Polymorphisms in Multiple Genes Contribute to the
... contributed to the high petite frequency of S288C and its derivatives by increasing the formation of petite colonies. By contrast, the S288C allele of MKT1 reduced the formation of petite colonies and compromised the growth of petite cells. The former three alleles were found in the EM93 strain, the ...
... contributed to the high petite frequency of S288C and its derivatives by increasing the formation of petite colonies. By contrast, the S288C allele of MKT1 reduced the formation of petite colonies and compromised the growth of petite cells. The former three alleles were found in the EM93 strain, the ...
Attanasio et al.
... Severe atrophy was the most notable pathogenic feature of the renal phenotype in Glis2lacZ/lacZ mutant mice. Therefore, we performed a TUNEL assay to test for apoptosis. At 4 weeks after birth, significant apoptosis was apparent throughout the renal tubules in homozygous Glis2lacZ/lacZ mice but not ...
... Severe atrophy was the most notable pathogenic feature of the renal phenotype in Glis2lacZ/lacZ mutant mice. Therefore, we performed a TUNEL assay to test for apoptosis. At 4 weeks after birth, significant apoptosis was apparent throughout the renal tubules in homozygous Glis2lacZ/lacZ mice but not ...
Toward a therapy for mitochondrial disease
... other components of vitamin B3. Nicotinic acid, for instance, although effectively increasing mitochondrial biogenesis, induces flushing by activation of GPR109A receptor, which is not stimulated by NR [16], while nicotinamide has been reported as an inhibitor of histone deacetylases, including sirtu ...
... other components of vitamin B3. Nicotinic acid, for instance, although effectively increasing mitochondrial biogenesis, induces flushing by activation of GPR109A receptor, which is not stimulated by NR [16], while nicotinamide has been reported as an inhibitor of histone deacetylases, including sirtu ...
Inferring gene-to-phenotype and gene-to
... Results: Using this algorithm derived gene-to-phenotype and gene-to-disease annotations were created for 16,000 and 2100 mouse markers, respectively, starting from over 57,900 and 4800 genotypes with at least one phenotype and disease annotation, respectively. Conclusions: Implementation of this alg ...
... Results: Using this algorithm derived gene-to-phenotype and gene-to-disease annotations were created for 16,000 and 2100 mouse markers, respectively, starting from over 57,900 and 4800 genotypes with at least one phenotype and disease annotation, respectively. Conclusions: Implementation of this alg ...
Genetic Counseling and Testing for FMR1 Gene Mutations: Practice
... Toledano-Alhadef et al. 2001; Seltzer et al. 2012), while the rate in males ranges from 1/468 to 1/813 (Dombrowski et al. 2002; Seltzer et al. 2012). Intermediate alleles are observed in approximately 1/35 to 1/57 females (Cronister et al. 2008; Seltzer et al. 2012) and are often coincidentally iden ...
... Toledano-Alhadef et al. 2001; Seltzer et al. 2012), while the rate in males ranges from 1/468 to 1/813 (Dombrowski et al. 2002; Seltzer et al. 2012). Intermediate alleles are observed in approximately 1/35 to 1/57 females (Cronister et al. 2008; Seltzer et al. 2012) and are often coincidentally iden ...
Epigenetic and genetic factors affect transgene
... phenotype giving rise to offspring with either the low or intermediate phenotype; and those sires with the high somatic phenotype giving rise to offspring with either the high or the intermediate phenotype. Which of the phenotypes appears among their progeny is dependent on the inbred strain backgro ...
... phenotype giving rise to offspring with either the low or intermediate phenotype; and those sires with the high somatic phenotype giving rise to offspring with either the high or the intermediate phenotype. Which of the phenotypes appears among their progeny is dependent on the inbred strain backgro ...
Neutral and Non-Neutral Evolution of Duplicated Genes with Gene
... event itself. There are many possible situations where gene conversion is selectively preferred or disfavored, but most cases can be theoretically handled by two simple forms of selection. To explain the evolutionary dynamics with selection in the framework of population genetics, we here consider a ...
