Gene Section PYY (peptide YY) Atlas of Genetics and Cytogenetics
... administration of PYY has been shown to improve amylase and cytokine release in pancreatitis cases. It has also been suggested that PYY in combination with vitamin E exhibit a significantly increased inhibitory effect on pancreatic cancer in vitro. ...
... administration of PYY has been shown to improve amylase and cytokine release in pancreatitis cases. It has also been suggested that PYY in combination with vitamin E exhibit a significantly increased inhibitory effect on pancreatic cancer in vitro. ...
Specialized techniques for site-directed mutagenesis in cyanobacteria
... can be directed to a particular locus. The simplest application is insertional inactivation of a gene, by replacing the gene of interest with an allele that has a heterologous cassette (generally an antibiotic-resistance cassette) inserted within its open reading frame. However, as prokaryotic organ ...
... can be directed to a particular locus. The simplest application is insertional inactivation of a gene, by replacing the gene of interest with an allele that has a heterologous cassette (generally an antibiotic-resistance cassette) inserted within its open reading frame. However, as prokaryotic organ ...
Evolution of the Y Sex Chromosome in AnimalsY chromosomes
... 17 were located on the sex chromoTight linkage to the G allele theresomes. Moreover, all of these were fore generates sex-biased gene translocated within two recombinational mission, which greatly facilitates the map units (centimorgans [cM]) of accumulation of male-benefit sexually the male-determi ...
... 17 were located on the sex chromoTight linkage to the G allele theresomes. Moreover, all of these were fore generates sex-biased gene translocated within two recombinational mission, which greatly facilitates the map units (centimorgans [cM]) of accumulation of male-benefit sexually the male-determi ...
Mutations changes of genetic information
... CFTR (cystic fibrosis conductance regulator gene) 1989, chromosome 7 - a big gene with 24 exons Codes a big transmembrane protein - Cl channel More than 1000 mutations found in the gene BUT 60 % patients have a triplet deletion - omission a Phe on 508th place of protein additional 15 % 8 other mutat ...
... CFTR (cystic fibrosis conductance regulator gene) 1989, chromosome 7 - a big gene with 24 exons Codes a big transmembrane protein - Cl channel More than 1000 mutations found in the gene BUT 60 % patients have a triplet deletion - omission a Phe on 508th place of protein additional 15 % 8 other mutat ...
Predicting TF affinities to Promoters of tissue specific genes
... indicates the maximal affinity found in the promoter. The last column shows the location of the window with largest affinity in respect to the TSS of the corresponding gene. Among the top genes according to affinity are many known SRF targets (indicated in bold). In contrast, when ranking according ...
... indicates the maximal affinity found in the promoter. The last column shows the location of the window with largest affinity in respect to the TSS of the corresponding gene. Among the top genes according to affinity are many known SRF targets (indicated in bold). In contrast, when ranking according ...
Colon Cancer Screening
... • Accumulation of additional mutations and abnormal DNA methylation further drives the malignant transformation from adenoma to carcinoma ...
... • Accumulation of additional mutations and abnormal DNA methylation further drives the malignant transformation from adenoma to carcinoma ...
Molecular basis of the adult i phenotype and the gene responsible
... cDNA encoding an I-branching 6GlcNAc-T. The gene, designated IGnT, is located on chromosome 6p24.19,20 Another gene, located on chromosome 15q21-22 and designated C2GnT-M19 or C2/4GnT,20 was identified and shown to encode another Ibranching–forming enzyme.19 The blood group I locus has not been con ...
... cDNA encoding an I-branching 6GlcNAc-T. The gene, designated IGnT, is located on chromosome 6p24.19,20 Another gene, located on chromosome 15q21-22 and designated C2GnT-M19 or C2/4GnT,20 was identified and shown to encode another Ibranching–forming enzyme.19 The blood group I locus has not been con ...
Complete mitochondrial genome of a natural triploid
... ABSTRACT. Carassius auratus var. pingxiangnensis is a natural triploid crucian carp mutant. In order to understand its placement and genetic background at the gene level, the characteristics of mitochondrial DNA sequences and phylogenetic relationship were examined. The results showed that the mitoc ...
... ABSTRACT. Carassius auratus var. pingxiangnensis is a natural triploid crucian carp mutant. In order to understand its placement and genetic background at the gene level, the characteristics of mitochondrial DNA sequences and phylogenetic relationship were examined. The results showed that the mitoc ...
