Educator Materials
... Constitutive pigmentation, or the pigmentation we are born with, is a polygenic trait, and many of the genes involved have been identified. These genes code for the enzymes that affect melanin synthesis and for the packaging, distribution, and degradation of melanosomes. Mutations in some of these g ...
... Constitutive pigmentation, or the pigmentation we are born with, is a polygenic trait, and many of the genes involved have been identified. These genes code for the enzymes that affect melanin synthesis and for the packaging, distribution, and degradation of melanosomes. Mutations in some of these g ...
Biology 164 Laboratory Genetic Mutants of the Prodigiosin
... Study of Biochemical Pathways The method for studying the genetic control of biochemical pathways is quite simple once the underlying principles are understood. The wild-type strain (prototroph) of the organism is able to produce the end product of the biochemical pathway being studied. The pathway ...
... Study of Biochemical Pathways The method for studying the genetic control of biochemical pathways is quite simple once the underlying principles are understood. The wild-type strain (prototroph) of the organism is able to produce the end product of the biochemical pathway being studied. The pathway ...
Recruitment of 5! Hoxa genes in the allantois is
... labyrinthine vasculature The early and transient co-expression of 5⬘Hoxa genes suggests that the precocious vascular defect in HoxAdel/del placenta, when compared with the single Hoxa13 loss of function, is due to the combined 5⬘Hoxa inactivation in the allantois and/or nascent chorio-allantoic in ...
... labyrinthine vasculature The early and transient co-expression of 5⬘Hoxa genes suggests that the precocious vascular defect in HoxAdel/del placenta, when compared with the single Hoxa13 loss of function, is due to the combined 5⬘Hoxa inactivation in the allantois and/or nascent chorio-allantoic in ...
DNA methylation controls histone H3 lysine 9 methylation
... Fig. 2. Location of repetitive and single-copy sequences in leaf interphase nuclei. (A) Sequences corresponding to the 180 bp centromeric pAL repeat (red) are always located at chromocenters. Sequences corresponding to the pericentromeric BAC F28D6 (green) are located at chromocenters in wild type, ...
... Fig. 2. Location of repetitive and single-copy sequences in leaf interphase nuclei. (A) Sequences corresponding to the 180 bp centromeric pAL repeat (red) are always located at chromocenters. Sequences corresponding to the pericentromeric BAC F28D6 (green) are located at chromocenters in wild type, ...
Martina Šeruga Musić, Mladen Krajačić, Dijana Škorić
... Single-strand conformation polymorphism (SSCP) analysis is a broadly used relatively simple technique for detecting mutations. The aim of this work was to evaluate the applicability of SSCP analysis as a new tool for detection of phytoplasma molecular variability. Seventy phytoplasma isolates from g ...
... Single-strand conformation polymorphism (SSCP) analysis is a broadly used relatively simple technique for detecting mutations. The aim of this work was to evaluate the applicability of SSCP analysis as a new tool for detection of phytoplasma molecular variability. Seventy phytoplasma isolates from g ...
Abdominal Aortic Aneurysms(AAA)
... MYH11 - Account for 2% of non-syndromic TAAD. - Heterozygous MYH11 mutations result in thoracic aortic aneurysms and are thought to act via a dominant negative mechanism with wild-type MYH11. ...
... MYH11 - Account for 2% of non-syndromic TAAD. - Heterozygous MYH11 mutations result in thoracic aortic aneurysms and are thought to act via a dominant negative mechanism with wild-type MYH11. ...
Manipulating the Plasmodium Genome
... Abstract Genome manipulation, the primary tool for assigning function to sequence, will be essential for understanding Plasmodium biology and malaria pathogenesis in molecular terms. The first success in transfecting Plasmodium was reported almost ten years ago. Genetargeting studies have since flou ...
