Familial nonrandom inactivation linked to the X inactivation
... out subsequent cell divisions and, by this process, the dosage of proteins encoded by genes on the X chromosome is equalised in males and females. The choice of which of the two X chromosomes is the active one is usually random. Although stochastic events may account for a less than equal distributi ...
... out subsequent cell divisions and, by this process, the dosage of proteins encoded by genes on the X chromosome is equalised in males and females. The choice of which of the two X chromosomes is the active one is usually random. Although stochastic events may account for a less than equal distributi ...
The Maize Genome Poster
... many spikes, the precursor to our familiar ear of corn. The small teosinte spikes had only two rows of nearly inedible kernels, or seeds, each enclosed by a hard covering. These seeds separated individually at maturity and were dispersed widely. In probably less than a thousand years, the tiny spike ...
... many spikes, the precursor to our familiar ear of corn. The small teosinte spikes had only two rows of nearly inedible kernels, or seeds, each enclosed by a hard covering. These seeds separated individually at maturity and were dispersed widely. In probably less than a thousand years, the tiny spike ...
Human cytochromes P450 in health and disease
... for mammalian P450 enzymes [19]—setting up a case for ‘animal–plant warfare’ being waged, and with P450 genes playing a central role [35]. A form of cytochrome P450 was proposed to be responsible for alveolar hypoxic pulmonary vasoconstriction in dogs [36]. P450-mediated peroxidation of acetaminophe ...
... for mammalian P450 enzymes [19]—setting up a case for ‘animal–plant warfare’ being waged, and with P450 genes playing a central role [35]. A form of cytochrome P450 was proposed to be responsible for alveolar hypoxic pulmonary vasoconstriction in dogs [36]. P450-mediated peroxidation of acetaminophe ...
Identification of Potential Corynebacterium ammoniagenes Purine
... (GMP), have been used as flavor-enhancing food additives. Corynebacterium ammoniagenes (C. ammoniagenes) is a Gram-positive coryneform bacterium used in the industrial production of metabolic compounds, including IMP and GMP purine nucleotides [7, 13]. The C. ammoniagenes strains used for the produc ...
... (GMP), have been used as flavor-enhancing food additives. Corynebacterium ammoniagenes (C. ammoniagenes) is a Gram-positive coryneform bacterium used in the industrial production of metabolic compounds, including IMP and GMP purine nucleotides [7, 13]. The C. ammoniagenes strains used for the produc ...
Parental Legacy Determines Methylation and Expression of an
... (Cattanach and Kirk, 1965; Cattanach, 1966; Searle and Beechey, 1976; Searle and Beechey, 1965; Solter, 1967; Surani, 1967). The implication of these studies is that both maternal and paternal contributions of specific chromosomal regions, and thus specific genes, are necessary for normal embryonic ...
... (Cattanach and Kirk, 1965; Cattanach, 1966; Searle and Beechey, 1976; Searle and Beechey, 1965; Solter, 1967; Surani, 1967). The implication of these studies is that both maternal and paternal contributions of specific chromosomal regions, and thus specific genes, are necessary for normal embryonic ...
The Comparison of Transcriptomes Undergoing Waterlogging at the
... under waterlogging stress. It is interesting to note that 3.1% of differentially expressed transcripts encode products that are involved in pathways related to cell-wall loosening enzymes. An additional 6.7% of the differentially expressed transcripts were predicted to encode enzymes related to prot ...
... under waterlogging stress. It is interesting to note that 3.1% of differentially expressed transcripts encode products that are involved in pathways related to cell-wall loosening enzymes. An additional 6.7% of the differentially expressed transcripts were predicted to encode enzymes related to prot ...
Control of Chromosome Pairing and Genome Evolution in Disomic
... form F2s, and a single F2 from each F1 was selfed to the F5 generation, and nine F5 plants from each synthetic allotetraploid were genotyped with 70 RFLP probes. An example of their results are shown in Fig. 1…why do the F2s sometimes differ from the parents? Why do the F5s sometimes differ from th ...
... form F2s, and a single F2 from each F1 was selfed to the F5 generation, and nine F5 plants from each synthetic allotetraploid were genotyped with 70 RFLP probes. An example of their results are shown in Fig. 1…why do the F2s sometimes differ from the parents? Why do the F5s sometimes differ from th ...
Detection of the Most Common Genetic Causes of
... genes/gene families, most of which are exclusively expressed in testises (Kuroda-Kawaguchi et al., 2001; Tilford et al., 2001, Scaletsky et al., 2003). An overlap of 1.5Mb between distal AZFb and proximal AZFc was also demonstrated (Repping et al., 2002). Ampliconic sequences make up almost all of t ...
... genes/gene families, most of which are exclusively expressed in testises (Kuroda-Kawaguchi et al., 2001; Tilford et al., 2001, Scaletsky et al., 2003). An overlap of 1.5Mb between distal AZFb and proximal AZFc was also demonstrated (Repping et al., 2002). Ampliconic sequences make up almost all of t ...
draft - IC
... Genome rearrangement, an evolutionary event where large, continuous pieces of the genome shu e around, has been studied since shortly after the very advent of genetics [1, 2, 3]. With the increased availability of whole genome sequences, gene order data have been used to estimate the evolutionary di ...