Genetic Variation and Natural Selection Detection
... • N diploid individuals. Generations are non-overlapping. At each generation, each chromosome inherits its genetic material from a uniformly chosen chromosome from the previous generation, independently from all other chromosomes. • In its most basic form, the Wright-Fisher model overlooks many impo ...
... • N diploid individuals. Generations are non-overlapping. At each generation, each chromosome inherits its genetic material from a uniformly chosen chromosome from the previous generation, independently from all other chromosomes. • In its most basic form, the Wright-Fisher model overlooks many impo ...
17q12 microdeletions but not intragenic HNF1B mutations are
... which includes HNF1B plus 14 additional genes. This 17q12 deletion has been linked with an increased risk of neurodevelopmental disorders, such as autism. We aimed to compare the neurodevelopmental phenotype of 38 patients with HNF1B-associated renal disease due to an intragenic mutation (n=18) or 1 ...
... which includes HNF1B plus 14 additional genes. This 17q12 deletion has been linked with an increased risk of neurodevelopmental disorders, such as autism. We aimed to compare the neurodevelopmental phenotype of 38 patients with HNF1B-associated renal disease due to an intragenic mutation (n=18) or 1 ...
Gene Section MLL (myeloid/lymphoid or mixed lineage leukemia) Atlas of Genetics and Cytogenetics
... t(6;11)(q27;q23)/ANLL → MLL/AF6 t(9;11)(p22;q23)/ANLL → MLL/AF9 Disease M5/M4 de novo and therapy related ANLL. Prognosis The prognosis may not be as poor as in other 11q23 leukaemias in de novo cases; very poor prognosis in secondary ANLL cases. Cytogenetics May be overlooked; often as a sole anoma ...
... t(6;11)(q27;q23)/ANLL → MLL/AF6 t(9;11)(p22;q23)/ANLL → MLL/AF9 Disease M5/M4 de novo and therapy related ANLL. Prognosis The prognosis may not be as poor as in other 11q23 leukaemias in de novo cases; very poor prognosis in secondary ANLL cases. Cytogenetics May be overlooked; often as a sole anoma ...
What Do You Mean, “Epigenetic”?
... geneticist Ernst Hadorn (1955) studied mutations by inducing changes in development through experimentation with chemicals or excision. Waddington, on the other hand, was more interested in the cellular processes that brought about these changes, rather than the stimuli that created them. One of Wad ...
... geneticist Ernst Hadorn (1955) studied mutations by inducing changes in development through experimentation with chemicals or excision. Waddington, on the other hand, was more interested in the cellular processes that brought about these changes, rather than the stimuli that created them. One of Wad ...
Hammond 1 Regulation of gene expression during flocculation in
... The goal of this project is to characterize promoter activity of a set of genes previously identified as being involved in regulating flocculation, a cell differentiation event in the alphaproteobacterium, Azospirillum brasilense (Mishra, 2012). This rhizospheric bacterial species is known to positi ...
... The goal of this project is to characterize promoter activity of a set of genes previously identified as being involved in regulating flocculation, a cell differentiation event in the alphaproteobacterium, Azospirillum brasilense (Mishra, 2012). This rhizospheric bacterial species is known to positi ...
A new method to detect causative mutations in fibrinogen
... most mutations are found in patients and/or families suffering from diseases of haemostasis, they allow us to study the relationship of the detected genetic variants with their manifestation in a given phenotype. Although most mutations in fibrinogen manifest as an increased bleeding tendency, some ...
... most mutations are found in patients and/or families suffering from diseases of haemostasis, they allow us to study the relationship of the detected genetic variants with their manifestation in a given phenotype. Although most mutations in fibrinogen manifest as an increased bleeding tendency, some ...
Dominant and recessive central core disease associated with
... When muscle samples were unavailable, RYR1 mutation screening was performed on genomic DNA extracted from blood samples using standard procedures. Exons 92±106 coding for the calcium channel domain and exons involved in the MH1 and MH2 domains were analysed by denaturating ...
... When muscle samples were unavailable, RYR1 mutation screening was performed on genomic DNA extracted from blood samples using standard procedures. Exons 92±106 coding for the calcium channel domain and exons involved in the MH1 and MH2 domains were analysed by denaturating ...
What does PCR stand for?
... settle to bottom of tube. We will collect the supernatant (contains DNA) and will freeze it. Set up PCR reaction on Thursday. ...
... settle to bottom of tube. We will collect the supernatant (contains DNA) and will freeze it. Set up PCR reaction on Thursday. ...
