Review Game
... • This is the most common lethal genetic disease in the United States that causes an over secretion of a thick mucus that clogs the respiratory passages and puts the child at risk for fatal respiratory infections. ...
... • This is the most common lethal genetic disease in the United States that causes an over secretion of a thick mucus that clogs the respiratory passages and puts the child at risk for fatal respiratory infections. ...
Participation of the proteasomal lid subunit Rpn11 in mitochondrial
... obtained from EUROSCARF (European Saccharomyces cerevisiae Archive for Functional Analysis; Institut für Mikrobiologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany), and was used to generate haploid strains to study complementation of rpn11 null. In brief, the diploid strain was ...
... obtained from EUROSCARF (European Saccharomyces cerevisiae Archive for Functional Analysis; Institut für Mikrobiologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany), and was used to generate haploid strains to study complementation of rpn11 null. In brief, the diploid strain was ...
EIN4 and ERS2 Are Members of the Putative Ethylene Receptor
... yeast osmolarity sensing pathway (Maeda et al., 1994). Alternately, the ethylene receptors could interact directly with CTR1 (Clark et al., 1998). EIN3 acts downstream of ETR1 and CTR1. It encodes a novel nuclear-localized protein and probably is involved in transcriptional regulation (Chao et al., ...
... yeast osmolarity sensing pathway (Maeda et al., 1994). Alternately, the ethylene receptors could interact directly with CTR1 (Clark et al., 1998). EIN3 acts downstream of ETR1 and CTR1. It encodes a novel nuclear-localized protein and probably is involved in transcriptional regulation (Chao et al., ...
Forkhead Transcription Factors: Key Players in Development and
... and mode of DNA recognition within the forkhead family. This has been confirmed by NMR structural analysis of the DNA binding domains of three additional forkhead proteins: FOXC2, Foxd3, and FOXO4 (Jin et al., 1999; Marsden et al., 1998; van Dongen et al., 2000; Weigelt et al., 2001). While Clark et ...
... and mode of DNA recognition within the forkhead family. This has been confirmed by NMR structural analysis of the DNA binding domains of three additional forkhead proteins: FOXC2, Foxd3, and FOXO4 (Jin et al., 1999; Marsden et al., 1998; van Dongen et al., 2000; Weigelt et al., 2001). While Clark et ...
Unsaturated Fatty Acids, Desaturases, and Human Health
... fatty acids (MUFA). MUFA is mostly catalyzed by stearoyl-CoA desaturase (SCD, delta-9 desaturase). SCD helps the introduction of a double bond at the ninth carbon-carbon bond from the carboxylic end in stearic acid (18:0) to generate oleic acid (18:1n-9). In addition, palmitoleic acid (16:1n-7) can ...
... fatty acids (MUFA). MUFA is mostly catalyzed by stearoyl-CoA desaturase (SCD, delta-9 desaturase). SCD helps the introduction of a double bond at the ninth carbon-carbon bond from the carboxylic end in stearic acid (18:0) to generate oleic acid (18:1n-9). In addition, palmitoleic acid (16:1n-7) can ...
Evolutionary history of the genus Capra
... Y-chromosome is a useful molecule for phylogenetic studies. This sex chromosome is paternally inherited and, with the exception of the pseudoautosomal region, it does not undergo homologous recombination at meiosis. Y-chromosome and mitochondrial DNA give independent and complementary information. S ...
... Y-chromosome is a useful molecule for phylogenetic studies. This sex chromosome is paternally inherited and, with the exception of the pseudoautosomal region, it does not undergo homologous recombination at meiosis. Y-chromosome and mitochondrial DNA give independent and complementary information. S ...
Fulltext PDF - Indian Academy of Sciences
... Origin and roles of DNA methylation patterns mutations and various types of extended addition–deletion mutations). Sites of cytosine methylations are themselves hotspots for occurrence of mutations. The cytosine methylation and histone modification marks amplify the genetic variation manifold epigen ...
... Origin and roles of DNA methylation patterns mutations and various types of extended addition–deletion mutations). Sites of cytosine methylations are themselves hotspots for occurrence of mutations. The cytosine methylation and histone modification marks amplify the genetic variation manifold epigen ...
A Complex Suite of Forces Drives Gene Traffic from Drosophila X
... A Complex Suite of Forces Drives Gene Traffic from Drosophila X Chromosomes Richard P. Meisel,* Mira V. Han,à and Matthew W. Hahnৠ*Department of Biology and Graduate Program in Genetics, The Pennsylvania State University; Department of Molecular Biology and Evolution, Cornell University; àSchool ...
