Mouse models of obesity
... to result in early-onset obesity, non–insulin-dependent diabetes, and other obesityassociated syndromes. These symptoms are a parallel to the yellow agouti mouse syndrome, indicating that agouti expression in the hypothalamus inhibits Mc4r function, leading to obesity. Targeted deletion of the Mc3r ...
... to result in early-onset obesity, non–insulin-dependent diabetes, and other obesityassociated syndromes. These symptoms are a parallel to the yellow agouti mouse syndrome, indicating that agouti expression in the hypothalamus inhibits Mc4r function, leading to obesity. Targeted deletion of the Mc3r ...
A plant dialect of the histone language
... biotinylation, which can all cause structural and functional rearrangements in chromatin and are therefore essential elements of the complex ‘epigenetic histone code’ [5,6]. To decipher this code, which is recognized and interpreted by transcriptional regulators and chromatin remodeling machines, is ...
... biotinylation, which can all cause structural and functional rearrangements in chromatin and are therefore essential elements of the complex ‘epigenetic histone code’ [5,6]. To decipher this code, which is recognized and interpreted by transcriptional regulators and chromatin remodeling machines, is ...
Enlis Genome Research - Release Notes
... search and the associated parent genomes. The tool will find genes with protein-coding variations from each parent and rank the genes based on severity of impact. Options are available to decide which type of variations to analyze and category of genes to search. - Main Application: Improved startup ...
... search and the associated parent genomes. The tool will find genes with protein-coding variations from each parent and rank the genes based on severity of impact. Options are available to decide which type of variations to analyze and category of genes to search. - Main Application: Improved startup ...
Tutorial - QIAGEN Bioinformatics
... Figure 1: Toolbox folder structure after installation of the Bisulfite Sequencing plugin. Bisulfite sequencing is the use of bisulphite treatment of DNA to determine its pattern of methylation. DNA methylation was the first discovered epigenetic mark, and remains the most studied. Changes in cytosin ...
... Figure 1: Toolbox folder structure after installation of the Bisulfite Sequencing plugin. Bisulfite sequencing is the use of bisulphite treatment of DNA to determine its pattern of methylation. DNA methylation was the first discovered epigenetic mark, and remains the most studied. Changes in cytosin ...
****Disclaimer- This is not an exhaustive list of everything that may
... How does DNA packaging regulate gene expression? Describe X chromosome inactivation. Describe activators and repressors and their role in transcription. Describe alternative splicing. Be able to name and describe the mechanisms for regulation of translation and later stages of gene expression. 7. De ...
... How does DNA packaging regulate gene expression? Describe X chromosome inactivation. Describe activators and repressors and their role in transcription. Describe alternative splicing. Be able to name and describe the mechanisms for regulation of translation and later stages of gene expression. 7. De ...
Adaptation of Sucrose Metabolism in the Escherichia coli Wild
... csc regulon comprises three genes for a sucrose permease, a fructokinase, and a sucrose hydrolase (genes cscB, cscK, and cscA, respectively). The genes are arranged in two operons and are negatively controlled at the transcriptional level by the repressor CscR. Furthermore, csc gene expression was f ...
... csc regulon comprises three genes for a sucrose permease, a fructokinase, and a sucrose hydrolase (genes cscB, cscK, and cscA, respectively). The genes are arranged in two operons and are negatively controlled at the transcriptional level by the repressor CscR. Furthermore, csc gene expression was f ...
Recurrence time statistics: Versatile tools for genomic DNA
... The structure of human genome and genomes of other organisms is very complicated. With the completion of many different types of genomes, especially the human genome, one of the grand challenges for the future genomics research is to comprehensively identify the structural and functional components ...
... The structure of human genome and genomes of other organisms is very complicated. With the completion of many different types of genomes, especially the human genome, one of the grand challenges for the future genomics research is to comprehensively identify the structural and functional components ...
Hereditary hemorrhagic telangiectasia: genetics and molecular
... both genes. Although less common than missense mutations in ENG and ACVRL1, the proportion of mutations causing a truncating frameshift or stop codon (i.e., indels and non-sense mutations) are more frequent in ENG than in ACVRL1 (Lesca et al., 2004 3 ). No common mutation “hotspots” have been observ ...
... both genes. Although less common than missense mutations in ENG and ACVRL1, the proportion of mutations causing a truncating frameshift or stop codon (i.e., indels and non-sense mutations) are more frequent in ENG than in ACVRL1 (Lesca et al., 2004 3 ). No common mutation “hotspots” have been observ ...