... event itself. There are many possible situations where gene conversion is selectively preferred or disfavored, but most cases can be theoretically handled by two simple forms of selection. To explain the evolutionary dynamics with selection in the framework of population genetics, we here consider a ...
sacB - GENI
... The framework enables integration of many techniques and genetic principles Bioinformatics (from simple BLAST through programming) Auxotrophy vs. prototrophy; Epistasis Basic molecular techniques such as PCR, cloning, selection, restriction endonuclease mapping, etc. Gene induction and regul ...
... The framework enables integration of many techniques and genetic principles Bioinformatics (from simple BLAST through programming) Auxotrophy vs. prototrophy; Epistasis Basic molecular techniques such as PCR, cloning, selection, restriction endonuclease mapping, etc. Gene induction and regul ...
Leukaemia Section t(3;12)(q26;p13) ETV6/MECOM / t(3;12)(q26;p13) ETV6/EVI1 Atlas of Genetics and Cytogenetics
... The ETV6 protein (452 amino acids) contains two major domains, the HLH (helix-loop-helix) and ETS domains. The HLH domain, also referred to as the pointed or sterile alpha motif domain, is encoded by exons 3 and 4 and functions as a homooligodimerization domain. The ETS domain, encoded by exons 6 th ...
... The ETV6 protein (452 amino acids) contains two major domains, the HLH (helix-loop-helix) and ETS domains. The HLH domain, also referred to as the pointed or sterile alpha motif domain, is encoded by exons 3 and 4 and functions as a homooligodimerization domain. The ETS domain, encoded by exons 6 th ...
A Twist-like bHLH gene is a downstream factor of an
... 2002). In the present study, we use the term ‘mesenchyme’ for all of these cells, except where indicated otherwise. In addition to these three lineages of mesenchymal cells, ascidian larvae develop trunk ventral cells (TVCs), which are often regarded as a kind of mesenchymal cell because they give r ...
... 2002). In the present study, we use the term ‘mesenchyme’ for all of these cells, except where indicated otherwise. In addition to these three lineages of mesenchymal cells, ascidian larvae develop trunk ventral cells (TVCs), which are often regarded as a kind of mesenchymal cell because they give r ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... Abstract: Orofacial cleft is one of the most significant birth defects across the globe. The focus of this work is to highlight the most recent advances in understanding of cleft lip and palate occurrence. Information regarding research on long time outcomes, genes, and their interactions with other ...
... Abstract: Orofacial cleft is one of the most significant birth defects across the globe. The focus of this work is to highlight the most recent advances in understanding of cleft lip and palate occurrence. Information regarding research on long time outcomes, genes, and their interactions with other ...
Adaptive Evolution of Proteins Secreted during Sperm Maturation
... Another potential signature of adaptive evolution in reproductive genes is their preferential location on the X chromosome (Vicoso and Charlesworth 2006). Genes with male-specific benefits are expected to accumulate on the X chromosome, especially if those same genes confer a cost in females (Rice 1 ...
... Another potential signature of adaptive evolution in reproductive genes is their preferential location on the X chromosome (Vicoso and Charlesworth 2006). Genes with male-specific benefits are expected to accumulate on the X chromosome, especially if those same genes confer a cost in females (Rice 1 ...
A genome-wide analysis of DNA methylation in buccal - VU-DARE
... restricting to the most variable CpG sites (for the top 10% CpGs of which methylation level varied most between subjects, the average heritability was 37%) 34. It was also found that gene body and intergenic regions showed higher average methylation levels, more variation between subjects, and highe ...
... restricting to the most variable CpG sites (for the top 10% CpGs of which methylation level varied most between subjects, the average heritability was 37%) 34. It was also found that gene body and intergenic regions showed higher average methylation levels, more variation between subjects, and highe ...
Get
... Why genetics for my students? • Will it change anything? • Knowledge of genes role in diseases • Immediately ~ still woke up and had cornflakes the next day • Short term • Long term ...
... Why genetics for my students? • Will it change anything? • Knowledge of genes role in diseases • Immediately ~ still woke up and had cornflakes the next day • Short term • Long term ...
GIN Transposons: Genetic Elements Linking Retrotransposons and
... to establish that they ended in characteristic 40- to 111-bplong terminal inverted repeats. These inverted repeats are element specific; their sizes and sequences are different for each of the four elements (table 1). Second, as is also typical in DNA transposons, direct duplications caused by the i ...
