LECTURE 13: EPIGENETICS – IMPRINTING Reading: Ch. 18, p
... pronucleus and a paternally-derived pronucleus developed normally, but embryos from the fusion of two maternally-derived pronuclei or two maternally-derived pronuclei did not develop normally. The only possible genetic difference between males and females in this experiment was the sex chromosomes, ...
... pronucleus and a paternally-derived pronucleus developed normally, but embryos from the fusion of two maternally-derived pronuclei or two maternally-derived pronuclei did not develop normally. The only possible genetic difference between males and females in this experiment was the sex chromosomes, ...
SAB-2010
... Based on the SAB suggestions, the progress has been made towards the goal of extending the annotation of pathway databases in Cyc and Wiki versions in an automated way. However to do that approach we have to streamline the data workflow and structure the current curated gene database as a central re ...
... Based on the SAB suggestions, the progress has been made towards the goal of extending the annotation of pathway databases in Cyc and Wiki versions in an automated way. However to do that approach we have to streamline the data workflow and structure the current curated gene database as a central re ...
gene duplication in the evolution of sexual dimorphism
... of unbiased, male-biased, and female-biased expression for each gene as a way to understand expression variation. We compared how often expression patterns were similar between the Ayroles et al. (2009) and Wyman et al. (2010) datasets for duplicate versus singleton genes. If duplicates can be used ...
... of unbiased, male-biased, and female-biased expression for each gene as a way to understand expression variation. We compared how often expression patterns were similar between the Ayroles et al. (2009) and Wyman et al. (2010) datasets for duplicate versus singleton genes. If duplicates can be used ...
The Mitochondrial Genome of Chara vulgaris
... mtDNA exhibit more similarity to their Marchantia and/or angiosperm homologs than to their Chaetosphaeridium homologs. This finding is illustrated clearly in Figure 2, which reports the results of overall genome comparisons with MultiPipMaker (Schwartz et al., 2000). It can be seen that for many Cha ...
... mtDNA exhibit more similarity to their Marchantia and/or angiosperm homologs than to their Chaetosphaeridium homologs. This finding is illustrated clearly in Figure 2, which reports the results of overall genome comparisons with MultiPipMaker (Schwartz et al., 2000). It can be seen that for many Cha ...
network models for genetic testing
... ways to prevent complications, such as undergoing preventive surgery [15]; (iii) notifying people about treatment planning and options [11]; (iv) becoming eligible for screening [15]; (v) helping people make decisions about having children [11]; and (iv) enhancing the quality of life and increasing ...
... ways to prevent complications, such as undergoing preventive surgery [15]; (iii) notifying people about treatment planning and options [11]; (iv) becoming eligible for screening [15]; (v) helping people make decisions about having children [11]; and (iv) enhancing the quality of life and increasing ...
Allele Mining Strategies: Principles and Utilisation for Blast
... the entire rice genome will be used to identify genes conferring important traits in the rice germplasm and to determine the function of unidentified genes in general. Molecular breeding approaches continue to be utilised in many countries to improve resistant and high-yielding commercial rice culti ...
... the entire rice genome will be used to identify genes conferring important traits in the rice germplasm and to determine the function of unidentified genes in general. Molecular breeding approaches continue to be utilised in many countries to improve resistant and high-yielding commercial rice culti ...
The β-Globin LCR is Not Necessary for an Open Chromatin
... LCR vital to transcription and regulation of β-globin locus LCR is necessary for normal levels of β-globin transcription LCR properties resemble those of enhancers Determines that LCR provides contributory rather then dominant functions for its native location Regulatory sequences in addition to the ...
... LCR vital to transcription and regulation of β-globin locus LCR is necessary for normal levels of β-globin transcription LCR properties resemble those of enhancers Determines that LCR provides contributory rather then dominant functions for its native location Regulatory sequences in addition to the ...
Myriad--Ambry -- Final Version of Ambry Preliminary Injunction
... sequence similarity with any particular gene requires an application of detailed knowledge from the discovery of that gene’s structure.2 A genetic variant is a change in the gene sequence. Any change, even one nucleotide, can constitute a variant. Some variants are harmless, but some—termed “mutatio ...
... sequence similarity with any particular gene requires an application of detailed knowledge from the discovery of that gene’s structure.2 A genetic variant is a change in the gene sequence. Any change, even one nucleotide, can constitute a variant. Some variants are harmless, but some—termed “mutatio ...
Article The Pseudoautosomal Regions of the U/V Sex
... focused on organisms with diploid sexual chromosome systems (XY and ZW), whereas in a large number of taxa including many red, brown, and green algae, land plants and fungi, sex is determined during the haploid phase of the life cycle (UV systems; Bachtrog et al. 2011). Many of the theoretical predi ...