CRISPR-Cas9 Mouse Toolbox
... of adenocarcinoma pathology. These plasmids as well as a backbone plasmid for cloning new targets are described here. 1. AAV:ITR-U6-sgRNA(Kras)-U6-sgRNA(p53)-U6-sgRNA(Lkb1)-pEFS-Rluc-2A-CreshortPA-KrasG12D_HDRdonor-ITR (AAV-KPL) This plasmid contains two expression cassettes, Renilla luciferase-2A-C ...
... of adenocarcinoma pathology. These plasmids as well as a backbone plasmid for cloning new targets are described here. 1. AAV:ITR-U6-sgRNA(Kras)-U6-sgRNA(p53)-U6-sgRNA(Lkb1)-pEFS-Rluc-2A-CreshortPA-KrasG12D_HDRdonor-ITR (AAV-KPL) This plasmid contains two expression cassettes, Renilla luciferase-2A-C ...
Genetic Testing for Marfan Syndrome, Thoracic Aortic Aneurysms
... patients without a defined coding sequence or splice site by sequence analysis is unknown, it is estimated to be about 30%. The most common testing strategy of a proband suspected of having MFS is sequence analysis followed by deletion/duplication analysis if a pathogenic variant is not identified.2 ...
... patients without a defined coding sequence or splice site by sequence analysis is unknown, it is estimated to be about 30%. The most common testing strategy of a proband suspected of having MFS is sequence analysis followed by deletion/duplication analysis if a pathogenic variant is not identified.2 ...
Comparative Genomics of Microbes
... CG helps to ask some interesting questions • Identification similarities/differences between genomes may allow us to understand : – How 2 organisms evolved? – Why certain bacteria cause diseases while others do not? – Identification and prioritization of drug targets ...
... CG helps to ask some interesting questions • Identification similarities/differences between genomes may allow us to understand : – How 2 organisms evolved? – Why certain bacteria cause diseases while others do not? – Identification and prioritization of drug targets ...
ORIGINAL ARTICLE NOTCH1-induced T
... novel cancer pathways.19 Comparisons of zebrafish and mammalian hematopoiesis and lymphopoiesis indicate that the genetic programs underlying vertebrate blood development have been highly conserved through evolution.20 The zebrafish exhibit thymic architecture similar to mammals, with a cortical and ...
... novel cancer pathways.19 Comparisons of zebrafish and mammalian hematopoiesis and lymphopoiesis indicate that the genetic programs underlying vertebrate blood development have been highly conserved through evolution.20 The zebrafish exhibit thymic architecture similar to mammals, with a cortical and ...
2006 - Genetics, development and evolution of adaptive
... William Russell created a T-stock mouse packed with seven recessive, viable, radiation-induced mutations, six of which were coat color mutations (Russell, 1951). By examining large numbers of progeny (485 000) from crosses of T-stock mice to mutagenized animals, Russell was able to estimate the rate ...
... William Russell created a T-stock mouse packed with seven recessive, viable, radiation-induced mutations, six of which were coat color mutations (Russell, 1951). By examining large numbers of progeny (485 000) from crosses of T-stock mice to mutagenized animals, Russell was able to estimate the rate ...
Recent advances in the molecular genetics of congenital
... gene may not develop the disease (incomplete penetrance) while other individuals without the susceptibility allele may have the disease (phenocopy). This lack of correlation between genotype and phenotype causes great dif®culties in de®ning the susceptibility loci for complex disorders (Lander & Sch ...
... gene may not develop the disease (incomplete penetrance) while other individuals without the susceptibility allele may have the disease (phenocopy). This lack of correlation between genotype and phenotype causes great dif®culties in de®ning the susceptibility loci for complex disorders (Lander & Sch ...
Homologous Recombination Between Episomal Plasmids and Chromosomes in Yeast.
... mitotic recombination between closely linked markers. This result was reproduced in the mitotic crosses in Table 3, where factors of increase of more than tenfold relative to the spontaneous rate were found. However, the stimulation of recombination between plasmid and chromosome by the same doses o ...
... mitotic recombination between closely linked markers. This result was reproduced in the mitotic crosses in Table 3, where factors of increase of more than tenfold relative to the spontaneous rate were found. However, the stimulation of recombination between plasmid and chromosome by the same doses o ...