... Abstract Genome manipulation, the primary tool for assigning function to sequence, will be essential for understanding Plasmodium biology and malaria pathogenesis in molecular terms. The first success in transfecting Plasmodium was reported almost ten years ago. Genetargeting studies have since flou ...
Table 3 - HAL Descartes
... demyelinating neuropathy-Central dysmyelinating leukodystrophy-Waardenburg syndromeHirschsprung disease) 57. This more severe disease is mostly due to mutations in the last coding exon of SOX10 and has been proposed to occur when the mutant mRNAs escape the non-sense RNA decay (NMD) pathway 57. Howe ...
... demyelinating neuropathy-Central dysmyelinating leukodystrophy-Waardenburg syndromeHirschsprung disease) 57. This more severe disease is mostly due to mutations in the last coding exon of SOX10 and has been proposed to occur when the mutant mRNAs escape the non-sense RNA decay (NMD) pathway 57. Howe ...
Identification of lineage-specific zygotic transcripts in early
... these conditions, many array spots, including all high abundance maternal mRNAs, were oversaturated, whereas the signals from a number of known low abundance transcripts were rendered detectable. Normalization of microarray data Our hybridization conditions resulted in oversaturation of highly abund ...
... these conditions, many array spots, including all high abundance maternal mRNAs, were oversaturated, whereas the signals from a number of known low abundance transcripts were rendered detectable. Normalization of microarray data Our hybridization conditions resulted in oversaturation of highly abund ...
Premature stop codons involved in muscular dystrophies
... offer an attractive option. In particular, pharmacological approaches aimed at modification of gene expression, rather than the gene itself, constitute an ideal strategy for a subset of genetic diseases in which the molecular defect is known and can be circumvented. This is the case for premature st ...
... offer an attractive option. In particular, pharmacological approaches aimed at modification of gene expression, rather than the gene itself, constitute an ideal strategy for a subset of genetic diseases in which the molecular defect is known and can be circumvented. This is the case for premature st ...
Genome
... In this exercise, we will use BLAST (Basic Local Alignment Search Tool) to search for significant occurrences of a class of transposable elements (TEs) called Short INterspersed Elements (SINEs), specifically of the ALU family, in the well-known VHL tumor suppressor gene. The goal of this exercise i ...
... In this exercise, we will use BLAST (Basic Local Alignment Search Tool) to search for significant occurrences of a class of transposable elements (TEs) called Short INterspersed Elements (SINEs), specifically of the ALU family, in the well-known VHL tumor suppressor gene. The goal of this exercise i ...
The Drosophila Gene Disruption Project: Progress
... ABSTRACT The Drosophila Gene Disruption Project (GDP) has created a public collection of mutant strains containing single transposon insertions associated with different genes. These strains often disrupt gene function directly, allow production of new alleles, and have many other applications for a ...
... ABSTRACT The Drosophila Gene Disruption Project (GDP) has created a public collection of mutant strains containing single transposon insertions associated with different genes. These strains often disrupt gene function directly, allow production of new alleles, and have many other applications for a ...
The Optimal Discovery Procedure II: Applications to Comparative
... are differentially expressed across varying biological conditions based on microarray data (3). It is now possible to simultaneously measure thousands of related variables or “features” in a variety of biological studies. A rich yet largely unknown structure is usually expected to be present among t ...
... are differentially expressed across varying biological conditions based on microarray data (3). It is now possible to simultaneously measure thousands of related variables or “features” in a variety of biological studies. A rich yet largely unknown structure is usually expected to be present among t ...
1 Oviduct-embryo interactions in cattle
... There is clear evidence of a two-way interaction between the uterus and developing conceptus. For example, it has been well demonstrated that circulating progesterone (P4) directly regulates uterine gene expression that, in turn, drives conceptus elongation [2, 3]. Up to the time of maternal recogni ...
... There is clear evidence of a two-way interaction between the uterus and developing conceptus. For example, it has been well demonstrated that circulating progesterone (P4) directly regulates uterine gene expression that, in turn, drives conceptus elongation [2, 3]. Up to the time of maternal recogni ...
