Promise – Spring 2009 - St. Jude Children`s Research Hospital
... IKAROS gene. Children with IKAROS mutations had a high risk of relapse. The researchers also tested whether the presence of IKAROS alterations was associated with levels of minimal residual disease, a term used to describe ...
... IKAROS gene. Children with IKAROS mutations had a high risk of relapse. The researchers also tested whether the presence of IKAROS alterations was associated with levels of minimal residual disease, a term used to describe ...
Document
... increased in the escitalopramtreated groups • mRNA level of the FSL-Esc group was not statistically different from FRL ...
... increased in the escitalopramtreated groups • mRNA level of the FSL-Esc group was not statistically different from FRL ...
Chapter 20
... Because the band patterns for the three samples are clearly different, this method can be used to identify heterozygous carriers of the sickle-cell allele (III), as well as those with the disease, who have two mutant alleles (II), and unaffected individuals, who have two normal alleles (I). The band ...
... Because the band patterns for the three samples are clearly different, this method can be used to identify heterozygous carriers of the sickle-cell allele (III), as well as those with the disease, who have two mutant alleles (II), and unaffected individuals, who have two normal alleles (I). The band ...
Lac A
... In a mRNA sequence (wt) there is a triplet UUU. After a mutation, the triplet changes in UUA. What kind of mutation happened and which effects have the mutation on the protein encoded by the gene? To switch from UUU to UUA is necessary a mutation in the DNA ...
... In a mRNA sequence (wt) there is a triplet UUU. After a mutation, the triplet changes in UUA. What kind of mutation happened and which effects have the mutation on the protein encoded by the gene? To switch from UUU to UUA is necessary a mutation in the DNA ...
Full-Text PDF
... Ca2+ storage (rewiewed in [1] and references therein). They play a central role in aging [2] and are subject to mitophagy, the pathway that mediates the selective elimination of dysfunctional or unwanted mitochondria and is critical to proper cellular functions [3]. Without a proper mitochondrial st ...
... Ca2+ storage (rewiewed in [1] and references therein). They play a central role in aging [2] and are subject to mitophagy, the pathway that mediates the selective elimination of dysfunctional or unwanted mitochondria and is critical to proper cellular functions [3]. Without a proper mitochondrial st ...
Transposable elements, genes and recombination in a 215
... a genome designated Am that is closely related to the genome of T. urartu, the A genome donor for tetraploid and hexaploid wheats. The large genome of T. monococcum (1C =5600 Mb; Bennett and Leitch 1995) is approximately 12 times larger than the genome of rice and 40 times larger than the genome of ...
... a genome designated Am that is closely related to the genome of T. urartu, the A genome donor for tetraploid and hexaploid wheats. The large genome of T. monococcum (1C =5600 Mb; Bennett and Leitch 1995) is approximately 12 times larger than the genome of rice and 40 times larger than the genome of ...
Secondary deformity following lateral closing wedge
... and in a variable proportion of patients with idiopathic short stature (ISS) ...
... and in a variable proportion of patients with idiopathic short stature (ISS) ...
allele 2 Proteins made from allele 1 chromosome Proteins made
... If a mutation occurs in the DNA of an allele, the protein made may have an incorrect structure and not work properly. Alternatively, some mutations can result in no protein being made at all. The tasks below will make you explore the differences between normal and mutated proteins and how changes in ...
... If a mutation occurs in the DNA of an allele, the protein made may have an incorrect structure and not work properly. Alternatively, some mutations can result in no protein being made at all. The tasks below will make you explore the differences between normal and mutated proteins and how changes in ...
Article
... in the absence of fertilization. According to Grossniklaus et al. (1998), the wild-type MEA gene is expressed in the female gametophyte of A. thaliana before fertilization, and is required for normal post-fertilization seed development, especially of the endosperm. Genetic analysis of the effect of ...
... in the absence of fertilization. According to Grossniklaus et al. (1998), the wild-type MEA gene is expressed in the female gametophyte of A. thaliana before fertilization, and is required for normal post-fertilization seed development, especially of the endosperm. Genetic analysis of the effect of ...
Genetic aspects of chronic pancreatitis
... AP and CP [10]. However, when successful therapeutic agents observed in animal models were administered to humans, treatment failure usually occurred. Steinberg et al. reported an 81% improvement in survival in 25 animal studies of AP, whereas in 13 human studies using the same therapeutic agents on ...
... AP and CP [10]. However, when successful therapeutic agents observed in animal models were administered to humans, treatment failure usually occurred. Steinberg et al. reported an 81% improvement in survival in 25 animal studies of AP, whereas in 13 human studies using the same therapeutic agents on ...
beckwith-wiedemann syndrome
... BWS is a complex multigenic disorder caused by alterations in growth regulatory genes on chromosome 11p15 that are subject to imprinting. Most autosomal genes are expressed from both the paternally and maternally derived alleles; however imprinted genes are expressed in a parent of origin specific m ...