... A Complex Suite of Forces Drives Gene Traffic from Drosophila X Chromosomes Richard P. Meisel,* Mira V. Han,à and Matthew W. Hahnৠ*Department of Biology and Graduate Program in Genetics, The Pennsylvania State University; Department of Molecular Biology and Evolution, Cornell University; àSchool ...
Reference genome sequence of the model plant Setaria
... Other element classes, such as long interspersed nuclear elements (LINEs) and most DNA elements, are rare in the pericentromeric regions. A notable exception is the CACTA family of DNA elements that, as in maize30, is found at fairly even distribution across all genomic regions. Using the standard L ...
... Other element classes, such as long interspersed nuclear elements (LINEs) and most DNA elements, are rare in the pericentromeric regions. A notable exception is the CACTA family of DNA elements that, as in maize30, is found at fairly even distribution across all genomic regions. Using the standard L ...
ppt - Chair of Computational Biology
... The analysis suggests that chromosomal breaks may have a tendency to reoccur in certain regions. With only two species, however, it is not yet possible to recover the ancestral chromosomal order or reconstruct the precise pathway of rearrangements. This will become possible in short time as more and ...
... The analysis suggests that chromosomal breaks may have a tendency to reoccur in certain regions. With only two species, however, it is not yet possible to recover the ancestral chromosomal order or reconstruct the precise pathway of rearrangements. This will become possible in short time as more and ...
PDF
... have not so far been studied. The phenotypes of other sex-linked heterozygotes discussed here (tabby, striated) are quite unlike those of the chimeras for colour genes, but no adequate descriptions of chimeras for genes for coat structure are yet available for comparison. On the other hand, the phen ...
... have not so far been studied. The phenotypes of other sex-linked heterozygotes discussed here (tabby, striated) are quite unlike those of the chimeras for colour genes, but no adequate descriptions of chimeras for genes for coat structure are yet available for comparison. On the other hand, the phen ...
Threshold phenomena versus cell heredity in the
... have not so far been studied. The phenotypes of other sex-linked heterozygotes discussed here (tabby, striated) are quite unlike those of the chimeras for colour genes, but no adequate descriptions of chimeras for genes for coat structure are yet available for comparison. On the other hand, the phen ...
... have not so far been studied. The phenotypes of other sex-linked heterozygotes discussed here (tabby, striated) are quite unlike those of the chimeras for colour genes, but no adequate descriptions of chimeras for genes for coat structure are yet available for comparison. On the other hand, the phen ...
TP53 mutations occur in 15.7% of ALL and are associated with MYC
... mutations has only rarely been studied in ALL thus far. Mutations in or deletion of TP53 are generally associated with advanced stages of disease,7 insufficient response to therapy,8,9 and a poor prognosis.10,11 TP53 is a transcription factor and functions as key tumor suppressor and master regulator ...
... mutations has only rarely been studied in ALL thus far. Mutations in or deletion of TP53 are generally associated with advanced stages of disease,7 insufficient response to therapy,8,9 and a poor prognosis.10,11 TP53 is a transcription factor and functions as key tumor suppressor and master regulator ...
Lecture 10: Control of gene expression
... A group of genes that are regulated together and are closely linked to each other is called an operon Genes of the same operon are transcribed together as a polycistronic (= polygenic) mRNA Lac operon is located at 8 min of the E. coli chromosome map. It contains three genes lacZ, lacY and lacA. The ...
... A group of genes that are regulated together and are closely linked to each other is called an operon Genes of the same operon are transcribed together as a polycistronic (= polygenic) mRNA Lac operon is located at 8 min of the E. coli chromosome map. It contains three genes lacZ, lacY and lacA. The ...
Oncogenic potential of the DNA replication licensing protein
... cellular DNA upstream of the retroviral insertion site. Genomic DNA from EB-PE cells was digested with SphI and DNA ranged from 2 ± 4 kb was excised from the agarose gel and eluted. DNA was then ligated intramolecularly and digested with either EcoRI (upstream) or HindIII (downstream). The ¯anking D ...
... cellular DNA upstream of the retroviral insertion site. Genomic DNA from EB-PE cells was digested with SphI and DNA ranged from 2 ± 4 kb was excised from the agarose gel and eluted. DNA was then ligated intramolecularly and digested with either EcoRI (upstream) or HindIII (downstream). The ¯anking D ...
