Genes@ Work: an efficient algorithm for pattern discovery and
... space. The value of the pattern discovery approach is demonstrated by finding a set of genes that differentiate between two types of lymphoma. Moreover, these genes are found to behave consistently in an independent dataset produced in a different laboratory using different arrays, thus validating t ...
... space. The value of the pattern discovery approach is demonstrated by finding a set of genes that differentiate between two types of lymphoma. Moreover, these genes are found to behave consistently in an independent dataset produced in a different laboratory using different arrays, thus validating t ...
FEBS Letters
... In addition to hoxH, the 5.0 kb segment contained upstream of hoxH the hydrogenase genes h o x Y (coding for the smaller subunit o f the hydrogenase dimer, sequence identity to the A. variabilis gene product 61% on an amino acid basis) and hoxU (coding for the smaller subunit of the diaphorase part, ...
... In addition to hoxH, the 5.0 kb segment contained upstream of hoxH the hydrogenase genes h o x Y (coding for the smaller subunit o f the hydrogenase dimer, sequence identity to the A. variabilis gene product 61% on an amino acid basis) and hoxU (coding for the smaller subunit of the diaphorase part, ...
Magnetic Resonance Imaging (MRI) of the Breast
... and use of statistical comparison. Results are not consistent. Personal history of breast cancer. Current studies are small and retrospective but suggest some benefit for surveillance MRI after breast cancer treatment. Although MRI may demonstrate new or recurrent cancers earlier than routine mammog ...
... and use of statistical comparison. Results are not consistent. Personal history of breast cancer. Current studies are small and retrospective but suggest some benefit for surveillance MRI after breast cancer treatment. Although MRI may demonstrate new or recurrent cancers earlier than routine mammog ...
Nucleotide Sequence of the SAC2 Gene of Saccharomyces cerevisiae .
... to 10 days at 11°C. Temperature-sensitivity of into M13 derivatives (Messing, 1983) and seactl-1 and suppression by SAC2 mutations were quenced by standard dideoxy sequencing methods scored after 3 days at 37°C. Growth tests were (Sanger et al., 1977). performed by spotting suspensions of cells in w ...
... to 10 days at 11°C. Temperature-sensitivity of into M13 derivatives (Messing, 1983) and seactl-1 and suppression by SAC2 mutations were quenced by standard dideoxy sequencing methods scored after 3 days at 37°C. Growth tests were (Sanger et al., 1977). performed by spotting suspensions of cells in w ...
Leukaemia Section del(17p) in myeloïd malignancies Atlas of Genetics and Cytogenetics
... Wattel E, Preudhomme C, Hecquet B, Vanrumbeke M, Quesnel B, Dervite I, Morel P, Fenaux P. p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood. 1994 Nov 1;84(9):3148-57 ...
... Wattel E, Preudhomme C, Hecquet B, Vanrumbeke M, Quesnel B, Dervite I, Morel P, Fenaux P. p53 mutations are associated with resistance to chemotherapy and short survival in hematologic malignancies. Blood. 1994 Nov 1;84(9):3148-57 ...
Mary Ann Osley*, Alastair Fleming, and Cheng
... pathway in the regulation of Ub-H2B formation in yeast are presented in section IV.1.1. Other factors have also been shown to regulate ub-H2b levels. In yeast, the product of the LGE1 gene was identified in the same synthetic lethal screen that picked up BRE1, and an lge1∆ mutant shows globally redu ...
... pathway in the regulation of Ub-H2B formation in yeast are presented in section IV.1.1. Other factors have also been shown to regulate ub-H2b levels. In yeast, the product of the LGE1 gene was identified in the same synthetic lethal screen that picked up BRE1, and an lge1∆ mutant shows globally redu ...
Magnetic Resonance Imaging (MRI) of the Breast
... and use of statistical comparison. Results are not consistent. Personal history of breast cancer. Current studies are small and retrospective but suggest some benefit for surveillance MRI after breast cancer treatment. Although MRI may demonstrate new or recurrent cancers earlier than routine mammog ...
