culture conditions, as well as a set of NPCs. They find that developmental pr ...
Haploidy, Diploidy and Evolution of Antifungal Drug Resistance Saccharomyces cerevisiae
... densities of ⵑ108 cells/ml after several days, this represented ⵑ22 generations. For all populations, including those that remained at low density after 5 days, the MIC of FLC was assayed for three single-colony isolates. To show that this increase in density was due to adaptation as a function of p ...
... densities of ⵑ108 cells/ml after several days, this represented ⵑ22 generations. For all populations, including those that remained at low density after 5 days, the MIC of FLC was assayed for three single-colony isolates. To show that this increase in density was due to adaptation as a function of p ...
Document
... increased in the escitalopramtreated groups • mRNA level of the FSL-Esc group was not statistically different from FRL ...
... increased in the escitalopramtreated groups • mRNA level of the FSL-Esc group was not statistically different from FRL ...
rational selection of pcr-based platforms for pharmacogenomic testing
... point mutations and small deletions will most probably keep their place in the diagnostic laboratory for a reasonable amount of time. Costs, however, are projected to be high and assay performance and results interpretation will remain strictly dependent on the availability of highly qualified and w ...
... point mutations and small deletions will most probably keep their place in the diagnostic laboratory for a reasonable amount of time. Costs, however, are projected to be high and assay performance and results interpretation will remain strictly dependent on the availability of highly qualified and w ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.