... BWS is a complex multigenic disorder caused by alterations in growth regulatory genes on chromosome 11p15 that are subject to imprinting. Most autosomal genes are expressed from both the paternally and maternally derived alleles; however imprinted genes are expressed in a parent of origin specific m ...
l Saccharomyces cerevisiae as a Genetic Model Organism
... carbon energy source must be added, such as glucose (dextrose), sucrose, lactic acid, or others depending on the genotype of the strain and its ability to utilize various carbon sources. Glucose is the richest and most readily available carbon source and a rich medium containing glucose is referred ...
... carbon energy source must be added, such as glucose (dextrose), sucrose, lactic acid, or others depending on the genotype of the strain and its ability to utilize various carbon sources. Glucose is the richest and most readily available carbon source and a rich medium containing glucose is referred ...
Evolutionary implications of non- neutral
... between two populations. The resulting daughters of each cross will then share an identical set of possible nuclear backgrounds but will have mtDNA that is derived from the maternal parental genotype and, thus, differences between the two crosses could be indicative of mtDNA fitness effects (see, fo ...
... between two populations. The resulting daughters of each cross will then share an identical set of possible nuclear backgrounds but will have mtDNA that is derived from the maternal parental genotype and, thus, differences between the two crosses could be indicative of mtDNA fitness effects (see, fo ...
Conflicting patterns of mitochondrial and nuclear DNA diversity in
... For the loci where we had data from viridanus/plumbeitarsus (Cyt b, CHD-W, CHD-Z and MC1R), these were used as outgroups as they appear the most distantly related taxa to the ingroup (Richman & Price 1992; Price et al. 1997). The gene tree for AFLP-WW1 was instead rooted with sibilatrix/bonelli. Tre ...
... For the loci where we had data from viridanus/plumbeitarsus (Cyt b, CHD-W, CHD-Z and MC1R), these were used as outgroups as they appear the most distantly related taxa to the ingroup (Richman & Price 1992; Price et al. 1997). The gene tree for AFLP-WW1 was instead rooted with sibilatrix/bonelli. Tre ...
Current Second Tier and Future Applications of Gene Sequencing in
... progressive scoliosis and diminished GAA activity. Predictive algorithms conflicting as to whether its pathogenic. Reported in dbSNP and ExAC, but rare. ...
... progressive scoliosis and diminished GAA activity. Predictive algorithms conflicting as to whether its pathogenic. Reported in dbSNP and ExAC, but rare. ...
C1. Genetics, DNA and Mutations - Bioscience Bioethics Friendship
... genes for certain proteins, this can have major affects, usually resulting in death. Trisomy 21, where there are three copies of chromosome number 21 results in Down's syndrome, and is an example where death may not necessarily be the result. In most other chromosome trisomies, death occurs during f ...
... genes for certain proteins, this can have major affects, usually resulting in death. Trisomy 21, where there are three copies of chromosome number 21 results in Down's syndrome, and is an example where death may not necessarily be the result. In most other chromosome trisomies, death occurs during f ...
Allele, phenotype and disease data at Mouse Genome Informatics
... more detailed categories of allele attributes. This allows improved discrimination between mutation types. Further, connections have been created between mutations involving multiple genes and each of the genes overlapping the mutation. This allows users to readily find all mutations affecting a gen ...
... more detailed categories of allele attributes. This allows improved discrimination between mutation types. Further, connections have been created between mutations involving multiple genes and each of the genes overlapping the mutation. This allows users to readily find all mutations affecting a gen ...
Horner VL, Caspary T. Methods Mol Biol. 2011;770:313-36. Creating a hopeful monster: mouse forward genetic screens.
... 1. Mice: 7- to 8-week-old males of the desired strain for mutagenization (Section 3.2). 2. N-ethyl-N-nitrosourea (ENU). ...
... 1. Mice: 7- to 8-week-old males of the desired strain for mutagenization (Section 3.2). 2. N-ethyl-N-nitrosourea (ENU). ...
Gain of multiple copies of the CBFB gene: a new genetic
... allowing a precise diagnosis [16,17]. In the present case, we would not have detected the CBFB gain of multiple copies without the FISH analysis. This aberration might be present in other similar cases, but could go unnoticed unless FISH techniques are applied. A normal karyotype in AML is suggestiv ...
... allowing a precise diagnosis [16,17]. In the present case, we would not have detected the CBFB gain of multiple copies without the FISH analysis. This aberration might be present in other similar cases, but could go unnoticed unless FISH techniques are applied. A normal karyotype in AML is suggestiv ...
Imprinted gene detection in Arabidopsis thaliana
... A.thaliana from microarray gene expression measurements in several interploidy and mutant A.thaliana crosses. In sexually reproducing organisms, the transcription of the maternally as well as the paternally inherited alleles of a gene is the rule. Imprinted genes are an exception to this rule. Their ...
... A.thaliana from microarray gene expression measurements in several interploidy and mutant A.thaliana crosses. In sexually reproducing organisms, the transcription of the maternally as well as the paternally inherited alleles of a gene is the rule. Imprinted genes are an exception to this rule. Their ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.