Less mastitis through targeted selective breeding Why a reduction of
... Research for healthier udders Genome-wide association analysis was used to identify genomic regions affecting the resistance to mastitis. Genome-wide expression profiling was used to identify genes involved in the local (mammary gland) and the systemic (e.g. liver) acute phase response in dairy cow ...
... Research for healthier udders Genome-wide association analysis was used to identify genomic regions affecting the resistance to mastitis. Genome-wide expression profiling was used to identify genes involved in the local (mammary gland) and the systemic (e.g. liver) acute phase response in dairy cow ...
A novel de novo frame-shift mutation of the EDA gene in a
... Ectodysplasin-A is involved in the regulation of ectodermal morphogenesis. By specific binding to the ectodysplasin receptor (EDAR), a member of the TNF receptor family, EDA may activate the NF-jB and cJun N-terminal kinase pathways (Yan et al. 2000). Mutations in EDAR (Chassaing et al. 2006), EDARA ...
... Ectodysplasin-A is involved in the regulation of ectodermal morphogenesis. By specific binding to the ectodysplasin receptor (EDAR), a member of the TNF receptor family, EDA may activate the NF-jB and cJun N-terminal kinase pathways (Yan et al. 2000). Mutations in EDAR (Chassaing et al. 2006), EDARA ...
Substitution Rates in a New Silene latifolia Sex
... significantly faster accumulation of nonsynonymous substitutions, which is consistent with the theoretical prediction of relaxed purifying selection in Y-linked genes, leading to the accumulation of nonsynonymous substitutions and genetic degeneration of the Y-linked genes. ...
... significantly faster accumulation of nonsynonymous substitutions, which is consistent with the theoretical prediction of relaxed purifying selection in Y-linked genes, leading to the accumulation of nonsynonymous substitutions and genetic degeneration of the Y-linked genes. ...
Local gene density predicts the spatial position of genetic loci in the
... t(4;11), and t(11;19)(q23;p13.3) are found primarily in acute lymphoblastic leukemia and t(6;11), t(9;11), t(10;11) and t(11;19)(q23;p13.1) predominantly in acute myeloblastic leukemia. The propensity of the MLL gene to rearrange, and the diversity of the partner genes that fuse to MLL, has made it ...
... t(4;11), and t(11;19)(q23;p13.3) are found primarily in acute lymphoblastic leukemia and t(6;11), t(9;11), t(10;11) and t(11;19)(q23;p13.1) predominantly in acute myeloblastic leukemia. The propensity of the MLL gene to rearrange, and the diversity of the partner genes that fuse to MLL, has made it ...
UBE3B developmental disorders and increased mortality in cattle
... retardation and significant reduction of total cholesterol and lathosterol. Additionally, increased embryonal and perinatal lethality was reported for UBE3B−/− mice [5]. Strikingly similar pathological signs were observed in PIRM Ayrshire cattle. UBE3B mutations in heterozygous form do not cause any ...
... retardation and significant reduction of total cholesterol and lathosterol. Additionally, increased embryonal and perinatal lethality was reported for UBE3B−/− mice [5]. Strikingly similar pathological signs were observed in PIRM Ayrshire cattle. UBE3B mutations in heterozygous form do not cause any ...
Introduction to GeneBreak
... * Correspondence to: Christian Rausch ([email protected]) or Sanne Abeln ([email protected]) ...
... * Correspondence to: Christian Rausch ([email protected]) or Sanne Abeln ([email protected]) ...
Get PDF - Wiley Online Library
... is first created with pixilated features which are automatically converted by an algorithm to create a .CEL file in which each individual feature is assigned a single intensity value. Once created, the .CEL image file can be evaluated by the Affymetrix MAS 5.0 software or imported into a number of t ...
... is first created with pixilated features which are automatically converted by an algorithm to create a .CEL file in which each individual feature is assigned a single intensity value. Once created, the .CEL image file can be evaluated by the Affymetrix MAS 5.0 software or imported into a number of t ...
Adaptive Protein Evolution of X-linked and Autosomal Genes in
... Drosophila melanogaster and D. simulans are separated by 2 X-linked and 3 autosomal inversion differences (1 on chromosome 2R; 2 on chromosome 3R; Lemeunier and Ashburner 1976)—in which 2 X-linked and 29 autosomal genes from this data set reside. All analyses involving interspecific divergence data ...
... Drosophila melanogaster and D. simulans are separated by 2 X-linked and 3 autosomal inversion differences (1 on chromosome 2R; 2 on chromosome 3R; Lemeunier and Ashburner 1976)—in which 2 X-linked and 29 autosomal genes from this data set reside. All analyses involving interspecific divergence data ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.