Risks from GMOs due to Horizontal Gene Transfer
... et al., 2004), whereas the simplified conditions in laboratory studies probably lack many of the appropriate biotic and abiotic signals that facilitate HGT in nature (Mel and Mekalanos, 1996; Nielsen and van Elsas, 2001). For example, the presence of algae stimulates the release of bacterial plasmid ...
... et al., 2004), whereas the simplified conditions in laboratory studies probably lack many of the appropriate biotic and abiotic signals that facilitate HGT in nature (Mel and Mekalanos, 1996; Nielsen and van Elsas, 2001). For example, the presence of algae stimulates the release of bacterial plasmid ...
No Slide Title
... Center for Biophysics & Computational Biology University of Illinois at Urbana-Champaign ...
... Center for Biophysics & Computational Biology University of Illinois at Urbana-Champaign ...
Molecular genetics of macular dystrophies
... disorders spanning a broad spectrum of clinical, histopathological, and laboratory findings. Despite this variability, funduscopic changes involving the macula and retinal pigment epithelium (RPE) and clinically significant loss of central or functional vision are characteristic of these disorders. ...
... disorders spanning a broad spectrum of clinical, histopathological, and laboratory findings. Despite this variability, funduscopic changes involving the macula and retinal pigment epithelium (RPE) and clinically significant loss of central or functional vision are characteristic of these disorders. ...
A method for finding molecular signatures from gene expression data
... particular biological response.” (Rosenwald et al., 2002, N. Eng. J. Med., 346, p. 1942) Often used as independent variables to model clinically relevant information (cancer vs. healthy, survival time, etc). Provide insight into biological mechanisms and processes and have potential diagnostic use. ...
... particular biological response.” (Rosenwald et al., 2002, N. Eng. J. Med., 346, p. 1942) Often used as independent variables to model clinically relevant information (cancer vs. healthy, survival time, etc). Provide insight into biological mechanisms and processes and have potential diagnostic use. ...
Gene Section AIP (aryl hydrocarbon receptor interacting protein) in Oncology and Haematology
... (aryl hydrocarbon receptor). AIP regulates its subcellular localization and degradation. AhR, also known as dioxin receptor is a ligand activated transcription factor found in the cytoplasm as part of a multiprotein complex with Hsp90 (Perdew, 1988), AIP (Carver and Bradfield, 1997; Meyer et al., 19 ...
... (aryl hydrocarbon receptor). AIP regulates its subcellular localization and degradation. AhR, also known as dioxin receptor is a ligand activated transcription factor found in the cytoplasm as part of a multiprotein complex with Hsp90 (Perdew, 1988), AIP (Carver and Bradfield, 1997; Meyer et al., 19 ...
- Global Genes
... “retail therapy” that makes you feel better after you buy a new pair of bootcut jeans. Gene therapy is a scientific approach to directly fixing the change in a gene or genes. There can be different approaches to gene therapy based on what the change in the gene is. Gene therapy can involve: • Inser ...
... “retail therapy” that makes you feel better after you buy a new pair of bootcut jeans. Gene therapy is a scientific approach to directly fixing the change in a gene or genes. There can be different approaches to gene therapy based on what the change in the gene is. Gene therapy can involve: • Inser ...
The human Y chromosome: a sole survivor Noordam, MJ - UvA-DARE
... Our results provide evidence that DAZ gene copy number has a significant effect on semen quality and thus reproductive fitness. This effect of DAZ on spermatogenesis was noticed previously in DAZL-knockout mice and in studies where human DAZ rescued spermatogenesis in the mouse DAZL-knockout and the ...
... Our results provide evidence that DAZ gene copy number has a significant effect on semen quality and thus reproductive fitness. This effect of DAZ on spermatogenesis was noticed previously in DAZL-knockout mice and in studies where human DAZ rescued spermatogenesis in the mouse DAZL-knockout and the ...
AnsteadSeniorHonorsThesis
... of Mcm10 in cancer is not yet fully known. One way to study a gene is to see the effects when it is no longer functioning. When eukaryotic organisms are homozygous deficient for Mcm10 they are still able to function despite the complete loss of the Mcm10 protein (Christensen, T. 2003). This suggests ...
... of Mcm10 in cancer is not yet fully known. One way to study a gene is to see the effects when it is no longer functioning. When eukaryotic organisms are homozygous deficient for Mcm10 they are still able to function despite the complete loss of the Mcm10 protein (Christensen, T. 2003). This suggests ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.