Introduction to Angelfish Genetics
... This angelfish also exhibits the combtail trait, which results in elongated tail rays, giving a fringed appearance. The genetics of combtail have not been ...
... This angelfish also exhibits the combtail trait, which results in elongated tail rays, giving a fringed appearance. The genetics of combtail have not been ...
Medicina Reproductiva y Embriología Clínica
... into succinyl-CoA during propionyl-CoA metabolism in the mitochondria. This metabolic blockage leads to progressive encephalopathy and hiperammonemia (Manoli and Venditti, 2005). Patients with mut MMA have been divided into two subgroups: mut◦ with no MCM activity and mut− with MCM residual activity ...
... into succinyl-CoA during propionyl-CoA metabolism in the mitochondria. This metabolic blockage leads to progressive encephalopathy and hiperammonemia (Manoli and Venditti, 2005). Patients with mut MMA have been divided into two subgroups: mut◦ with no MCM activity and mut− with MCM residual activity ...
X chromosome inactivation failed to explain normal phenotype Clin
... mother. Patterns of XCI were determined in the peripheral blood cells (a). The polymorphic repeated sequence at the androgen receptor locus was amplified by polymerase chain reaction (PCR) using the Hpa II undigested or digested genomic DNA as the template. After digestion with the methylation-sensi ...
... mother. Patterns of XCI were determined in the peripheral blood cells (a). The polymorphic repeated sequence at the androgen receptor locus was amplified by polymerase chain reaction (PCR) using the Hpa II undigested or digested genomic DNA as the template. After digestion with the methylation-sensi ...
P D G E
... The transcriptome is never synthesized de novo; instead, it is maintained by gene expression replacing mRNA’s that have been degraded, with changes in composition brought about by switching different sets of genes on and off. To understand the mechanisms of cells, involved in a given biological proc ...
... The transcriptome is never synthesized de novo; instead, it is maintained by gene expression replacing mRNA’s that have been degraded, with changes in composition brought about by switching different sets of genes on and off. To understand the mechanisms of cells, involved in a given biological proc ...
A GENETIC LINKAGE MAP OF Phycomyces blakesleeanus
... immunosuppressive disorders, solid-organ or bone marrow transplantation) and can be acute as well as chronic. The genome sequence of R. oryzae was recently published (Ma et al. 2009). Certain genetic factors in this fungal genome are thought to influence its ability to cause disease in contrast to n ...
... immunosuppressive disorders, solid-organ or bone marrow transplantation) and can be acute as well as chronic. The genome sequence of R. oryzae was recently published (Ma et al. 2009). Certain genetic factors in this fungal genome are thought to influence its ability to cause disease in contrast to n ...
Interplay between copy number, dosage compensation and
... copy deletions is fundamental for better understanding of diseases that originate from gene copy number changes. In humans, reduction in gene dosage for many transcription factors leads to haploinsufficient developmental disorders [12]. Thus it is likely that genomic responses to alterations in gene ...
... copy deletions is fundamental for better understanding of diseases that originate from gene copy number changes. In humans, reduction in gene dosage for many transcription factors leads to haploinsufficient developmental disorders [12]. Thus it is likely that genomic responses to alterations in gene ...
White Paper: DMET™ Plus allele translation
... PharmaADME consortium to be of primary importance in drug metabolism. The gene tables include primary literature reference citations, genomic locations, mRNA positions, and notation of coding changes that result when variants are detected at allele-defining probe sets. The translation reports are fl ...
... PharmaADME consortium to be of primary importance in drug metabolism. The gene tables include primary literature reference citations, genomic locations, mRNA positions, and notation of coding changes that result when variants are detected at allele-defining probe sets. The translation reports are fl ...
The landscape of microbial phenotypic traits and associated genes
... ecosystem type. For instance, organisms annotated as ‘marine’ were used as provisional negatives for ‘soil’ or for ’thermal springs’. In GOLD, each organism can have more than one assigned value, e.g. being annotated as both ‘marine’ and ‘freshwater’ and thus receiving positive labels for these two ...
... ecosystem type. For instance, organisms annotated as ‘marine’ were used as provisional negatives for ‘soil’ or for ’thermal springs’. In GOLD, each organism can have more than one assigned value, e.g. being annotated as both ‘marine’ and ‘freshwater’ and thus receiving positive labels for these two ...
IMSR File Format
... distributed from the provider’s site, and the “states” in which these strains or stocks are held. The list of valid states supported by the IMSR can be found in Table 3. The definition of the columns that should be provided in the tab-delimited IMSR load files can be found in Table 1, below. A singl ...
... distributed from the provider’s site, and the “states” in which these strains or stocks are held. The list of valid states supported by the IMSR can be found in Table 3. The definition of the columns that should be provided in the tab-delimited IMSR load files can be found in Table 1, below. A singl ...
The role of humans in facilitating and sustaining coat
... coat colour variation is one of the few characteristics that distinguishes all domestic animals from their wild progenitors. A number of recent reviews have discussed and synthesised the hundreds of genes known to underlie specific coat colour patterns in a wide range of domestic animals. This review ...
... coat colour variation is one of the few characteristics that distinguishes all domestic animals from their wild progenitors. A number of recent reviews have discussed and synthesised the hundreds of genes known to underlie specific coat colour patterns in a wide range of domestic animals. This review ...
current micro 40/5 - Bashan Foundation
... nidulans, the hox genes are organized on two separate loci, whereas they are contiguous in one cluster, though interspersed with two unidentified reading frames, ORF 3 and 8, in the heterocystous Anabaena variabilis. The hox gene clusters of these two cyanobacteria have now been transcriptionally an ...