Genome Biology - Institute for Applied Ecology
... for compensated and non-compensated genes in each tissue were unexpected if the genes were drawn at random from the set of all Z genes (p<0.02 in each case). The level of expression of Z genes in each tissue in males was significantly positively correlated with the M:F ratio of Z genes (Pearson corr ...
... for compensated and non-compensated genes in each tissue were unexpected if the genes were drawn at random from the set of all Z genes (p<0.02 in each case). The level of expression of Z genes in each tissue in males was significantly positively correlated with the M:F ratio of Z genes (Pearson corr ...
Patterns of Segmental Duplication in the Human Genome
... except for pericentromeric and subtelomeric regions (see the definition used in Bailey et al. [2001]). For each region, we calculated the duplication-enrichment index, which is defined as the ratio of the observed percentage of duplications in the region to the percentage of duplications in the enti ...
... except for pericentromeric and subtelomeric regions (see the definition used in Bailey et al. [2001]). For each region, we calculated the duplication-enrichment index, which is defined as the ratio of the observed percentage of duplications in the region to the percentage of duplications in the enti ...
Targeted gene inactivation in Clostridium phytofermentans shows
... containing either glucose, cellobiose, or hemicellulose xylan as the sole carbon source. As expected, wild-type and AT02-1 showed similar growth rates on glucose (Fig 4A). The comparable growth rates of wild-type and AT02-1 on cellobiose (Fig 4B) supports that the glucanase activity of the Cphy3367 ...
... containing either glucose, cellobiose, or hemicellulose xylan as the sole carbon source. As expected, wild-type and AT02-1 showed similar growth rates on glucose (Fig 4A). The comparable growth rates of wild-type and AT02-1 on cellobiose (Fig 4B) supports that the glucanase activity of the Cphy3367 ...
The Tel-PDGFRß fusion gene produces a chronic
... associated with the chronic myeloproliferative syndromes suggests that they, too, are pre-leukemic states. In both syndromes, the dysregulation of hematopoiesis predisposes to leukemia. Investigation of possible mechanisms of this dysregulation might elucidate early events in leukemogenesis. Chronic ...
... associated with the chronic myeloproliferative syndromes suggests that they, too, are pre-leukemic states. In both syndromes, the dysregulation of hematopoiesis predisposes to leukemia. Investigation of possible mechanisms of this dysregulation might elucidate early events in leukemogenesis. Chronic ...
Complete Thyroxine-Binding Globulin (TBG) Deficiency Produced
... mRNA. TBG mRNA is transcribed in liver and therefore is not readily accessible for sampling. We attempted illegitimate amplification of TBG mRNA from peripheral blood leukocytes, as previously accomplished for the TSH receptor and other mRNA (14), and failed on several attempts, though the extracted ...
... mRNA. TBG mRNA is transcribed in liver and therefore is not readily accessible for sampling. We attempted illegitimate amplification of TBG mRNA from peripheral blood leukocytes, as previously accomplished for the TSH receptor and other mRNA (14), and failed on several attempts, though the extracted ...
Faculty Details proforma for DU Web-site Title First Name
... Masanao Murakami, Rajeev Kaul, and Erle S Robertson. 2008. MTA1 expression linked to ovarian cancer. Cancer Biology and Therapy. 2008 Sep (9): 1468-1470 Masanao Murakami, Rajeev Kaul, Pankaj Kumar and Erle S Robertson. 2009. Nucleoside Diphosphate Kinase/Nm23 and Epstein Barr Virus. Molecular and Ce ...
... Masanao Murakami, Rajeev Kaul, and Erle S Robertson. 2008. MTA1 expression linked to ovarian cancer. Cancer Biology and Therapy. 2008 Sep (9): 1468-1470 Masanao Murakami, Rajeev Kaul, Pankaj Kumar and Erle S Robertson. 2009. Nucleoside Diphosphate Kinase/Nm23 and Epstein Barr Virus. Molecular and Ce ...
Families of SMA - Children with Spinal Muscular Atrophy
... Two SMN1 copies on one chromosome and none on other Frequency ~8% of people not affected with SMA We have seen 1 case with 2 copies in blood and <2 copies in sperm Resolve new mutation from 2+0 by linkage analysis If new mutation, test father’s sperm for mosaicism ...
... Two SMN1 copies on one chromosome and none on other Frequency ~8% of people not affected with SMA We have seen 1 case with 2 copies in blood and <2 copies in sperm Resolve new mutation from 2+0 by linkage analysis If new mutation, test father’s sperm for mosaicism ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.