Detection of mutation status of IgVH genes and minimal residual
... disease. The fact that overall survival was inferior for the subgroups with unmutated IgVH, 11q-, or 17p-, suggests that response to therapy may be different in genetic subgroups[19-21]. In particular, the deletion 17p- and -possibly- abnormalities of the p53 gene involved in this aberration have be ...
... disease. The fact that overall survival was inferior for the subgroups with unmutated IgVH, 11q-, or 17p-, suggests that response to therapy may be different in genetic subgroups[19-21]. In particular, the deletion 17p- and -possibly- abnormalities of the p53 gene involved in this aberration have be ...
Loss of heterozygosity at D8S262: an early genetic event of
... precancerous lesion of HCC. However, many professional scholars considered that the histopathological characteristics of NAH was similar to that of DN when our previous studies were reviewed by them [10], and it should be classified as DN according to their comments and WHO criteria. As the scheme o ...
... precancerous lesion of HCC. However, many professional scholars considered that the histopathological characteristics of NAH was similar to that of DN when our previous studies were reviewed by them [10], and it should be classified as DN according to their comments and WHO criteria. As the scheme o ...
A series of promoters for constitutive expression of heterologous
... several harmful genes. Despite their usefulness, however, it may be a drawback that these promoters should be stimulated under the specific conditions that allow their activation. The nmt1 promoter, for ...
... several harmful genes. Despite their usefulness, however, it may be a drawback that these promoters should be stimulated under the specific conditions that allow their activation. The nmt1 promoter, for ...
Population Differences in the Polyalanine Domain and 6
... (4, 5 ). The phenotype of the disease is variable (39% of patients present with a severe phenotype, 29% are clinically apparent, 28% have changes apparent only on x-ray, and 4% are asymptomatic), indicating that the manifestation and severity of the disease might depend not only on HLXB9 mutations, ...
... (4, 5 ). The phenotype of the disease is variable (39% of patients present with a severe phenotype, 29% are clinically apparent, 28% have changes apparent only on x-ray, and 4% are asymptomatic), indicating that the manifestation and severity of the disease might depend not only on HLXB9 mutations, ...
CHAPTER 17 Variation in Chromosomal Number and Structure
... iii. Chemicals. iv.Transposable elements. v. Errors in recombination. b. Deletions do not revert, because the DNA is missing. ...
... iii. Chemicals. iv.Transposable elements. v. Errors in recombination. b. Deletions do not revert, because the DNA is missing. ...
Spontaneous Mutations in the CsrRS Two
... q 2001 by the Infectious Diseases Society of America. All rights reserved. ...
... q 2001 by the Infectious Diseases Society of America. All rights reserved. ...
Playing by pair-rules?
... c-hairy1.(35) Using MyoD as a marker, it was determined that the stripes resulting from this cyclical pattern in fact correspond to every somite, rather than every other somite.(34) Controversy, however, is often resilient. her1, it turns out, is expressed in largely overlapping patterns with a clos ...
... c-hairy1.(35) Using MyoD as a marker, it was determined that the stripes resulting from this cyclical pattern in fact correspond to every somite, rather than every other somite.(34) Controversy, however, is often resilient. her1, it turns out, is expressed in largely overlapping patterns with a clos ...
Mutations affecting development of the zebrafish retina
... Mutations in this category also lead to an abnormal brain shape (Schier et al., 1996), curved body axis and frequently reduced or absent circulation. The phenotypes caused by omem98 and nokm227 are very similar to each other. The glom117 phenotype is more pleiotropic, causing a much stronger brain d ...
... Mutations in this category also lead to an abnormal brain shape (Schier et al., 1996), curved body axis and frequently reduced or absent circulation. The phenotypes caused by omem98 and nokm227 are very similar to each other. The glom117 phenotype is more pleiotropic, causing a much stronger brain d ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.