... to establish that they ended in characteristic 40- to 111-bplong terminal inverted repeats. These inverted repeats are element specific; their sizes and sequences are different for each of the four elements (table 1). Second, as is also typical in DNA transposons, direct duplications caused by the i ...
Increasing the denaturation temperature during the first cycles of
... sometimes occurs with conventional PCR, often because of size differences in the amplified fragments (Walsh et al., 1992), random ADO has not been reported with non-limiting target DNA. It seems likely, therefore, that ADO is specific for single cell PCR or at least very low target copy number. With ...
... sometimes occurs with conventional PCR, often because of size differences in the amplified fragments (Walsh et al., 1992), random ADO has not been reported with non-limiting target DNA. It seems likely, therefore, that ADO is specific for single cell PCR or at least very low target copy number. With ...
Increasing the denaturation temperature during the first cycles of
... sometimes occurs with conventional PCR, often because of size differences in the amplified fragments (Walsh et al., 1992), random ADO has not been reported with non-limiting target DNA. It seems likely, therefore, that ADO is specific for single cell PCR or at least very low target copy number. With ...
... sometimes occurs with conventional PCR, often because of size differences in the amplified fragments (Walsh et al., 1992), random ADO has not been reported with non-limiting target DNA. It seems likely, therefore, that ADO is specific for single cell PCR or at least very low target copy number. With ...
Arabidopsis thaliana: A Model Plant for Genome Analysis
... play in understanding basic principles of biology relevant to a variety of species, including humans. The emergence of a large, multinational research community devoted to the complete analysis of a single plant represents a dramatic paradigm shift for plant biology. Traditionally, advances in our u ...
... play in understanding basic principles of biology relevant to a variety of species, including humans. The emergence of a large, multinational research community devoted to the complete analysis of a single plant represents a dramatic paradigm shift for plant biology. Traditionally, advances in our u ...
genetic studies of the human complement c4 region in mhc class iii
... the converted C4 gene, it was screened for mutations. No prominent mutations were found that would conclusively explain the loss of gene function. However, 25 novel nucleotide alterations were revealed bringing substantiation for the vast polymorphism of the C4 genes. The identification of structura ...
... the converted C4 gene, it was screened for mutations. No prominent mutations were found that would conclusively explain the loss of gene function. However, 25 novel nucleotide alterations were revealed bringing substantiation for the vast polymorphism of the C4 genes. The identification of structura ...
The Mean Between Meme and Gene Comparison
... fundamental differences between memes and genes , such as their defining units, relationship to one another, and expression, is ultimately too difficult to reconcile.. Dennett cites variation, heredity or replication, and “differential fitness” as the conditions of evolution and supports Dawkin’s cl ...
... fundamental differences between memes and genes , such as their defining units, relationship to one another, and expression, is ultimately too difficult to reconcile.. Dennett cites variation, heredity or replication, and “differential fitness” as the conditions of evolution and supports Dawkin’s cl ...
Developmental and genetic disorders in
... (KAL-1) (Figure 2). KAL-1 is deleted in ~50% of the patients with the Xp22 contiguous gene syndrome, causing a primary deficiency in GnRH production. Patients lacking GnRH are hypogonadal and fail to produce spermatozoa. Translocations of X-chromosome genes to autosomes and the Y chromosome. Translo ...
... (KAL-1) (Figure 2). KAL-1 is deleted in ~50% of the patients with the Xp22 contiguous gene syndrome, causing a primary deficiency in GnRH production. Patients lacking GnRH are hypogonadal and fail to produce spermatozoa. Translocations of X-chromosome genes to autosomes and the Y chromosome. Translo ...
The gene responsible for Clouston hidrotic
... 21 was unexpected. However, not all keratin genes have been mapped and the HED locus could still correspond to an unlocalized keratin. Another hypothesis has been proposed to explain all types of ectodermal dysplasias, including HED, where the disease is caused by a disturbed mesoderm–ectoderm inter ...
... 21 was unexpected. However, not all keratin genes have been mapped and the HED locus could still correspond to an unlocalized keratin. Another hypothesis has been proposed to explain all types of ectodermal dysplasias, including HED, where the disease is caused by a disturbed mesoderm–ectoderm inter ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.