... and use of statistical comparison. Results are not consistent. Personal history of breast cancer. Current studies are small and retrospective but suggest some benefit for surveillance MRI after breast cancer treatment. Although MRI may demonstrate new or recurrent cancers earlier than routine mammog ...
Determining the cause of patchwork HBA1 and HBA2 genes
... respectively, followed by heteroduplex formation, mismatch repair, and finally synthesis of the complementary strand of the recipient gene directed by the donor strand as template. This results in the formation of either an α212-like or α121-like patchwork gene, but not both. Although it has been su ...
... respectively, followed by heteroduplex formation, mismatch repair, and finally synthesis of the complementary strand of the recipient gene directed by the donor strand as template. This results in the formation of either an α212-like or α121-like patchwork gene, but not both. Although it has been su ...
Two ParaHox genes, SpLox and SpCdx, interact to
... In addition to the morphological effect, the absence of SpLox function alters the digestive properties of the embryonic gut. We analyzed food ingestion in mutant and control larvae by regularly feeding animals with a culture of single-celled alga, Isochrysis galbana, starting at 72 hours of developm ...
... In addition to the morphological effect, the absence of SpLox function alters the digestive properties of the embryonic gut. We analyzed food ingestion in mutant and control larvae by regularly feeding animals with a culture of single-celled alga, Isochrysis galbana, starting at 72 hours of developm ...
Site-Directed Mutagenesis Using Oligonucleotide
... 1.2 Use of λ Red recombination for manipulation of bacterial genomes The basic strategy of the λ Red system is the replacement of a chromosomal sequence with a (e.g., PCR-amplified) selectable antibiotic resistance gene flanked by homology extensions of distinct lengths. For genetic engineering in t ...
... 1.2 Use of λ Red recombination for manipulation of bacterial genomes The basic strategy of the λ Red system is the replacement of a chromosomal sequence with a (e.g., PCR-amplified) selectable antibiotic resistance gene flanked by homology extensions of distinct lengths. For genetic engineering in t ...
- LSHTM Research Online
... vaccine. B. pseudomallei is listed as a tier 1 select agent, and as current therapeutic options are limited due to its natural resistance to most antibiotics, the development of new antimicrobial therapies is imperative. To identify drug targets and better understand the complex B. pseudomallei geno ...
... vaccine. B. pseudomallei is listed as a tier 1 select agent, and as current therapeutic options are limited due to its natural resistance to most antibiotics, the development of new antimicrobial therapies is imperative. To identify drug targets and better understand the complex B. pseudomallei geno ...
D:\My Documents\WordPerfect\WordPerfect 8.0\2001Report
... diseases and their classification into Mendelian (those due to mutations in single genes), chromosomal (those due to chromosomal abnormalities), and multifactorial (those due to complex interactions between genetic and environmental factors) is retained, as was used in the earlier assessments of the ...
... diseases and their classification into Mendelian (those due to mutations in single genes), chromosomal (those due to chromosomal abnormalities), and multifactorial (those due to complex interactions between genetic and environmental factors) is retained, as was used in the earlier assessments of the ...
developmental genetics of the external genitalia
... are that highly conserved developmental genetic programs play a key role in morphogenesis of urethral canal. In a screen for genes expressed in tissues affected by hypospadias, we identified a growth factor receptor, FgfR2, that is expressed in the prepuce and urethral plate of mouse embryos. Moreov ...
... are that highly conserved developmental genetic programs play a key role in morphogenesis of urethral canal. In a screen for genes expressed in tissues affected by hypospadias, we identified a growth factor receptor, FgfR2, that is expressed in the prepuce and urethral plate of mouse embryos. Moreov ...
Leukaemia Section del (13q) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... (AML) and myeloproloferative disorders (MPD). The deletion is described as interstitial in most cases although a few cases of terminal deletion are reported. A survey of 640 patients with primary MDS showed that del(13q) was rare, and existed as the sole abnormality in 2 cases of refractory anaemia. ...