... focused on organisms with diploid sexual chromosome systems (XY and ZW), whereas in a large number of taxa including many red, brown, and green algae, land plants and fungi, sex is determined during the haploid phase of the life cycle (UV systems; Bachtrog et al. 2011). Many of the theoretical predi ...
The Rate and Tract Length of Gene Conversion between
... technical problem is that, in a simple experimental design with a single selected marker, an estimated rate may include both gene conversion and unequal crossing-over because they have an identical outcome. Such a rate cannot be fairly compared with an estimate from a more sophisticated experiment, ...
... technical problem is that, in a simple experimental design with a single selected marker, an estimated rate may include both gene conversion and unequal crossing-over because they have an identical outcome. Such a rate cannot be fairly compared with an estimate from a more sophisticated experiment, ...
Hemophilia A
... factor VIII gene are responsible for most cases of hemophilia A and only a small proportion of these mutations can be recognized by restriction endonuclease analysis, PCR and denaturing gradient gel electrophoresis (DGGE) were used to characterize single nucleotide substitutions. A GC clamp was at ...
... factor VIII gene are responsible for most cases of hemophilia A and only a small proportion of these mutations can be recognized by restriction endonuclease analysis, PCR and denaturing gradient gel electrophoresis (DGGE) were used to characterize single nucleotide substitutions. A GC clamp was at ...
Genetic balancers
... Maintenance of mutations is an important aspect of C. elegans genetics. Genetic strains carrying non-conditional recessive lethal mutations, at present the largest class of lethal, cannot be kept as homozygotes, and in heterozygotes the mutations can be lost easily through segregation unless there i ...
... Maintenance of mutations is an important aspect of C. elegans genetics. Genetic strains carrying non-conditional recessive lethal mutations, at present the largest class of lethal, cannot be kept as homozygotes, and in heterozygotes the mutations can be lost easily through segregation unless there i ...
Student Accomplishments for 2005 – 2006
... Genetic health status of the corn snake, Elaphe gutatta, an endangered species in New Jersey Tim Jarvela (Senior) Mentor: Dr. Amanda Norvell Development of a genetic screen in Drosophila melanogaster for identifying new genes that are required for the production of correctly formed eggs Jordan Kapla ...
... Genetic health status of the corn snake, Elaphe gutatta, an endangered species in New Jersey Tim Jarvela (Senior) Mentor: Dr. Amanda Norvell Development of a genetic screen in Drosophila melanogaster for identifying new genes that are required for the production of correctly formed eggs Jordan Kapla ...
Identification of genes involved in the same
... A milestone in molecular and computational biology has been reached with the sequencing of a complete human genome, marking the beginning of the post-genomic era (Venter et al., 2001). With a wealth of genomic sequence data now available from multiple species, the main goal in molecular and computat ...
... A milestone in molecular and computational biology has been reached with the sequencing of a complete human genome, marking the beginning of the post-genomic era (Venter et al., 2001). With a wealth of genomic sequence data now available from multiple species, the main goal in molecular and computat ...
IGA 8/e Chapter 4
... 12. The four classes of data correspond to the parentals (largest), two groups of single crossovers (intermediate), and double crossovers (smallest). 13. By comparing the parentals with the double crossovers, gene order can be determined. The gene in the middle flips with respect to the two flanking ...
... 12. The four classes of data correspond to the parentals (largest), two groups of single crossovers (intermediate), and double crossovers (smallest). 13. By comparing the parentals with the double crossovers, gene order can be determined. The gene in the middle flips with respect to the two flanking ...
Sequence of the Tribolium castaneum Homeotic Complex
... of the total sequence, only two of which contain any G/C. A total of 203 regions of low complexity, which are dispersed randomly throughout the contig, are predominantly A, T, or A/T rich and comprise 3.25% of the total sequence. Polymorphisms in Tribolium DNA: The sequences of Bmxp1 and 35E10 match ...
... of the total sequence, only two of which contain any G/C. A total of 203 regions of low complexity, which are dispersed randomly throughout the contig, are predominantly A, T, or A/T rich and comprise 3.25% of the total sequence. Polymorphisms in Tribolium DNA: The sequences of Bmxp1 and 35E10 match ...
Cluster Analysis in DNA Microarray Experiments
... • Clustering strengthens the signal when averages are taken within clusters of genes (Eisen et al., 1998). • Clustering can be helpful for identifying gene expression patterns in time or space. • Clustering is useful, perhaps essential, when seeking new subclasses of cell samples (tumors, etc). • Cl ...