... Genome rearrangement, an evolutionary event where large, continuous pieces of the genome shu e around, has been studied since shortly after the very advent of genetics [1, 2, 3]. With the increased availability of whole genome sequences, gene order data have been used to estimate the evolutionary di ...
Could distal MSH2 upstream deletions cause HNPCC?
... The primer set for MSH2P4 is 10 kb upstream of MSH2 ...
... The primer set for MSH2P4 is 10 kb upstream of MSH2 ...
08_chapter 1
... property under evolutionary pressures. Moreover the actual symmetry levels in biological sequences were found to be lower and more variable than those obtained using statistical models. The phenomenon of strand symmetry has been conSIdered in the article as an outcome of the compound effects of a wi ...
... property under evolutionary pressures. Moreover the actual symmetry levels in biological sequences were found to be lower and more variable than those obtained using statistical models. The phenomenon of strand symmetry has been conSIdered in the article as an outcome of the compound effects of a wi ...
Selection of Suitable Endogenous Reference Genes for Relative
... phenotypes. Therefore, the method with high-throughput and with the capability to estimate high transgene copy numbers should be an ideal complementary to the other methods such as Southern blotting. To overcome those limitations, a fast, sensitive and effective method has been developed for estimat ...
... phenotypes. Therefore, the method with high-throughput and with the capability to estimate high transgene copy numbers should be an ideal complementary to the other methods such as Southern blotting. To overcome those limitations, a fast, sensitive and effective method has been developed for estimat ...
Adherin - Semantic Scholar
... acts directly on cohesin [17]. Recent chromatin immunoprecipitation experiments with scc2 mutants by Lengronne et al. [14] support this idea, because they indicate that cohesin loads at adherin binding sites and translocates away (Figure 1). Recent experiments with Xenopus egg extracts by Gillespie ...
... acts directly on cohesin [17]. Recent chromatin immunoprecipitation experiments with scc2 mutants by Lengronne et al. [14] support this idea, because they indicate that cohesin loads at adherin binding sites and translocates away (Figure 1). Recent experiments with Xenopus egg extracts by Gillespie ...
Leukaemia Section +21 or trisomy 21 Atlas of Genetics and Cytogenetics
... Acquired trisomy 21 is not to be confused with constitutional trisomy 21 (Down syndrome, DS) which is a factor of predisposition to childhood acute leukemia but whose significance and clinical context are quite different. ...
... Acquired trisomy 21 is not to be confused with constitutional trisomy 21 (Down syndrome, DS) which is a factor of predisposition to childhood acute leukemia but whose significance and clinical context are quite different. ...
Touring Ensembl: A practical guide to genome browsing Open Access
... valuable information is available, data can be difficult to access, compare and integrate due to different formats and presentations of web interfaces. This paper offers a practical guide to the integration of gene, comparative genomic, and functional genomics data using the Ensembl website at http: ...
... valuable information is available, data can be difficult to access, compare and integrate due to different formats and presentations of web interfaces. This paper offers a practical guide to the integration of gene, comparative genomic, and functional genomics data using the Ensembl website at http: ...
Ensembl Introduction
... • Joint project between EBI and Sanger • Funded primarily by the Wellcome Trust, additional funding by EMBL, NIH-NIAID, EU, BBSRC and MRC • Team of ca. 40 people, led by Ewan Birney (EBI) and Tim Hubbard (Sanger) ...
... • Joint project between EBI and Sanger • Funded primarily by the Wellcome Trust, additional funding by EMBL, NIH-NIAID, EU, BBSRC and MRC • Team of ca. 40 people, led by Ewan Birney (EBI) and Tim Hubbard (Sanger) ...
Gene Section (Drosophila). Atlas of Genetics and Cytogenetics
... and telomeric (45g21, yellow) of NKX2-5. (See below for map.) The rearrangement may be a simple insertion or, a double translocation whereby chromosome 14 material is first translocated onto the der(5) and then returned by a nonreciprocal copying process to the der(14) accompanied by genomic materia ...
... and telomeric (45g21, yellow) of NKX2-5. (See below for map.) The rearrangement may be a simple insertion or, a double translocation whereby chromosome 14 material is first translocated onto the der(5) and then returned by a nonreciprocal copying process to the der(14) accompanied by genomic materia ...
Stress Responsive Signal Transduction and the Control of Longevity Dirk Bohmann
... CncC activation protects from acute oxidative stress ...
... CncC activation protects from acute oxidative stress ...
Genetics of Skin Colour
... externally visible characteristics, including skin, hair and eye colour from DNA has important forensic implications. This information can be used, backed-up by legislation, to provide identifiable characteristics of perpetrators from DNA recovered from a crime scene. Such technology will also permi ...
... externally visible characteristics, including skin, hair and eye colour from DNA has important forensic implications. This information can be used, backed-up by legislation, to provide identifiable characteristics of perpetrators from DNA recovered from a crime scene. Such technology will also permi ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.