... (AML) and myeloproloferative disorders (MPD). The deletion is described as interstitial in most cases although a few cases of terminal deletion are reported. A survey of 640 patients with primary MDS showed that del(13q) was rare, and existed as the sole abnormality in 2 cases of refractory anaemia. ...
Testing Guidelines for molecular diagnosis of Cystic Fibrosis.
... insufficiency (Ratjen and Doring, 2003). The defective CFTR protein causes the exocrine pancreas to produce digestive enzymes with reduced volume and fluidity. However, Choi et al (2001) showed CFTR to play an important role in the regulation of other transporters, notably the chloride-bicarbonate a ...
... insufficiency (Ratjen and Doring, 2003). The defective CFTR protein causes the exocrine pancreas to produce digestive enzymes with reduced volume and fluidity. However, Choi et al (2001) showed CFTR to play an important role in the regulation of other transporters, notably the chloride-bicarbonate a ...
Mutations in Escherichiu coZi that Mutations Distant
... grow when replicated to glucose-minimal plates with indole and 5-methyltryptophan. In fact all of the valine-resistant transductants from strains ~ ~ 2 and 3 6 ~ ~ 2 grew 4 2 when replicated to such plates. This surprising result suggests that the mutations in strains ~ ~ 2 and 3 6 ~ ~ 2 are 4 2extr ...
... grow when replicated to glucose-minimal plates with indole and 5-methyltryptophan. In fact all of the valine-resistant transductants from strains ~ ~ 2 and 3 6 ~ ~ 2 grew 4 2 when replicated to such plates. This surprising result suggests that the mutations in strains ~ ~ 2 and 3 6 ~ ~ 2 are 4 2extr ...
Differential roles of TGIF family genes in mammalian reproduction Open Access
... Human TGIFLX and its orthologue, Tex1 in the mouse, are X-linked genes that are only expressed in the adult testis. TGIF2 arose from TGIF1 by duplication, whereas TGIFLX arose by retrotransposition to the X-chromosome. These genes have not been characterised in any non-eutherian mammals. We therefor ...
... Human TGIFLX and its orthologue, Tex1 in the mouse, are X-linked genes that are only expressed in the adult testis. TGIF2 arose from TGIF1 by duplication, whereas TGIFLX arose by retrotransposition to the X-chromosome. These genes have not been characterised in any non-eutherian mammals. We therefor ...
Turning floral organs into leaves, leaves into floral organs Koji Goto
... of the basic leaves. Thus, there should exist as yet unidentified factors required for this transformation or, alternatively, it might be that vegetative leaves are not the ‘basic organ’ from which the floral organs were derived. Recently, Honma and Goto [42••] found the missing factor by searching ...
... of the basic leaves. Thus, there should exist as yet unidentified factors required for this transformation or, alternatively, it might be that vegetative leaves are not the ‘basic organ’ from which the floral organs were derived. Recently, Honma and Goto [42••] found the missing factor by searching ...
Concept_Paper
... Genes are compact in genomic space. Introns are few, small and are not spliced in alternative forms. They comprise at most about a third of the transcribed DNA [from ref. 37]. This compactness is also evident in the related ciliate Paramecium, in which an 8- ...
... Genes are compact in genomic space. Introns are few, small and are not spliced in alternative forms. They comprise at most about a third of the transcribed DNA [from ref. 37]. This compactness is also evident in the related ciliate Paramecium, in which an 8- ...
- bioRxiv
... copy deletions is fundamental for better understanding of diseases that originate from gene copy number changes. In humans, reduction in gene dosage for many transcription factors leads to haploinsufficient developmental disorders [12]. Thus it is likely that genomic responses to alterations in gene ...
... copy deletions is fundamental for better understanding of diseases that originate from gene copy number changes. In humans, reduction in gene dosage for many transcription factors leads to haploinsufficient developmental disorders [12]. Thus it is likely that genomic responses to alterations in gene ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.