... • Clustering strengthens the signal when averages are taken within clusters of genes (Eisen et al., 1998). • Clustering can be helpful for identifying gene expression patterns in time or space. • Clustering is useful, perhaps essential, when seeking new subclasses of cell samples (tumors, etc). • Cl ...
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... statistic of an SNP combination is defined by the number of times it is selected from all the training sets. The higher the CVC, the more robust the SNP combination as a predictive interaction model. By default, in this step, only those SNP combinations with CVCs.(K/2)/K are outputted as possible G6 ...
... statistic of an SNP combination is defined by the number of times it is selected from all the training sets. The higher the CVC, the more robust the SNP combination as a predictive interaction model. By default, in this step, only those SNP combinations with CVCs.(K/2)/K are outputted as possible G6 ...
CNS Tumors
... cancers of childhood, accounting for as many of 20% of all tumors • CNS tumors in childhood differ from those in adults both in histologic subtype and location • In childhood, tumors are likely to arise in the posterior fossa, while in adults they are mostly supratentorial ...
... cancers of childhood, accounting for as many of 20% of all tumors • CNS tumors in childhood differ from those in adults both in histologic subtype and location • In childhood, tumors are likely to arise in the posterior fossa, while in adults they are mostly supratentorial ...
A Comparative Genomic Analysis of Two Distant Diptera, the Fruit
... respectively; the map is accessible at http://www.anodb.gr/ AnoDB/Cytomap/). The binomial test is an exact probability test that is used to examine the distribution of a single dichotomy in conditions when only a relatively small sample is available, as is the case here. It provides a one-sample tes ...
... respectively; the map is accessible at http://www.anodb.gr/ AnoDB/Cytomap/). The binomial test is an exact probability test that is used to examine the distribution of a single dichotomy in conditions when only a relatively small sample is available, as is the case here. It provides a one-sample tes ...
recurrent episodes of acute pancreatitis in a cystic fibrosis carrier
... fibrosis) or pancreas specific injury or can be a part of a more complex trait.(8,9,10) In early onset idiopathic pancreatitis, this factor may be a heterozygous SPINK1 mutation but stronger environmental factors such as alcoholism and smoking may be causative.(5) In adult population, presenting sym ...
... fibrosis) or pancreas specific injury or can be a part of a more complex trait.(8,9,10) In early onset idiopathic pancreatitis, this factor may be a heterozygous SPINK1 mutation but stronger environmental factors such as alcoholism and smoking may be causative.(5) In adult population, presenting sym ...
Clinical and molecular genetic examinations of patients with
... Distinction of between the complete and incomplete forms of achromatopsia Psychophysical test were suitable to distinguish the complete and incomplete forms of the disease during clinical examinations. Using spectral luminosity testing and relative brightness matching we were able to detect some re ...
... Distinction of between the complete and incomplete forms of achromatopsia Psychophysical test were suitable to distinguish the complete and incomplete forms of the disease during clinical examinations. Using spectral luminosity testing and relative brightness matching we were able to detect some re ...
BMC Developmental Biology
... However, the influence of Eya3 on developmental processes in mice and other mammals is rather unknown. Invitro experiments showed that Eya3 is important for cellautonomous proliferation of murine myoblast C2C12 cells [17]. In addition, studies in Xenopus revealed a strong influence of the Eya3 homol ...
... However, the influence of Eya3 on developmental processes in mice and other mammals is rather unknown. Invitro experiments showed that Eya3 is important for cellautonomous proliferation of murine myoblast C2C12 cells [17]. In addition, studies in Xenopus revealed a strong influence of the Eya3 homol ...
Multiple Barriers to Nonhomologous DNA End Joining
... construction of a new double mutant stock and observed a similar suppression in g-H2AV persistence (P , 0.0001, Figure 2). In contrast, mei-218; spn-A double mutants exhibited similar levels of persistent g-H2AV foci to that of spn-A single mutants (P = 0.2841), indicating mei-218 mutants retain the ...
... construction of a new double mutant stock and observed a similar suppression in g-H2AV persistence (P , 0.0001, Figure 2). In contrast, mei-218; spn-A double mutants exhibited similar levels of persistent g-H2AV foci to that of spn-A single mutants (P = 0.2841), indicating mei-218 mutants retain the ...
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... A YEp13-based high-copy-number genomic library was introduced into the Sir4C-overexpressing strain, and transformants were screened for red sectoring, indicative of ADE2 repression. Screening of 5.0 3 103 transformants identified 30 sectored transformants, each carrying a different plasmid. Only one ...
... A YEp13-based high-copy-number genomic library was introduced into the Sir4C-overexpressing strain, and transformants were screened for red sectoring, indicative of ADE2 repression. Screening of 5.0 3 103 transformants identified 30 sectored transformants, each carrying a different plasmid. Only one ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.