... nidulans, the hox genes are organized on two separate loci, whereas they are contiguous in one cluster, though interspersed with two unidentified reading frames, ORF 3 and 8, in the heterocystous Anabaena variabilis. The hox gene clusters of these two cyanobacteria have now been transcriptionally an ...
ELMER: An R/Bioconductor Tool Inferring Regulatory Element
... DNA methyaltion data feeding to ELMER should be a matrix of DNA methylation beta (β) value for samples (column) and probes (row) processed from row HM450K array data. If TCGA data were used, level 3 processed data from TCGA website will be downloaded and automatically transformed to the matrix by EL ...
... DNA methyaltion data feeding to ELMER should be a matrix of DNA methylation beta (β) value for samples (column) and probes (row) processed from row HM450K array data. If TCGA data were used, level 3 processed data from TCGA website will be downloaded and automatically transformed to the matrix by EL ...
Leukaemia Section MLL amplification in leukemia Atlas of Genetics and Cytogenetics
... rearrangement of this gene. RNA overexpression is the result of the increase copy number of MLL (gain of function). Moreover, the amplified region is not limited to the MLL/11q23.3 gene locus, and other genes in the MLL flanking region have been also amplified. FISH and other molecular techniques ha ...
... rearrangement of this gene. RNA overexpression is the result of the increase copy number of MLL (gain of function). Moreover, the amplified region is not limited to the MLL/11q23.3 gene locus, and other genes in the MLL flanking region have been also amplified. FISH and other molecular techniques ha ...
Genes for Two Mitochondrial Ribosomal Proteins in
... Numit rps13 from Arabidopsis contains two introns. The genomic sequence of numit rps13 from soybean was determined by polymerase chain reaction amplification and sequencing, revealing two introns in the same positions as those in Arabidopsis. Because the rps13 genes from legumes and Arabidopsis have ...
... Numit rps13 from Arabidopsis contains two introns. The genomic sequence of numit rps13 from soybean was determined by polymerase chain reaction amplification and sequencing, revealing two introns in the same positions as those in Arabidopsis. Because the rps13 genes from legumes and Arabidopsis have ...
An assessment of the risks associated with the
... bacterial resistance genes are with us. It would also be desirable to have selectable markers other than bacterial resistance genes with which to select desired transformed plant cells. Again, developments are in progress. In the meantime, it is worth emphasizing that a full inventory of the genetic ...
... bacterial resistance genes are with us. It would also be desirable to have selectable markers other than bacterial resistance genes with which to select desired transformed plant cells. Again, developments are in progress. In the meantime, it is worth emphasizing that a full inventory of the genetic ...
Gene Duplication, Gene Conversion and the Evolution of
... Nonrecombining chromosomes, such as the Y, are expected to degenerate over time due to reduced efficacy of natural selection compared to chromosomes that recombine. However, gene duplication, coupled with gene conversion between duplicate pairs, can potentially counteract forces of evolutionary deca ...
... Nonrecombining chromosomes, such as the Y, are expected to degenerate over time due to reduced efficacy of natural selection compared to chromosomes that recombine. However, gene duplication, coupled with gene conversion between duplicate pairs, can potentially counteract forces of evolutionary deca ...
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... hypothesis is supported by the observation that many genes on the human X escape inactivation, although they have no active Y partner (Carrel and Willard, 2005). The clustering of these escapees in domains in the recently added layer of the X suggests that the process lags behind Y degradation and i ...
... hypothesis is supported by the observation that many genes on the human X escape inactivation, although they have no active Y partner (Carrel and Willard, 2005). The clustering of these escapees in domains in the recently added layer of the X suggests that the process lags behind Y degradation and i ...
Chromatin Domain Boundaries: Defining the Functional Domains in
... Eukaryotic genome is packaged in the nucleus with the help of several proteins. While this packaging is needed to accommodate the large genome within the nuclear volume it also has functional consequences. It is well known that enhancers can act over a long distance to regulate expression of genes, ...
... Eukaryotic genome is packaged in the nucleus with the help of several proteins. While this packaging is needed to accommodate the large genome within the nuclear volume it also has functional consequences. It is well known that enhancers can act over a long distance to regulate expression of genes, ...
Estrogen receptor β gene polymorphisms and susceptibility to
... decided to specifically focus on the second type of polymorphisms with potential functional significance, SNPs in the promoter of ESR2 gene. The promoter region of ESR2 gene is only beginning to be characterized, and thus it is possible that SNPs localized in this region are able to affect binding o ...
... decided to specifically focus on the second type of polymorphisms with potential functional significance, SNPs in the promoter of ESR2 gene. The promoter region of ESR2 gene is only beginning to be characterized, and thus it is possible that SNPs localized in this region are able to affect binding o ...
Functional significance of the discordance between
... LV remodeling following mechanical circulatory support. Persistence of the HF gene program was associated with an exaggerated hypertrophic response and increased mortality in tTA-TRAF2dox4W mice following transaortic constriction (TAC). These effects were no longer observed following TAC in tTA-TRAF ...
... LV remodeling following mechanical circulatory support. Persistence of the HF gene program was associated with an exaggerated hypertrophic response and increased mortality in tTA-TRAF2dox4W mice following transaortic constriction (TAC). These effects were no longer observed following TAC in tTA-TRAF ...
Konopka benzer clock mutants of drosophila pnas 1971
... device at the end of a light cycle. In these records, the offset of activity was typically more abrupt than the onset, so that the free-running period could be best determined by measurement of the average drift in time of offset per day. The rhythm shown in Fig. 2A, therefore, has a period of about ...
... device at the end of a light cycle. In these records, the offset of activity was typically more abrupt than the onset, so that the free-running period could be best determined by measurement of the average drift in time of offset per day. The rhythm shown in Fig. 2A, therefore, has a period of about ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.